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UniProtKB - Q9NWC5 (TM45A_HUMAN)
Protein
Transmembrane protein 45A
Gene
TMEM45A
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 45AAlternative name(s): DNA polymerase-transactivated protein 4 Dermal papilla-derived protein 7 |
Gene namesi | Name:TMEM45A Synonyms:DERP7, DNAPTP4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25480, TMEM45A |
neXtProti | NX_Q9NWC5 |
VEuPathDBi | HostDB:ENSG00000181458 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 7 – 27 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 51 – 71 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 100 – 120 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 150 – 170 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 218 – 238 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 55076 |
OpenTargetsi | ENSG00000181458 |
PharmGKBi | PA134868262 |
Miscellaneous databases
Pharosi | Q9NWC5, Tbio |
Genetic variation databases
BioMutai | TMEM45A |
DMDMi | 28380044 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072569 | 1 – 275 | Transmembrane protein 45AAdd BLAST | 275 |
Proteomic databases
jPOSTi | Q9NWC5 |
MassIVEi | Q9NWC5 |
MaxQBi | Q9NWC5 |
PaxDbi | Q9NWC5 |
PeptideAtlasi | Q9NWC5 |
PRIDEi | Q9NWC5 |
ProteomicsDBi | 82926 |
PTM databases
iPTMneti | Q9NWC5 |
PhosphoSitePlusi | Q9NWC5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000181458, Expressed in zone of skin and 208 other tissues |
ExpressionAtlasi | Q9NWC5, baseline and differential |
Genevisiblei | Q9NWC5, HS |
Organism-specific databases
HPAi | ENSG00000181458, Tissue enriched (skin) |
Interactioni
Binary interactionsi
Q9NWC5
Protein-protein interaction databases
BioGRIDi | 120393, 18 interactors |
IntActi | Q9NWC5, 12 interactors |
MINTi | Q9NWC5 |
STRINGi | 9606.ENSP00000319009 |
Miscellaneous databases
RNActi | Q9NWC5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TMEM45 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QU0J, Eukaryota |
GeneTreei | ENSGT00940000155530 |
HOGENOMi | CLU_059568_0_1_1 |
InParanoidi | Q9NWC5 |
PhylomeDBi | Q9NWC5 |
TreeFami | TF328673 |
Family and domain databases
InterProi | View protein in InterPro IPR006904, DUF716 IPR042127, TMEM45 |
PANTHERi | PTHR16007, PTHR16007, 1 hit |
Pfami | View protein in Pfam PF04819, DUF716, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9NWC5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGNFRGHALP GTFFFIIGLW WCTKSILKYI CKKQKRTCYL GSKTLFYRLE
60 70 80 90 100
ILEGITIVGM ALTGMAGEQF IPGGPHLMLY DYKQGHWNQL LGWHHFTMYF
110 120 130 140 150
FFGLLGVADI LCFTISSLPV SLTKLMLSNA LFVEAFIFYN HTHGREMLDI
160 170 180 190 200
FVHQLLVLVV FLTGLVAFLE FLVRNNVLLE LLRSSLILLQ GSWFFQIGFV
210 220 230 240 250
LYPPSGGPAW DLMDHENILF LTICFCWHYA VTIVIVGMNY AFITWLVKSR
260 270
LKRLCSSEVG LLKNAEREQE SEEEM
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KQ06 | J3KQ06_HUMAN | Transmembrane protein 45A | TMEM45A hCG_1811389 | 291 | Annotation score: | ||
C9J9Z5 | C9J9Z5_HUMAN | Transmembrane protein 45A | TMEM45A | 191 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB013911 mRNA Translation: BAB87801.1 AY450392 mRNA Translation: AAR21085.1 AK000996 mRNA Translation: BAA91458.1 BC040355 mRNA Translation: AAH40355.1 |
CCDSi | CCDS2937.1 |
RefSeqi | NP_060474.1, NM_018004.2 |
Genome annotation databases
Ensembli | ENST00000323523; ENSP00000319009; ENSG00000181458 |
GeneIDi | 55076 |
KEGGi | hsa:55076 |
MANE-Selecti | ENST00000323523.8; ENSP00000319009.4; NM_018004.3; NP_060474.1 |
UCSCi | uc003dtz.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB013911 mRNA Translation: BAB87801.1 AY450392 mRNA Translation: AAR21085.1 AK000996 mRNA Translation: BAA91458.1 BC040355 mRNA Translation: AAH40355.1 |
CCDSi | CCDS2937.1 |
RefSeqi | NP_060474.1, NM_018004.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7OQZ | electron microscopy | 3.27 | A/B/C/D | 3-275 | [»] | |
SMRi | Q9NWC5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120393, 18 interactors |
IntActi | Q9NWC5, 12 interactors |
MINTi | Q9NWC5 |
STRINGi | 9606.ENSP00000319009 |
PTM databases
iPTMneti | Q9NWC5 |
PhosphoSitePlusi | Q9NWC5 |
Genetic variation databases
BioMutai | TMEM45A |
DMDMi | 28380044 |
Proteomic databases
jPOSTi | Q9NWC5 |
MassIVEi | Q9NWC5 |
MaxQBi | Q9NWC5 |
PaxDbi | Q9NWC5 |
PeptideAtlasi | Q9NWC5 |
PRIDEi | Q9NWC5 |
ProteomicsDBi | 82926 |
Protocols and materials databases
Antibodypediai | 15847, 43 antibodies from 12 providers |
DNASUi | 55076 |
Genome annotation databases
Ensembli | ENST00000323523; ENSP00000319009; ENSG00000181458 |
GeneIDi | 55076 |
KEGGi | hsa:55076 |
MANE-Selecti | ENST00000323523.8; ENSP00000319009.4; NM_018004.3; NP_060474.1 |
UCSCi | uc003dtz.2, human |
Organism-specific databases
CTDi | 55076 |
DisGeNETi | 55076 |
GeneCardsi | TMEM45A |
HGNCi | HGNC:25480, TMEM45A |
HPAi | ENSG00000181458, Tissue enriched (skin) |
neXtProti | NX_Q9NWC5 |
OpenTargetsi | ENSG00000181458 |
PharmGKBi | PA134868262 |
VEuPathDBi | HostDB:ENSG00000181458 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QU0J, Eukaryota |
GeneTreei | ENSGT00940000155530 |
HOGENOMi | CLU_059568_0_1_1 |
InParanoidi | Q9NWC5 |
PhylomeDBi | Q9NWC5 |
TreeFami | TF328673 |
Enzyme and pathway databases
PathwayCommonsi | Q9NWC5 |
SignaLinki | Q9NWC5 |
Miscellaneous databases
BioGRID-ORCSi | 55076, 7 hits in 1011 CRISPR screens |
ChiTaRSi | TMEM45A, human |
GenomeRNAii | 55076 |
Pharosi | Q9NWC5, Tbio |
PROi | PR:Q9NWC5 |
RNActi | Q9NWC5, protein |
Gene expression databases
Bgeei | ENSG00000181458, Expressed in zone of skin and 208 other tissues |
ExpressionAtlasi | Q9NWC5, baseline and differential |
Genevisiblei | Q9NWC5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006904, DUF716 IPR042127, TMEM45 |
PANTHERi | PTHR16007, PTHR16007, 1 hit |
Pfami | View protein in Pfam PF04819, DUF716, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TM45A_HUMAN | |
Accessioni | Q9NWC5Primary (citable) accession number: Q9NWC5 Secondary accession number(s): Q53YW5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 12, 2003 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families