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Protein

Anoctamin-10

Gene

ANO10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.2 Publications

Miscellaneous

The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2672351 Stimuli-sensing channels

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.17.1.26 the calcium-dependent chloride channel (ca-clc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anoctamin-10
Alternative name(s):
Transmembrane protein 16K
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANO10
Synonyms:TMEM16K
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000160746.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25519 ANO10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613726 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NW15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 207CytoplasmicSequence analysisAdd BLAST207
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 240ExtracellularSequence analysisAdd BLAST12
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 316CytoplasmicSequence analysisAdd BLAST55
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Topological domaini338 – 352ExtracellularSequence analysisAdd BLAST15
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Topological domaini374 – 400CytoplasmicSequence analysisAdd BLAST27
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Topological domaini422 – 500ExtracellularSequence analysisAdd BLAST79
Transmembranei501 – 521HelicalSequence analysisAdd BLAST21
Topological domaini522 – 553CytoplasmicSequence analysisAdd BLAST32
Transmembranei554 – 574HelicalSequence analysisAdd BLAST21
Topological domaini575 – 590ExtracellularSequence analysisAdd BLAST16
Transmembranei591 – 611HelicalSequence analysisAdd BLAST21
Topological domaini612 – 660CytoplasmicSequence analysisAdd BLAST49

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spinocerebellar ataxia, autosomal recessive, 10 (SCAR10)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionSpinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR10 is characterized by onset in the teenage or young adult years of gait and limb ataxia, dysarthria, and nystagmus associated with marked cerebellar atrophy on brain imaging.
See also OMIM:613728
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_064888510L → R in SCAR10. 1 PublicationCorresponds to variant dbSNP:rs387907089EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNET

More...
DisGeNETi
55129

MalaCards human disease database

More...
MalaCardsi
ANO10
MIMi613728 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000160746

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
284289 Adult-onset autosomal recessive cerebellar ataxia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164715433

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANO10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
148887071

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002899571 – 660Anoctamin-10Add BLAST660

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NW15

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NW15

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NW15

PeptideAtlas

More...
PeptideAtlasi
Q9NW15

PRoteomics IDEntifications database

More...
PRIDEi
Q9NW15

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82887
82888 [Q9NW15-2]
82889 [Q9NW15-3]
82890 [Q9NW15-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NW15

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NW15

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the brain. Intermediate levels in the retina and heart and low levels in the placenta, liver, lung, duodenum, kidney, testis and spleen. In brain areas, highest expression in the frontal and occipital cortices and in the cerebellum. Lower expression in the fetal brain than in the adult brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160746 Expressed in 215 organ(s), highest expression level in amniotic fluid

CleanEx database of gene expression profiles

More...
CleanExi
HS_ANO10

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NW15 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NW15 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051569

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120435, 4 interactors

Protein interaction database and analysis system

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IntActi
Q9NW15, 4 interactors

Molecular INTeraction database

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MINTi
Q9NW15

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000292246

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1660
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9NW15

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NW15

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the anoctamin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2513 Eukaryota
ENOG410XPYE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157537

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007605

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG071385

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NW15

KEGG Orthology (KO)

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KOi
K19327

Identification of Orthologs from Complete Genome Data

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OMAi
YIIKHEL

Database of Orthologous Groups

More...
OrthoDBi
EOG091G06A3

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NW15

TreeFam database of animal gene trees

More...
TreeFami
TF314265

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007632 Anoctamin
IPR031291 Anoctamin-10

The PANTHER Classification System

More...
PANTHERi
PTHR12308 PTHR12308, 1 hit
PTHR12308:SF40 PTHR12308:SF40, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04547 Anoctamin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NW15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVTLSALDT SESSFTPLVV IELAQDVKEE TKEWLKNRII AKKKDGGAQL
60 70 80 90 100
LFRPLLNKYE QETLENQNLY LVGASKIRML LGAEAVGLVK ECNDNTMRAF
110 120 130 140 150
TYRTRQNFKG FDDNNDDFLT MAECQFIIKH ELENLRAKDE KMIPGYPQAK
160 170 180 190 200
LYPGKSLLRR LLTSGIVIQV FPLHDSEALK KLEDTWYTRF ALKYQPIDSI
210 220 230 240 250
RGYFGETIAL YFGFLEYFTF ALIPMAVIGL PYYLFVWEDY DKYVIFASFN
260 270 280 290 300
LIWSTVILEL WKRGCANMTY RWGTLLMKRK FEEPRPGFHG VLGINSITGK
310 320 330 340 350
EEPLYPSYKR QLRIYLVSLP FVCLCLYFSL YVMMIYFDME VWALGLHENS
360 370 380 390 400
GSEWTSVLLY VPSIIYAIVI EIMNRLYRYA AEFLTSWENH RLESAYQNHL
410 420 430 440 450
ILKVLVFNFL NCFASLFYIA FVLKDMKLLR QSLATLLITS QILNQIMESF
460 470 480 490 500
LPYWLQRKHG VRVKRKVQAL KADIDATLYE QVILEKEMGT YLGTFDDYLE
510 520 530 540 550
LFLQFGYVSL FSCVYPLAAA FAVLNNFTEV NSDALKMCRV FKRPFSEPSA
560 570 580 590 600
NIGVWQLAFE TMSVISVVTN CALIGMSPQV NAVFPESKAD LILIVVAVEH
610 620 630 640 650
ALLALKFILA FAIPDKPRHI QMKLARLEFE SLEALKQQQM KLVTENLKEE
660
PMESGKEKAT
Length:660
Mass (Da):76,329
Last modified:May 29, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i21582D364497ADFD
GO
Isoform 2 (identifier: Q9NW15-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-387: Missing.

Note: No experimental confirmation available.
Show »
Length:470
Mass (Da):53,843
Checksum:iE19D897F9DE194AE
GO
Isoform 3 (identifier: Q9NW15-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-112: Missing.

Note: No experimental confirmation available.
Show »
Length:594
Mass (Da):68,748
Checksum:iC9DEE8503AC34E78
GO
Isoform 4 (identifier: Q9NW15-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-158: GAQLLFRPLL...AKLYPGKSLL → V

Note: No experimental confirmation available.
Show »
Length:549
Mass (Da):63,526
Checksum:i2BDE5BF63C2BD6E0
GO
Isoform 5 (identifier: Q9NW15-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     600-660: HALLALKFIL...PMESGKEKAT → AASCKLVSLPRYSWSTNSVPGTVIGPGV

Note: No experimental confirmation available.Curated
Show »
Length:627
Mass (Da):72,144
Checksum:i3758F65009CEDDE7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JH90C9JH90_HUMAN
Anoctamin
ANO10
162Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3N6H7C3N6_HUMAN
Anoctamin
ANO10
188Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JPY2C9JPY2_HUMAN
Anoctamin-10
ANO10
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J670C9J670_HUMAN
Anoctamin-10
ANO10
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IZD0C9IZD0_HUMAN
Anoctamin-10
ANO10
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IYD3C9IYD3_HUMAN
Anoctamin-10
ANO10
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JJS5C9JJS5_HUMAN
Anoctamin-10
ANO10
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JA49C9JA49_HUMAN
Anoctamin-10
ANO10
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQC9C9JQC9_HUMAN
Anoctamin-10
ANO10
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91573 differs from that shown. Contaminating sequence.Curated
The sequence BC038855 differs from that shown. Reason: Frameshift at position 42.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 5 (identifier: Q9NW15-5)
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti607S → P in BAG60264 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032638462R → Q1 PublicationCorresponds to variant dbSNP:rs3772165EnsemblClinVar.1
Natural variantiVAR_064888510L → R in SCAR10. 1 PublicationCorresponds to variant dbSNP:rs387907089EnsemblClinVar.1
Natural variantiVAR_032639561T → M1 PublicationCorresponds to variant dbSNP:rs17409162EnsemblClinVar.1
Natural variantiVAR_032640583V → A1 PublicationCorresponds to variant dbSNP:rs17853862Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03821147 – 158GAQLL…GKSLL → V in isoform 4. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_03821247 – 112Missing in isoform 3. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_026033198 – 387Missing in isoform 2. 1 PublicationAdd BLAST190
Alternative sequenceiVSP_045885600 – 660HALLA…KEKAT → AASCKLVSLPRYSWSTNSVP GTVIGPGV in isoform 5. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001237 mRNA Translation: BAA91573.1 Sequence problems.
AK096302 mRNA Translation: BAG53253.1
AK131223 mRNA Translation: BAG54755.1
AK292368 mRNA Translation: BAF85057.1
AK295969 mRNA Translation: BAG58745.1
AK297949 mRNA Translation: BAG60264.1
AC097638 Genomic DNA No translation available.
AC104184 Genomic DNA No translation available.
AC105903 Genomic DNA No translation available.
AC135852 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64696.1
CH471055 Genomic DNA Translation: EAW64697.1
BC038855 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2710.2 [Q9NW15-1]
CCDS56247.1 [Q9NW15-4]
CCDS56248.1 [Q9NW15-3]
CCDS56249.1 [Q9NW15-2]
CCDS56250.1 [Q9NW15-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001191760.1, NM_001204831.2 [Q9NW15-5]
NP_001191761.1, NM_001204832.2 [Q9NW15-3]
NP_001191762.1, NM_001204833.2 [Q9NW15-4]
NP_001191763.1, NM_001204834.2 [Q9NW15-2]
NP_001333392.1, NM_001346463.1
NP_001333393.1, NM_001346464.1
NP_001333394.1, NM_001346465.1
NP_001333395.1, NM_001346466.1 [Q9NW15-3]
NP_001333396.1, NM_001346467.1
NP_001333397.1, NM_001346468.1 [Q9NW15-1]
NP_001333398.1, NM_001346469.1 [Q9NW15-3]
NP_060545.3, NM_018075.4 [Q9NW15-1]
XP_016862211.1, XM_017006722.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.656657

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000292246; ENSP00000292246; ENSG00000160746 [Q9NW15-1]
ENST00000350459; ENSP00000327767; ENSG00000160746 [Q9NW15-2]
ENST00000396091; ENSP00000379398; ENSG00000160746 [Q9NW15-3]
ENST00000414522; ENSP00000396990; ENSG00000160746 [Q9NW15-5]
ENST00000451430; ENSP00000394119; ENSG00000160746 [Q9NW15-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55129

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55129

UCSC genome browser

More...
UCSCi
uc003cmv.4 human [Q9NW15-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001237 mRNA Translation: BAA91573.1 Sequence problems.
AK096302 mRNA Translation: BAG53253.1
AK131223 mRNA Translation: BAG54755.1
AK292368 mRNA Translation: BAF85057.1
AK295969 mRNA Translation: BAG58745.1
AK297949 mRNA Translation: BAG60264.1
AC097638 Genomic DNA No translation available.
AC104184 Genomic DNA No translation available.
AC105903 Genomic DNA No translation available.
AC135852 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64696.1
CH471055 Genomic DNA Translation: EAW64697.1
BC038855 mRNA No translation available.
CCDSiCCDS2710.2 [Q9NW15-1]
CCDS56247.1 [Q9NW15-4]
CCDS56248.1 [Q9NW15-3]
CCDS56249.1 [Q9NW15-2]
CCDS56250.1 [Q9NW15-5]
RefSeqiNP_001191760.1, NM_001204831.2 [Q9NW15-5]
NP_001191761.1, NM_001204832.2 [Q9NW15-3]
NP_001191762.1, NM_001204833.2 [Q9NW15-4]
NP_001191763.1, NM_001204834.2 [Q9NW15-2]
NP_001333392.1, NM_001346463.1
NP_001333393.1, NM_001346464.1
NP_001333394.1, NM_001346465.1
NP_001333395.1, NM_001346466.1 [Q9NW15-3]
NP_001333396.1, NM_001346467.1
NP_001333397.1, NM_001346468.1 [Q9NW15-1]
NP_001333398.1, NM_001346469.1 [Q9NW15-3]
NP_060545.3, NM_018075.4 [Q9NW15-1]
XP_016862211.1, XM_017006722.1
UniGeneiHs.656657

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5OC9X-ray3.20A/B1-660[»]
ProteinModelPortaliQ9NW15
SMRiQ9NW15
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120435, 4 interactors
IntActiQ9NW15, 4 interactors
MINTiQ9NW15
STRINGi9606.ENSP00000292246

Protein family/group databases

TCDBi1.A.17.1.26 the calcium-dependent chloride channel (ca-clc) family

PTM databases

iPTMnetiQ9NW15
PhosphoSitePlusiQ9NW15

Polymorphism and mutation databases

BioMutaiANO10
DMDMi148887071

Proteomic databases

EPDiQ9NW15
MaxQBiQ9NW15
PaxDbiQ9NW15
PeptideAtlasiQ9NW15
PRIDEiQ9NW15
ProteomicsDBi82887
82888 [Q9NW15-2]
82889 [Q9NW15-3]
82890 [Q9NW15-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55129
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292246; ENSP00000292246; ENSG00000160746 [Q9NW15-1]
ENST00000350459; ENSP00000327767; ENSG00000160746 [Q9NW15-2]
ENST00000396091; ENSP00000379398; ENSG00000160746 [Q9NW15-3]
ENST00000414522; ENSP00000396990; ENSG00000160746 [Q9NW15-5]
ENST00000451430; ENSP00000394119; ENSG00000160746 [Q9NW15-4]
GeneIDi55129
KEGGihsa:55129
UCSCiuc003cmv.4 human [Q9NW15-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55129
DisGeNETi55129
EuPathDBiHostDB:ENSG00000160746.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ANO10
HGNCiHGNC:25519 ANO10
HPAiHPA051569
MalaCardsiANO10
MIMi613726 gene
613728 phenotype
neXtProtiNX_Q9NW15
OpenTargetsiENSG00000160746
Orphaneti284289 Adult-onset autosomal recessive cerebellar ataxia
PharmGKBiPA164715433

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2513 Eukaryota
ENOG410XPYE LUCA
GeneTreeiENSGT00940000157537
HOGENOMiHOG000007605
HOVERGENiHBG071385
InParanoidiQ9NW15
KOiK19327
OMAiYIIKHEL
OrthoDBiEOG091G06A3
PhylomeDBiQ9NW15
TreeFamiTF314265

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ANO10 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55129

Protein Ontology

More...
PROi
PR:Q9NW15

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160746 Expressed in 215 organ(s), highest expression level in amniotic fluid
CleanExiHS_ANO10
ExpressionAtlasiQ9NW15 baseline and differential
GenevisibleiQ9NW15 HS

Family and domain databases

InterProiView protein in InterPro
IPR007632 Anoctamin
IPR031291 Anoctamin-10
PANTHERiPTHR12308 PTHR12308, 1 hit
PTHR12308:SF40 PTHR12308:SF40, 1 hit
PfamiView protein in Pfam
PF04547 Anoctamin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANO10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NW15
Secondary accession number(s): A8K8K3
, A8MV74, B3KTZ1, B3KY93, B4DJ83, B4DNK2, B7WP12, C9JHS1, Q8IXX9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: December 5, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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