Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Distal membrane-arm assembly complex protein 2

Gene

DMAC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I.1 Publication

GO - Biological processi

  • mitochondrial respiratory chain complex I assembly Source: UniProtKB
  • protein ubiquitination Source: GOC
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central
  • ubiquitin-dependent protein catabolic process Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Distal membrane-arm assembly complex protein 2Curated
Alternative name(s):
ATP synthase subunit s-like proteinCurated
Gene namesi
Name:DMAC2Imported
Synonyms:ATP5SLImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105341.18
HGNCiHGNC:25496 DMAC2
neXtProtiNX_Q9NW81

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105341
PharmGKBiPA162377263

Polymorphism and mutation databases

BioMutaiATP5SL
DMDMi296439436

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003186951 – 257Distal membrane-arm assembly complex protein 2Add BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei253PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NW81
MaxQBiQ9NW81
PaxDbiQ9NW81
PeptideAtlasiQ9NW81
PRIDEiQ9NW81
ProteomicsDBi82910
82911 [Q9NW81-2]
82912 [Q9NW81-3]

PTM databases

iPTMnetiQ9NW81
PhosphoSitePlusiQ9NW81

Expressioni

Gene expression databases

BgeeiENSG00000105341 Expressed in 222 organ(s), highest expression level in apex of heart
CleanExiHS_ATP5SL
ExpressionAtlasiQ9NW81 baseline and differential
GenevisibleiQ9NW81 HS

Organism-specific databases

HPAiHPA041427

Interactioni

Subunit structurei

Interacts with incompletely assembled mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).1 Publication

Protein-protein interaction databases

BioGridi120411, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9NW81
SMRiQ9NW81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP synthase subunit s family.Curated

Phylogenomic databases

eggNOGiENOG410IS4E Eukaryota
ENOG4111PMF LUCA
GeneTreeiENSGT00530000063680
HOGENOMiHOG000034116
HOVERGENiHBG056046
InParanoidiQ9NW81
OMAiHFYDVEA
OrthoDBiEOG091G07CX
PhylomeDBiQ9NW81
TreeFamiTF315274

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR026303 DMAC2
IPR032675 LRR_dom_sf
PANTHERiPTHR13318 PTHR13318, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NW81-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPWASLRL VAPMWNGRIR GIHRLGAAVA PEGNQKKKRT ILQFLTNYFY
60 70 80 90 100
DVEALRDYLL QREMYKVHEK NRSYTWLEKQ HGPYGAGAFF ILKQGGAVKF
110 120 130 140 150
RDKEWIRPDK YGHFSQEFWN FCEVPVEAVD AGDCDINYEG LDNLLRLKEL
160 170 180 190 200
QSLSLQRCCH VDDWCLSRLY PLADSLQELS LAGCPRISER GLACLHHLQN
210 220 230 240 250
LRRLDISDLP AVSNPGLTQI LVEEMLPNCE VVGVDWAEGL KSGPEEQPRD

TASPVPA
Length:257
Mass (Da):29,267
Last modified:May 18, 2010 - v3
Checksum:i29CBFD02143DE806
GO
Isoform 2 (identifier: Q9NW81-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-99: Missing.
     145-257: LRLKELQSLS...PRDTASPVPA → RTSAGWTSRT...RLWESTGLRA

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):18,602
Checksum:i8387C635C5F26D39
GO
Isoform 3 (identifier: Q9NW81-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAAPWA → MWDLVLEDRRMN
     145-257: LRLKELQSLS...PRDTASPVPA → RTSAGWTSRT...RLWESTGLRA

Show »
Length:191
Mass (Da):22,471
Checksum:i7F1EEBB93765A5EE
GO
Isoform 4 (identifier: Q9NW81-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAAPWA → MWDLVLEDRRMN

Note: No experimental confirmation available.
Show »
Length:263
Mass (Da):30,200
Checksum:iB8A3EFDDE672C998
GO
Isoform 5 (identifier: Q9NW81-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-99: Missing.

Note: No experimental confirmation available.
Show »
Length:230
Mass (Da):26,331
Checksum:i430D9722498CE8E3
GO
Isoform 6 (identifier: Q9NW81-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-257: LRLKELQSLS...PRDTASPVPA → RTSAGWTSRT...RLWESTGLRA

Note: No experimental confirmation available.
Show »
Length:185
Mass (Da):21,539
Checksum:i310CA9F8CAB2E26E
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DFT4B4DFT4_HUMAN
Distal membrane-arm assembly comple...
DMAC2
178Annotation score:
M0QZC4M0QZC4_HUMAN
Distal membrane-arm assembly comple...
DMAC2
172Annotation score:
K7ESN5K7ESN5_HUMAN
Distal membrane-arm assembly comple...
DMAC2
101Annotation score:
M0QZP7M0QZP7_HUMAN
Distal membrane-arm assembly comple...
DMAC2
150Annotation score:
K7EIV4K7EIV4_HUMAN
Distal membrane-arm assembly comple...
DMAC2
176Annotation score:
M0R078M0R078_HUMAN
Distal membrane-arm assembly comple...
DMAC2
121Annotation score:
M0QX81M0QX81_HUMAN
Distal membrane-arm assembly comple...
DMAC2
22Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128A → S in BAG60467 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0577989R → C. Corresponds to variant dbSNP:rs2231938Ensembl.1
Natural variantiVAR_05779923H → R1 PublicationCorresponds to variant dbSNP:rs2231939Ensembl.1
Natural variantiVAR_05780034N → S1 PublicationCorresponds to variant dbSNP:rs2231940Ensembl.1
Natural variantiVAR_060165159C → S1 PublicationCorresponds to variant dbSNP:rs1043413Ensembl.1
Natural variantiVAR_057801230E → K. Corresponds to variant dbSNP:rs2231943Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0438071 – 6MAAPWA → MWDLVLEDRRMN in isoform 3 and isoform 4. 1 Publication6
Alternative sequenceiVSP_03127073 – 99Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST27
Alternative sequenceiVSP_031271145 – 257LRLKE…SPVPA → RTSAGWTSRTSLPCPTLASL RYWWRRCCPIARLWESTGLR A in isoform 2, isoform 3 and isoform 6. 2 PublicationsAdd BLAST113

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001103 mRNA Translation: BAA91503.1
AK293132 mRNA Translation: BAG56681.1
AK297698 mRNA Translation: BAG60056.1
AK298197 mRNA Translation: BAG60467.1
AK301940 mRNA Translation: BAG63360.1
AC011526 Genomic DNA No translation available.
AC005795 Genomic DNA No translation available.
AC005945 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57042.1
CH471126 Genomic DNA Translation: EAW57043.1
BC013323 mRNA Translation: AAH13323.1
CCDSiCCDS33032.1 [Q9NW81-1]
CCDS54269.1 [Q9NW81-3]
CCDS54270.1 [Q9NW81-4]
CCDS54271.1 [Q9NW81-5]
CCDS59389.1 [Q9NW81-2]
CCDS59390.1 [Q9NW81-6]
RefSeqiNP_001161339.1, NM_001167867.1 [Q9NW81-4]
NP_001161340.1, NM_001167868.1 [Q9NW81-3]
NP_001161341.1, NM_001167869.1 [Q9NW81-6]
NP_001161342.1, NM_001167870.1 [Q9NW81-2]
NP_001161343.1, NM_001167871.1 [Q9NW81-5]
NP_001307767.1, NM_001320838.1
NP_001307769.1, NM_001320840.1
NP_001307770.1, NM_001320841.1
NP_060505.2, NM_018035.2 [Q9NW81-1]
UniGeneiHs.351099

Genome annotation databases

EnsembliENST00000221943; ENSP00000221943; ENSG00000105341 [Q9NW81-1]
ENST00000301183; ENSP00000301183; ENSG00000105341 [Q9NW81-3]
ENST00000417807; ENSP00000403910; ENSG00000105341 [Q9NW81-4]
ENST00000438807; ENSP00000397413; ENSG00000105341 [Q9NW81-2]
ENST00000589970; ENSP00000466485; ENSG00000105341 [Q9NW81-6]
ENST00000592922; ENSP00000467205; ENSG00000105341 [Q9NW81-5]
GeneIDi55101
KEGGihsa:55101
UCSCiuc002oqv.4 human [Q9NW81-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001103 mRNA Translation: BAA91503.1
AK293132 mRNA Translation: BAG56681.1
AK297698 mRNA Translation: BAG60056.1
AK298197 mRNA Translation: BAG60467.1
AK301940 mRNA Translation: BAG63360.1
AC011526 Genomic DNA No translation available.
AC005795 Genomic DNA No translation available.
AC005945 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57042.1
CH471126 Genomic DNA Translation: EAW57043.1
BC013323 mRNA Translation: AAH13323.1
CCDSiCCDS33032.1 [Q9NW81-1]
CCDS54269.1 [Q9NW81-3]
CCDS54270.1 [Q9NW81-4]
CCDS54271.1 [Q9NW81-5]
CCDS59389.1 [Q9NW81-2]
CCDS59390.1 [Q9NW81-6]
RefSeqiNP_001161339.1, NM_001167867.1 [Q9NW81-4]
NP_001161340.1, NM_001167868.1 [Q9NW81-3]
NP_001161341.1, NM_001167869.1 [Q9NW81-6]
NP_001161342.1, NM_001167870.1 [Q9NW81-2]
NP_001161343.1, NM_001167871.1 [Q9NW81-5]
NP_001307767.1, NM_001320838.1
NP_001307769.1, NM_001320840.1
NP_001307770.1, NM_001320841.1
NP_060505.2, NM_018035.2 [Q9NW81-1]
UniGeneiHs.351099

3D structure databases

ProteinModelPortaliQ9NW81
SMRiQ9NW81
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120411, 3 interactors

PTM databases

iPTMnetiQ9NW81
PhosphoSitePlusiQ9NW81

Polymorphism and mutation databases

BioMutaiATP5SL
DMDMi296439436

Proteomic databases

EPDiQ9NW81
MaxQBiQ9NW81
PaxDbiQ9NW81
PeptideAtlasiQ9NW81
PRIDEiQ9NW81
ProteomicsDBi82910
82911 [Q9NW81-2]
82912 [Q9NW81-3]

Protocols and materials databases

DNASUi55101
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221943; ENSP00000221943; ENSG00000105341 [Q9NW81-1]
ENST00000301183; ENSP00000301183; ENSG00000105341 [Q9NW81-3]
ENST00000417807; ENSP00000403910; ENSG00000105341 [Q9NW81-4]
ENST00000438807; ENSP00000397413; ENSG00000105341 [Q9NW81-2]
ENST00000589970; ENSP00000466485; ENSG00000105341 [Q9NW81-6]
ENST00000592922; ENSP00000467205; ENSG00000105341 [Q9NW81-5]
GeneIDi55101
KEGGihsa:55101
UCSCiuc002oqv.4 human [Q9NW81-1]

Organism-specific databases

CTDi55101
EuPathDBiHostDB:ENSG00000105341.18
GeneCardsiDMAC2
HGNCiHGNC:25496 DMAC2
HPAiHPA041427
neXtProtiNX_Q9NW81
OpenTargetsiENSG00000105341
PharmGKBiPA162377263
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS4E Eukaryota
ENOG4111PMF LUCA
GeneTreeiENSGT00530000063680
HOGENOMiHOG000034116
HOVERGENiHBG056046
InParanoidiQ9NW81
OMAiHFYDVEA
OrthoDBiEOG091G07CX
PhylomeDBiQ9NW81
TreeFamiTF315274

Miscellaneous databases

GeneWikiiATP5SL
GenomeRNAii55101
PROiPR:Q9NW81

Gene expression databases

BgeeiENSG00000105341 Expressed in 222 organ(s), highest expression level in apex of heart
CleanExiHS_ATP5SL
ExpressionAtlasiQ9NW81 baseline and differential
GenevisibleiQ9NW81 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR026303 DMAC2
IPR032675 LRR_dom_sf
PANTHERiPTHR13318 PTHR13318, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDMAC2_HUMAN
AccessioniPrimary (citable) accession number: Q9NW81
Secondary accession number(s): B4DDC0
, B4DMZ4, B4DP55, B4DXE8, F5H4W7, K7EMF6, Q96D43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again