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Entry version 123 (11 Dec 2019)
Sequence version 2 (03 Apr 2007)
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Protein

Calcium uniporter regulatory subunit MCUb, mitochondrial

Gene

MCUB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8949215 Mitochondrial calcium ion transport
R-HSA-8949664 Processing of SMDT1

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.77.1.12 the mg(2+)/ca(2+) uniporter (mcu) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium uniporter regulatory subunit MCUb, mitochondrialCurated
Short name:
MCUbBy similarity
Alternative name(s):
Coiled-coil domain-containing protein 109BCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MCUB1 PublicationImported
Synonyms:CCDC109BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000005059.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26076 MCUB

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NWR8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55013

Open Targets

More...
OpenTargetsi
ENSG00000005059

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145008731

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NWR8 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MCUB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143955289

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 35MitochondrionSequence analysisAdd BLAST35
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000028298036 – 336Calcium uniporter regulatory subunit MCUb, mitochondrialAdd BLAST301

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NWR8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NWR8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NWR8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NWR8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NWR8

PeptideAtlas

More...
PeptideAtlasi
Q9NWR8

PRoteomics IDEntifications database

More...
PRIDEi
Q9NWR8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82963

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NWR8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NWR8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000005059 Expressed in 204 organ(s), highest expression level in blood

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NWR8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048776

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterooligomer with MCU; this reduces MCU channel activity. Homooligomer (By similarity).

Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1.

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120345, 9 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NWR8

Protein interaction database and analysis system

More...
IntActi
Q9NWR8, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000378145

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NWR8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NWR8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili179 – 210Sequence analysisAdd BLAST32
Coiled coili297 – 323Sequence analysisAdd BLAST27

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2966 Eukaryota
ENOG410Y3YU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158059

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008081

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NWR8

KEGG Orthology (KO)

More...
KOi
K22829

Identification of Orthologs from Complete Genome Data

More...
OMAi
LCGNLKY

Database of Orthologous Groups

More...
OrthoDBi
1076768at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NWR8

TreeFam database of animal gene trees

More...
TreeFami
TF314435

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006769 MCU_C
IPR039055 MCU_fam

The PANTHER Classification System

More...
PANTHERi
PTHR13462 PTHR13462, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04678 MCU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NWR8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLQRGLWPWR TRLLPTPGTW RPARPWPLPP PPQVLRVKLC GNVKYYQSHH
60 70 80 90 100
YSTVVPPDEI TVIYRHGLPL VTLTLPSRKE RCQFVVKPML STVGSFLQDL
110 120 130 140 150
QNEDKGIKTA AIFTADGNMI SASTLMDILL MNDFKLVINK IAYDVQCPKR
160 170 180 190 200
EKPSNEHTAE MEHMKSLVHR LFTILHLEES QKKREHHLLE KIDHLKEQLQ
210 220 230 240 250
PLEQVKAGIE AHSEAKTSGL LWAGLALLSI QGGALAWLTW WVYSWDIMEP
260 270 280 290 300
VTYFITFANS MVFFAYFIVT RQDYTYSAVK SRQFLQFFHK KSKQQHFDVQ
310 320 330
QYNKLKEDLA KAKESLKQAR HSLCLQMQVE ELNEKN
Length:336
Mass (Da):39,082
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90C4BEBD5B1EFFD9
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH02633 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91309 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti193D → G in CAG33515 (Ref. 4) Curated1
Sequence conflicti214E → G in CAG33515 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06014963I → N. Corresponds to variant dbSNP:rs4698744Ensembl.1
Natural variantiVAR_031443253Y → F. Corresponds to variant dbSNP:rs13846Ensembl.1
Natural variantiVAR_031444255I → V1 PublicationCorresponds to variant dbSNP:rs1053680Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000654 mRNA Translation: BAA91309.1 Different initiation.
AK291098 mRNA Translation: BAF83787.1
CH471057 Genomic DNA Translation: EAX06242.1
BC002633 mRNA Translation: AAH02633.1 Different initiation.
CR457234 mRNA Translation: CAG33515.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3683.2

NCBI Reference Sequences

More...
RefSeqi
NP_060388.2, NM_017918.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000394650; ENSP00000378145; ENSG00000005059

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55013

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55013

UCSC genome browser

More...
UCSCi
uc011cfs.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000654 mRNA Translation: BAA91309.1 Different initiation.
AK291098 mRNA Translation: BAF83787.1
CH471057 Genomic DNA Translation: EAX06242.1
BC002633 mRNA Translation: AAH02633.1 Different initiation.
CR457234 mRNA Translation: CAG33515.1
CCDSiCCDS3683.2
RefSeqiNP_060388.2, NM_017918.4

3D structure databases

SMRiQ9NWR8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120345, 9 interactors
CORUMiQ9NWR8
IntActiQ9NWR8, 9 interactors
STRINGi9606.ENSP00000378145

Protein family/group databases

TCDBi1.A.77.1.12 the mg(2+)/ca(2+) uniporter (mcu) family

PTM databases

iPTMnetiQ9NWR8
PhosphoSitePlusiQ9NWR8

Polymorphism and mutation databases

BioMutaiMCUB
DMDMi143955289

Proteomic databases

EPDiQ9NWR8
jPOSTiQ9NWR8
MassIVEiQ9NWR8
MaxQBiQ9NWR8
PaxDbiQ9NWR8
PeptideAtlasiQ9NWR8
PRIDEiQ9NWR8
ProteomicsDBi82963

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55013

Genome annotation databases

EnsembliENST00000394650; ENSP00000378145; ENSG00000005059
GeneIDi55013
KEGGihsa:55013
UCSCiuc011cfs.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55013
DisGeNETi55013
EuPathDBiHostDB:ENSG00000005059.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MCUB
HGNCiHGNC:26076 MCUB
HPAiHPA048776
neXtProtiNX_Q9NWR8
OpenTargetsiENSG00000005059
PharmGKBiPA145008731

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2966 Eukaryota
ENOG410Y3YU LUCA
GeneTreeiENSGT00940000158059
HOGENOMiHOG000008081
InParanoidiQ9NWR8
KOiK22829
OMAiLCGNLKY
OrthoDBi1076768at2759
PhylomeDBiQ9NWR8
TreeFamiTF314435

Enzyme and pathway databases

ReactomeiR-HSA-8949215 Mitochondrial calcium ion transport
R-HSA-8949664 Processing of SMDT1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MCUB human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55013
PharosiQ9NWR8 Tdark

Protein Ontology

More...
PROi
PR:Q9NWR8
RNActiQ9NWR8 protein

Gene expression databases

BgeeiENSG00000005059 Expressed in 204 organ(s), highest expression level in blood
GenevisibleiQ9NWR8 HS

Family and domain databases

InterProiView protein in InterPro
IPR006769 MCU_C
IPR039055 MCU_fam
PANTHERiPTHR13462 PTHR13462, 1 hit
PfamiView protein in Pfam
PF04678 MCU, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMCUB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NWR8
Secondary accession number(s): A8K4Y3, Q6IAC1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: December 11, 2019
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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