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UniProtKB - Q9NWB1 (RFOX1_HUMAN)

Entry version 174 (10 Feb 2021)
Sequence version 2 (05 Feb 2008)
Previous versions | rss
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Protein

RNA binding protein fox-1 homolog 1

Gene

RBFOX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • protein C-terminus binding Source: UniProtKB
  • RNA binding Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NWB1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9022707, MECP2 regulates transcription factors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA binding protein fox-1 homolog 1
Alternative name(s):
Ataxin-2-binding protein 1
Fox-1 homolog A
Hexaribonucleotide-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBFOX1
Synonyms:A2BP, A2BP1, FOX1, HRNBP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18222, RBFOX1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605104, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NWB1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000078328.19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi120H → A: Reduces RNA-binding affinity 160-fold. 1 Publication1
Mutagenesisi126F → A, I or R: Reduces RNA-binding affinity 1500-fold. 1 Publication1
Mutagenesisi126F → H or W: Reduces RNA-binding affinity 15-fold. 1 Publication1
Mutagenesisi126F → Y: No effect on RNA-binding. 1 Publication1
Mutagenesisi158F → A: Reduces RNA-binding affinity 700-fold. 1 Publication1
Mutagenesisi160F → A: Reduces RNA-binding affinity 30'000-fold. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		54715

MalaCards human disease database

More...MalaCardsi		RBFOX1

Open Targets

More...OpenTargetsi		ENSG00000078328

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NWB1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RBFOX1

Domain mapping of disease mutations (DMDM)

More...DMDMi		166897979

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000814801 – 397RNA binding protein fox-1 homolog 1Add BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei317Asymmetric dimethylarginineBy similarity1
Modified residuei388Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NWB1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NWB1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NWB1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NWB1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NWB1

PeptideAtlas

More...PeptideAtlasi		Q9NWB1

PRoteomics IDEntifications database

More...PRIDEi		Q9NWB1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82917 [Q9NWB1-1]
82918 [Q9NWB1-2]
82919 [Q9NWB1-3]
82920 [Q9NWB1-4]
82921 [Q9NWB1-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NWB1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NWB1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in muscle and brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000078328, Expressed in putamen and 196 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NWB1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NWB1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000078328, Group enriched (brain, heart muscle, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to the C-terminus of ATXN2.

1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei118Interaction with RNA1
Sitei126Interaction with RNA1
Sitei127Interaction with RNA1
Sitei151Interaction with RNA1
Sitei156Interaction with RNA1
Sitei160Interaction with RNA1
Sitei184Interaction with RNA1
Sitei194Interaction with RNA1

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q9NWB1
With#Exp.IntAct
ATN1 [P54259]2EBI-945906,EBI-945980
ATXN1 [P54253]2EBI-945906,EBI-930964
C1orf94 [Q6P1W5]3EBI-945906,EBI-946029
NUMBL [Q9Y6R0]2EBI-945906,EBI-945925
PLEKHA5 [Q9HAU0]2EBI-945906,EBI-945934
PSMF1 [Q92530]2EBI-945906,EBI-945916
QKI [Q96PU8]2EBI-945906,EBI-945792
RBFOX2 [O43251]2EBI-945906,EBI-746056
RBPMS [Q93062]3EBI-945906,EBI-740322
Isoform 5 [Q9NWB1-5]
With#Exp.IntAct
AGR2 [O95994]3EBI-12123390,EBI-712648
ARID5A [Q03989]3EBI-12123390,EBI-948603
ATN1 [Q86V38]3EBI-12123390,EBI-11954292
ATXN1 [P54253]6EBI-12123390,EBI-930964
ATXN1L [P0C7T5]3EBI-12123390,EBI-8624731
ATXN2 - isoform 5 [Q99700-5]3EBI-12123390,EBI-25891409
BHLHE40 [O14503]3EBI-12123390,EBI-711810
CRYAA2 [A0A140G945]3EBI-12123390,EBI-25838900
DAZAP2 [Q15038]4EBI-12123390,EBI-724310
DMWD [G5E9A7]3EBI-12123390,EBI-10976677
FAM168A - isoform 2 [Q92567-2]4EBI-12123390,EBI-11978259
FGFR3 [P22607]3EBI-12123390,EBI-348399
hCG_2003792 [A0A024R5S0]3EBI-12123390,EBI-10188461
KLK6 [Q92876]3EBI-12123390,EBI-2432309
LASP1 - isoform 2 [Q14847-2]3EBI-12123390,EBI-9088686
LMNA [P02545]3EBI-12123390,EBI-351935
P4HA3 [Q7Z4N8]3EBI-12123390,EBI-10181968
POGZ [Q7Z3K3]5EBI-12123390,EBI-1389308
RBM47 [A0AV96]3EBI-12123390,EBI-2823850
RBPMS - isoform C [Q93062-3]4EBI-12123390,EBI-740343
RBPMS2 [Q6ZRY4]3EBI-12123390,EBI-11987469
SIRPB1 - isoform 2 [O00241-2]3EBI-12123390,EBI-10179231
STRBP [A0A0S2Z5K8]3EBI-12123390,EBI-16433759
STRBP [Q96SI9]3EBI-12123390,EBI-740355
TEX37 [Q96LM6]3EBI-12123390,EBI-743976
TOLLIP [Q9H0E2]3EBI-12123390,EBI-74615
TSC1 [Q86WV8]3EBI-12123390,EBI-12806590
UBL3 [O95164]3EBI-12123390,EBI-12876508
VENTX [O95231]3EBI-12123390,EBI-10191303

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120107, 76 interactors

Protein interaction database and analysis system

More...IntActi		Q9NWB1, 78 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000309117

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NWB1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1397
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9NWB1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NWB1

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9NWB1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini117 – 193RRMPROSITE-ProRule annotationAdd BLAST77

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0125, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160685

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NWB1

Identification of Orthologs from Complete Genome Data

More...OMAi		LVYTSAX

Database of Orthologous Groups

More...OrthoDBi		871288at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NWB1

TreeFam database of animal gene trees

More...TreeFami		TF315942

Family and domain databases

Conserved Domains Database

More...CDDi		cd12407, RRM_FOX1_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025670, Fox-1_C_dom
IPR034237, FOX1_RRM
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR017325, RNA-bd_Fox-1
IPR000504, RRM_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12414, Fox-1_C, 1 hit
PF00076, RRM_1, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037932, Ataxin_2_bd_A2BP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360, RRM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102, RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NWB1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNCEREQLRG NQEAAAAPDT MAQPYASAQF APPQNGIPAE YTAPHPHPAP 
        60         70         80         90        100
EYTGQTTVPE HTLNLYPPAQ THSEQSPADT SAQTVSGTAT QTDDAAPTDG 
       110        120        130        140        150
QPQTQPSENT ENKSQPKRLH VSNIPFRFRD PDLRQMFGQF GKILDVEIIF 
       160        170        180        190        200
NERGSKGFGF VTFENSADAD RAREKLHGTV VEGRKIEVNN ATARVMTNKK 
       210        220        230        240        250
TVNPYTNGWK LNPVVGAVYS PEFYAGTVLL CQANQEGSSM YSAPSSLVYT 
       260        270        280        290        300
SAMPGFPYPA ATAAAAYRGA HLRGRGRTVY NTFRAAAPPP PIPAYGGVVY 
       310        320        330        340        350
QDGFYGADIY GGYAAYRYAQ PTPATAAAYS DSYGRVYAAD PYHHALAPAP 
       360        370        380        390 
TYGVGAMNAF APLTDAKTRS HADDVGLVLS SLQASIYRGG YNRFAPY
Length:397
Mass (Da):42,784
Last modified:February 5, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA96AA7B6E144D80
GO
Isoform 2 (identifier: Q9NWB1-2) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MNCEREQLR → MLASQGVLLHPYGVPMIVPAAPYLPGLIQ
     302-310: DGFYGADIY → EPVYGNKLLQ

Show »
Length:418
Mass (Da):44,793
Checksum:i47D6FC140F75D01A
GO
Isoform 3 (identifier: Q9NWB1-3) [UniParc]FASTAAdd to basket
Also known as: 1

The sequence of this isoform differs from the canonical sequence as follows:
     226-253: GTVLLCQANQEGSSMYSAPSSLVYTSAM → V

Show »
Length:370
Mass (Da):40,005
Checksum:i26DBC3263B7E5EA9
GO
Isoform 4 (identifier: Q9NWB1-4) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MNCEREQLR → MLASQGVLLHPYGVPMIVPAAPYLPGLIQ
     302-310: DGFYGADIY → EPVYGNKLLQ
     358-383: Missing.

Show »
Length:392
Mass (Da):42,084
Checksum:i68F8CEFE2FC6D674
GO
Isoform 5 (identifier: Q9NWB1-5) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MNCEREQLR → MLASQGVLLHPYGVPMIVPAAPYLPGLIQ
     302-310: DGFYGADIY → EPVYGNKLLQ
     332-397: SYGRVYAADP...RGGYNRFAPY → RNQFVFVAAD...LQPPPTALVP

Show »
Length:395
Mass (Da):42,402
Checksum:i2299F9127AA1DE39
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z1U7B7Z1U7_HUMAN
RNA binding protein fox-1 homolog 1
RBFOX1
425Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KNW3J3KNW3_HUMAN
RNA binding protein fox-1 homolog 1
RBFOX1
402Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X2B1A0A087X2B1_HUMAN
RNA binding protein fox-1 homolog 1
RBFOX1
375Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VRS4F8VRS4_HUMAN
RNA binding protein fox-1 homolog 1
RBFOX1
391Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YEU2A0A286YEU2_HUMAN
RNA-binding protein fox-1 homolog 1
RBFOX1
582Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H0M1F5H0M1_HUMAN
RNA binding protein fox-1 homolog 1
RBFOX1
380Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZG9F8VZG9_HUMAN
RNA-binding protein fox-1 homolog 1
RBFOX1
466Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PGE0A0A6Q8PGE0_HUMAN
RNA binding protein fox-1 homolog 1
RBFOX1 A2BP1, hCG_1811870
354Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PH77A0A6Q8PH77_HUMAN
RNA binding protein fox-1 homolog 1
RBFOX1
374Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PFM4A0A6Q8PFM4_HUMAN
RNA binding protein fox-1 homolog 1
RBFOX1
415Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF78291 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti92T → A in BAA91472 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0308741 – 9MNCEREQLR → MLASQGVLLHPYGVPMIVPA APYLPGLIQ in isoform 2, isoform 4 and isoform 5. 2 Publications9
Alternative sequenceiVSP_030875226 – 253GTVLL…YTSAM → V in isoform 3. 3 PublicationsAdd BLAST28
Alternative sequenceiVSP_030876302 – 310DGFYGADIY → EPVYGNKLLQ in isoform 2, isoform 4 and isoform 5. 2 Publications9
Alternative sequenceiVSP_030877332 – 397SYGRV…RFAPY → RNQFVFVAADEISCNTSAVT DEFMLPTPTTTHLLQPPPTA LVP in isoform 5. 2 PublicationsAdd BLAST66
Alternative sequenceiVSP_030878358 – 383Missing in isoform 4. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF107203 mRNA Translation: AAF78291.1 Different initiation.
AF229057 mRNA Translation: AAL71904.1
AF094849 mRNA Translation: AAL83405.1
AF109106 mRNA Translation: AAL83406.1
AF109120 AF109119 Genomic DNA Translation: AAL83407.1
AF109120 AF109119 Genomic DNA Translation: AAL83408.1
AF109120 AF109119 Genomic DNA Translation: AAL83409.1
AF448859 mRNA Translation: AAP41925.1
AK001027 mRNA Translation: BAA91472.1
AC005774 Genomic DNA No translation available.
AC006075 Genomic DNA No translation available.
AC006112 Genomic DNA No translation available.
AC007012 Genomic DNA No translation available.
AC007217 Genomic DNA No translation available.
AC007222 Genomic DNA No translation available.
AC007223 Genomic DNA No translation available.
AC009135 Genomic DNA No translation available.
AC022206 Genomic DNA No translation available.
AC023829 Genomic DNA No translation available.
AC027683 Genomic DNA No translation available.
AC079410 Genomic DNA No translation available.
AC125796 Genomic DNA No translation available.
AC131390 Genomic DNA No translation available.
BC113691 mRNA Translation: AAI13692.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10531.1 [Q9NWB1-2]
CCDS10532.1 [Q9NWB1-5]
CCDS45405.1 [Q9NWB1-4]
CCDS55983.1 [Q9NWB1-1]
CCDS55984.1 [Q9NWB1-3]

NCBI Reference Sequences

More...RefSeqi		NP_001135805.1, NM_001142333.1 [Q9NWB1-3]
NP_001135806.1, NM_001142334.1 [Q9NWB1-1]
NP_061193.2, NM_018723.3 [Q9NWB1-1]
NP_665898.1, NM_145891.2 [Q9NWB1-2]
NP_665899.1, NM_145892.2 [Q9NWB1-4]
NP_665900.1, NM_145893.2 [Q9NWB1-5]
XP_016878822.1, XM_017023333.1 [Q9NWB1-1]
XP_016878827.1, XM_017023338.1 [Q9NWB1-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000311745; ENSP00000309117; ENSG00000078328 [Q9NWB1-2]
ENST00000355637; ENSP00000347855; ENSG00000078328 [Q9NWB1-5]
ENST00000436368; ENSP00000402745; ENSG00000078328 [Q9NWB1-4]
ENST00000547338; ENSP00000447717; ENSG00000078328 [Q9NWB1-1]
ENST00000550418; ENSP00000450031; ENSG00000078328 [Q9NWB1-1]
ENST00000553186; ENSP00000447753; ENSG00000078328 [Q9NWB1-3]
ENST00000675653; ENSP00000502718; ENSG00000078328 [Q9NWB1-1]
ENST00000675842; ENSP00000501599; ENSG00000078328 [Q9NWB1-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54715

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54715

UCSC genome browser

More...UCSCi		uc002cys.2, human [Q9NWB1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107203 mRNA Translation: AAF78291.1 Different initiation.
AF229057 mRNA Translation: AAL71904.1
AF094849 mRNA Translation: AAL83405.1
AF109106 mRNA Translation: AAL83406.1
AF109120 AF109119 Genomic DNA Translation: AAL83407.1
AF109120 AF109119 Genomic DNA Translation: AAL83408.1
AF109120 AF109119 Genomic DNA Translation: AAL83409.1
AF448859 mRNA Translation: AAP41925.1
AK001027 mRNA Translation: BAA91472.1
AC005774 Genomic DNA No translation available.
AC006075 Genomic DNA No translation available.
AC006112 Genomic DNA No translation available.
AC007012 Genomic DNA No translation available.
AC007217 Genomic DNA No translation available.
AC007222 Genomic DNA No translation available.
AC007223 Genomic DNA No translation available.
AC009135 Genomic DNA No translation available.
AC022206 Genomic DNA No translation available.
AC023829 Genomic DNA No translation available.
AC027683 Genomic DNA No translation available.
AC079410 Genomic DNA No translation available.
AC125796 Genomic DNA No translation available.
AC131390 Genomic DNA No translation available.
BC113691 mRNA Translation: AAI13692.1
CCDSiCCDS10531.1 [Q9NWB1-2]
CCDS10532.1 [Q9NWB1-5]
CCDS45405.1 [Q9NWB1-4]
CCDS55983.1 [Q9NWB1-1]
CCDS55984.1 [Q9NWB1-3]
RefSeqiNP_001135805.1, NM_001142333.1 [Q9NWB1-3]
NP_001135806.1, NM_001142334.1 [Q9NWB1-1]
NP_061193.2, NM_018723.3 [Q9NWB1-1]
NP_665898.1, NM_145891.2 [Q9NWB1-2]
NP_665899.1, NM_145892.2 [Q9NWB1-4]
NP_665900.1, NM_145893.2 [Q9NWB1-5]
XP_016878822.1, XM_017023333.1 [Q9NWB1-1]
XP_016878827.1, XM_017023338.1 [Q9NWB1-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ERRNMR-A109-196[»]
2N82NMR-B109-208[»]
4ZKAX-ray1.80A/B/C/D/E/F109-208[»]
BMRBiQ9NWB1
SMRiQ9NWB1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120107, 76 interactors
IntActiQ9NWB1, 78 interactors
STRINGi9606.ENSP00000309117

PTM databases

iPTMnetiQ9NWB1
PhosphoSitePlusiQ9NWB1

Genetic variation databases

BioMutaiRBFOX1
DMDMi166897979

Proteomic databases

EPDiQ9NWB1
jPOSTiQ9NWB1
MassIVEiQ9NWB1
MaxQBiQ9NWB1
PaxDbiQ9NWB1
PeptideAtlasiQ9NWB1
PRIDEiQ9NWB1
ProteomicsDBi82917 [Q9NWB1-1]
82918 [Q9NWB1-2]
82919 [Q9NWB1-3]
82920 [Q9NWB1-4]
82921 [Q9NWB1-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24505, 365 antibodies

Genome annotation databases

EnsembliENST00000311745; ENSP00000309117; ENSG00000078328 [Q9NWB1-2]
ENST00000355637; ENSP00000347855; ENSG00000078328 [Q9NWB1-5]
ENST00000436368; ENSP00000402745; ENSG00000078328 [Q9NWB1-4]
ENST00000547338; ENSP00000447717; ENSG00000078328 [Q9NWB1-1]
ENST00000550418; ENSP00000450031; ENSG00000078328 [Q9NWB1-1]
ENST00000553186; ENSP00000447753; ENSG00000078328 [Q9NWB1-3]
ENST00000675653; ENSP00000502718; ENSG00000078328 [Q9NWB1-1]
ENST00000675842; ENSP00000501599; ENSG00000078328 [Q9NWB1-1]
GeneIDi54715
KEGGihsa:54715
UCSCiuc002cys.2, human [Q9NWB1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54715
DisGeNETi54715

GeneCards: human genes, protein and diseases

More...GeneCardsi		RBFOX1
HGNCiHGNC:18222, RBFOX1
HPAiENSG00000078328, Group enriched (brain, heart muscle, skeletal muscle)
MalaCardsiRBFOX1
MIMi605104, gene
neXtProtiNX_Q9NWB1
OpenTargetsiENSG00000078328
VEuPathDBiHostDB:ENSG00000078328.19

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0125, Eukaryota
GeneTreeiENSGT00940000160685
InParanoidiQ9NWB1
OMAiLVYTSAX
OrthoDBi871288at2759
PhylomeDBiQ9NWB1
TreeFamiTF315942

Enzyme and pathway databases

PathwayCommonsiQ9NWB1
ReactomeiR-HSA-9022707, MECP2 regulates transcription factors

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54715, 3 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RBFOX1, human
EvolutionaryTraceiQ9NWB1

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RBFOX1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54715
PharosiQ9NWB1, Tbio

Protein Ontology

More...PROi		PR:Q9NWB1
RNActiQ9NWB1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000078328, Expressed in putamen and 196 other tissues
ExpressionAtlasiQ9NWB1, baseline and differential
GenevisibleiQ9NWB1, HS

Family and domain databases

CDDicd12407, RRM_FOX1_like, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR025670, Fox-1_C_dom
IPR034237, FOX1_RRM
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR017325, RNA-bd_Fox-1
IPR000504, RRM_dom
PfamiView protein in Pfam
PF12414, Fox-1_C, 1 hit
PF00076, RRM_1, 1 hit
PIRSFiPIRSF037932, Ataxin_2_bd_A2BP, 1 hit
SMARTiView protein in SMART
SM00360, RRM, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRFOX1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NWB1
Secondary accession number(s): Q7Z7I7
, Q8TAE3, Q8TAF2, Q8WYB2, Q9NS20
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 5, 2008
Last modified: February 10, 2021
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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