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Entry version 142 (26 Feb 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Arginine and glutamate-rich protein 1

Gene

ARGLU1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arginine and glutamate-rich protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARGLU1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25482 ARGLU1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614046 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NWB6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55082

Open Targets

More...
OpenTargetsi
ENSG00000134884

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162376869

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NWB6 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARGLU1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74753014

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002884381 – 273Arginine and glutamate-rich protein 1Add BLAST273

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei58PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei61PhosphothreonineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei266PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NWB6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NWB6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NWB6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NWB6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NWB6

PeptideAtlas

More...
PeptideAtlasi
Q9NWB6

PRoteomics IDEntifications database

More...
PRIDEi
Q9NWB6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82923 [Q9NWB6-1]
82924 [Q9NWB6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NWB6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NWB6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9NWB6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000134884 Expressed in left lobe of thyroid gland and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NWB6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NWB6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA034962
HPA056792

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Directly interacts with MED1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P783622EBI-2808785,EBI-593303

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120397, 52 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NWB6, 22 interactors

Molecular INTeraction database

More...
MINTi
Q9NWB6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000383059

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NWB6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NWB6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3 – 74Arg-richAdd BLAST72
Compositional biasi97 – 251Glu-richAdd BLAST155

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPF0430 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHEN Eukaryota
ENOG4111J08 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111249

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_076749_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NWB6

KEGG Orthology (KO)

More...
KOi
K13173

Identification of Orthologs from Complete Genome Data

More...
OMAi
THTERDY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NWB6

TreeFam database of animal gene trees

More...
TreeFami
TF324123

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033371 ARGLU1

The PANTHER Classification System

More...
PANTHERi
PTHR31711 PTHR31711, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15346 ARGLU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NWB6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRSRSRSSS RSKHTKSSKH NKKRSRSRSR SRDKERVRKR SKSRESKRNR
60 70 80 90 100
RRESRSRSRS TNTAVSRRER DRERASSPPD RIDIFGRTVS KRSSLDEKQK
110 120 130 140 150
REEEEKKAEF ERQRKIRQQE IEEKLIEEET ARRVEELVAK RVEEELEKRK
160 170 180 190 200
DEIEREVLRR VEEAKRIMEK QLLEELERQR QAELAAQKAR EEEERAKREE
210 220 230 240 250
LERILEENNR KIAEAQAKLA EEQLRIVEEQ RKIHEERMKL EQERQRQQKE
260 270
EQKIILGKGK SRPKLSFSLK TQD
Length:273
Mass (Da):33,216
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70B88496BF18AAE0
GO
Isoform 2 (identifier: Q9NWB6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-273: EEERAKREEL...KLSFSLKTQD → VTLGRLESRD...ILFDLMELAI

Show »
Length:273
Mass (Da):32,885
Checksum:iB5940853C1085382
GO
Isoform 3 (identifier: Q9NWB6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-90: Missing.
     192-273: EEERAKREEL...KLSFSLKTQD → VTLGRLESRD...ILFDLMELAI

Show »
Length:198
Mass (Da):23,834
Checksum:i1A015D05EC248B4E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05368516 – 90Missing in isoform 3. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_025674192 – 273EEERA…LKTQD → VTLGRLESRDSPWQNFQCWV LPPAQFRKRWNTDYLIPFSS KLNIAAKVNFLAYSEVLTDN LKVGSFYKTYSRILFDLMEL AI in isoform 2 and isoform 3. 2 PublicationsAdd BLAST82

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001016 mRNA Translation: BAA91467.1
AK303575 mRNA Translation: BAG64595.1
AL442127 Genomic DNA No translation available.
BC050434 mRNA Translation: AAH50434.1
BC071587 mRNA Translation: AAH71587.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41906.1 [Q9NWB6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060481.3, NM_018011.3 [Q9NWB6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000400198; ENSP00000383059; ENSG00000134884 [Q9NWB6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55082

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55082

UCSC genome browser

More...
UCSCi
uc001vqk.5 human [Q9NWB6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001016 mRNA Translation: BAA91467.1
AK303575 mRNA Translation: BAG64595.1
AL442127 Genomic DNA No translation available.
BC050434 mRNA Translation: AAH50434.1
BC071587 mRNA Translation: AAH71587.1
CCDSiCCDS41906.1 [Q9NWB6-1]
RefSeqiNP_060481.3, NM_018011.3 [Q9NWB6-1]

3D structure databases

SMRiQ9NWB6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120397, 52 interactors
IntActiQ9NWB6, 22 interactors
MINTiQ9NWB6
STRINGi9606.ENSP00000383059

PTM databases

iPTMnetiQ9NWB6
PhosphoSitePlusiQ9NWB6
SwissPalmiQ9NWB6

Polymorphism and mutation databases

BioMutaiARGLU1
DMDMi74753014

Proteomic databases

EPDiQ9NWB6
jPOSTiQ9NWB6
MassIVEiQ9NWB6
MaxQBiQ9NWB6
PaxDbiQ9NWB6
PeptideAtlasiQ9NWB6
PRIDEiQ9NWB6
ProteomicsDBi82923 [Q9NWB6-1]
82924 [Q9NWB6-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55082

Genome annotation databases

EnsembliENST00000400198; ENSP00000383059; ENSG00000134884 [Q9NWB6-1]
GeneIDi55082
KEGGihsa:55082
UCSCiuc001vqk.5 human [Q9NWB6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55082
DisGeNETi55082

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARGLU1
HGNCiHGNC:25482 ARGLU1
HPAiHPA034962
HPA056792
MIMi614046 gene
neXtProtiNX_Q9NWB6
OpenTargetsiENSG00000134884
PharmGKBiPA162376869

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHEN Eukaryota
ENOG4111J08 LUCA
GeneTreeiENSGT00730000111249
HOGENOMiCLU_076749_0_0_1
InParanoidiQ9NWB6
KOiK13173
OMAiTHTERDY
PhylomeDBiQ9NWB6
TreeFamiTF324123

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARGLU1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ARGLU1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55082
PharosiQ9NWB6 Tdark

Protein Ontology

More...
PROi
PR:Q9NWB6
RNActiQ9NWB6 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000134884 Expressed in left lobe of thyroid gland and 226 other tissues
ExpressionAtlasiQ9NWB6 baseline and differential
GenevisibleiQ9NWB6 HS

Family and domain databases

InterProiView protein in InterPro
IPR033371 ARGLU1
PANTHERiPTHR31711 PTHR31711, 1 hit
PfamiView protein in Pfam
PF15346 ARGLU, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARGL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NWB6
Secondary accession number(s): B4E0Y3, Q5T257, Q6IQ34
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2000
Last modified: February 26, 2020
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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