UniProtKB - Q9NW07 (ZN358_HUMAN)
Protein
Zinc finger protein 358
Gene
ZNF358
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 151 – 173 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 179 – 201 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 207 – 229 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 235 – 257 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 263 – 285 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 291 – 313 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 319 – 341 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 347 – 369 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 375 – 397 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- embryonic forelimb morphogenesis Source: UniProtKB
- neural tube development Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- stem cell population maintenance Source: UniProtKB
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9NW07 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 358 |
Gene namesi | Name:ZNF358 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16838, ZNF358 |
neXtProti | NX_Q9NW07 |
VEuPathDBi | HostDB:ENSG00000198816.5 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nuclear chromatin Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 140467 |
OpenTargetsi | ENSG00000198816 |
PharmGKBi | PA38189 |
Miscellaneous databases
Pharosi | Q9NW07, Tdark |
Genetic variation databases
BioMutai | ZNF358 |
DMDMi | 251757418 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047547 | 1 – 568 | Zinc finger protein 358Add BLAST | 568 |
Proteomic databases
EPDi | Q9NW07 |
jPOSTi | Q9NW07 |
MassIVEi | Q9NW07 |
MaxQBi | Q9NW07 |
PaxDbi | Q9NW07 |
PeptideAtlasi | Q9NW07 |
PRIDEi | Q9NW07 |
ProteomicsDBi | 82884 |
PTM databases
iPTMneti | Q9NW07 |
PhosphoSitePlusi | Q9NW07 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198816, Expressed in apex of heart and 209 other tissues |
ExpressionAtlasi | Q9NW07, baseline and differential |
Genevisiblei | Q9NW07, HS |
Organism-specific databases
HPAi | ENSG00000198816, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 126619, 7 interactors |
IntActi | Q9NW07, 4 interactors |
STRINGi | 9606.ENSP00000472305 |
Miscellaneous databases
RNActi | Q9NW07, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 400 – 416 | Poly-AlaAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 151 – 173 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 179 – 201 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 207 – 229 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 235 – 257 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 263 – 285 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 291 – 313 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 319 – 341 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 347 – 369 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 375 – 397 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162948 |
HOGENOMi | CLU_025444_0_0_1 |
InParanoidi | Q9NW07 |
OMAi | WVKEEGA |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9NW07 |
TreeFami | TF350840 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 7 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9NW07-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRRSVLVRNP GHKGLRPVYE ELDSDSEDLD PNPEDLDPVS EDPEPDPEDL
60 70 80 90 100
NTVPEDVDPS YEDLEPVSED LDPDAEAPGS EPQDPDPMSS SFDLDPDVIG
110 120 130 140 150
PVPLILDPNS DTLSPGDPKV DPISSGLTAT PQVLATSPAV LPAPASPPRP
160 170 180 190 200
FSCPDCGRAF RRSSGLSQHR RTHSGEKPYR CPDCGKSFSH GATLAQHRGI
210 220 230 240 250
HTGARPYQCA ACGKAFGWRS TLLKHRSSHS GEKPHHCPVC GKAFGHGSLL
260 270 280 290 300
AQHLRTHGGP RPHKCPVCAK GFGQGSALLK HLRTHTGERP YPCPQCGKAF
310 320 330 340 350
GQSSALLQHQ RTHTAERPYR CPHCGKAFGQ SSNLQHHLRI HTGERPYACP
360 370 380 390 400
HCSKAFGQSS ALLQHLHVHS GERPYRCQLC GKAFGQASSL TKHKRVHEGA
410 420 430 440 450
AAAAAAAAAA AAAAAAGLGL GPGLSPASMM RPGQVSLLGP DAVSVLGSGL
460 470 480 490 500
GLSPGTSSGR NPDPGSGPGT LPDPSSKPLP GSRSTPSPTP VESSDPKAGH
510 520 530 540 550
DAGPDLVPSP DLDPVPSPDP DPVPSPDPNP VSCPDPCSPT RGTVSPALPT
560
GESPEWVQEQ GALLGPDG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0R2S5 | M0R2S5_HUMAN | Zinc finger protein 358 | ZNF358 | 169 | Annotation score: |
Sequence cautioni
The sequence AAH14002 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91582 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 242 | K → Q in CX782162 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061944 | 32 | N → S. Corresponds to variant dbSNP:rs11555037Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008878 Genomic DNA No translation available. BC003585 mRNA Translation: AAH03585.1 BC014002 mRNA Translation: AAH14002.1 Different initiation. CX782162 mRNA No translation available. AK001252 mRNA Translation: BAA91582.1 Different initiation. |
CCDSi | CCDS32890.2 |
RefSeqi | NP_060553.4, NM_018083.4 XP_005272517.1, XM_005272460.3 XP_011525997.1, XM_011527695.1 |
Genome annotation databases
Ensembli | ENST00000597229; ENSP00000472305; ENSG00000198816 |
GeneIDi | 140467 |
KEGGi | hsa:140467 |
UCSCi | uc002mgn.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008878 Genomic DNA No translation available. BC003585 mRNA Translation: AAH03585.1 BC014002 mRNA Translation: AAH14002.1 Different initiation. CX782162 mRNA No translation available. AK001252 mRNA Translation: BAA91582.1 Different initiation. |
CCDSi | CCDS32890.2 |
RefSeqi | NP_060553.4, NM_018083.4 XP_005272517.1, XM_005272460.3 XP_011525997.1, XM_011527695.1 |
3D structure databases
SMRi | Q9NW07 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126619, 7 interactors |
IntActi | Q9NW07, 4 interactors |
STRINGi | 9606.ENSP00000472305 |
PTM databases
iPTMneti | Q9NW07 |
PhosphoSitePlusi | Q9NW07 |
Genetic variation databases
BioMutai | ZNF358 |
DMDMi | 251757418 |
Proteomic databases
EPDi | Q9NW07 |
jPOSTi | Q9NW07 |
MassIVEi | Q9NW07 |
MaxQBi | Q9NW07 |
PaxDbi | Q9NW07 |
PeptideAtlasi | Q9NW07 |
PRIDEi | Q9NW07 |
ProteomicsDBi | 82884 |
Protocols and materials databases
Antibodypediai | 12050, 120 antibodies |
Genome annotation databases
Ensembli | ENST00000597229; ENSP00000472305; ENSG00000198816 |
GeneIDi | 140467 |
KEGGi | hsa:140467 |
UCSCi | uc002mgn.3, human |
Organism-specific databases
CTDi | 140467 |
DisGeNETi | 140467 |
GeneCardsi | ZNF358 |
HGNCi | HGNC:16838, ZNF358 |
HPAi | ENSG00000198816, Low tissue specificity |
neXtProti | NX_Q9NW07 |
OpenTargetsi | ENSG00000198816 |
PharmGKBi | PA38189 |
VEuPathDBi | HostDB:ENSG00000198816.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162948 |
HOGENOMi | CLU_025444_0_0_1 |
InParanoidi | Q9NW07 |
OMAi | WVKEEGA |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9NW07 |
TreeFami | TF350840 |
Enzyme and pathway databases
PathwayCommonsi | Q9NW07 |
Miscellaneous databases
BioGRID-ORCSi | 140467, 6 hits in 900 CRISPR screens |
ChiTaRSi | ZNF358, human |
GenomeRNAii | 140467 |
Pharosi | Q9NW07, Tdark |
PROi | PR:Q9NW07 |
RNActi | Q9NW07, protein |
Gene expression databases
Bgeei | ENSG00000198816, Expressed in apex of heart and 209 other tissues |
ExpressionAtlasi | Q9NW07, baseline and differential |
Genevisiblei | Q9NW07, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 7 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN358_HUMAN | |
Accessioni | Q9NW07Primary (citable) accession number: Q9NW07 Secondary accession number(s): Q9BTM7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | July 7, 2009 | |
Last modified: | February 10, 2021 | |
This is version 162 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families