UniProtKB - Q9NW97 (TMM51_HUMAN)

BLAST

>sp|Q9NW97|TMM51_HUMAN Transmembrane protein 51 OS=Homo sapiens OX=9606 GN=TMEM51 PE=1 SV=1
MMAQSKANGSHYALTAIGLGMLVLGVIMAMWNLVPGFSAAEKPTAQGSNKTEVGGGILKS
KTFSVAYVLVGAGVMLLLLSICLSIRDKRKQRQGEDLAHVQHPTGAGPHAQEEDSQEEEE
EDEEAASRYYVPSYEEVMNTNYSEARGEEQNPRLSISLPSYESLTGLDETTPTSTRADVE
ASPGNPPDRQNSKLAKRLKPLKVRRIKSEKLHLKDFRINLPDKNVPPPSIEPLTPPPQYD
EVQEKAPDTRPPD

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History
Entry version 119 (12 Sep 2018)
Sequence version 1 (01 Oct 2000)
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Protein

Transmembrane protein 51

Gene

TMEM51

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protein 51
Gene namesⁱ	Name:TMEM51 Synonyms:C1orf72
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000171729.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25488 TMEM51
neXtProtⁱ	NX_Q9NW97

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	17 – 37	HelicalSequence analysisAdd BLAST		21
Transmembraneⁱ	65 – 85	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55092
Open Targets More...OpenTargetsⁱ	ENSG00000171729
PharmGKBⁱ	PA142670767

Polymorphism and mutation databases

BioMutaⁱ	TMEM51
DMDMⁱ	68053240

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000072577	1 – 253	Transmembrane protein 51Add BLAST		253

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	115	PhosphoserineCombined sources	1
Modified residueⁱ	182	PhosphoserineCombined sources	1
Modified residueⁱ	192	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9NW97
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NW97
PaxDbⁱ	Q9NW97
PeptideAtlas More...PeptideAtlasⁱ	Q9NW97
PRIDEⁱ	Q9NW97
ProteomicsDBⁱ	82915

PTM databases

iPTMnetⁱ	Q9NW97
PhosphoSitePlusⁱ	Q9NW97

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000171729 Expressed in 153 organ(s), highest expression level in islet of Langerhans
CleanExⁱ	HS_TMEM51
ExpressionAtlasⁱ	Q9NW97 baseline and differential
Genevisibleⁱ	Q9NW97 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA014547 HPA019441

HPAⁱ

HPA014547
HPA019441

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PTPN5	P54829	3	EBI-726044,EBI-1220572

With

Entry

#Exp.

IntAct

Notes

PTPN5

P54829

EBI-726044,EBI-1220572

Protein-protein interaction databases

BioGridⁱ	120404, 28 interactors
IntActⁱ	Q9NW97, 27 interactors
Molecular INTeraction database More...MINTⁱ	Q9NW97

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NW97
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IJTH Eukaryota ENOG4111TGG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009278
HOGENOMⁱ	HOG000233553
HOVERGENⁱ	HBG061167
InParanoidⁱ	Q9NW97
OMAⁱ	KPTAQGN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LPK
PhylomeDBⁱ	Q9NW97
TreeFamⁱ	TF332361

Family and domain databases

InterProⁱ	View protein in InterPro IPR029265 TMEM51
PANTHERⁱ	PTHR16015 PTHR16015, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9NW97-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MMAQSKANGS HYALTAIGLG MLVLGVIMAM WNLVPGFSAA EKPTAQGSNK 
        60         70         80         90        100
TEVGGGILKS KTFSVAYVLV GAGVMLLLLS ICLSIRDKRK QRQGEDLAHV 
       110        120        130        140        150
QHPTGAGPHA QEEDSQEEEE EDEEAASRYY VPSYEEVMNT NYSEARGEEQ 
       160        170        180        190        200
NPRLSISLPS YESLTGLDET TPTSTRADVE ASPGNPPDRQ NSKLAKRLKP 
       210        220        230        240        250
LKVRRIKSEK LHLKDFRINL PDKNVPPPSI EPLTPPPQYD EVQEKAPDTR 

PPD

Length:253

Mass (Da):27,759

Last modified:October 1, 2000 - v1

Checksum:ⁱC0CC36D41C57157C

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q9BSA0	Q9BSA0_HUMAN	TMEM51 protein TMEM51 protein (Transmembrane protein 51) (Transmembrane protein 51, isoform CRA_c)	TMEM51 hCG_25381	135	Annotation score:
B1AP03	B1AP03_HUMAN	Transmembrane protein 51 Transmembrane protein 51	TMEM51	121	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051446	34	V → A. Corresponds to variant dbSNP:rs17405421Ensembl.		1
Natural variantⁱVAR_051447	92	R → Q. Corresponds to variant dbSNP:rs3766158Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK001061 mRNA Translation: BAA91486.1 AK292184 mRNA Translation: BAF84873.1 CR457120 mRNA Translation: CAG33401.1 AL391094 Genomic DNA No translation available. CH471167 Genomic DNA Translation: EAW51711.1 BC000202 mRNA Translation: AAH00202.1 BC000593 mRNA Translation: AAH00593.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS154.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001129688.1, NM_001136216.1 NP_001129689.1, NM_001136217.1 NP_001129690.1, NM_001136218.1 NP_001306594.1, NM_001319665.1 NP_060492.1, NM_018022.2 XP_005245976.1, XM_005245919.1 XP_011539978.1, XM_011541676.1 XP_016857079.1, XM_017001590.1
UniGeneⁱ	Hs.465305

Genome annotation databases

Ensemblⁱ	ENST00000376008; ENSP00000365176; ENSG00000171729 ENST00000376014; ENSP00000365182; ENSG00000171729 ENST00000400796; ENSP00000383600; ENSG00000171729 ENST00000428417; ENSP00000394899; ENSG00000171729
GeneIDⁱ	55092
KEGGⁱ	hsa:55092
UCSC genome browser More...UCSCⁱ	uc001avw.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NW97	Transmembrane protein 51, isoform CRA_b		HUMAN		253	UniRef100_Q9NW97
TMEM51 isoform 1		PANTR		253
Uncharacterized protein		PANPA		253
Transmembrane protein 51 (Fragment)		HUMAN		121
TMEM51 isoform 6 (Fragment)		PANTR		121

Protein	Similar proteins		Species	Score	Length	Source
Q9NW97	Transmembrane protein 51, isoform CRA_b		HUMAN		253	UniRef90_Q9NW97
TMEM51 isoform 1		PANTR		253
Uncharacterized protein		PANPA		253
TMEM51 isoform 1 (Fragment)		PONAB		253
Uncharacterized protein		NOMLE		253
+50

Protein	Similar proteins		Species	Score	Length	Source
Q9NW97	Transmembrane protein 51		MOUSE		249	UniRef50_Q9NW97
Transmembrane protein 51, isoform CRA_b		HUMAN		253
TMEM51 isoform 1		PANTR		253
Uncharacterized protein		PANPA		253
Transmembrane protein 51		GORGO		253
+199

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK001061 mRNA Translation: BAA91486.1 AK292184 mRNA Translation: BAF84873.1 CR457120 mRNA Translation: CAG33401.1 AL391094 Genomic DNA No translation available. CH471167 Genomic DNA Translation: EAW51711.1 BC000202 mRNA Translation: AAH00202.1 BC000593 mRNA Translation: AAH00593.1
CCDSⁱ	CCDS154.1
RefSeqⁱ	NP_001129688.1, NM_001136216.1 NP_001129689.1, NM_001136217.1 NP_001129690.1, NM_001136218.1 NP_001306594.1, NM_001319665.1 NP_060492.1, NM_018022.2 XP_005245976.1, XM_005245919.1 XP_011539978.1, XM_011541676.1 XP_016857079.1, XM_017001590.1
UniGeneⁱ	Hs.465305

3D structure databases

ProteinModelPortalⁱ	Q9NW97
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120404, 28 interactors
IntActⁱ	Q9NW97, 27 interactors
MINTⁱ	Q9NW97

PTM databases

iPTMnetⁱ	Q9NW97
PhosphoSitePlusⁱ	Q9NW97

Polymorphism and mutation databases

BioMutaⁱ	TMEM51
DMDMⁱ	68053240

Proteomic databases

EPDⁱ	Q9NW97
MaxQBⁱ	Q9NW97
PaxDbⁱ	Q9NW97
PeptideAtlasⁱ	Q9NW97
PRIDEⁱ	Q9NW97
ProteomicsDBⁱ	82915

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000376008; ENSP00000365176; ENSG00000171729 ENST00000376014; ENSP00000365182; ENSG00000171729 ENST00000400796; ENSP00000383600; ENSG00000171729 ENST00000428417; ENSP00000394899; ENSG00000171729
GeneIDⁱ	55092
KEGGⁱ	hsa:55092
UCSCⁱ	uc001avw.5 human

Organism-specific databases

CTDⁱ	55092
DisGeNETⁱ	55092
EuPathDBⁱ	HostDB:ENSG00000171729.13
GeneCardsⁱ	TMEM51
HGNCⁱ	HGNC:25488 TMEM51
HPAⁱ	HPA014547 HPA019441
neXtProtⁱ	NX_Q9NW97
OpenTargetsⁱ	ENSG00000171729
PharmGKBⁱ	PA142670767
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJTH Eukaryota ENOG4111TGG LUCA
GeneTreeⁱ	ENSGT00390000009278
HOGENOMⁱ	HOG000233553
HOVERGENⁱ	HBG061167
InParanoidⁱ	Q9NW97
OMAⁱ	KPTAQGN
OrthoDBⁱ	EOG091G0LPK
PhylomeDBⁱ	Q9NW97
TreeFamⁱ	TF332361

Miscellaneous databases

ChiTaRSⁱ	TMEM51 human
GeneWikiⁱ	TMEM51_(gene)
GenomeRNAiⁱ	55092
Protein Ontology More...PROⁱ	PR:Q9NW97

Gene expression databases

Bgeeⁱ	ENSG00000171729 Expressed in 153 organ(s), highest expression level in islet of Langerhans
CleanExⁱ	HS_TMEM51
ExpressionAtlasⁱ	Q9NW97 baseline and differential
Genevisibleⁱ	Q9NW97 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR029265 TMEM51
PANTHERⁱ	PTHR16015 PTHR16015, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TMM51_HUMAN
Accessionⁱ	Q9NW97Primary (citable) accession number: Q9NW97 Secondary accession number(s): A8K819
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
	Last sequence update:	October 1, 2000
	Last modified:	September 12, 2018
	This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - Q9NW97 (TMM51_HUMAN)

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Transmembrane protein 51

TMEM51

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ