UniProtKB - Q9NW13 (RBM28_HUMAN)

BLAST

>sp|Q9NW13|RBM28_HUMAN RNA-binding protein 28 OS=Homo sapiens OX=9606 GN=RBM28 PE=1 SV=3
MAGLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQR
ALKEITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRN
LSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIK
GRTVAVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEENDDDDDDD
DEEDGVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDHSEEDSDLEESDSIDDGE
ELAQSDTSTEEQEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEELGELLQQFGE
LKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLKVDLAVTR
DEAAKLQTTKVKKPTGTRNLYLAREGLIRAGTKAAEGVSAADMAKRERFELLKHQKLKDQ
NIFVSRTRLCLHNLPKAVDDKQLRKLLLSATSGEKGVRIKECRVMRDLKGVHGNMKGQSL
GYAFAEFQEHEHALKALRLINNNPEIFGPLKRPIVEFSLEDRRKLKMKELRIQRSLQKMR
SKPATGEPQKGQPEPAKDQQQKAAQHHTEEQSKVPPEQKRKAGSTSWTGFQTKAEVEQVE
LPDGKKRRKVLALPSHRGPKIRLRDKGKVKPVHPKKPKPQINQWKQEKQQLSSEQVSRKK
AKGNKTETRFNQLVEQYKQKLLGPSKGAPLAKRSKWFDS

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History
Entry version 154 (07 Nov 2018)
Sequence version 3 (23 Jan 2007)
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Protein

RNA-binding protein 28

Gene

RBM28

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Nucleolar component of the spliceosomal ribonucleoprotein complexes.1 Publication

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA processing Source: UniProtKB-KW
RNA splicing Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: RNA-binding protein 28 Alternative name(s): RNA-binding motif protein 28
Gene namesⁱ	Name:RBM28
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000106344.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21863 RBM28
MIMⁱ	612074 gene
neXtProtⁱ	NX_Q9NW13

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Alopecia, neurologic defects, and endocrinopathy syndrome (ANES)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAffected individuals have hair loss of variable severity, ranging from complete alopecia to near-normal scalp hair with absence of body hair. All have moderate to severe mental retardation, progressive motor deterioration and central hypogonadotropic hypogonadism with delayed or absent puberty and central adrenal insufficiency. Additional features included short stature, microcephaly, gynecomastia, pigmentary anomalies, hypodontia, kyphoscoliosis, ulnar deviation of the hands, and loss of subcutaneous fat.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_045655	351	L → P in ANES. 1 PublicationCorresponds to variant dbSNP:rs118204055EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55131
MalaCards human disease database More...MalaCardsⁱ	RBM28
MIMⁱ	612079 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000106344
Orphanetⁱ	157954 ANE syndrome
PharmGKBⁱ	PA134867266

Polymorphism and mutation databases

BioMutaⁱ	RBM28
DMDMⁱ	55976611

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000081785	2 – 759	RNA-binding protein 28Add BLAST		758

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanine1 Publication	1
Modified residueⁱ	122	PhosphoserineCombined sources	1
Modified residueⁱ	397	PhosphoserineCombined sources	1
Cross-linkⁱ	653	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9NW13
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NW13
PaxDbⁱ	Q9NW13
PeptideAtlas More...PeptideAtlasⁱ	Q9NW13
PRIDEⁱ	Q9NW13
ProteomicsDBⁱ	82886

2D gel databases

SWISS-2DPAGEⁱ	Q9NW13

SWISS-2DPAGEⁱ

Q9NW13

PTM databases

iPTMnetⁱ	Q9NW13
PhosphoSitePlusⁱ	Q9NW13
SwissPalmⁱ	Q9NW13

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000106344 Expressed in 224 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_RBM28
ExpressionAtlasⁱ	Q9NW13 baseline and differential
Genevisibleⁱ	Q9NW13 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019058 HPA026672 HPA031519

HPAⁱ

HPA019058
HPA026672
HPA031519

Interactionⁱ

Subunit structureⁱ

Interacts with U1, U2, U4, U5, and U6 spliceosomal small nuclear RNAs (snRNAs).1 Publication

Protein-protein interaction databases

BioGridⁱ	120437, 105 interactors
CORUMⁱ	Q9NW13
IntActⁱ	Q9NW13, 34 interactors
Molecular INTeraction database More...MINTⁱ	Q9NW13
STRINGⁱ	9606.ENSP00000223073

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NW13
SMRⁱ	Q9NW13
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	4 – 80	RRM 1PROSITE-ProRule annotationAdd BLAST	77
Domainⁱ	114 – 191	RRM 2PROSITE-ProRule annotationAdd BLAST	78
Domainⁱ	335 – 419	RRM 3PROSITE-ProRule annotationAdd BLAST	85
Domainⁱ	487 – 597	RRM 4PROSITE-ProRule annotationAdd BLAST	111

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	224 – 258	Asp/Glu-rich (acidic)Add BLAST		35

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0127 Eukaryota ENOG410XSHP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074976
HOGENOMⁱ	HOG000124666
HOVERGENⁱ	HBG073213
InParanoidⁱ	Q9NW13
KEGG Orthology (KO) More...KOⁱ	K14573
OMAⁱ	VGCAFVQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JKS
PhylomeDBⁱ	Q9NW13
TreeFamⁱ	TF312798

Family and domain databases

Gene3Dⁱ	3.30.70.330, 4 hits
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 3 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 4 hits
SUPFAMⁱ	SSF54928 SSF54928, 4 hits
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 4 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NW13-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGLTLFVGR LPPSARSEQL EELFSQVGPV KQCFVVTEKG SKACRGFGYV 
        60         70         80         90        100
TFSMLEDVQR ALKEITTFEG CKINVTVAKK KLRNKTKEKG KNENSECPKK 
       110        120        130        140        150
EPKAKKAKVA DKKARLIIRN LSFKCSEDDL KTVFAQFGAV LEVNIPRKPD 
       160        170        180        190        200
GKMRGFGFVQ FKNLLEAGKA LKGMNMKEIK GRTVAVDWAV AKDKYKDTQS 
       210        220        230        240        250
VSAIGEEKSH ESKHQESVKK KGREEEDMEE EENDDDDDDD DEEDGVFDDE 
       260        270        280        290        300
DEEEENIESK VTKPVQIQKR AVKRPAPAKS SDHSEEDSDL EESDSIDDGE 
       310        320        330        340        350
ELAQSDTSTE EQEDKAVQVS NKKKRKLPSD VNEGKTVFIR NLSFDSEEEE 
       360        370        380        390        400
LGELLQQFGE LKYVRIVLHP DTEHSKGCAF AQFMTQEAAQ KCLLAASPEN 
       410        420        430        440        450
EAGGLKLDGR QLKVDLAVTR DEAAKLQTTK VKKPTGTRNL YLAREGLIRA 
       460        470        480        490        500
GTKAAEGVSA ADMAKRERFE LLKHQKLKDQ NIFVSRTRLC LHNLPKAVDD 
       510        520        530        540        550
KQLRKLLLSA TSGEKGVRIK ECRVMRDLKG VHGNMKGQSL GYAFAEFQEH 
       560        570        580        590        600
EHALKALRLI NNNPEIFGPL KRPIVEFSLE DRRKLKMKEL RIQRSLQKMR 
       610        620        630        640        650
SKPATGEPQK GQPEPAKDQQ QKAAQHHTEE QSKVPPEQKR KAGSTSWTGF 
       660        670        680        690        700
QTKAEVEQVE LPDGKKRRKV LALPSHRGPK IRLRDKGKVK PVHPKKPKPQ 
       710        720        730        740        750
INQWKQEKQQ LSSEQVSRKK AKGNKTETRF NQLVEQYKQK LLGPSKGAPL 

AKRSKWFDS

Length:759

Mass (Da):85,738

Last modified:January 23, 2007 - v3

Checksum:ⁱB477EDB9561D6771

Isoform 2 (identifier: Q9NW13-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
39-179: Missing.

« Hide

        10         20         30         40         50
MAGLTLFVGR LPPSARSEQL EELFSQVGPV KQCFVVTEKG RTVAVDWAVA 
        60         70         80         90        100
KDKYKDTQSV SAIGEEKSHE SKHQESVKKK GREEEDMEEE ENDDDDDDDD 
       110        120        130        140        150
EEDGVFDDED EEEENIESKV TKPVQIQKRA VKRPAPAKSS DHSEEDSDLE 
       160        170        180        190        200
ESDSIDDGEE LAQSDTSTEE QEDKAVQVSN KKKRKLPSDV NEGKTVFIRN 
       210        220        230        240        250
LSFDSEEEEL GELLQQFGEL KYVRIVLHPD TEHSKGCAFA QFMTQEAAQK 
       260        270        280        290        300
CLLAASPENE AGGLKLDGRQ LKVDLAVTRD EAAKLQTTKV KKPTGTRNLY 
       310        320        330        340        350
LAREGLIRAG TKAAEGVSAA DMAKRERFEL LKHQKLKDQN IFVSRTRLCL 
       360        370        380        390        400
HNLPKAVDDK QLRKLLLSAT SGEKGVRIKE CRVMRDLKGV HGNMKGQSLG 
       410        420        430        440        450
YAFAEFQEHE HALKALRLIN NNPEIFGPLK RPIVEFSLED RRKLKMKELR 
       460        470        480        490        500
IQRSLQKMRS KPATGEPQKG QPEPAKDQQQ KAAQHHTEEQ SKVPPEQKRK 
       510        520        530        540        550
AGSTSWTGFQ TKAEVEQVEL PDGKKRRKVL ALPSHRGPKI RLRDKGKVKP 
       560        570        580        590        600
VHPKKPKPQI NQWKQEKQQL SSEQVSRKKA KGNKTETRFN QLVEQYKQKL 
       610 
LGPSKGAPLA KRSKWFDS

Note: No experimental confirmation available.

Show »

Length:618

Mass (Da):69,923

Checksum:ⁱ324AB7A8031B9838

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JAA9	C9JAA9_HUMAN	RNA-binding protein 28 RNA-binding protein 28	RBM28	283	Annotation score:
H7C5G8	H7C5G8_HUMAN	RNA-binding protein 28 RNA-binding protein 28	RBM28	186	Annotation score:
C9JE21	C9JE21_HUMAN	RNA-binding protein 28 RNA-binding protein 28	RBM28	204	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	21	E → G in BAD96436 (Ref. 2) Curated	1
Sequence conflictⁱ	361	L → P in BAG62214 (PubMed:14702039).Curated	1
Sequence conflictⁱ	668	R → K in BAG62214 (PubMed:14702039).Curated	1
Sequence conflictⁱ	739	Q → R in BAA91575 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_045654	253	E → Q. Corresponds to variant dbSNP:rs11554671Ensembl.		1
Natural variantⁱVAR_045655	351	L → P in ANES. 1 PublicationCorresponds to variant dbSNP:rs118204055EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046111	39 – 179	Missing in isoform 2. 1 PublicationAdd BLAST		141

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK001239 mRNA Translation: BAA91575.1 AK300500 mRNA Translation: BAG62214.1 AK222716 mRNA Translation: BAD96436.1 AC010655 Genomic DNA No translation available. AC018635 Genomic DNA No translation available. CH236947 Genomic DNA Translation: EAL24314.1 CH471070 Genomic DNA Translation: EAW83643.1 BC013889 mRNA Translation: AAH13889.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS55159.1 [Q9NW13-2] CCDS5801.1 [Q9NW13-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001159607.1, NM_001166135.1 [Q9NW13-2] NP_060547.2, NM_018077.2 [Q9NW13-1]
UniGeneⁱ	Hs.274263 Hs.552129

Genome annotation databases

Ensemblⁱ	ENST00000223073; ENSP00000223073; ENSG00000106344 [Q9NW13-1] ENST00000415472; ENSP00000390517; ENSG00000106344 [Q9NW13-2]
GeneIDⁱ	55131
KEGGⁱ	hsa:55131
UCSC genome browser More...UCSCⁱ	uc011koj.2 human [Q9NW13-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NW13	RNA binding motif protein 28 isoform 1		HUMAN		759	UniRef100_Q9NW13

Protein	Similar proteins		Species	Score	Length	Source
Q9NW13	RNA binding motif protein 28 isoform 1		HUMAN		759	UniRef90_Q9NW13
Uncharacterized protein		MACNE		766
RNA-binding protein 28 isoform 1		MACMU		763
Uncharacterized protein		NOMLE		763
Uncharacterized protein		RHIBE		763
+24
Q9NW13-2	Uncharacterized protein		NOMLE		622	UniRef90_Q9NW13-2
Uncharacterized protein		RHIBE		622
Uncharacterized protein		RHIRO		621
Uncharacterized protein		PAPAN		621
RBM28 isoform 4		PANTR		620
+3

Protein	Similar proteins		Species	Score	Length	Source
Q9NW13	RNA-binding protein 28	)	MOUSE		750	UniRef50_Q9NW13
RNA binding motif protein 28 isoform 1		HUMAN		759
Uncharacterized protein		MACNE		766
RNA-binding protein 28 isoform 1		MACMU		763
Uncharacterized protein		NOMLE		763
+154
Q9NW13-2	Uncharacterized protein		NOMLE		622	UniRef50_Q9NW13-2
Uncharacterized protein		RHIBE		622
Uncharacterized protein		PAPAN		621
Uncharacterized protein		RHIRO		621
Uncharacterized protein		PANPA		620
+14

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK001239 mRNA Translation: BAA91575.1 AK300500 mRNA Translation: BAG62214.1 AK222716 mRNA Translation: BAD96436.1 AC010655 Genomic DNA No translation available. AC018635 Genomic DNA No translation available. CH236947 Genomic DNA Translation: EAL24314.1 CH471070 Genomic DNA Translation: EAW83643.1 BC013889 mRNA Translation: AAH13889.1
CCDSⁱ	CCDS55159.1 [Q9NW13-2] CCDS5801.1 [Q9NW13-1]
RefSeqⁱ	NP_001159607.1, NM_001166135.1 [Q9NW13-2] NP_060547.2, NM_018077.2 [Q9NW13-1]
UniGeneⁱ	Hs.274263 Hs.552129

3D structure databases

ProteinModelPortalⁱ	Q9NW13
SMRⁱ	Q9NW13
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120437, 105 interactors
CORUMⁱ	Q9NW13
IntActⁱ	Q9NW13, 34 interactors
MINTⁱ	Q9NW13
STRINGⁱ	9606.ENSP00000223073

PTM databases

iPTMnetⁱ	Q9NW13
PhosphoSitePlusⁱ	Q9NW13
SwissPalmⁱ	Q9NW13

Polymorphism and mutation databases

BioMutaⁱ	RBM28
DMDMⁱ	55976611

2D gel databases

SWISS-2DPAGEⁱ	Q9NW13

SWISS-2DPAGEⁱ

Q9NW13

Proteomic databases

EPDⁱ	Q9NW13
MaxQBⁱ	Q9NW13
PaxDbⁱ	Q9NW13
PeptideAtlasⁱ	Q9NW13
PRIDEⁱ	Q9NW13
ProteomicsDBⁱ	82886

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000223073; ENSP00000223073; ENSG00000106344 [Q9NW13-1] ENST00000415472; ENSP00000390517; ENSG00000106344 [Q9NW13-2]
GeneIDⁱ	55131
KEGGⁱ	hsa:55131
UCSCⁱ	uc011koj.2 human [Q9NW13-1]

Organism-specific databases

CTDⁱ	55131
DisGeNETⁱ	55131
EuPathDBⁱ	HostDB:ENSG00000106344.8
GeneCardsⁱ	RBM28
HGNCⁱ	HGNC:21863 RBM28
HPAⁱ	HPA019058 HPA026672 HPA031519
MalaCardsⁱ	RBM28
MIMⁱ	612074 gene 612079 phenotype
neXtProtⁱ	NX_Q9NW13
OpenTargetsⁱ	ENSG00000106344
Orphanetⁱ	157954 ANE syndrome
PharmGKBⁱ	PA134867266
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0127 Eukaryota ENOG410XSHP LUCA
GeneTreeⁱ	ENSGT00550000074976
HOGENOMⁱ	HOG000124666
HOVERGENⁱ	HBG073213
InParanoidⁱ	Q9NW13
KOⁱ	K14573
OMAⁱ	VGCAFVQ
OrthoDBⁱ	EOG091G0JKS
PhylomeDBⁱ	Q9NW13
TreeFamⁱ	TF312798

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSⁱ	RBM28 human
GeneWikiⁱ	RBM28
GenomeRNAiⁱ	55131
Protein Ontology More...PROⁱ	PR:Q9NW13
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000106344 Expressed in 224 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_RBM28
ExpressionAtlasⁱ	Q9NW13 baseline and differential
Genevisibleⁱ	Q9NW13 HS

Family and domain databases

Gene3Dⁱ	3.30.70.330, 4 hits
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 3 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 4 hits
SUPFAMⁱ	SSF54928 SSF54928, 4 hits
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RBM28_HUMAN
Accessionⁱ	Q9NW13Primary (citable) accession number: Q9NW13 Secondary accession number(s): A4D100 , B4DU52, E9PDD9, Q53H65, Q96CV3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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UniProtKB - Q9NW13 (RBM28_HUMAN)

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RNA-binding protein 28

RBM28

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ