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Protein

Calcium uniporter regulatory subunit MCUb, mitochondrial

Gene

MCUB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-8949215 Mitochondrial calcium ion transport
R-HSA-8949664 Processing of SMDT1

Protein family/group databases

TCDBi1.A.77.1.12 the mg(2+)/ca(2+) uniporter (mcu) family

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium uniporter regulatory subunit MCUb, mitochondrialCurated
Short name:
MCUbBy similarity
Alternative name(s):
Coiled-coil domain-containing protein 109BCurated
Gene namesi
Name:MCUB1 PublicationImported
Synonyms:CCDC109BImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000005059.15
HGNCiHGNC:26076 MCUB
neXtProtiNX_Q9NWR8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55013
OpenTargetsiENSG00000005059
PharmGKBiPA145008731

Polymorphism and mutation databases

BioMutaiCCDC109B
DMDMi143955289

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionSequence analysisAdd BLAST35
ChainiPRO_000028298036 – 336Calcium uniporter regulatory subunit MCUb, mitochondrialAdd BLAST301

Proteomic databases

EPDiQ9NWR8
MaxQBiQ9NWR8
PaxDbiQ9NWR8
PeptideAtlasiQ9NWR8
PRIDEiQ9NWR8
ProteomicsDBi82963

PTM databases

iPTMnetiQ9NWR8
PhosphoSitePlusiQ9NWR8

Expressioni

Gene expression databases

BgeeiENSG00000005059
CleanExiHS_CCDC109B
GenevisibleiQ9NWR8 HS

Organism-specific databases

HPAiHPA048776

Interactioni

Subunit structurei

Heterooligomer with MCU; this reduces MCU channel activity. Homooligomer (By similarity). Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1.By similarity1 Publication

Protein-protein interaction databases

BioGridi120345, 8 interactors
CORUMiQ9NWR8
IntActiQ9NWR8, 2 interactors
STRINGi9606.ENSP00000378145

Structurei

3D structure databases

ProteinModelPortaliQ9NWR8
SMRiQ9NWR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili179 – 210Sequence analysisAdd BLAST32
Coiled coili297 – 323Sequence analysisAdd BLAST27

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2966 Eukaryota
ENOG410Y3YU LUCA
GeneTreeiENSGT00390000004496
HOGENOMiHOG000008081
HOVERGENiHBG060246
InParanoidiQ9NWR8
OMAiVTYFITF
OrthoDBiEOG091G092C
PhylomeDBiQ9NWR8
TreeFamiTF314435

Family and domain databases

InterProiView protein in InterPro
IPR006769 MCU_C
IPR039055 MCU_fam
PANTHERiPTHR13462 PTHR13462, 1 hit
PfamiView protein in Pfam
PF04678 MCU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NWR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQRGLWPWR TRLLPTPGTW RPARPWPLPP PPQVLRVKLC GNVKYYQSHH
60 70 80 90 100
YSTVVPPDEI TVIYRHGLPL VTLTLPSRKE RCQFVVKPML STVGSFLQDL
110 120 130 140 150
QNEDKGIKTA AIFTADGNMI SASTLMDILL MNDFKLVINK IAYDVQCPKR
160 170 180 190 200
EKPSNEHTAE MEHMKSLVHR LFTILHLEES QKKREHHLLE KIDHLKEQLQ
210 220 230 240 250
PLEQVKAGIE AHSEAKTSGL LWAGLALLSI QGGALAWLTW WVYSWDIMEP
260 270 280 290 300
VTYFITFANS MVFFAYFIVT RQDYTYSAVK SRQFLQFFHK KSKQQHFDVQ
310 320 330
QYNKLKEDLA KAKESLKQAR HSLCLQMQVE ELNEKN
Length:336
Mass (Da):39,082
Last modified:April 3, 2007 - v2
Checksum:i90C4BEBD5B1EFFD9
GO

Sequence cautioni

The sequence AAH02633 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91309 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti193D → G in CAG33515 (Ref. 4) Curated1
Sequence conflicti214E → G in CAG33515 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06014963I → N. Corresponds to variant dbSNP:rs4698744Ensembl.1
Natural variantiVAR_031443253Y → F. Corresponds to variant dbSNP:rs13846Ensembl.1
Natural variantiVAR_031444255I → V1 PublicationCorresponds to variant dbSNP:rs1053680Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000654 mRNA Translation: BAA91309.1 Different initiation.
AK291098 mRNA Translation: BAF83787.1
CH471057 Genomic DNA Translation: EAX06242.1
BC002633 mRNA Translation: AAH02633.1 Different initiation.
CR457234 mRNA Translation: CAG33515.1
CCDSiCCDS3683.2
RefSeqiNP_060388.2, NM_017918.4
UniGeneiHs.234149

Genome annotation databases

EnsembliENST00000394650; ENSP00000378145; ENSG00000005059
GeneIDi55013
KEGGihsa:55013
UCSCiuc011cfs.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMCUB_HUMAN
AccessioniPrimary (citable) accession number: Q9NWR8
Secondary accession number(s): A8K4Y3, Q6IAC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: July 18, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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