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Protein

SAFB-like transcription modulator

Gene

SLTM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • sequence-specific DNA binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor, RNA-binding
Biological processApoptosis, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SAFB-like transcription modulator
Alternative name(s):
Modulator of estrogen-induced transcription
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLTM
Synonyms:MET
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000137776.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20709 SLTM

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NWH9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000137776

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670898

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLTM

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160185645

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003077982 – 1034SAFB-like transcription modulatorAdd BLAST1033

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei93PhosphoserineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Modified residuei139PhosphoserineBy similarity1
Modified residuei144PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1
Modified residuei401N6-acetyllysineCombined sources1
Modified residuei421PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki500Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei550PhosphoserineCombined sources1
Modified residuei551PhosphoserineCombined sources1
Modified residuei553PhosphoserineCombined sources1
Modified residuei748PhosphoserineCombined sources1
Modified residuei789PhosphoserineCombined sources1
Modified residuei800PhosphoserineCombined sources1
Modified residuei815PhosphoserineCombined sources1
Cross-linki884Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei909PhosphoserineCombined sources1
Modified residuei923PhosphoserineCombined sources1
Modified residuei929PhosphoserineCombined sources1
Modified residuei944PhosphoserineCombined sources1
Modified residuei998PhosphoserineCombined sources1
Modified residuei1002PhosphoserineCombined sources1
Modified residuei1014PhosphoserineCombined sources1
Modified residuei1017Omega-N-methylarginineCombined sources1
Modified residuei1019PhosphoserineCombined sources1
Modified residuei1021PhosphoserineCombined sources1
Modified residuei1024N6-acetyllysine; alternateCombined sources1
Cross-linki1024Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki1027Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NWH9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NWH9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NWH9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NWH9

PeptideAtlas

More...
PeptideAtlasi
Q9NWH9

PRoteomics IDEntifications database

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PRIDEi
Q9NWH9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82940

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NWH9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9NWH9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137776 Expressed in 226 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_MET
HS_SLTM

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NWH9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NWH9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040256
HPA040381

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122906, 36 interactors

Protein interaction database and analysis system

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IntActi
Q9NWH9, 14 interactors

Molecular INTeraction database

More...
MINTi
Q9NWH9

STRING: functional protein association networks

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STRINGi
9606.ENSP00000369887

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9NWH9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NWH9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 56SAPPROSITE-ProRule annotationAdd BLAST35
Domaini384 – 462RRMPROSITE-ProRule annotationAdd BLAST79

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili609 – 728Sequence analysisAdd BLAST120

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi108 – 239Glu-richAdd BLAST132
Compositional biasi569 – 906Arg/Glu-richAdd BLAST338

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4661 Eukaryota
ENOG4111FBJ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156573

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG096731

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NWH9

Identification of Orthologs from Complete Genome Data

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OMAi
RFSHGSD

Database of Orthologous Groups

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OrthoDBi
803886at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NWH9

TreeFam database of animal gene trees

More...
TreeFami
TF325240

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.720.30, 1 hit
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
IPR034780 SLTM

The PANTHER Classification System

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PANTHERi
PTHR15683:SF5 PTHR15683:SF5, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00076 RRM_1, 1 hit
PF02037 SAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00360 RRM, 1 hit
SM00513 SAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit
SSF68906 SSF68906, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 1 hit
PS50800 SAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NWH9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAATGAVAA SAASGQAEGK KITDLRVIDL KSELKRRNLD ITGVKTVLIS
60 70 80 90 100
RLKQAIEEEG GDPDNIELTV STDTPNKKPT KGKGKKHEAD ELSGDASVED
110 120 130 140 150
DAFIKDCELE NQEAHEQDGN DELKDSEEFG ENEEENVHSK ELLSAEENKR
160 170 180 190 200
AHELIEAEGI EDIEKEDIES QEIEAQEGED DTFLTAQDGE EEENEKDIAG
210 220 230 240 250
SGDGTQEVSK PLPSEGSLAE ADHTAHEEME AHTTVKEAED DNISVTIQAE
260 270 280 290 300
DAITLDFDGD DLLETGKNVK ITDSEASKPK DGQDAIAQSP EKESKDYEMN
310 320 330 340 350
ANHKDGKKED CVKGDPVEKE ARESSKKAES GDKEKDTLKK GPSSTGASGQ
360 370 380 390 400
AKSSSKESKD SKTSSKDDKG STSSTSGSSG SSTKNIWVSG LSSNTKAADL
410 420 430 440 450
KNLFGKYGKV LSAKVVTNAR SPGAKCYGIV TMSSSTEVSR CIAHLHRTEL
460 470 480 490 500
HGQLISVEKV KGDPSKKEMK KENDEKSSSR SSGDKKNTSD RSSKTQASVK
510 520 530 540 550
KEEKRSSEKS EKKESKDTKK IEGKDEKNDN GASGQTSESI KKSEEKKRIS
560 570 580 590 600
SKSPGHMVIL DQTKGDHCRP SRRGRYEKIH GRSKEKERAS LDKKRDKDYR
610 620 630 640 650
RKEILPFEKM KEQRLREHLV RFERLRRAME LRRRREIAER ERRERERIRI
660 670 680 690 700
IREREERERL QRERERLEIE RQKLERERME RERLERERIR IEQERRKEAE
710 720 730 740 750
RIAREREELR RQQQQLRYEQ EKRNSLKRPR DVDHRRDDPY WSENKKLSLD
760 770 780 790 800
TDARFGHGSD YSRQQNRFND FDHRERGRFP ESSAVQSSSF ERRDRFVGQS
810 820 830 840 850
EGKKARPTAR REDPSFERYP KNFSDSRRNE PPPPRNELRE SDRREVRGER
860 870 880 890 900
DERRTVIIHD RPDITHPRHP REAGPNPSRP TSWKSEGSMS TDKRETRVER
910 920 930 940 950
PERSGREVSG HSVRGAPPGN RSSASGYGSR EGDRGVITDR GGGSQHYPEE
960 970 980 990 1000
RHVVERHGRD TSGPRKEWHG PPSQGPSYHD TRRMGDGRAG AGMITQHSSN
1010 1020 1030
ASPINRIVQI SGNSMPRGSG SGFKPFKGGP PRRF
Length:1,034
Mass (Da):117,148
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF63F506929CFD6F
GO
Isoform 2 (identifier: Q9NWH9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-431: Missing.

Note: No experimental confirmation available.
Show »
Length:603
Mass (Da):71,067
Checksum:i853D368AF075F7E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXE3H7BXE3_HUMAN
SAFB-like transcription modulator
SLTM
453Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YL55H0YL55_HUMAN
SAFB-like transcription modulator
SLTM
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLE6H0YLE6_HUMAN
SAFB-like transcription modulator
SLTM
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3F4H7C3F4_HUMAN
SAFB-like transcription modulator
SLTM
600Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMW8H0YMW8_HUMAN
SAFB-like transcription modulator
SLTM
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNF3H0YNF3_HUMAN
SAFB-like transcription modulator
SLTM
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLW7H0YLW7_HUMAN
SAFB-like transcription modulator
SLTM
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMR6H0YMR6_HUMAN
SAFB-like transcription modulator
SLTM
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKU6H0YKU6_HUMAN
SAFB-like transcription modulator
SLTM
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKH2H0YKH2_HUMAN
SAFB-like transcription modulator
SLTM
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI08657 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB14502 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14971 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB14971 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti126S → F in BAA91401 (PubMed:14702039).Curated1
Sequence conflicti511E → V in BAA91401 (PubMed:14702039).Curated1
Sequence conflicti606P → S in AAH14944 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037088235V → L. Corresponds to variant dbSNP:rs7175939Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0560511 – 431Missing in isoform 2. 1 PublicationAdd BLAST431

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK000867 mRNA Translation: BAA91401.1
AK023275 mRNA Translation: BAB14502.1 Different initiation.
AK024710 mRNA Translation: BAB14971.1 Sequence problems.
AK055195 mRNA Translation: BAG51484.1
AK291423 mRNA Translation: BAF84112.1
AC025918 Genomic DNA No translation available.
AC090515 Genomic DNA No translation available.
BC014944 mRNA Translation: AAH14944.1
BC046119 mRNA Translation: AAH46119.3
BC108656 mRNA Translation: AAI08657.1 Sequence problems.
BC140851 mRNA Translation: AAI40852.1
AL834297 mRNA Translation: CAH56362.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10168.2 [Q9NWH9-1]

NCBI Reference Sequences

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RefSeqi
NP_001013865.1, NM_001013843.2
NP_079031.2, NM_024755.3 [Q9NWH9-1]
XP_006720753.1, XM_006720690.1 [Q9NWH9-3]
XP_016878069.1, XM_017022580.1 [Q9NWH9-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.512932

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000380516; ENSP00000369887; ENSG00000137776 [Q9NWH9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79811

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79811

UCSC genome browser

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UCSCi
uc002afp.3 human [Q9NWH9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000867 mRNA Translation: BAA91401.1
AK023275 mRNA Translation: BAB14502.1 Different initiation.
AK024710 mRNA Translation: BAB14971.1 Sequence problems.
AK055195 mRNA Translation: BAG51484.1
AK291423 mRNA Translation: BAF84112.1
AC025918 Genomic DNA No translation available.
AC090515 Genomic DNA No translation available.
BC014944 mRNA Translation: AAH14944.1
BC046119 mRNA Translation: AAH46119.3
BC108656 mRNA Translation: AAI08657.1 Sequence problems.
BC140851 mRNA Translation: AAI40852.1
AL834297 mRNA Translation: CAH56362.1
CCDSiCCDS10168.2 [Q9NWH9-1]
RefSeqiNP_001013865.1, NM_001013843.2
NP_079031.2, NM_024755.3 [Q9NWH9-1]
XP_006720753.1, XM_006720690.1 [Q9NWH9-3]
XP_016878069.1, XM_017022580.1 [Q9NWH9-3]
UniGeneiHs.512932

3D structure databases

ProteinModelPortaliQ9NWH9
SMRiQ9NWH9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122906, 36 interactors
IntActiQ9NWH9, 14 interactors
MINTiQ9NWH9
STRINGi9606.ENSP00000369887

PTM databases

iPTMnetiQ9NWH9
PhosphoSitePlusiQ9NWH9

Polymorphism and mutation databases

BioMutaiSLTM
DMDMi160185645

Proteomic databases

EPDiQ9NWH9
jPOSTiQ9NWH9
MaxQBiQ9NWH9
PaxDbiQ9NWH9
PeptideAtlasiQ9NWH9
PRIDEiQ9NWH9
ProteomicsDBi82940

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380516; ENSP00000369887; ENSG00000137776 [Q9NWH9-1]
GeneIDi79811
KEGGihsa:79811
UCSCiuc002afp.3 human [Q9NWH9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79811
EuPathDBiHostDB:ENSG00000137776.16

GeneCards: human genes, protein and diseases

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GeneCardsi
SLTM

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0012286
HGNCiHGNC:20709 SLTM
HPAiHPA040256
HPA040381
neXtProtiNX_Q9NWH9
OpenTargetsiENSG00000137776
PharmGKBiPA142670898

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4661 Eukaryota
ENOG4111FBJ LUCA
GeneTreeiENSGT00940000156573
HOVERGENiHBG096731
InParanoidiQ9NWH9
OMAiRFSHGSD
OrthoDBi803886at2759
PhylomeDBiQ9NWH9
TreeFamiTF325240

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLTM human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79811

Protein Ontology

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PROi
PR:Q9NWH9

Gene expression databases

BgeeiENSG00000137776 Expressed in 226 organ(s), highest expression level in testis
CleanExiHS_MET
HS_SLTM
ExpressionAtlasiQ9NWH9 baseline and differential
GenevisibleiQ9NWH9 HS

Family and domain databases

Gene3Di1.10.720.30, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
IPR034780 SLTM
PANTHERiPTHR15683:SF5 PTHR15683:SF5, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PF02037 SAP, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00513 SAP, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
SSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS50800 SAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLTM_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NWH9
Secondary accession number(s): A8K5V8
, B2RTX3, Q2VPK7, Q52MB3, Q658J7, Q6ZNF2, Q86TK6, Q9H7C3, Q9H8U9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: January 16, 2019
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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