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Protein

G patch domain-containing protein 2

Gene

GPATCH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances the ATPase activity of DHX15 in vitro.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of phosphatase activity Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
G patch domain-containing protein 2
Gene namesi
Name:GPATCH2
Synonyms:GPATC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000092978.10
HGNCiHGNC:25499 GPATCH2
neXtProtiNX_Q9NW75

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55105
OpenTargetsiENSG00000092978
PharmGKBiPA162390064

Polymorphism and mutation databases

BioMutaiGPATCH2
DMDMi48428171

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000875661 – 528G patch domain-containing protein 2Add BLAST528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei115PhosphoserineCombined sources1
Modified residuei117PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1
Modified residuei195PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NW75
MaxQBiQ9NW75
PaxDbiQ9NW75
PeptideAtlasiQ9NW75
PRIDEiQ9NW75
ProteomicsDBi82908
82909 [Q9NW75-2]

PTM databases

iPTMnetiQ9NW75
PhosphoSitePlusiQ9NW75

Expressioni

Tissue specificityi

Testis.1 Publication

Gene expression databases

BgeeiENSG00000092978 Expressed in 187 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_GPATCH2
GenevisibleiQ9NW75 HS

Organism-specific databases

HPAiHPA027181
HPA027322

Interactioni

Subunit structurei

Interacts with DHX15.1 Publication

Protein-protein interaction databases

BioGridi120415, 11 interactors
IntActiQ9NW75, 8 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9NW75
SMRiQ9NW75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini467 – 513G-patchPROSITE-ProRule annotationAdd BLAST47

Phylogenomic databases

eggNOGiENOG410IQDT Eukaryota
ENOG410ZH5F LUCA
GeneTreeiENSGT00410000025698
HOGENOMiHOG000294060
HOVERGENiHBG062801
InParanoidiQ9NW75
KOiK17569
OMAiCTGDVKR
OrthoDBiEOG091G0Z4W
PhylomeDBiQ9NW75
TreeFamiTF331954

Family and domain databases

InterProiView protein in InterPro
IPR000467 G_patch_dom
IPR026291 Gpatch2
PANTHERiPTHR14195 PTHR14195, 1 hit
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NW75-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFGAAGRQPI GAPAAGNSWH FSRTMEELVH DLVSALEESS EQARGGFAET
60 70 80 90 100
GDHSRSISCP LKRQARKRRG RKRRSYNVHH PWETGHCLSE GSDSSLEEPS
110 120 130 140 150
KDYRENHNNN KKDHSDSDDQ MLVAKRRPSS NLNNNVRGKR PLWHESDFAV
160 170 180 190 200
DNVGNRTLRR RRKVKRMAVD LPQDISNKRT MTQPPEGCRD QDMDSDRAYQ
210 220 230 240 250
YQEFTKNKVK KRKLKIIRQG PKIQDEGVVL ESEETNQTNK DKMECEEQKV
260 270 280 290 300
SDELMSESDS SSLSSTDAGL FTNDEGRQGD DEQSDWFYEK ESGGACGITG
310 320 330 340 350
VVPWWEKEDP TELDKNVPDP VFESILTGSF PLMSHPSRRG FQARLSRLHG
360 370 380 390 400
MSSKNIKKSG GTPTSMVPIP GPVGNKRMVH FSPDSHHHDH WFSPGARTEH
410 420 430 440 450
DQHQLLRDNR AERGHKKNCS VRTASRQTSM HLGSLCTGDI KRRRKAAPLP
460 470 480 490 500
GPTTAGFVGE NAQPILENNI GNRMLQNMGW TPGSGLGRDG KGISEPIQAM
510 520
QRPKGLGLGF PLPKSTSATT TPNAGKSA
Length:528
Mass (Da):58,944
Last modified:October 1, 2000 - v1
Checksum:i472143144700DC26
GO
Isoform 2 (identifier: Q9NW75-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     367-376: VPIPGPVGNK → ATNWTSEIPL
     377-528: Missing.

Note: No experimental confirmation available.
Show »
Length:376
Mass (Da):42,599
Checksum:i42E7688983E717E5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti220G → A in AAH63474 (PubMed:15489334).Curated1
Sequence conflicti225D → N in AAH42193 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010527367 – 376VPIPGPVGNK → ATNWTSEIPL in isoform 2. 1 Publication10
Alternative sequenceiVSP_010528377 – 528Missing in isoform 2. 1 PublicationAdd BLAST152

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001114 mRNA Translation: BAA91509.1
AC096641 Genomic DNA No translation available.
AL354659 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93333.1
BC042193 mRNA Translation: AAH42193.1
BC063474 mRNA Translation: AAH63474.1
CCDSiCCDS1518.1 [Q9NW75-1]
CCDS73031.1 [Q9NW75-2]
RefSeqiNP_001284683.1, NM_001297754.2 [Q9NW75-2]
NP_060510.1, NM_018040.4 [Q9NW75-1]
UniGeneiHs.362343
Hs.420757

Genome annotation databases

EnsembliENST00000366934; ENSP00000355901; ENSG00000092978 [Q9NW75-2]
ENST00000366935; ENSP00000355902; ENSG00000092978 [Q9NW75-1]
GeneIDi55105
KEGGihsa:55105
UCSCiuc001hlf.2 human [Q9NW75-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001114 mRNA Translation: BAA91509.1
AC096641 Genomic DNA No translation available.
AL354659 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93333.1
BC042193 mRNA Translation: AAH42193.1
BC063474 mRNA Translation: AAH63474.1
CCDSiCCDS1518.1 [Q9NW75-1]
CCDS73031.1 [Q9NW75-2]
RefSeqiNP_001284683.1, NM_001297754.2 [Q9NW75-2]
NP_060510.1, NM_018040.4 [Q9NW75-1]
UniGeneiHs.362343
Hs.420757

3D structure databases

ProteinModelPortaliQ9NW75
SMRiQ9NW75
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120415, 11 interactors
IntActiQ9NW75, 8 interactors

PTM databases

iPTMnetiQ9NW75
PhosphoSitePlusiQ9NW75

Polymorphism and mutation databases

BioMutaiGPATCH2
DMDMi48428171

Proteomic databases

EPDiQ9NW75
MaxQBiQ9NW75
PaxDbiQ9NW75
PeptideAtlasiQ9NW75
PRIDEiQ9NW75
ProteomicsDBi82908
82909 [Q9NW75-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366934; ENSP00000355901; ENSG00000092978 [Q9NW75-2]
ENST00000366935; ENSP00000355902; ENSG00000092978 [Q9NW75-1]
GeneIDi55105
KEGGihsa:55105
UCSCiuc001hlf.2 human [Q9NW75-1]

Organism-specific databases

CTDi55105
DisGeNETi55105
EuPathDBiHostDB:ENSG00000092978.10
GeneCardsiGPATCH2
HGNCiHGNC:25499 GPATCH2
HPAiHPA027181
HPA027322
neXtProtiNX_Q9NW75
OpenTargetsiENSG00000092978
PharmGKBiPA162390064
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQDT Eukaryota
ENOG410ZH5F LUCA
GeneTreeiENSGT00410000025698
HOGENOMiHOG000294060
HOVERGENiHBG062801
InParanoidiQ9NW75
KOiK17569
OMAiCTGDVKR
OrthoDBiEOG091G0Z4W
PhylomeDBiQ9NW75
TreeFamiTF331954

Miscellaneous databases

ChiTaRSiGPATCH2 human
GenomeRNAii55105
PROiPR:Q9NW75

Gene expression databases

BgeeiENSG00000092978 Expressed in 187 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_GPATCH2
GenevisibleiQ9NW75 HS

Family and domain databases

InterProiView protein in InterPro
IPR000467 G_patch_dom
IPR026291 Gpatch2
PANTHERiPTHR14195 PTHR14195, 1 hit
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPTC2_HUMAN
AccessioniPrimary (citable) accession number: Q9NW75
Secondary accession number(s): Q5VYK7, Q5VYK8, Q86YE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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