UniProtKB - Q9NW61 (PKHJ1_HUMAN)
Protein
Pleckstrin homology domain-containing family J member 1
Gene
PLEKHJ1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- endosome organization Source: GO_Central
- receptor recycling Source: GO_Central
- retrograde transport, endosome to Golgi Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9NW61 |
Names & Taxonomyi
Protein namesi | Recommended name: Pleckstrin homology domain-containing family J member 1Short name: PH domain-containing family J member 1 Alternative name(s): Guanine nucleotide-releasing protein x |
Gene namesi | Name:PLEKHJ1 Synonyms:GNRPX |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000104886.9 |
HGNCi | HGNC:18211, PLEKHJ1 |
MIMi | 617834, gene |
neXtProti | NX_Q9NW61 |
Subcellular locationi
Cytosol
- cytosol Source: GOC
Endosome
- early endosome Source: GO_Central
- recycling endosome Source: GO_Central
Golgi apparatus
- trans-Golgi network Source: GO_Central
Pathology & Biotechi
Organism-specific databases
PharmGKBi | PA134936152 |
Miscellaneous databases
Pharosi | Q9NW61, Tbio |
Polymorphism and mutation databases
BioMutai | PLEKHJ1 |
DMDMi | 74753007 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000309230 | 1 – 149 | Pleckstrin homology domain-containing family J member 1Add BLAST | 149 |
Proteomic databases
EPDi | Q9NW61 |
MassIVEi | Q9NW61 |
MaxQBi | Q9NW61 |
PaxDbi | Q9NW61 |
PeptideAtlasi | Q9NW61 |
PRIDEi | Q9NW61 |
ProteomicsDBi | 82896 |
PTM databases
iPTMneti | Q9NW61 |
PhosphoSitePlusi | Q9NW61 |
Expressioni
Tissue specificityi
Expressed in testis and liver.1 Publication
Gene expression databases
Bgeei | ENSG00000104886, Expressed in mucosa of transverse colon and 117 other tissues |
ExpressionAtlasi | Q9NW61, baseline and differential |
Genevisiblei | Q9NW61, HS |
Organism-specific databases
HPAi | ENSG00000104886, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9NW61
Protein-protein interaction databases
BioGRIDi | 120421, 33 interactors |
IntActi | Q9NW61, 11 interactors |
MINTi | Q9NW61 |
STRINGi | 9606.ENSP00000464955 |
Miscellaneous databases
RNActi | Q9NW61, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 108 | PHPROSITE-ProRule annotationAdd BLAST | 94 |
Phylogenomic databases
eggNOGi | KOG0017, Eukaryota |
GeneTreei | ENSGT00390000005235 |
HOGENOMi | CLU_141382_0_0_1 |
InParanoidi | Q9NW61 |
PhylomeDBi | Q9NW61 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR001849, PH_domain |
Pfami | View protein in Pfam PF00169, PH, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q9NW61-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRYNEKELQA LSRQPAEMAA ELGMRGPKKG SVLKRRLVKL VVNFLFYFRT
60 70 80 90 100
DEAEPVGALL LERCRVVREE PGTFSISFIE DPERKYHFEC SSEEQCQEWM
110 120 130 140
EALRRASYEF MRRSLIFYRN EIRKVTGKDP LEQFGISEEA RFQLSGLQA
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EIZ3 | K7EIZ3_HUMAN | Pleckstrin homology domain-containi... | PLEKHJ1 | 277 | Annotation score: | ||
K7ERW3 | K7ERW3_HUMAN | Pleckstrin homology domain-containi... | PLEKHJ1 | 174 | Annotation score: | ||
K7ERH2 | K7ERH2_HUMAN | Pleckstrin homology domain-containi... | PLEKHJ1 | 94 | Annotation score: | ||
K7EIW9 | K7EIW9_HUMAN | Pleckstrin homology domain-containi... | PLEKHJ1 | 150 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001159 mRNA Translation: BAA91525.1 AK097723 mRNA Translation: BAG53521.1 CR457253 mRNA Translation: CAG33534.1 CH471139 Genomic DNA Translation: EAW69405.1 CH471139 Genomic DNA Translation: EAW69406.1 BC003084 mRNA Translation: AAH03084.1 BC008966 mRNA Translation: AAH08966.1 |
CCDSi | CCDS12083.1 |
RefSeqi | NP_060519.1, NM_018049.2 |
Genome annotation databases
Ensembli | ENST00000326631; ENSP00000318075; ENSG00000104886 ENST00000589097; ENSP00000465391; ENSG00000104886 |
GeneIDi | 55111 |
KEGGi | hsa:55111 |
UCSCi | uc002lvf.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001159 mRNA Translation: BAA91525.1 AK097723 mRNA Translation: BAG53521.1 CR457253 mRNA Translation: CAG33534.1 CH471139 Genomic DNA Translation: EAW69405.1 CH471139 Genomic DNA Translation: EAW69406.1 BC003084 mRNA Translation: AAH03084.1 BC008966 mRNA Translation: AAH08966.1 |
CCDSi | CCDS12083.1 |
RefSeqi | NP_060519.1, NM_018049.2 |
3D structure databases
SMRi | Q9NW61 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120421, 33 interactors |
IntActi | Q9NW61, 11 interactors |
MINTi | Q9NW61 |
STRINGi | 9606.ENSP00000464955 |
PTM databases
iPTMneti | Q9NW61 |
PhosphoSitePlusi | Q9NW61 |
Polymorphism and mutation databases
BioMutai | PLEKHJ1 |
DMDMi | 74753007 |
Proteomic databases
EPDi | Q9NW61 |
MassIVEi | Q9NW61 |
MaxQBi | Q9NW61 |
PaxDbi | Q9NW61 |
PeptideAtlasi | Q9NW61 |
PRIDEi | Q9NW61 |
ProteomicsDBi | 82896 |
Protocols and materials databases
Antibodypediai | 22945, 133 antibodies |
DNASUi | 55111 |
Genome annotation databases
Ensembli | ENST00000326631; ENSP00000318075; ENSG00000104886 ENST00000589097; ENSP00000465391; ENSG00000104886 |
GeneIDi | 55111 |
KEGGi | hsa:55111 |
UCSCi | uc002lvf.2, human |
Organism-specific databases
CTDi | 55111 |
EuPathDBi | HostDB:ENSG00000104886.9 |
GeneCardsi | PLEKHJ1 |
HGNCi | HGNC:18211, PLEKHJ1 |
HPAi | ENSG00000104886, Low tissue specificity |
MIMi | 617834, gene |
neXtProti | NX_Q9NW61 |
PharmGKBi | PA134936152 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0017, Eukaryota |
GeneTreei | ENSGT00390000005235 |
HOGENOMi | CLU_141382_0_0_1 |
InParanoidi | Q9NW61 |
PhylomeDBi | Q9NW61 |
Enzyme and pathway databases
PathwayCommonsi | Q9NW61 |
Miscellaneous databases
BioGRID-ORCSi | 55111, 25 hits in 842 CRISPR screens |
ChiTaRSi | PLEKHJ1, human |
GenomeRNAii | 55111 |
Pharosi | Q9NW61, Tbio |
PROi | PR:Q9NW61 |
RNActi | Q9NW61, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104886, Expressed in mucosa of transverse colon and 117 other tissues |
ExpressionAtlasi | Q9NW61, baseline and differential |
Genevisiblei | Q9NW61, HS |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR001849, PH_domain |
Pfami | View protein in Pfam PF00169, PH, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PKHJ1_HUMAN | |
Accessioni | Q9NW61Primary (citable) accession number: Q9NW61 Secondary accession number(s): B3KUQ9, D6W604 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM