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Protein

THAP domain-containing protein 1

Gene

THAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1 – 81THAP-typePROSITE-ProRule annotationAdd BLAST81

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
THAP domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THAP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000131931.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20856 THAP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609520 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NVV9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Dystonia 6, torsion (DYT6)20 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary torsion dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Dystonia type 6 is characterized by onset in early adulthood, cranial or cervical involvement in about half of the cases, and frequent progression to involve multiple body regions.
See also OMIM:602629
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0666776S → F in DYT6. 1 Publication1
Natural variantiVAR_0666786S → P in DYT6. 1 Publication1
Natural variantiVAR_0673567A → D in DYT6. 1 Publication1
Natural variantiVAR_0666798Y → C in DYT6. 1 Publication1
Natural variantiVAR_0666809G → C in DYT6. 1 PublicationCorresponds to variant dbSNP:rs267607112EnsemblClinVar.1
Natural variantiVAR_06588012N → K in DYT6. 1 Publication1
Natural variantiVAR_06668113R → H in DYT6. 1 Publication1
Natural variantiVAR_06668216K → E in DYT6; lower activity than wild-type. 2 Publications1
Natural variantiVAR_06668317D → G in DYT6. 1 PublicationCorresponds to variant dbSNP:rs766483829Ensembl.1
Natural variantiVAR_06735721S → C in DYT6. 1 Publication1
Natural variantiVAR_06588121S → T in DYT6. 1 Publication1
Natural variantiVAR_06668423H → P in DYT6; lower activity than wild-type. 1 PublicationCorresponds to variant dbSNP:rs387907177EnsemblClinVar.1
Natural variantiVAR_06668524K → E in DYT6; lower activity than wild-type. 1 PublicationCorresponds to variant dbSNP:rs387907176EnsemblClinVar.1
Natural variantiVAR_06668626P → L in DYT6; lower activity than wild-type. 1 Publication1
Natural variantiVAR_06668726P → R in DYT6. 1 Publication1
Natural variantiVAR_06588229R → P in DYT6. 1 Publication1
Natural variantiVAR_06668829R → Q in DYT6. 2 PublicationsCorresponds to variant dbSNP:rs767952378Ensembl.1
Natural variantiVAR_06668930P → R in DYT6. 1 Publication1
Natural variantiVAR_06669032L → H in DYT6; lower activity than wild-type. 1 Publication1
Natural variantiVAR_06588339A → T in DYT6. 1 Publication1
Natural variantiVAR_06669154C → F in DYT6. 1 Publication1
Natural variantiVAR_07227256E → G in DYT6. 1 Publication1
Natural variantiVAR_06669257H → N in DYT6. 1 Publication1
Natural variantiVAR_06588459T → I in DYT6. 1 Publication1
Natural variantiVAR_06669369Missing in DYT6. 2 Publications1
Natural variantiVAR_06669472L → R in DYT6. 1 Publication1
Natural variantiVAR_06669575N → I in DYT6. 2 Publications1
Natural variantiVAR_06669680I → V in DYT6; mild phenotype; does not affect activity. 2 PublicationsCorresponds to variant dbSNP:rs372080941EnsemblClinVar.1
Natural variantiVAR_05478881F → L in DYT6; affects DNA-binding. 2 PublicationsCorresponds to variant dbSNP:rs118204013EnsemblClinVar.1
Natural variantiVAR_06669783C → R in DYT6. 1 PublicationCorresponds to variant dbSNP:rs768017019Ensembl.1
Natural variantiVAR_06588589K → R in DYT6. 2 PublicationsCorresponds to variant dbSNP:rs267607111EnsemblClinVar.1
Natural variantiVAR_066698132F → S in DYT6. 1 PublicationCorresponds to variant dbSNP:rs950435041Ensembl.1
Natural variantiVAR_065886136N → K in DYT6. 1 Publication1
Natural variantiVAR_066699136N → S in DYT6. 1 PublicationCorresponds to variant dbSNP:rs769988455Ensembl.1
Natural variantiVAR_066700137Y → C in DYT6. 1 Publication1
Natural variantiVAR_066701143M → V in DYT6; no effect on dimerization. 2 PublicationsCorresponds to variant dbSNP:rs374512193EnsemblClinVar.1
Natural variantiVAR_066702149I → T in DYT6; no effect on dimerization. 3 Publications1
Natural variantiVAR_066703150H → P in DYT6; no effect on dimerization. 3 Publications1
Natural variantiVAR_066704166A → T in DYT6; no effect on dimerization. 2 PublicationsCorresponds to variant dbSNP:rs138918468Ensembl.1
Natural variantiVAR_066705169R → Q in DYT6; no effect on dimerization. 2 PublicationsCorresponds to variant dbSNP:rs767519301EnsemblClinVar.1
Natural variantiVAR_065887170C → R in DYT6; no effect on dimerization. 2 Publications1
Natural variantiVAR_066706174E → G in DYT6; no effect on dimerization. 2 PublicationsCorresponds to variant dbSNP:rs759392096Ensembl.1
Natural variantiVAR_079366177L → P in DYT6; no effect on dimerization. 1 Publication1
Natural variantiVAR_066707180L → S in DYT6; no effect on dimerization. 2 Publications1
Natural variantiVAR_066708187Q → K in DYT6. 1 Publication1
Natural variantiVAR_066709192D → N in DYT6. 1 PublicationCorresponds to variant dbSNP:rs377725442EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi4S → A: Does not affect DNA-binding. 1 Publication1
Mutagenesisi5C → A: Abolishes DNA- and zinc-binding. 2 Publications1
Mutagenesisi6S → A: Does not affect DNA-binding. 1 Publication1
Mutagenesisi8Y → A: Does not affect DNA-binding. 1 Publication1
Mutagenesisi10C → A: Abolishes DNA- and zinc-binding. 2 Publications1
Mutagenesisi11K → A: Partially affects DNA-binding. 1 Publication1
Mutagenesisi16K → A: Does not affect DNA-binding. 1 Publication1
Mutagenesisi24K → A: Strongly affects DNA-binding. 1 Publication1
Mutagenesisi26P → A: Abolishes DNA- and zinc-binding. 2 Publications1
Mutagenesisi27L → A: Partially affects DNA-binding. 1 Publication1
Mutagenesisi28 – 30TRP → AAA: Strongly affects DNA-binding. 3
Mutagenesisi28T → A: Does not affect DNA-binding. 1 Publication1
Mutagenesisi29R → A: Strongly affects DNA-binding. 1 Publication1
Mutagenesisi30P → A: Does not affect DNA-binding. 1 Publication1
Mutagenesisi31S → A: Does not affect DNA-binding. 1 Publication1
Mutagenesisi32L → A: Does not affect DNA-binding. 1 Publication1
Mutagenesisi33C → A: Does not affect DNA-binding. 1 Publication1
Mutagenesisi34K → A: Does not affect DNA-binding. 1 Publication1
Mutagenesisi35E → A: Does not affect DNA-binding. 1 Publication1
Mutagenesisi36W → A: Abolishes DNA- and zinc-binding. 2 Publications1
Mutagenesisi37E → A: Partially affects DNA-binding. 1 Publication1
Mutagenesisi40V → A: Partially affects DNA-binding. 1 Publication1
Mutagenesisi41 – 43RRK → AAA: Strongly affects DNA-binding. 3
Mutagenesisi41R → A: Does not affect DNA-binding. 1 Publication1
Mutagenesisi42R → A: Strongly affects DNA-binding. 1 Publication1
Mutagenesisi43K → A: Does not affect DNA-binding. 1 Publication1
Mutagenesisi44N → A: Does not affect DNA-binding. 1 Publication1
Mutagenesisi45F → A: Strongly affects DNA-binding. 1 Publication1
Mutagenesisi46K → A: Does not affect DNA-binding. 1 Publication1
Mutagenesisi47 – 49PTK → AAA: Strongly affects DNA-binding. 3
Mutagenesisi47P → A: Does not affect DNA-binding. 1 Publication1
Mutagenesisi48T → A: Strongly affects DNA-binding. 1 Publication1
Mutagenesisi49K → A: Does not affect DNA-binding. 1
Mutagenesisi50 – 52YSS → AAA: Strongly affects DNA-binding. 3
Mutagenesisi50Y → A: Partially affects DNA-binding. 1 Publication1
Mutagenesisi51S → A: Does not affect DNA-binding. 1 Publication1
Mutagenesisi52S → A: Does not affect DNA-binding. 1 Publication1
Mutagenesisi54C → A: Abolishes DNA- and zinc-binding. 2 Publications1
Mutagenesisi55S → A: Does not affect DNA-binding. 1 Publication1
Mutagenesisi57H → A: Abolishes DNA- and zinc-binding. 2 Publications1
Mutagenesisi58F → A: Abolishes DNA- and zinc-binding. 2 Publications1
Mutagenesisi78P → A: Abolishes DNA- and zinc-binding. 2 Publications1

Keywords - Diseasei

Disease mutation, Dystonia

Organism-specific databases

DisGeNET

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DisGeNETi
55145

MalaCards human disease database

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MalaCardsi
THAP1
MIMi602629 phenotype

Open Targets

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OpenTargetsi
ENSG00000131931

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
98806 Primary dystonia, DYT6 type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134920361

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
THAP1

Domain mapping of disease mutations (DMDM)

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DMDMi
29839656

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000686371 – 213THAP domain-containing protein 1Add BLAST213

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NVV9

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NVV9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NVV9

PeptideAtlas

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PeptideAtlasi
Q9NVV9

PRoteomics IDEntifications database

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PRIDEi
Q9NVV9

ProteomicsDB human proteome resource

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ProteomicsDBi
82871

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9NVV9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9NVV9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000131931 Expressed in 200 organ(s), highest expression level in forebrain

CleanEx database of gene expression profiles

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CleanExi
HS_THAP1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NVV9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NVV9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA071310

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:28299530). Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter (PubMed:12717420, PubMed:20144952, PubMed:20200153).4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself8EBI-741515,EBI-741515
ABCF3A0A0S2Z6453EBI-741515,EBI-16432404
ACOT7O001543EBI-741515,EBI-948905
AKAP17AQ02040-33EBI-741515,EBI-10222656
AKAP9Q99996-23EBI-741515,EBI-9641546
AP2B1P630104EBI-741515,EBI-432924
ARL6IP4Q66PJ3-33EBI-741515,EBI-10248982
BAG5Q9UL155EBI-741515,EBI-356517
BYSLQ138957EBI-741515,EBI-358049
C7orf50Q9BRJ65EBI-741515,EBI-751612
CDKN1BP465273EBI-741515,EBI-519280
CHD2O146473EBI-741515,EBI-1210503
CSNK2A1P684005EBI-741515,EBI-347804
DCAF8Q5TAQ93EBI-741515,EBI-740686
FAM124AQ86V423EBI-741515,EBI-744506
FAM133AQ8N9E05EBI-741515,EBI-10268158
GPATCH2LQ9NWQ43EBI-741515,EBI-5666657
hCG_1744368A0A024RA765EBI-741515,EBI-10180729
hCG_2003792A0A024R5S05EBI-741515,EBI-10188461
HNRNPLLQ8WVV93EBI-741515,EBI-535849
KLF12Q9Y4X43EBI-741515,EBI-750750
KRTAP10-7P604093EBI-741515,EBI-10172290
LASP1Q148473EBI-741515,EBI-742828
METTL13Q8N6R03EBI-741515,EBI-1053295
MMTAG2Q9BU766EBI-741515,EBI-742459
MORF4L1Q9UBU83EBI-741515,EBI-399246
MORF4L2Q150143EBI-741515,EBI-399257
MRPL11Q9Y3B73EBI-741515,EBI-5453723
NKAPD1Q6ZUT15EBI-741515,EBI-3920396
NKAPD1Q6ZUT1-23EBI-741515,EBI-10180231
NUP62P3719811EBI-741515,EBI-347978
PHF1O431893EBI-741515,EBI-530034
PID1Q7Z2X43EBI-741515,EBI-10256685
POLR2LP628753EBI-741515,EBI-359527
PPIGQ134273EBI-741515,EBI-396072
PRKAA1Q131313EBI-741515,EBI-1181405
PRR20CP864793EBI-741515,EBI-10172814
RALYLQ86SE54EBI-741515,EBI-741520
RALYLQ86SE5-35EBI-741515,EBI-11526555
RBM10P981755EBI-741515,EBI-721525
RBM39Q144985EBI-741515,EBI-395290
RIPPLY1Q0D2K35EBI-741515,EBI-10226430
RPS25P628513EBI-741515,EBI-353054
SAP30BPQ9UHR53EBI-741515,EBI-751683
SLU7O953913EBI-741515,EBI-750559
STRBPQ96SI96EBI-741515,EBI-740355
TCEA2Q155605EBI-741515,EBI-710310
TPM3P067534EBI-741515,EBI-355607
TPM3Q5VU623EBI-741515,EBI-10184033
TRAF5O004635EBI-741515,EBI-523498
TRIM26Q128995EBI-741515,EBI-2341136
TTLL10Q6ZVT03EBI-741515,EBI-7844656
U2AF2P263684EBI-741515,EBI-742339
WDYHV1Q96HA86EBI-741515,EBI-741158
YES1P079475EBI-741515,EBI-515331
ZCCHC10Q8TBK66EBI-741515,EBI-597063
ZNF385CQ66K414EBI-741515,EBI-8651919
ZNF408Q9H9D45EBI-741515,EBI-347633

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120448, 78 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q9NVV9

Protein interaction database and analysis system

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IntActi
Q9NVV9, 102 interactors

Molecular INTeraction database

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MINTi
Q9NVV9

STRING: functional protein association networks

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STRINGi
9606.ENSP00000254250

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1213
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JTGNMR-A1-81[»]
2KO0NMR-A1-82[»]
2L1GNMR-A1-82[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9NVV9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NVV9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9NVV9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni139 – 185Involved in homodimer formation1 PublicationAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili139 – 190Sequence analysisAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi134 – 137HCFC1-binding motif (HBM)4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi96 – 108Pro-richAdd BLAST13

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the THAP1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 81THAP-typePROSITE-ProRule annotationAdd BLAST81

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGDI Eukaryota
ENOG4111FGC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159383

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231117

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG057457

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NVV9

Identification of Orthologs from Complete Genome Data

More...
OMAi
HQRKRIQ

Database of Orthologous Groups

More...
OrthoDBi
1382095at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NVV9

TreeFam database of animal gene trees

More...
TreeFami
TF330127

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.180, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026516 THAP1
IPR006612 THAP_Znf
IPR038441 THAP_Znf_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23080:SF85 PTHR23080:SF85, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05485 THAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00692 DM3, 1 hit
SM00980 THAP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50950 ZF_THAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NVV9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVQSCSAYGC KNRYDKDKPV SFHKFPLTRP SLCKEWEAAV RRKNFKPTKY
60 70 80 90 100
SSICSEHFTP DCFKRECNNK LLKENAVPTI FLCTEPHDKK EDLLEPQEQL
110 120 130 140 150
PPPPLPPPVS QVDAAIGLLM PPLQTPVNLS VFCDHNYTVE DTMHQRKRIH
160 170 180 190 200
QLEQQVEKLR KKLKTAQQRC RRQERQLEKL KEVVHFQKEK DDVSERGYVI
210
LPNDYFEIVE VPA
Length:213
Mass (Da):24,944
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3769B0F4CC56539
GO
Isoform 2 (identifier: Q9NVV9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-53: FPLTRPSLCKEWEAAVRRKNFKPTKYSSI → KKIFWSHRNSFPHLLYRLLFPRLMLLLDY
     54-213: Missing.

Note: No experimental confirmation available.
Show »
Length:53
Mass (Da):6,493
Checksum:i5F29C2F675B375B7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PIS9E9PIS9_HUMAN
THAP domain-containing protein 1
THAP1
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti171R → G in CAG33537 (Ref. 2) Curated1
Sequence conflicti213A → T in BAD96951 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0666776S → F in DYT6. 1 Publication1
Natural variantiVAR_0666786S → P in DYT6. 1 Publication1
Natural variantiVAR_0673567A → D in DYT6. 1 Publication1
Natural variantiVAR_0666798Y → C in DYT6. 1 Publication1
Natural variantiVAR_0666809G → C in DYT6. 1 PublicationCorresponds to variant dbSNP:rs267607112EnsemblClinVar.1
Natural variantiVAR_06588012N → K in DYT6. 1 Publication1
Natural variantiVAR_06668113R → H in DYT6. 1 Publication1
Natural variantiVAR_06668216K → E in DYT6; lower activity than wild-type. 2 Publications1
Natural variantiVAR_06668317D → G in DYT6. 1 PublicationCorresponds to variant dbSNP:rs766483829Ensembl.1
Natural variantiVAR_06735721S → C in DYT6. 1 Publication1
Natural variantiVAR_06588121S → T in DYT6. 1 Publication1
Natural variantiVAR_06668423H → P in DYT6; lower activity than wild-type. 1 PublicationCorresponds to variant dbSNP:rs387907177EnsemblClinVar.1
Natural variantiVAR_06668524K → E in DYT6; lower activity than wild-type. 1 PublicationCorresponds to variant dbSNP:rs387907176EnsemblClinVar.1
Natural variantiVAR_06668626P → L in DYT6; lower activity than wild-type. 1 Publication1
Natural variantiVAR_06668726P → R in DYT6. 1 Publication1
Natural variantiVAR_06588229R → P in DYT6. 1 Publication1
Natural variantiVAR_06668829R → Q in DYT6. 2 PublicationsCorresponds to variant dbSNP:rs767952378Ensembl.1
Natural variantiVAR_06668930P → R in DYT6. 1 Publication1
Natural variantiVAR_06669032L → H in DYT6; lower activity than wild-type. 1 Publication1
Natural variantiVAR_06588339A → T in DYT6. 1 Publication1
Natural variantiVAR_06669154C → F in DYT6. 1 Publication1
Natural variantiVAR_07227256E → G in DYT6. 1 Publication1
Natural variantiVAR_06669257H → N in DYT6. 1 Publication1
Natural variantiVAR_06588459T → I in DYT6. 1 Publication1
Natural variantiVAR_06669369Missing in DYT6. 2 Publications1
Natural variantiVAR_06669472L → R in DYT6. 1 Publication1
Natural variantiVAR_06669575N → I in DYT6. 2 Publications1
Natural variantiVAR_06669680I → V in DYT6; mild phenotype; does not affect activity. 2 PublicationsCorresponds to variant dbSNP:rs372080941EnsemblClinVar.1
Natural variantiVAR_05478881F → L in DYT6; affects DNA-binding. 2 PublicationsCorresponds to variant dbSNP:rs118204013EnsemblClinVar.1
Natural variantiVAR_06669783C → R in DYT6. 1 PublicationCorresponds to variant dbSNP:rs768017019Ensembl.1
Natural variantiVAR_06588589K → R in DYT6. 2 PublicationsCorresponds to variant dbSNP:rs267607111EnsemblClinVar.1
Natural variantiVAR_066698132F → S in DYT6. 1 PublicationCorresponds to variant dbSNP:rs950435041Ensembl.1
Natural variantiVAR_065886136N → K in DYT6. 1 Publication1
Natural variantiVAR_066699136N → S in DYT6. 1 PublicationCorresponds to variant dbSNP:rs769988455Ensembl.1
Natural variantiVAR_066700137Y → C in DYT6. 1 Publication1
Natural variantiVAR_066701143M → V in DYT6; no effect on dimerization. 2 PublicationsCorresponds to variant dbSNP:rs374512193EnsemblClinVar.1
Natural variantiVAR_066702149I → T in DYT6; no effect on dimerization. 3 Publications1
Natural variantiVAR_066703150H → P in DYT6; no effect on dimerization. 3 Publications1
Natural variantiVAR_066704166A → T in DYT6; no effect on dimerization. 2 PublicationsCorresponds to variant dbSNP:rs138918468Ensembl.1
Natural variantiVAR_066705169R → Q in DYT6; no effect on dimerization. 2 PublicationsCorresponds to variant dbSNP:rs767519301EnsemblClinVar.1
Natural variantiVAR_065887170C → R in DYT6; no effect on dimerization. 2 Publications1
Natural variantiVAR_066706174E → G in DYT6; no effect on dimerization. 2 PublicationsCorresponds to variant dbSNP:rs759392096Ensembl.1
Natural variantiVAR_079366177L → P in DYT6; no effect on dimerization. 1 Publication1
Natural variantiVAR_066707180L → S in DYT6; no effect on dimerization. 2 Publications1
Natural variantiVAR_066708187Q → K in DYT6. 1 Publication1
Natural variantiVAR_066709192D → N in DYT6. 1 PublicationCorresponds to variant dbSNP:rs377725442EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04466525 – 53FPLTR…KYSSI → KKIFWSHRNSFPHLLYRLLF PRLMLLLDY in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_04466654 – 213Missing in isoform 2. 1 PublicationAdd BLAST160

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001339 mRNA Translation: BAA91635.1
CR457256 mRNA Translation: CAG33537.1
AK223231 mRNA Translation: BAD96951.1
AL832077 mRNA No translation available.
AC087533 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63205.1
CH471080 Genomic DNA Translation: EAW63206.1
BC021721 mRNA Translation: AAH21721.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6136.1 [Q9NVV9-1]
CCDS6137.1 [Q9NVV9-2]

NCBI Reference Sequences

More...
RefSeqi
NP_060575.1, NM_018105.2 [Q9NVV9-1]
NP_945354.1, NM_199003.1 [Q9NVV9-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.7432

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000254250; ENSP00000254250; ENSG00000131931 [Q9NVV9-1]
ENST00000345117; ENSP00000344966; ENSG00000131931 [Q9NVV9-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55145

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55145

UCSC genome browser

More...
UCSCi
uc003xpk.4 human [Q9NVV9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001339 mRNA Translation: BAA91635.1
CR457256 mRNA Translation: CAG33537.1
AK223231 mRNA Translation: BAD96951.1
AL832077 mRNA No translation available.
AC087533 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63205.1
CH471080 Genomic DNA Translation: EAW63206.1
BC021721 mRNA Translation: AAH21721.1
CCDSiCCDS6136.1 [Q9NVV9-1]
CCDS6137.1 [Q9NVV9-2]
RefSeqiNP_060575.1, NM_018105.2 [Q9NVV9-1]
NP_945354.1, NM_199003.1 [Q9NVV9-2]
UniGeneiHs.7432

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JTGNMR-A1-81[»]
2KO0NMR-A1-82[»]
2L1GNMR-A1-82[»]
ProteinModelPortaliQ9NVV9
SMRiQ9NVV9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120448, 78 interactors
ELMiQ9NVV9
IntActiQ9NVV9, 102 interactors
MINTiQ9NVV9
STRINGi9606.ENSP00000254250

PTM databases

iPTMnetiQ9NVV9
PhosphoSitePlusiQ9NVV9

Polymorphism and mutation databases

BioMutaiTHAP1
DMDMi29839656

Proteomic databases

EPDiQ9NVV9
MaxQBiQ9NVV9
PaxDbiQ9NVV9
PeptideAtlasiQ9NVV9
PRIDEiQ9NVV9
ProteomicsDBi82871

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55145
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254250; ENSP00000254250; ENSG00000131931 [Q9NVV9-1]
ENST00000345117; ENSP00000344966; ENSG00000131931 [Q9NVV9-2]
GeneIDi55145
KEGGihsa:55145
UCSCiuc003xpk.4 human [Q9NVV9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55145
DisGeNETi55145
EuPathDBiHostDB:ENSG00000131931.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
THAP1
HGNCiHGNC:20856 THAP1
HPAiHPA071310
MalaCardsiTHAP1
MIMi602629 phenotype
609520 gene
neXtProtiNX_Q9NVV9
OpenTargetsiENSG00000131931
Orphaneti98806 Primary dystonia, DYT6 type
PharmGKBiPA134920361

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGDI Eukaryota
ENOG4111FGC LUCA
GeneTreeiENSGT00940000159383
HOGENOMiHOG000231117
HOVERGENiHBG057457
InParanoidiQ9NVV9
OMAiHQRKRIQ
OrthoDBi1382095at2759
PhylomeDBiQ9NVV9
TreeFamiTF330127

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
THAP1 human
EvolutionaryTraceiQ9NVV9

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
THAP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55145

Protein Ontology

More...
PROi
PR:Q9NVV9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000131931 Expressed in 200 organ(s), highest expression level in forebrain
CleanExiHS_THAP1
ExpressionAtlasiQ9NVV9 baseline and differential
GenevisibleiQ9NVV9 HS

Family and domain databases

Gene3Di3.30.40.180, 1 hit
InterProiView protein in InterPro
IPR026516 THAP1
IPR006612 THAP_Znf
IPR038441 THAP_Znf_sf
PANTHERiPTHR23080:SF85 PTHR23080:SF85, 1 hit
PfamiView protein in Pfam
PF05485 THAP, 1 hit
SMARTiView protein in SMART
SM00692 DM3, 1 hit
SM00980 THAP, 1 hit
PROSITEiView protein in PROSITE
PS50950 ZF_THAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHAP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NVV9
Secondary accession number(s): A6NCB6
, D3DSY5, H9KV49, Q53FQ1, Q6IA99
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: January 16, 2019
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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