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Protein

Transmembrane protein 51

Gene

TMEM51

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 51
Gene namesi
Name:TMEM51
Synonyms:C1orf72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000171729.13
HGNCiHGNC:25488 TMEM51
neXtProtiNX_Q9NW97

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55092
OpenTargetsiENSG00000171729
PharmGKBiPA142670767

Polymorphism and mutation databases

BioMutaiTMEM51
DMDMi68053240

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725771 – 253Transmembrane protein 51Add BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei115PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei192PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NW97
MaxQBiQ9NW97
PaxDbiQ9NW97
PeptideAtlasiQ9NW97
PRIDEiQ9NW97
ProteomicsDBi82915

PTM databases

iPTMnetiQ9NW97
PhosphoSitePlusiQ9NW97

Expressioni

Gene expression databases

BgeeiENSG00000171729 Expressed in 153 organ(s), highest expression level in islet of Langerhans
CleanExiHS_TMEM51
ExpressionAtlasiQ9NW97 baseline and differential
GenevisibleiQ9NW97 HS

Organism-specific databases

HPAiHPA014547
HPA019441

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PTPN5P548293EBI-726044,EBI-1220572

Protein-protein interaction databases

BioGridi120404, 28 interactors
IntActiQ9NW97, 27 interactors
MINTiQ9NW97

Structurei

3D structure databases

ProteinModelPortaliQ9NW97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJTH Eukaryota
ENOG4111TGG LUCA
GeneTreeiENSGT00390000009278
HOGENOMiHOG000233553
HOVERGENiHBG061167
InParanoidiQ9NW97
OMAiKPTAQGN
OrthoDBiEOG091G0LPK
PhylomeDBiQ9NW97
TreeFamiTF332361

Family and domain databases

InterProiView protein in InterPro
IPR029265 TMEM51
PANTHERiPTHR16015 PTHR16015, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9NW97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMAQSKANGS HYALTAIGLG MLVLGVIMAM WNLVPGFSAA EKPTAQGSNK
60 70 80 90 100
TEVGGGILKS KTFSVAYVLV GAGVMLLLLS ICLSIRDKRK QRQGEDLAHV
110 120 130 140 150
QHPTGAGPHA QEEDSQEEEE EDEEAASRYY VPSYEEVMNT NYSEARGEEQ
160 170 180 190 200
NPRLSISLPS YESLTGLDET TPTSTRADVE ASPGNPPDRQ NSKLAKRLKP
210 220 230 240 250
LKVRRIKSEK LHLKDFRINL PDKNVPPPSI EPLTPPPQYD EVQEKAPDTR

PPD
Length:253
Mass (Da):27,759
Last modified:October 1, 2000 - v1
Checksum:iC0CC36D41C57157C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BSA0Q9BSA0_HUMAN
TMEM51 protein
TMEM51 hCG_25381
135Annotation score:
B1AP03B1AP03_HUMAN
Transmembrane protein 51
TMEM51
121Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05144634V → A. Corresponds to variant dbSNP:rs17405421Ensembl.1
Natural variantiVAR_05144792R → Q. Corresponds to variant dbSNP:rs3766158Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001061 mRNA Translation: BAA91486.1
AK292184 mRNA Translation: BAF84873.1
CR457120 mRNA Translation: CAG33401.1
AL391094 Genomic DNA No translation available.
CH471167 Genomic DNA Translation: EAW51711.1
BC000202 mRNA Translation: AAH00202.1
BC000593 mRNA Translation: AAH00593.1
CCDSiCCDS154.1
RefSeqiNP_001129688.1, NM_001136216.1
NP_001129689.1, NM_001136217.1
NP_001129690.1, NM_001136218.1
NP_001306594.1, NM_001319665.1
NP_060492.1, NM_018022.2
XP_005245976.1, XM_005245919.1
XP_011539978.1, XM_011541676.1
XP_016857079.1, XM_017001590.1
UniGeneiHs.465305

Genome annotation databases

EnsembliENST00000376008; ENSP00000365176; ENSG00000171729
ENST00000376014; ENSP00000365182; ENSG00000171729
ENST00000400796; ENSP00000383600; ENSG00000171729
ENST00000428417; ENSP00000394899; ENSG00000171729
GeneIDi55092
KEGGihsa:55092
UCSCiuc001avw.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001061 mRNA Translation: BAA91486.1
AK292184 mRNA Translation: BAF84873.1
CR457120 mRNA Translation: CAG33401.1
AL391094 Genomic DNA No translation available.
CH471167 Genomic DNA Translation: EAW51711.1
BC000202 mRNA Translation: AAH00202.1
BC000593 mRNA Translation: AAH00593.1
CCDSiCCDS154.1
RefSeqiNP_001129688.1, NM_001136216.1
NP_001129689.1, NM_001136217.1
NP_001129690.1, NM_001136218.1
NP_001306594.1, NM_001319665.1
NP_060492.1, NM_018022.2
XP_005245976.1, XM_005245919.1
XP_011539978.1, XM_011541676.1
XP_016857079.1, XM_017001590.1
UniGeneiHs.465305

3D structure databases

ProteinModelPortaliQ9NW97
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120404, 28 interactors
IntActiQ9NW97, 27 interactors
MINTiQ9NW97

PTM databases

iPTMnetiQ9NW97
PhosphoSitePlusiQ9NW97

Polymorphism and mutation databases

BioMutaiTMEM51
DMDMi68053240

Proteomic databases

EPDiQ9NW97
MaxQBiQ9NW97
PaxDbiQ9NW97
PeptideAtlasiQ9NW97
PRIDEiQ9NW97
ProteomicsDBi82915

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376008; ENSP00000365176; ENSG00000171729
ENST00000376014; ENSP00000365182; ENSG00000171729
ENST00000400796; ENSP00000383600; ENSG00000171729
ENST00000428417; ENSP00000394899; ENSG00000171729
GeneIDi55092
KEGGihsa:55092
UCSCiuc001avw.5 human

Organism-specific databases

CTDi55092
DisGeNETi55092
EuPathDBiHostDB:ENSG00000171729.13
GeneCardsiTMEM51
HGNCiHGNC:25488 TMEM51
HPAiHPA014547
HPA019441
neXtProtiNX_Q9NW97
OpenTargetsiENSG00000171729
PharmGKBiPA142670767
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJTH Eukaryota
ENOG4111TGG LUCA
GeneTreeiENSGT00390000009278
HOGENOMiHOG000233553
HOVERGENiHBG061167
InParanoidiQ9NW97
OMAiKPTAQGN
OrthoDBiEOG091G0LPK
PhylomeDBiQ9NW97
TreeFamiTF332361

Miscellaneous databases

ChiTaRSiTMEM51 human
GeneWikiiTMEM51_(gene)
GenomeRNAii55092
PROiPR:Q9NW97

Gene expression databases

BgeeiENSG00000171729 Expressed in 153 organ(s), highest expression level in islet of Langerhans
CleanExiHS_TMEM51
ExpressionAtlasiQ9NW97 baseline and differential
GenevisibleiQ9NW97 HS

Family and domain databases

InterProiView protein in InterPro
IPR029265 TMEM51
PANTHERiPTHR16015 PTHR16015, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMM51_HUMAN
AccessioniPrimary (citable) accession number: Q9NW97
Secondary accession number(s): A8K819
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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