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Protein

Solute carrier family 52, riboflavin transporter, member 1

Gene

SLC52A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Riboflavin transporter. Riboflavin transport is Na+-independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.38 µM for riboflavin1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • riboflavin transmembrane transporter activity Source: UniProtKB
    • virus receptor activity Source: UniProtKB-KW

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHost cell receptor for virus entry, Receptor
    Biological processTransport

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-196843 Vitamin B2 (riboflavin) metabolism

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.125.1.1 the eukaryotic riboflavin transporter (e-rft) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Solute carrier family 52, riboflavin transporter, member 1
    Alternative name(s):
    Porcine endogenous retrovirus A receptor 2
    Short name:
    PERV-A receptor 2
    Protein GPR172B
    Riboflavin transporter 1
    Short name:
    hRFT1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLC52A1Imported
    Synonyms:GPR172B, PAR2, RFT1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000132517.14

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:30225 SLC52A1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    607883 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9NWF4

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
    Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
    Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
    Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
    Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
    Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
    Transmembranei280 – 300HelicalSequence analysisAdd BLAST21
    Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
    Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
    Transmembranei369 – 389HelicalSequence analysisAdd BLAST21
    Transmembranei407 – 427HelicalSequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Riboflavin deficiency (RBFVD)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA disorder caused by a primary defect in riboflavin metabolism, or by dietary riboflavin deficiency. Riboflavin deficiency during pregnancy results in hypoglycemia, metabolic acidosis, dicarboxylic aciduria and elevated plasma acylcarnitine levels in the newborn. Treatment with oral riboflavin results in complete resolution of the clinical and biochemical findings.
    See also OMIM:615026

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    55065

    MalaCards human disease database

    More...
    MalaCardsi
    SLC52A1
    MIMi615026 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000132517

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    411712 Maternal riboflavin deficiency

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134991217

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SLC52A1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    308153487

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000426321 – 448Solute carrier family 52, riboflavin transporter, member 1Add BLAST448

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9NWF4

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9NWF4

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9NWF4

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    82930
    82931 [Q9NWF4-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9NWF4

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9NWF4

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed. Highly expressed in the testis, placenta and small intestine. Expressed at lower level in other tissues.3 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000132517 Expressed in 66 organ(s), highest expression level in placenta

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_GPR172B

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9NWF4 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9NWF4 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB011449

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    Protein interaction database and analysis system

    More...
    IntActi
    Q9NWF4, 8 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000254853

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q9NWF4

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi241 – 249Poly-Glu9

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the riboflavin transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG4255 Eukaryota
    ENOG410YE1U LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000003774

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000247012

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG051170

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9NWF4

    KEGG Orthology (KO)

    More...
    KOi
    K22117

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    SVNSLWV

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G0BZA

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9NWF4

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314820

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR009357 Riboflavin_transptr

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR12929 PTHR12929, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF06237 DUF1011, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9NWF4-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAAPTLGRLV LTHLLVALFG MGSWAAVNGI WVELPVVVKD LPEGWSLPSY
    60 70 80 90 100
    LSVVVALGNL GLLVVTLWRQ LAPGKGEQVP IQVVQVLSVV GTALLAPLWH
    110 120 130 140 150
    HVAPVAGQLH SVAFLTLALV LAMACCTSNV TFLPFLSHLP PPFLRSFFLG
    160 170 180 190 200
    QGLSALLPCV LALVQGVGRL ECPPAPTNGT SGPPLDFPER FPASTFFWAL
    210 220 230 240 250
    TALLVTSAAA FRGLLLLLPS LPSVTTGGSG PELQLGSPGA EEEEKEEEEA
    260 270 280 290 300
    LPLQEPPSQA AGTIPGPDPE AHQLFSAHGA FLLGLMAFTS AVTNGVLPSV
    310 320 330 340 350
    QSFSCLPYGR LAYHLAVVLG SAANPLACFL AMGVLCRSLA GLVGLSLLGM
    360 370 380 390 400
    LFGAYLMALA ILSPCPPLVG TTAGVVLVVL SWVLCLCVFS YVKVAASSLL
    410 420 430 440
    HGGGRPALLA AGVAIQVGSL LGAGAMFPPT SIYHVFQSRK DCVDPCGP
    Length:448
    Mass (Da):46,317
    Last modified:October 5, 2010 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9D2EDEE75405668
    GO
    Isoform 2 (identifier: Q9NWF4-2) [UniParc]FASTAAdd to basket
    Also known as: RFT1sv

    The sequence of this isoform differs from the canonical sequence as follows:
         45-167: WSLPSYLSVV...PCVLALVQGV → EWEGGTGKRG...LGVGNGLLYL
         168-448: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    Show »
    Length:167
    Mass (Da):16,360
    Checksum:iBADFC9E5E1C865E9
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    F5H5Y1F5H5Y1_HUMAN
    Solute carrier family 52, riboflavi...
    SLC52A1
    350Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02836170Q → R Riboflavin transport is unaffected. 5 PublicationsCorresponds to variant dbSNP:rs346822Ensembl.1
    Natural variantiVAR_028362271A → V2 PublicationsCorresponds to variant dbSNP:rs346821Ensembl.1
    Natural variantiVAR_028363296V → M Riboflavin transport is unaffected. 1 PublicationCorresponds to variant dbSNP:rs2304445Ensembl.1
    Natural variantiVAR_079006386L → V1 PublicationCorresponds to variant dbSNP:rs187609896Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03988845 – 167WSLPS…LVQGV → EWEGGTGKRGAGMPRKVACG SSLSLSHCAPDMASFLPCRL EPPLIPLCGCGAGKPGSAGG DPVEAAGPGQGRAGPHPGGT GAECSGHSPAGPSVAPRGPS GRAAPLCGLPNSGLGVGNGL LYL in isoform 2. 1 PublicationAdd BLAST123
    Alternative sequenceiVSP_039889168 – 448Missing in isoform 2. 1 PublicationAdd BLAST281

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AY070775 mRNA Translation: AAL59883.1
    AB362533 mRNA Translation: BAG71128.1
    AB362534 mRNA Translation: BAG71129.1
    AK000922 mRNA Translation: BAA91427.1
    AC012146 Genomic DNA No translation available.
    CH471108 Genomic DNA Translation: EAW90363.1
    CH471108 Genomic DNA Translation: EAW90364.1
    BC060810 mRNA Translation: AAH60810.1
    BC092473 mRNA Translation: AAH92473.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS11066.1 [Q9NWF4-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001098047.1, NM_001104577.1 [Q9NWF4-1]
    NP_060456.3, NM_017986.3 [Q9NWF4-1]
    XP_011522253.1, XM_011523951.1 [Q9NWF4-1]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.632247

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000254853; ENSP00000254853; ENSG00000132517 [Q9NWF4-1]
    ENST00000424747; ENSP00000399979; ENSG00000132517 [Q9NWF4-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    55065

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:55065

    UCSC genome browser

    More...
    UCSCi
    uc002gao.5 human [Q9NWF4-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY070775 mRNA Translation: AAL59883.1
    AB362533 mRNA Translation: BAG71128.1
    AB362534 mRNA Translation: BAG71129.1
    AK000922 mRNA Translation: BAA91427.1
    AC012146 Genomic DNA No translation available.
    CH471108 Genomic DNA Translation: EAW90363.1
    CH471108 Genomic DNA Translation: EAW90364.1
    BC060810 mRNA Translation: AAH60810.1
    BC092473 mRNA Translation: AAH92473.1
    CCDSiCCDS11066.1 [Q9NWF4-1]
    RefSeqiNP_001098047.1, NM_001104577.1 [Q9NWF4-1]
    NP_060456.3, NM_017986.3 [Q9NWF4-1]
    XP_011522253.1, XM_011523951.1 [Q9NWF4-1]
    UniGeneiHs.632247

    3D structure databases

    ProteinModelPortaliQ9NWF4
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    IntActiQ9NWF4, 8 interactors
    STRINGi9606.ENSP00000254853

    Protein family/group databases

    TCDBi2.A.125.1.1 the eukaryotic riboflavin transporter (e-rft) family

    PTM databases

    iPTMnetiQ9NWF4
    PhosphoSitePlusiQ9NWF4

    Polymorphism and mutation databases

    BioMutaiSLC52A1
    DMDMi308153487

    Proteomic databases

    PaxDbiQ9NWF4
    PeptideAtlasiQ9NWF4
    PRIDEiQ9NWF4
    ProteomicsDBi82930
    82931 [Q9NWF4-2]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    55065
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000254853; ENSP00000254853; ENSG00000132517 [Q9NWF4-1]
    ENST00000424747; ENSP00000399979; ENSG00000132517 [Q9NWF4-1]
    GeneIDi55065
    KEGGihsa:55065
    UCSCiuc002gao.5 human [Q9NWF4-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    55065
    DisGeNETi55065
    EuPathDBiHostDB:ENSG00000132517.14

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SLC52A1

    H-Invitational Database, human transcriptome db

    More...
    H-InvDBi
    HIX0023130
    HGNCiHGNC:30225 SLC52A1
    HPAiCAB011449
    MalaCardsiSLC52A1
    MIMi607883 gene
    615026 phenotype
    neXtProtiNX_Q9NWF4
    OpenTargetsiENSG00000132517
    Orphaneti411712 Maternal riboflavin deficiency
    PharmGKBiPA134991217

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG4255 Eukaryota
    ENOG410YE1U LUCA
    GeneTreeiENSGT00390000003774
    HOGENOMiHOG000247012
    HOVERGENiHBG051170
    InParanoidiQ9NWF4
    KOiK22117
    OMAiSVNSLWV
    OrthoDBiEOG091G0BZA
    PhylomeDBiQ9NWF4
    TreeFamiTF314820

    Enzyme and pathway databases

    ReactomeiR-HSA-196843 Vitamin B2 (riboflavin) metabolism

    Miscellaneous databases

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    55065

    Protein Ontology

    More...
    PROi
    PR:Q9NWF4

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000132517 Expressed in 66 organ(s), highest expression level in placenta
    CleanExiHS_GPR172B
    ExpressionAtlasiQ9NWF4 baseline and differential
    GenevisibleiQ9NWF4 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR009357 Riboflavin_transptr
    PANTHERiPTHR12929 PTHR12929, 1 hit
    PfamiView protein in Pfam
    PF06237 DUF1011, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS52A1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NWF4
    Secondary accession number(s): B5MEV1
    , B5MEV2, Q6P9E0, Q86UT0
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
    Last sequence update: October 5, 2010
    Last modified: November 7, 2018
    This is version 122 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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