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Protein

Asparagine synthetase domain-containing protein 1

Gene

ASNSD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2For GATase activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid biosynthesis, Asparagine biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Asparagine synthetase domain-containing protein 1
Alternative name(s):
HCV NS3-transactivated protein 1
Gene namesi
Name:ASNSD1
Synonyms:NS3TP1
ORF Names:Nbla00058
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000138381.9
HGNCiHGNC:24910 ASNSD1
neXtProtiNX_Q9NWL6

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000138381
PharmGKBiPA143485312

Polymorphism and mutation databases

BioMutaiASNSD1
DMDMi311033363

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003247602 – 643Asparagine synthetase domain-containing protein 1Add BLAST642

Proteomic databases

EPDiQ9NWL6
MaxQBiQ9NWL6
PaxDbiQ9NWL6
PeptideAtlasiQ9NWL6
PRIDEiQ9NWL6
ProteomicsDBi82945

PTM databases

iPTMnetiQ9NWL6
PhosphoSitePlusiQ9NWL6

Expressioni

Gene expression databases

BgeeiENSG00000138381 Expressed in 230 organ(s), highest expression level in kidney
CleanExiHS_ASNSD1
ExpressionAtlasiQ9NWL6 baseline and differential
GenevisibleiQ9NWL6 HS

Organism-specific databases

HPAiHPA036132
HPA036133
HPA075042

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120017, 4 interactors
STRINGi9606.ENSP00000260952

Structurei

3D structure databases

ProteinModelPortaliQ9NWL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 184Glutamine amidotransferase type-2PROSITE-ProRule annotationAdd BLAST183
Domaini285 – 601Asparagine synthetaseAdd BLAST317

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiKOG0573 Eukaryota
COG0367 LUCA
GeneTreeiENSGT00390000012446
HOGENOMiHOG000038438
HOVERGENiHBG105031
InParanoidiQ9NWL6
OMAiSVLCWNG
OrthoDBiEOG091G09V2
PhylomeDBiQ9NWL6
TreeFamiTF314578

Family and domain databases

CDDicd01991 Asn_Synthase_B_C, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR001962 Asn_synthase
IPR017932 GATase_2_dom
IPR029055 Ntn_hydrolases_N
PfamiView protein in Pfam
PF00733 Asn_synthase, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NWL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCGICCSVNF SAEHFSQDLK EDLLYNLKQR GPNSSKQLLK SDVNYQCLFS
60 70 80 90 100
AHVLHLRGVL TTQPVEDERG NVFLWNGEIF SGIKVEAEEN DTQILFNYLS
110 120 130 140 150
SCKNESEILS LFSEVQGPWS FIYYQASSHY LWFGRDFFGR RSLLWHFSNL
160 170 180 190 200
GKSFCLSSVG TQTSGLANQW QEVPASGLFR IDLKSTVISG CIILQLYPWK
210 220 230 240 250
YISRENIIEE NVNSLSQISA DLPAFVSVVA NEAKLYLEKP VVPLNMMLPQ
260 270 280 290 300
AALETHCSNI SNVPPTREIL QVFLTDVHMK EVIQQFIDVL SVAVKKRVLC
310 320 330 340 350
LPRDENLTAN EVLKTCDRKA NVAILFSGGI DSMVIATLAD RHIPLDEPID
360 370 380 390 400
LLNVAFIAEE KTMPTTFNRE GNKQKNKCEI PSEEFSKDVA AAAADSPNKH
410 420 430 440 450
VSVPDRITGR AGLKELQAVS PSRIWNFVEI NVSMEELQKL RRTRICHLIR
460 470 480 490 500
PLDTVLDDSI GCAVWFASRG IGWLVAQEGV KSYQSNAKVV LTGIGADEQL
510 520 530 540 550
AGYSRHRVRF QSHGLEGLNK EIMMELGRIS SRNLGRDDRV IGDHGKEARF
560 570 580 590 600
PFLDENVVSF LNSLPIWEKA NLTLPRGIGE KLLLRLAAVE LGLTASALLP
610 620 630 640
KRAMQFGSRI AKMEKINEKA SDKCGRLQIM SLENLSIEKE TKL
Length:643
Mass (Da):72,080
Last modified:November 2, 2010 - v2
Checksum:iC40C4AAC1607299F
GO
Isoform 2 (identifier: L0R819-1) [UniParc]FASTAAdd to basket
Also known as: uORF1 Publication
The sequence of this isoform can be found in the external entry L0R819.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Product of the upstream open reading frame of this bicistronic gene.3 Publications
Length:96
Mass (Da):11,250
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IYZ1C9IYZ1_HUMAN
Asparagine synthetase domain-contai...
ASNSD1
618Annotation score:
U3KQK8U3KQK8_HUMAN
Asparagine synthetase domain-contai...
ASNSD1
162Annotation score:
U3KQP1U3KQP1_HUMAN
Asparagine synthetase domain-contai...
ASNSD1
246Annotation score:
U3KQP6U3KQP6_HUMAN
Asparagine synthetase domain-contai...
ASNSD1
57Annotation score:
U3KQ49U3KQ49_HUMAN
Asparagine synthetase domain-contai...
ASNSD1
63Annotation score:
C9J6C1C9J6C1_HUMAN
Asparagine synthetase domain-contai...
ASNSD1
73Annotation score:
U3KQE3U3KQE3_HUMAN
Asparagine synthetase domain-contai...
ASNSD1
45Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039876190G → R5 PublicationsCorresponds to variant dbSNP:rs1437880Ensembl.1
Natural variantiVAR_039877434M → T. Corresponds to variant dbSNP:rs35137531Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY116969 mRNA Translation: AAM77212.1
AK000759 mRNA Translation: BAA91364.1
AC012488 Genomic DNA Translation: AAX88843.1
CH471058 Genomic DNA Translation: EAX10898.1
CH471058 Genomic DNA Translation: EAX10899.1
CH471058 Genomic DNA Translation: EAX10900.1
BC001243 mRNA Translation: AAH01243.1
AB075481 mRNA Translation: BAE45745.1
CCDSiCCDS2300.1 [Q9NWL6-1]
RefSeqiNP_061921.1, NM_019048.2 [Q9NWL6-1]
XP_016859870.1, XM_017004381.1
XP_016859871.1, XM_017004382.1
UniGeneiHs.101364

Genome annotation databases

EnsembliENST00000260952; ENSP00000260952; ENSG00000138381 [Q9NWL6-1]
GeneIDi54529
KEGGihsa:54529
UCSCiuc002uqt.4 human [Q9NWL6-1]

Keywords - Coding sequence diversityi

Alternative initiation, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY116969 mRNA Translation: AAM77212.1
AK000759 mRNA Translation: BAA91364.1
AC012488 Genomic DNA Translation: AAX88843.1
CH471058 Genomic DNA Translation: EAX10898.1
CH471058 Genomic DNA Translation: EAX10899.1
CH471058 Genomic DNA Translation: EAX10900.1
BC001243 mRNA Translation: AAH01243.1
AB075481 mRNA Translation: BAE45745.1
CCDSiCCDS2300.1 [Q9NWL6-1]
RefSeqiNP_061921.1, NM_019048.2 [Q9NWL6-1]
XP_016859870.1, XM_017004381.1
XP_016859871.1, XM_017004382.1
UniGeneiHs.101364

3D structure databases

ProteinModelPortaliQ9NWL6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120017, 4 interactors
STRINGi9606.ENSP00000260952

PTM databases

iPTMnetiQ9NWL6
PhosphoSitePlusiQ9NWL6

Polymorphism and mutation databases

BioMutaiASNSD1
DMDMi311033363

Proteomic databases

EPDiQ9NWL6
MaxQBiQ9NWL6
PaxDbiQ9NWL6
PeptideAtlasiQ9NWL6
PRIDEiQ9NWL6
ProteomicsDBi82945

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260952; ENSP00000260952; ENSG00000138381 [Q9NWL6-1]
GeneIDi54529
KEGGihsa:54529
UCSCiuc002uqt.4 human [Q9NWL6-1]

Organism-specific databases

CTDi54529
EuPathDBiHostDB:ENSG00000138381.9
GeneCardsiASNSD1
HGNCiHGNC:24910 ASNSD1
HPAiHPA036132
HPA036133
HPA075042
neXtProtiNX_Q9NWL6
OpenTargetsiENSG00000138381
PharmGKBiPA143485312
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0573 Eukaryota
COG0367 LUCA
GeneTreeiENSGT00390000012446
HOGENOMiHOG000038438
HOVERGENiHBG105031
InParanoidiQ9NWL6
OMAiSVLCWNG
OrthoDBiEOG091G09V2
PhylomeDBiQ9NWL6
TreeFamiTF314578

Miscellaneous databases

ChiTaRSiASNSD1 human
GenomeRNAii54529
PROiPR:Q9NWL6

Gene expression databases

BgeeiENSG00000138381 Expressed in 230 organ(s), highest expression level in kidney
CleanExiHS_ASNSD1
ExpressionAtlasiQ9NWL6 baseline and differential
GenevisibleiQ9NWL6 HS

Family and domain databases

CDDicd01991 Asn_Synthase_B_C, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR001962 Asn_synthase
IPR017932 GATase_2_dom
IPR029055 Ntn_hydrolases_N
PfamiView protein in Pfam
PF00733 Asn_synthase, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASND1_HUMAN
AccessioniPrimary (citable) accession number: Q9NWL6
Secondary accession number(s): D3DPH6, Q3LIC3, Q4ZG45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 2, 2010
Last modified: October 10, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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