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UniProtKB - Q9NVV5 (AIG1_HUMAN)

Entry version 136 (16 Oct 2019)
Sequence version 2 (21 Dec 2004)
Previous versions | rss
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Protein

Androgen-induced gene 1 protein

Gene

AIG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by N-hydroxyhydantoin carbamate JJH260 and beta-lactone KC01.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei43Important for catalytic activity1 Publication1
Sitei134Important for catalytic activity1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • hydrolase activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid metabolism

Protein family/group databases

Transport Classification Database

More...TCDBi		9.B.203.1.1 the aig1 lipid hydrolase (aig1) family

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001682

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Androgen-induced gene 1 protein
Short name:
AIG-1
Alternative name(s):
Fatty acid esters of hydroxy fatty acids hydrolase AIG11 Publication (EC:3.1.-.-1 Publication)
Short name:
FAHFA hydrolase AIG11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AIG1
ORF Names:CGI-103
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:21607 AIG1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608514 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NVV5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 12Cytoplasmic1 PublicationAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 30HelicalSequence analysisAdd BLAST18
Topological domaini31 – 44Extracellular1 PublicationAdd BLAST14
Transmembranei45 – 67HelicalSequence analysisAdd BLAST23
Topological domaini68 – 87Cytoplasmic1 PublicationAdd BLAST20
Transmembranei88 – 110HelicalSequence analysisAdd BLAST23
Topological domaini111 – 124Extracellular1 PublicationAdd BLAST14
Transmembranei125 – 144HelicalSequence analysisAdd BLAST20
Topological domaini145 – 156Cytoplasmic1 PublicationAdd BLAST12
Transmembranei157 – 179HelicalSequence analysisAdd BLAST23
Topological domaini180 – 193Extracellular1 PublicationAdd BLAST14
Transmembranei194 – 216HelicalSequence analysisAdd BLAST23
Topological domaini217 – 245Cytoplasmic1 PublicationAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi43T → A: Loss of hydrolase activity. 1 Publication1
Mutagenesisi134H → A: Loss of hydrolase activity. 1 Publication1

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000146416

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134991331

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NVV5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AIG1

Domain mapping of disease mutations (DMDM)

More...DMDMi		56748615

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001900981 – 245Androgen-induced gene 1 proteinAdd BLAST245

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NVV5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NVV5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NVV5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NVV5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NVV5

PeptideAtlas

More...PeptideAtlasi		Q9NVV5

PRoteomics IDEntifications database

More...PRIDEi		Q9NVV5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4823
82866 [Q9NVV5-1]
82867 [Q9NVV5-2]
82868 [Q9NVV5-3]
82869 [Q9NVV5-4]
82870 [Q9NVV5-5]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q9NVV5-4 [Q9NVV5-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NVV5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NVV5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart, ovary, testis, liver, and kidney, at lower levels in spleen, prostate, brain, skeletal muscle, pancreas, small intestine and colon, and undetected in peripheral blood leukocytes, thymus, lung and placenta. AIG1 expression is higher in hair follicles from males than from females.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By dihydrotestosterone (DHT).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000146416 Expressed in 208 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NVV5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NVV5 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA060766

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		119519, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q9NVV5, 48 interactors

Molecular INTeraction database

More...MINTi		Q9NVV5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000350509

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9NVV5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AIG1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3989 Eukaryota
ENOG4111HQA LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158696

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NVV5

Identification of Orthologs from Complete Genome Data

More...OMAi		HVTGVWV

Database of Orthologous Groups

More...OrthoDBi		1482757at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NVV5

TreeFam database of animal gene trees

More...TreeFami		TF318170

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006838 Far-17a_AIG1

The PANTHER Classification System

More...PANTHERi		PTHR10989 PTHR10989, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04750 Far-17a_AIG1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NVV5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALVPCQVLR MAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLVIQ 
        60         70         80         90        100
AVFFGICVLT DLSSLLTRGS GNQEQERQLK KLISLRDWML AVLAFPVGVF 
       110        120        130        140        150
VVAVFWIIYA YDREMIYPKL LDNFIPGWLN HGMHTTVLPF ILIEMRTSHH 
       160        170        180        190        200
QYPSRSSGLT AICTFSVGYI LWVCWVHHVT GMWVYPFLEH IGPGARIIFF 
       210        220        230        240 
GSTTILMNFL YLLGEVLNNY IWDTQKKPPS WQDMKIKFMY LGPSS
Length:245
Mass (Da):28,222
Last modified:December 21, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06C0C8A6BDBF3694
GO
Isoform 2 (identifier: Q9NVV5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-245: KPPSWQDMKIKFMYLGPSS → SMEEEKEKPKLE

Show »
Length:238
Mass (Da):27,458
Checksum:iDF5D5B8FC41A2C95
GO
Isoform 3 (identifier: Q9NVV5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-99: Missing.
     227-245: KPPSWQDMKIKFMYLGPSS → SMEEEKEKPKLE

Show »
Length:186
Mass (Da):21,715
Checksum:i77322CC43C44F5C2
GO
Isoform 4 (identifier: Q9NVV5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.
     227-245: KPPSWQDMKIKFMYLGPSS → SMEEEKEKPKLE

Note: No experimental confirmation available.
Show »
Length:228
Mass (Da):26,347
Checksum:i761CD65BB7F9F159
GO
Isoform 5 (identifier: Q9NVV5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-137: TTV → FKA
     138-245: Missing.

Note: No experimental confirmation available.
Show »
Length:137
Mass (Da):15,713
Checksum:i7EEF2A92A3787CA3
GO
Isoform 6 (identifier: Q9NVV5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-245: HTTVLPFILI...IKFMYLGPSS → L

Note: No experimental confirmation available.
Show »
Length:134
Mass (Da):15,342
Checksum:i6463787CA31E154B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5THU2Q5THU2_HUMAN
Androgen-induced gene 1 protein
AIG1
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T2H0Q5T2H0_HUMAN
Androgen-induced gene 1 protein
AIG1
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T2H4Q5T2H4_HUMAN
Androgen-induced gene 1 protein
AIG1
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T2H3Q5T2H3_HUMAN
Androgen-induced gene 1 protein
AIG1
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YCJ8A0A2R8YCJ8_HUMAN
Androgen-induced gene 1 protein
AIG1
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD34098 differs from that shown. Reason: Frameshift.Curated
The sequence CAE45823 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti70S → I in AAD41087 (PubMed:11266118).Curated1
Sequence conflicti191I → F in BAA91640 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057502151Q → E. Corresponds to variant dbSNP:rs1053193Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0123141 – 10Missing in isoform 4. 1 Publication10
Alternative sequenceiVSP_01231548 – 99Missing in isoform 3. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_054641134 – 245HTTVL…LGPSS → L in isoform 6. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_012316135 – 137TTV → FKA in isoform 5. 1 Publication3
Alternative sequenceiVSP_012317138 – 245Missing in isoform 5. 1 PublicationAdd BLAST108
Alternative sequenceiVSP_012318227 – 245KPPSW…LGPSS → SMEEEKEKPKLE in isoform 2, isoform 3 and isoform 4. 4 PublicationsAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF153605 mRNA Translation: AAD41087.1
AF151861 mRNA Translation: AAD34098.1 Frameshift.
AK001347 mRNA Translation: BAA91640.1
BX538067 mRNA Translation: CAD97997.1
BX640703 mRNA Translation: CAE45823.1 Different initiation.
AK298533 mRNA Translation: BAG60734.1
AL023581 Genomic DNA No translation available.
AL136116 Genomic DNA No translation available.
AL391726 Genomic DNA No translation available.
AL450335 Genomic DNA No translation available.
BC025278 mRNA Translation: AAH25278.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5198.1 [Q9NVV5-2]
CCDS69215.1 [Q9NVV5-6]
CCDS69216.1 [Q9NVV5-5]

NCBI Reference Sequences

More...RefSeqi		NP_001273516.1, NM_001286587.1 [Q9NVV5-4]
NP_001273517.1, NM_001286588.1 [Q9NVV5-6]
NP_001273518.1, NM_001286589.1 [Q9NVV5-5]
NP_057192.2, NM_016108.3 [Q9NVV5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000275235; ENSP00000275235; ENSG00000146416 [Q9NVV5-1]
ENST00000357847; ENSP00000350509; ENSG00000146416 [Q9NVV5-2]
ENST00000494282; ENSP00000473952; ENSG00000146416 [Q9NVV5-5]
ENST00000629020; ENSP00000485875; ENSG00000146416 [Q9NVV5-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51390

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51390

UCSC genome browser

More...UCSCi		uc003qjg.5 human [Q9NVV5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153605 mRNA Translation: AAD41087.1
AF151861 mRNA Translation: AAD34098.1 Frameshift.
AK001347 mRNA Translation: BAA91640.1
BX538067 mRNA Translation: CAD97997.1
BX640703 mRNA Translation: CAE45823.1 Different initiation.
AK298533 mRNA Translation: BAG60734.1
AL023581 Genomic DNA No translation available.
AL136116 Genomic DNA No translation available.
AL391726 Genomic DNA No translation available.
AL450335 Genomic DNA No translation available.
BC025278 mRNA Translation: AAH25278.1
CCDSiCCDS5198.1 [Q9NVV5-2]
CCDS69215.1 [Q9NVV5-6]
CCDS69216.1 [Q9NVV5-5]
RefSeqiNP_001273516.1, NM_001286587.1 [Q9NVV5-4]
NP_001273517.1, NM_001286588.1 [Q9NVV5-6]
NP_001273518.1, NM_001286589.1 [Q9NVV5-5]
NP_057192.2, NM_016108.3 [Q9NVV5-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi119519, 7 interactors
IntActiQ9NVV5, 48 interactors
MINTiQ9NVV5
STRINGi9606.ENSP00000350509

Chemistry databases

BindingDBiQ9NVV5
SwissLipidsiSLP:000001682

Protein family/group databases

TCDBi9.B.203.1.1 the aig1 lipid hydrolase (aig1) family

PTM databases

iPTMnetiQ9NVV5
PhosphoSitePlusiQ9NVV5

Polymorphism and mutation databases

BioMutaiAIG1
DMDMi56748615

Proteomic databases

EPDiQ9NVV5
jPOSTiQ9NVV5
MassIVEiQ9NVV5
MaxQBiQ9NVV5
PaxDbiQ9NVV5
PeptideAtlasiQ9NVV5
PRIDEiQ9NVV5
ProteomicsDBi4823
82866 [Q9NVV5-1]
82867 [Q9NVV5-2]
82868 [Q9NVV5-3]
82869 [Q9NVV5-4]
82870 [Q9NVV5-5]
TopDownProteomicsiQ9NVV5-4 [Q9NVV5-4]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		51390

Genome annotation databases

EnsembliENST00000275235; ENSP00000275235; ENSG00000146416 [Q9NVV5-1]
ENST00000357847; ENSP00000350509; ENSG00000146416 [Q9NVV5-2]
ENST00000494282; ENSP00000473952; ENSG00000146416 [Q9NVV5-5]
ENST00000629020; ENSP00000485875; ENSG00000146416 [Q9NVV5-6]
GeneIDi51390
KEGGihsa:51390
UCSCiuc003qjg.5 human [Q9NVV5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51390

GeneCards: human genes, protein and diseases

More...GeneCardsi		AIG1
HGNCiHGNC:21607 AIG1
HPAiHPA060766
MIMi608514 gene
neXtProtiNX_Q9NVV5
OpenTargetsiENSG00000146416
PharmGKBiPA134991331

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3989 Eukaryota
ENOG4111HQA LUCA
GeneTreeiENSGT00940000158696
InParanoidiQ9NVV5
OMAiHVTGVWV
OrthoDBi1482757at2759
PhylomeDBiQ9NVV5
TreeFamiTF318170

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AIG1 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		AIG1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51390
PharosiQ9NVV5

Protein Ontology

More...PROi		PR:Q9NVV5

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000146416 Expressed in 208 organ(s), highest expression level in liver
ExpressionAtlasiQ9NVV5 baseline and differential
GenevisibleiQ9NVV5 HS

Family and domain databases

InterProiView protein in InterPro
IPR006838 Far-17a_AIG1
PANTHERiPTHR10989 PTHR10989, 1 hit
PfamiView protein in Pfam
PF04750 Far-17a_AIG1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAIG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NVV5
Secondary accession number(s): B4DPX2
, C9J569, Q5T2H2, Q6N047, Q7Z378, Q8TB14, Q9Y3A9, Q9Y5B4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: October 16, 2019
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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