UniProtKB - Q9NVX0 (HAUS2_HUMAN)
Protein
HAUS augmin-like complex subunit 2
Gene
HAUS2
Organism
Homo sapiens (Human)
Status
Functioni
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.2 Publications
GO - Biological processi
- cell division Source: UniProtKB-KW
- centrosome cycle Source: UniProtKB
- ciliary basal body-plasma membrane docking Source: Reactome
- G2/M transition of mitotic cell cycle Source: Reactome
- regulation of G2/M transition of mitotic cell cycle Source: Reactome
- spindle assembly Source: UniProtKB
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Enzyme and pathway databases
PathwayCommonsi | Q9NVX0 |
Reactomei | R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-8854518, AURKA Activation by TPX2 |
Names & Taxonomyi
Protein namesi | Recommended name: HAUS augmin-like complex subunit 2Alternative name(s): Centrosomal protein of 27 kDa Short name: Cep27 |
Gene namesi | Name:HAUS2 Synonyms:C15orf25, CEP27 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25530, HAUS2 |
MIMi | 613429, gene |
neXtProti | NX_Q9NVX0 |
VEuPathDBi | HostDB:ENSG00000137814.9 |
Subcellular locationi
Cytoskeleton
- centrosome 3 Publications
- spindle 3 Publications
Note: Localizes to interphase centrosomes and to mitotic spindle microtubules.3 Publications
Cytoskeleton
- centrosome Source: UniProtKB
- HAUS complex Source: UniProtKB
- spindle microtubule Source: Ensembl
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000137814 |
PharmGKBi | PA165479051 |
Miscellaneous databases
Pharosi | Q9NVX0, Tbio |
Genetic variation databases
BioMutai | HAUS2 |
DMDMi | 56748883 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089484 | 1 – 235 | HAUS augmin-like complex subunit 2Add BLAST | 235 |
Proteomic databases
EPDi | Q9NVX0 |
jPOSTi | Q9NVX0 |
MassIVEi | Q9NVX0 |
MaxQBi | Q9NVX0 |
PaxDbi | Q9NVX0 |
PeptideAtlasi | Q9NVX0 |
PRIDEi | Q9NVX0 |
ProteomicsDBi | 82873 [Q9NVX0-1] 82874 [Q9NVX0-2] 82875 [Q9NVX0-3] |
PTM databases
iPTMneti | Q9NVX0 |
PhosphoSitePlusi | Q9NVX0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000137814, Expressed in occipital lobe and 249 other tissues |
ExpressionAtlasi | Q9NVX0, baseline and differential |
Genevisiblei | Q9NVX0, HS |
Organism-specific databases
HPAi | ENSG00000137814, Low tissue specificity |
Interactioni
Subunit structurei
Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.
Interacts with EML3 (phosphorylated at 'Thr-881') (PubMed:30723163).
3 PublicationsBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 120445, 107 interactors |
ComplexPortali | CPX-1847, HAUS complex |
CORUMi | Q9NVX0 |
DIPi | DIP-48836N |
IntActi | Q9NVX0, 47 interactors |
MINTi | Q9NVX0 |
STRINGi | 9606.ENSP00000260372 |
Miscellaneous databases
RNActi | Q9NVX0, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 51 – 115 | Sequence analysisAdd BLAST | 65 |
Sequence similaritiesi
Belongs to the HAUS2 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502RY4E, Eukaryota |
GeneTreei | ENSGT00390000004927 |
InParanoidi | Q9NVX0 |
PhylomeDBi | Q9NVX0 |
TreeFami | TF333194 |
Family and domain databases
InterProi | View protein in InterPro IPR028346, HAUS2 IPR026242, HAUS2_metazoa |
PANTHERi | PTHR16039, PTHR16039, 1 hit |
Pfami | View protein in Pfam PF15003, HAUS2, 1 hit |
PRINTSi | PR02088, HAUSAUGMINL2 |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NVX0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAANPWDPA SAPNGAGLVL GHFIASGMVN QEMLNMSKKT VSCFVNFTRL
60 70 80 90 100
QQITNIQAEI YQKNLEIELL KLEKDTADVV HPFFLAQKCH TLQSMNNHLE
110 120 130 140 150
AVLKEKRSLR QRLLKPMCQE NLPIEAVYHR YMVHLLELAV TFIERLETHL
160 170 180 190 200
ETIRNIPHLA ANLKKMNQAL AKMDILVTET EELAENILKW RKQQNEVSSC
210 220 230
IPKILAEESY LYKHDIIMPP LPFTSKVHVQ TINAK
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketU3KQI5 | U3KQI5_HUMAN | HAUS augmin-like complex subunit 2 | HAUS2 | 55 | Annotation score: | ||
H3BQU2 | H3BQU2_HUMAN | HAUS augmin-like complex subunit 2 | HAUS2 | 180 | Annotation score: | ||
H3BP16 | H3BP16_HUMAN | HAUS augmin-like complex subunit 2 | HAUS2 | 124 | Annotation score: | ||
H3BP24 | H3BP24_HUMAN | HAUS augmin-like complex subunit 2 | HAUS2 | 95 | Annotation score: | ||
H3BR32 | H3BR32_HUMAN | HAUS augmin-like complex subunit 2 | HAUS2 | 71 | Annotation score: | ||
H3BTG9 | H3BTG9_HUMAN | HAUS augmin-like complex subunit 2 | HAUS2 | 63 | Annotation score: | ||
J3QT48 | J3QT48_HUMAN | HAUS augmin-like complex subunit 2 | HAUS2 | 93 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050793 | 76 | T → P. Corresponds to variant dbSNP:rs34678957Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012223 | 1 – 94 | Missing in isoform 2. 1 PublicationAdd BLAST | 94 | |
Alternative sequenceiVSP_040918 | 32 – 62 | Missing in isoform 3. CuratedAdd BLAST | 31 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001322 mRNA Translation: BAA91623.1 AK022939 mRNA Translation: BAB14319.1 AC018362 Genomic DNA No translation available. BC010903 mRNA Translation: AAH10903.1 |
CCDSi | CCDS10090.1 [Q9NVX0-1] CCDS45247.1 [Q9NVX0-3] |
RefSeqi | NP_001123919.1, NM_001130447.1 [Q9NVX0-3] NP_001310560.1, NM_001323631.1 [Q9NVX0-2] NP_001310561.1, NM_001323632.1 [Q9NVX0-2] NP_060567.1, NM_018097.2 [Q9NVX0-1] XP_016877885.1, XM_017022396.1 [Q9NVX0-2] XP_016877886.1, XM_017022397.1 [Q9NVX0-2] |
Genome annotation databases
Ensembli | ENST00000260372; ENSP00000260372; ENSG00000137814 [Q9NVX0-1] ENST00000568876; ENSP00000456578; ENSG00000137814 [Q9NVX0-3] |
GeneIDi | 55142 |
KEGGi | hsa:55142 |
UCSCi | uc001zqe.4, human [Q9NVX0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001322 mRNA Translation: BAA91623.1 AK022939 mRNA Translation: BAB14319.1 AC018362 Genomic DNA No translation available. BC010903 mRNA Translation: AAH10903.1 |
CCDSi | CCDS10090.1 [Q9NVX0-1] CCDS45247.1 [Q9NVX0-3] |
RefSeqi | NP_001123919.1, NM_001130447.1 [Q9NVX0-3] NP_001310560.1, NM_001323631.1 [Q9NVX0-2] NP_001310561.1, NM_001323632.1 [Q9NVX0-2] NP_060567.1, NM_018097.2 [Q9NVX0-1] XP_016877885.1, XM_017022396.1 [Q9NVX0-2] XP_016877886.1, XM_017022397.1 [Q9NVX0-2] |
3D structure databases
SMRi | Q9NVX0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120445, 107 interactors |
ComplexPortali | CPX-1847, HAUS complex |
CORUMi | Q9NVX0 |
DIPi | DIP-48836N |
IntActi | Q9NVX0, 47 interactors |
MINTi | Q9NVX0 |
STRINGi | 9606.ENSP00000260372 |
PTM databases
iPTMneti | Q9NVX0 |
PhosphoSitePlusi | Q9NVX0 |
Genetic variation databases
BioMutai | HAUS2 |
DMDMi | 56748883 |
Proteomic databases
EPDi | Q9NVX0 |
jPOSTi | Q9NVX0 |
MassIVEi | Q9NVX0 |
MaxQBi | Q9NVX0 |
PaxDbi | Q9NVX0 |
PeptideAtlasi | Q9NVX0 |
PRIDEi | Q9NVX0 |
ProteomicsDBi | 82873 [Q9NVX0-1] 82874 [Q9NVX0-2] 82875 [Q9NVX0-3] |
Protocols and materials databases
Antibodypediai | 23697, 64 antibodies |
DNASUi | 55142 |
Genome annotation databases
Ensembli | ENST00000260372; ENSP00000260372; ENSG00000137814 [Q9NVX0-1] ENST00000568876; ENSP00000456578; ENSG00000137814 [Q9NVX0-3] |
GeneIDi | 55142 |
KEGGi | hsa:55142 |
UCSCi | uc001zqe.4, human [Q9NVX0-1] |
Organism-specific databases
CTDi | 55142 |
GeneCardsi | HAUS2 |
HGNCi | HGNC:25530, HAUS2 |
HPAi | ENSG00000137814, Low tissue specificity |
MIMi | 613429, gene |
neXtProti | NX_Q9NVX0 |
OpenTargetsi | ENSG00000137814 |
PharmGKBi | PA165479051 |
VEuPathDBi | HostDB:ENSG00000137814.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RY4E, Eukaryota |
GeneTreei | ENSGT00390000004927 |
InParanoidi | Q9NVX0 |
PhylomeDBi | Q9NVX0 |
TreeFami | TF333194 |
Enzyme and pathway databases
PathwayCommonsi | Q9NVX0 |
Reactomei | R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-8854518, AURKA Activation by TPX2 |
Miscellaneous databases
BioGRID-ORCSi | 55142, 267 hits in 879 CRISPR screens |
ChiTaRSi | HAUS2, human |
GenomeRNAii | 55142 |
Pharosi | Q9NVX0, Tbio |
PROi | PR:Q9NVX0 |
RNActi | Q9NVX0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137814, Expressed in occipital lobe and 249 other tissues |
ExpressionAtlasi | Q9NVX0, baseline and differential |
Genevisiblei | Q9NVX0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028346, HAUS2 IPR026242, HAUS2_metazoa |
PANTHERi | PTHR16039, PTHR16039, 1 hit |
Pfami | View protein in Pfam PF15003, HAUS2, 1 hit |
PRINTSi | PR02088, HAUSAUGMINL2 |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HAUS2_HUMAN | |
Accessioni | Q9NVX0Primary (citable) accession number: Q9NVX0 Secondary accession number(s): C9JH36, Q9H9B3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 21, 2004 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants