UniProtKB - Q9NWN3 (FBX34_HUMAN)
Protein
F-box only protein 34
Gene
FBXO34
Organism
Homo sapiens (Human)
Status
Functioni
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9NWN3 |
Names & Taxonomyi
Protein namesi | Recommended name: F-box only protein 34 |
Gene namesi | Name:FBXO34 Synonyms:FBX34 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000178974.9 |
HGNCi | HGNC:20201, FBXO34 |
MIMi | 609104, gene |
neXtProti | NX_Q9NWN3 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 55030 |
OpenTargetsi | ENSG00000178974 |
PharmGKBi | PA134910884 |
Miscellaneous databases
Pharosi | Q9NWN3, Tdark |
Polymorphism and mutation databases
BioMutai | FBXO34 |
DMDMi | 61252689 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119926 | 1 – 711 | F-box only protein 34Add BLAST | 711 |
Proteomic databases
MassIVEi | Q9NWN3 |
PaxDbi | Q9NWN3 |
PeptideAtlasi | Q9NWN3 |
PRIDEi | Q9NWN3 |
ProteomicsDBi | 82956 |
PTM databases
iPTMneti | Q9NWN3 |
PhosphoSitePlusi | Q9NWN3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000178974, Expressed in secondary oocyte and 244 other tissues |
ExpressionAtlasi | Q9NWN3, baseline and differential |
Genevisiblei | Q9NWN3, HS |
Organism-specific databases
HPAi | ENSG00000178974, Low tissue specificity |
Interactioni
Subunit structurei
Directly interacts with SKP1 and CUL1.
By similarityBinary interactionsi
Hide detailsQ9NWN3
Protein-protein interaction databases
BioGRIDi | 120359, 34 interactors |
IntActi | Q9NWN3, 32 interactors |
STRINGi | 9606.ENSP00000313159 |
Miscellaneous databases
RNActi | Q9NWN3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 572 – 624 | F-boxPROSITE-ProRule annotationAdd BLAST | 53 |
Phylogenomic databases
eggNOGi | ENOG502QRQQ, Eukaryota |
GeneTreei | ENSGT00530000064222 |
InParanoidi | Q9NWN3 |
OMAi | NSNRYDV |
OrthoDBi | 329015at2759 |
PhylomeDBi | Q9NWN3 |
TreeFami | TF331673 |
Family and domain databases
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR039594, FBXO34/46 |
PANTHERi | PTHR16271, PTHR16271, 1 hit |
SUPFAMi | SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9NWN3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHLKPYWKLQ KKEHPPEVSR ETQRTPMNHQ KAVNDETCKA SHITSSVFPS
60 70 80 90 100
ASLGKASSRK PFGILSPNVL CSMSGKSPVE SSLNVKTKKN APSATIHQGE
110 120 130 140 150
EEGPLDIWAV VKPGNTKEKI AFFASHQCSN RIGSMKIKSS WDIDGRATKR
160 170 180 190 200
RKKSGDLKKA KVQVERMREV NSRCYQPEPF ACGIEHCSVH YVSDSGDGVY
210 220 230 240 250
AGRPLSVIQM VAFLEQRASA LLASCSKNCT NSPAIVRFSG QSRGVPAVSE
260 270 280 290 300
SYSAPGACEE PTERGNLEVG EPQSEPVRVL DMVAKLESEC LKRQGQREPG
310 320 330 340 350
SLSRNNSFRR NVGRVLLANS TQADEGKTKK GVLEAPDTQV NPVGSVSVDC
360 370 380 390 400
GPSRADRCSP KEDQAWDGAS QDCPPLPAGV SFHIDSAELE PGSQTAVKNS
410 420 430 440 450
NRYDVEMTDE LVGLPFSSHT YSQASELPTD AVDCMSRELV SLTSRNPDQR
460 470 480 490 500
KESLCISITV SKVDKDQPSI LNSCEDPVPG MLFFLPPGQH LSDYSQLNES
510 520 530 540 550
TTKESSEASQ LEDAAGGDSA SEEKSGSAEP FVLPASSVES TLPVLEASSW
560 570 580 590 600
KKQVSHDFLE TRFKIQQLLE PQQYMAFLPH HIMVKIFRLL PTKSLVALKC
610 620 630 640 650
TCCYFKFIIE YYNIRPADSR WVRDPRYRED PCKQCKKKYV KGDVSLCRWH
660 670 680 690 700
PKPYCQALPY GPGYWMCCHR SQKGFPGCKL GLHDNHWVPA CHSFNRAIHK
710
KAKGTEAEEE Y
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V2U9 | G3V2U9_HUMAN | F-box only protein 34 | FBXO34 | 577 | Annotation score: |
Sequence cautioni
The sequence BAA91346 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD62596 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049047 | 432 | V → A. Corresponds to variant dbSNP:rs35070799Ensembl. | 1 | |
Natural variantiVAR_021489 | 470 | I → N3 PublicationsCorresponds to variant dbSNP:rs1045002Ensembl. | 1 | |
Natural variantiVAR_021490 | 533 | L → P3 PublicationsCorresponds to variant dbSNP:rs3742569Ensembl. | 1 | |
Natural variantiVAR_049048 | 704 | G → V. Corresponds to variant dbSNP:rs10138395Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX248268 mRNA Translation: CAD62596.1 Different initiation. BC095482 mRNA Translation: AAH95482.2 BC109120 mRNA Translation: AAI09121.1 BC109121 mRNA Translation: AAI09122.1 AK000732 mRNA Translation: BAA91346.1 Different initiation. CR457249 mRNA Translation: CAG33530.1 |
CCDSi | CCDS32086.1 |
RefSeqi | NP_060413.2, NM_017943.3 NP_689417.1, NM_152231.1 XP_005267848.1, XM_005267791.4 XP_006720248.1, XM_006720185.3 XP_016876881.1, XM_017021392.1 XP_016876882.1, XM_017021393.1 |
Genome annotation databases
Ensembli | ENST00000313833; ENSP00000313159; ENSG00000178974 ENST00000440021; ENSP00000394117; ENSG00000178974 |
GeneIDi | 55030 |
KEGGi | hsa:55030 |
UCSCi | uc001xbu.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX248268 mRNA Translation: CAD62596.1 Different initiation. BC095482 mRNA Translation: AAH95482.2 BC109120 mRNA Translation: AAI09121.1 BC109121 mRNA Translation: AAI09122.1 AK000732 mRNA Translation: BAA91346.1 Different initiation. CR457249 mRNA Translation: CAG33530.1 |
CCDSi | CCDS32086.1 |
RefSeqi | NP_060413.2, NM_017943.3 NP_689417.1, NM_152231.1 XP_005267848.1, XM_005267791.4 XP_006720248.1, XM_006720185.3 XP_016876881.1, XM_017021392.1 XP_016876882.1, XM_017021393.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120359, 34 interactors |
IntActi | Q9NWN3, 32 interactors |
STRINGi | 9606.ENSP00000313159 |
PTM databases
iPTMneti | Q9NWN3 |
PhosphoSitePlusi | Q9NWN3 |
Polymorphism and mutation databases
BioMutai | FBXO34 |
DMDMi | 61252689 |
Proteomic databases
MassIVEi | Q9NWN3 |
PaxDbi | Q9NWN3 |
PeptideAtlasi | Q9NWN3 |
PRIDEi | Q9NWN3 |
ProteomicsDBi | 82956 |
Protocols and materials databases
Antibodypediai | 24028, 105 antibodies |
Genome annotation databases
Ensembli | ENST00000313833; ENSP00000313159; ENSG00000178974 ENST00000440021; ENSP00000394117; ENSG00000178974 |
GeneIDi | 55030 |
KEGGi | hsa:55030 |
UCSCi | uc001xbu.4, human |
Organism-specific databases
CTDi | 55030 |
DisGeNETi | 55030 |
EuPathDBi | HostDB:ENSG00000178974.9 |
GeneCardsi | FBXO34 |
HGNCi | HGNC:20201, FBXO34 |
HPAi | ENSG00000178974, Low tissue specificity |
MIMi | 609104, gene |
neXtProti | NX_Q9NWN3 |
OpenTargetsi | ENSG00000178974 |
PharmGKBi | PA134910884 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRQQ, Eukaryota |
GeneTreei | ENSGT00530000064222 |
InParanoidi | Q9NWN3 |
OMAi | NSNRYDV |
OrthoDBi | 329015at2759 |
PhylomeDBi | Q9NWN3 |
TreeFami | TF331673 |
Enzyme and pathway databases
PathwayCommonsi | Q9NWN3 |
Miscellaneous databases
BioGRID-ORCSi | 55030, 1 hit in 845 CRISPR screens |
ChiTaRSi | FBXO34, human |
GenomeRNAii | 55030 |
Pharosi | Q9NWN3, Tdark |
PROi | PR:Q9NWN3 |
RNActi | Q9NWN3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000178974, Expressed in secondary oocyte and 244 other tissues |
ExpressionAtlasi | Q9NWN3, baseline and differential |
Genevisiblei | Q9NWN3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR039594, FBXO34/46 |
PANTHERi | PTHR16271, PTHR16271, 1 hit |
SUPFAMi | SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FBX34_HUMAN | |
Accessioni | Q9NWN3Primary (citable) accession number: Q9NWN3 Secondary accession number(s): Q2VPB5, Q4VBP5, Q86TY4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 12, 2003 |
Last sequence update: | March 15, 2005 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations