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Protein

Transmembrane protein 242

Gene

TMEM242

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 242
Gene namesi
Name:TMEM242
Synonyms:C6orf35
ORF Names:BM-033, HSPC287
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000215712.10
HGNCiHGNC:17206 TMEM242
neXtProtiNX_Q9NWH2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000215712
PharmGKBiPA25936

Polymorphism and mutation databases

BioMutaiTMEM242
DMDMi74753021

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002958481 – 141Transmembrane protein 242Add BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NWH2
MaxQBiQ9NWH2
PaxDbiQ9NWH2
PeptideAtlasiQ9NWH2
PRIDEiQ9NWH2
ProteomicsDBi82937
TopDownProteomicsiQ9NWH2

PTM databases

iPTMnetiQ9NWH2
PhosphoSitePlusiQ9NWH2

Expressioni

Gene expression databases

BgeeiENSG00000215712 Expressed in 215 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_C6orf35
ExpressionAtlasiQ9NWH2 baseline and differential
GenevisibleiQ9NWH2 HS

Organism-specific databases

HPAiHPA025764

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi609914, 11 interactors
IntActiQ9NWH2, 21 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9NWH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM242 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVW9 Eukaryota
ENOG4111SBW LUCA
GeneTreeiENSGT00390000008642
HOGENOMiHOG000047628
HOVERGENiHBG057272
InParanoidiQ9NWH2
OMAiQEFRLKM
OrthoDBiEOG091G0YBU
PhylomeDBiQ9NWH2
TreeFamiTF323317

Family and domain databases

InterProiView protein in InterPro
IPR009792 TMEM242
PANTHERiPTHR13141 PTHR13141, 1 hit
PfamiView protein in Pfam
PF07096 DUF1358, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NWH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METAGAATGQ PASGLEAPGS TNDRLFLVKG GIFLGTVAAA GMLAGFITTL
60 70 80 90 100
SLAKKKSPEW FNKGSMATAA LPESGSSLAL RALGWGSLYA WCGVGVISFA
110 120 130 140
VWKALGVHSM NDFRSKMQSI FPTIPKNSES AVEWEETLKS K
Length:141
Mass (Da):14,758
Last modified:October 1, 2000 - v1
Checksum:i448CDA01809A2B37
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T2S1Q5T2S1_HUMAN
Transmembrane protein 242
TMEM242
128Annotation score:

Sequence cautioni

The sequence AAF28965 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAF67621 differs from that shown. Reason: Frameshift at position 130.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161405 mRNA Translation: AAF28965.1 Different initiation.
AF217510 mRNA Translation: AAF67621.1 Frameshift.
AK000891 mRNA Translation: BAA91409.1
AL607068 Genomic DNA No translation available.
AL390955 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47677.1
BC029130 mRNA Translation: AAH29130.1
BC146893 mRNA Translation: AAI46894.1
BC146895 mRNA Translation: AAI46896.1
CCDSiCCDS43519.1
RefSeqiNP_060922.2, NM_018452.5
UniGeneiHs.157212

Genome annotation databases

EnsembliENST00000400788; ENSP00000383594; ENSG00000215712
GeneIDi729515
KEGGihsa:729515
UCSCiuc003sih.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161405 mRNA Translation: AAF28965.1 Different initiation.
AF217510 mRNA Translation: AAF67621.1 Frameshift.
AK000891 mRNA Translation: BAA91409.1
AL607068 Genomic DNA No translation available.
AL390955 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47677.1
BC029130 mRNA Translation: AAH29130.1
BC146893 mRNA Translation: AAI46894.1
BC146895 mRNA Translation: AAI46896.1
CCDSiCCDS43519.1
RefSeqiNP_060922.2, NM_018452.5
UniGeneiHs.157212

3D structure databases

ProteinModelPortaliQ9NWH2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi609914, 11 interactors
IntActiQ9NWH2, 21 interactors

PTM databases

iPTMnetiQ9NWH2
PhosphoSitePlusiQ9NWH2

Polymorphism and mutation databases

BioMutaiTMEM242
DMDMi74753021

Proteomic databases

EPDiQ9NWH2
MaxQBiQ9NWH2
PaxDbiQ9NWH2
PeptideAtlasiQ9NWH2
PRIDEiQ9NWH2
ProteomicsDBi82937
TopDownProteomicsiQ9NWH2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400788; ENSP00000383594; ENSG00000215712
GeneIDi729515
KEGGihsa:729515
UCSCiuc003sih.5 human

Organism-specific databases

CTDi729515
EuPathDBiHostDB:ENSG00000215712.10
GeneCardsiTMEM242
HGNCiHGNC:17206 TMEM242
HPAiHPA025764
neXtProtiNX_Q9NWH2
OpenTargetsiENSG00000215712
PharmGKBiPA25936
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVW9 Eukaryota
ENOG4111SBW LUCA
GeneTreeiENSGT00390000008642
HOGENOMiHOG000047628
HOVERGENiHBG057272
InParanoidiQ9NWH2
OMAiQEFRLKM
OrthoDBiEOG091G0YBU
PhylomeDBiQ9NWH2
TreeFamiTF323317

Miscellaneous databases

GeneWikiiC6orf35
GenomeRNAii729515
PROiPR:Q9NWH2

Gene expression databases

BgeeiENSG00000215712 Expressed in 215 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_C6orf35
ExpressionAtlasiQ9NWH2 baseline and differential
GenevisibleiQ9NWH2 HS

Family and domain databases

InterProiView protein in InterPro
IPR009792 TMEM242
PANTHERiPTHR13141 PTHR13141, 1 hit
PfamiView protein in Pfam
PF07096 DUF1358, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM242_HUMAN
AccessioniPrimary (citable) accession number: Q9NWH2
Secondary accession number(s): B9EJD0, Q9NZ88, Q9P094
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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