UniProtKB - Q9NW97 (TMM51_HUMAN)
Protein
Transmembrane protein 51
Gene
TMEM51
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 51 |
Gene namesi | Name:TMEM51 Synonyms:C1orf72 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25488 TMEM51 |
neXtProti | NX_Q9NW97 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 17 – 37 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 65 – 85 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000171729 |
PharmGKBi | PA142670767 |
Miscellaneous databases
Pharosi | Q9NW97 |
Polymorphism and mutation databases
BioMutai | TMEM51 |
DMDMi | 68053240 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072577 | 1 – 253 | Transmembrane protein 51Add BLAST | 253 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 115 | PhosphoserineCombined sources | 1 | |
Modified residuei | 182 | PhosphoserineCombined sources | 1 | |
Modified residuei | 192 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NW97 |
jPOSTi | Q9NW97 |
MassIVEi | Q9NW97 |
MaxQBi | Q9NW97 |
PaxDbi | Q9NW97 |
PeptideAtlasi | Q9NW97 |
PRIDEi | Q9NW97 |
ProteomicsDBi | 82915 |
PTM databases
iPTMneti | Q9NW97 |
PhosphoSitePlusi | Q9NW97 |
Expressioni
Gene expression databases
Bgeei | ENSG00000171729 Expressed in 153 organ(s), highest expression level in islet of Langerhans |
ExpressionAtlasi | Q9NW97 baseline and differential |
Genevisiblei | Q9NW97 HS |
Organism-specific databases
HPAi | HPA014547 HPA019441 |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGridi | 120404, 31 interactors |
IntActi | Q9NW97, 45 interactors |
MINTi | Q9NW97 |
STRINGi | 9606.ENSP00000394899 |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IJTH Eukaryota ENOG4111TGG LUCA |
GeneTreei | ENSGT00390000009278 |
HOGENOMi | HOG000233553 |
InParanoidi | Q9NW97 |
OMAi | CLGMRNK |
OrthoDBi | 1229287at2759 |
PhylomeDBi | Q9NW97 |
TreeFami | TF332361 |
Family and domain databases
InterProi | View protein in InterPro IPR029265 TMEM51 |
PANTHERi | PTHR16015 PTHR16015, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9NW97-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMAQSKANGS HYALTAIGLG MLVLGVIMAM WNLVPGFSAA EKPTAQGSNK
60 70 80 90 100
TEVGGGILKS KTFSVAYVLV GAGVMLLLLS ICLSIRDKRK QRQGEDLAHV
110 120 130 140 150
QHPTGAGPHA QEEDSQEEEE EDEEAASRYY VPSYEEVMNT NYSEARGEEQ
160 170 180 190 200
NPRLSISLPS YESLTGLDET TPTSTRADVE ASPGNPPDRQ NSKLAKRLKP
210 220 230 240 250
LKVRRIKSEK LHLKDFRINL PDKNVPPPSI EPLTPPPQYD EVQEKAPDTR
PPD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9BSA0 | Q9BSA0_HUMAN | TMEM51 protein | TMEM51 hCG_25381 | 135 | Annotation score: | ||
B1AP03 | B1AP03_HUMAN | Transmembrane protein 51 | TMEM51 | 121 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051446 | 34 | V → A. Corresponds to variant dbSNP:rs17405421Ensembl. | 1 | |
Natural variantiVAR_051447 | 92 | R → Q. Corresponds to variant dbSNP:rs3766158Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001061 mRNA Translation: BAA91486.1 AK292184 mRNA Translation: BAF84873.1 CR457120 mRNA Translation: CAG33401.1 AL391094 Genomic DNA No translation available. CH471167 Genomic DNA Translation: EAW51711.1 BC000202 mRNA Translation: AAH00202.1 BC000593 mRNA Translation: AAH00593.1 |
CCDSi | CCDS154.1 |
RefSeqi | NP_001129688.1, NM_001136216.1 NP_001129689.1, NM_001136217.1 NP_001129690.1, NM_001136218.1 NP_001306594.1, NM_001319665.1 NP_060492.1, NM_018022.2 XP_005245976.1, XM_005245919.1 XP_011539978.1, XM_011541676.1 XP_016857079.1, XM_017001590.1 |
Genome annotation databases
Ensembli | ENST00000376008; ENSP00000365176; ENSG00000171729 ENST00000376014; ENSP00000365182; ENSG00000171729 ENST00000400796; ENSP00000383600; ENSG00000171729 ENST00000428417; ENSP00000394899; ENSG00000171729 |
GeneIDi | 55092 |
KEGGi | hsa:55092 |
UCSCi | uc001avw.5 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001061 mRNA Translation: BAA91486.1 AK292184 mRNA Translation: BAF84873.1 CR457120 mRNA Translation: CAG33401.1 AL391094 Genomic DNA No translation available. CH471167 Genomic DNA Translation: EAW51711.1 BC000202 mRNA Translation: AAH00202.1 BC000593 mRNA Translation: AAH00593.1 |
CCDSi | CCDS154.1 |
RefSeqi | NP_001129688.1, NM_001136216.1 NP_001129689.1, NM_001136217.1 NP_001129690.1, NM_001136218.1 NP_001306594.1, NM_001319665.1 NP_060492.1, NM_018022.2 XP_005245976.1, XM_005245919.1 XP_011539978.1, XM_011541676.1 XP_016857079.1, XM_017001590.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 120404, 31 interactors |
IntActi | Q9NW97, 45 interactors |
MINTi | Q9NW97 |
STRINGi | 9606.ENSP00000394899 |
PTM databases
iPTMneti | Q9NW97 |
PhosphoSitePlusi | Q9NW97 |
Polymorphism and mutation databases
BioMutai | TMEM51 |
DMDMi | 68053240 |
Proteomic databases
EPDi | Q9NW97 |
jPOSTi | Q9NW97 |
MassIVEi | Q9NW97 |
MaxQBi | Q9NW97 |
PaxDbi | Q9NW97 |
PeptideAtlasi | Q9NW97 |
PRIDEi | Q9NW97 |
ProteomicsDBi | 82915 |
Genome annotation databases
Ensembli | ENST00000376008; ENSP00000365176; ENSG00000171729 ENST00000376014; ENSP00000365182; ENSG00000171729 ENST00000400796; ENSP00000383600; ENSG00000171729 ENST00000428417; ENSP00000394899; ENSG00000171729 |
GeneIDi | 55092 |
KEGGi | hsa:55092 |
UCSCi | uc001avw.5 human |
Organism-specific databases
CTDi | 55092 |
GeneCardsi | TMEM51 |
HGNCi | HGNC:25488 TMEM51 |
HPAi | HPA014547 HPA019441 |
neXtProti | NX_Q9NW97 |
OpenTargetsi | ENSG00000171729 |
PharmGKBi | PA142670767 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IJTH Eukaryota ENOG4111TGG LUCA |
GeneTreei | ENSGT00390000009278 |
HOGENOMi | HOG000233553 |
InParanoidi | Q9NW97 |
OMAi | CLGMRNK |
OrthoDBi | 1229287at2759 |
PhylomeDBi | Q9NW97 |
TreeFami | TF332361 |
Miscellaneous databases
ChiTaRSi | TMEM51 human |
GeneWikii | TMEM51_(gene) |
GenomeRNAii | 55092 |
Pharosi | Q9NW97 |
PROi | PR:Q9NW97 |
Gene expression databases
Bgeei | ENSG00000171729 Expressed in 153 organ(s), highest expression level in islet of Langerhans |
ExpressionAtlasi | Q9NW97 baseline and differential |
Genevisiblei | Q9NW97 HS |
Family and domain databases
InterProi | View protein in InterPro IPR029265 TMEM51 |
PANTHERi | PTHR16015 PTHR16015, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TMM51_HUMAN | |
Accessioni | Q9NW97Primary (citable) accession number: Q9NW97 Secondary accession number(s): A8K819 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2005 |
Last sequence update: | October 1, 2000 | |
Last modified: | October 16, 2019 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations