UniProtKB - Q9NVV5 (AIG1_HUMAN)
Protein
Androgen-induced gene 1 protein
Gene
AIG1
Organism
Homo sapiens (Human)
Status
Functioni
Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888).1 Publication
Catalytic activityi
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- 9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- 9-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 12-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 13-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 5-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
Activity regulationi
Inhibited by N-hydroxyhydantoin carbamate JJH260 and beta-lactone KC01.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 43 | Important for catalytic activity1 Publication | 1 | |
Sitei | 134 | Important for catalytic activity1 Publication | 1 |
GO - Molecular functioni
- hydrolase activity Source: UniProtKB
GO - Biological processi
- long-chain fatty acid catabolic process Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid metabolism |
Enzyme and pathway databases
PathwayCommonsi | Q9NVV5 |
Protein family/group databases
TCDBi | 9.B.203.1.1, the aig1 lipid hydrolase (aig1) family |
Chemistry databases
SwissLipidsi | SLP:000001682 |
Names & Taxonomyi
Protein namesi | Recommended name: Androgen-induced gene 1 proteinShort name: AIG-1 Alternative name(s): Fatty acid esters of hydroxy fatty acids hydrolase AIG11 Publication (EC:3.1.-.-1 Publication) Short name: FAHFA hydrolase AIG11 Publication |
Gene namesi | Name:AIG1 ORF Names:CGI-103 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21607, AIG1 |
MIMi | 608514, gene |
neXtProti | NX_Q9NVV5 |
VEuPathDBi | HostDB:ENSG00000146416.16 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 12 | Cytoplasmic1 PublicationAdd BLAST | 12 | |
Transmembranei | 13 – 30 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 31 – 44 | Extracellular1 PublicationAdd BLAST | 14 | |
Transmembranei | 45 – 67 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 68 – 87 | Cytoplasmic1 PublicationAdd BLAST | 20 | |
Transmembranei | 88 – 110 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 111 – 124 | Extracellular1 PublicationAdd BLAST | 14 | |
Transmembranei | 125 – 144 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 145 – 156 | Cytoplasmic1 PublicationAdd BLAST | 12 | |
Transmembranei | 157 – 179 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 180 – 193 | Extracellular1 PublicationAdd BLAST | 14 | |
Transmembranei | 194 – 216 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 217 – 238 | Cytoplasmic1 PublicationAdd BLAST | 22 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 43 | T → A: Loss of hydrolase activity. 1 Publication | 1 | |
Mutagenesisi | 134 | H → A: Loss of hydrolase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 51390 |
OpenTargetsi | ENSG00000146416 |
PharmGKBi | PA134991331 |
Miscellaneous databases
Pharosi | Q9NVV5, Tbio |
Genetic variation databases
BioMutai | AIG1 |
DMDMi | 56748615 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190098 | 1 – 238 | Androgen-induced gene 1 proteinAdd BLAST | 238 |
Proteomic databases
EPDi | Q9NVV5 |
jPOSTi | Q9NVV5 |
MassIVEi | Q9NVV5 |
MaxQBi | Q9NVV5 |
PaxDbi | Q9NVV5 |
PeptideAtlasi | Q9NVV5 |
PRIDEi | Q9NVV5 |
ProteomicsDBi | 4823 82866 [Q9NVV5-1] 82867 [Q9NVV5-2] 82868 [Q9NVV5-3] 82869 [Q9NVV5-4] 82870 [Q9NVV5-5] |
TopDownProteomicsi | Q9NVV5-4 [Q9NVV5-4] |
PTM databases
iPTMneti | Q9NVV5 |
PhosphoSitePlusi | Q9NVV5 |
Expressioni
Tissue specificityi
Highly expressed in heart, ovary, testis, liver, and kidney, at lower levels in spleen, prostate, brain, skeletal muscle, pancreas, small intestine and colon, and undetected in peripheral blood leukocytes, thymus, lung and placenta. AIG1 expression is higher in hair follicles from males than from females.1 Publication
Inductioni
By dihydrotestosterone (DHT).1 Publication
Gene expression databases
Bgeei | ENSG00000146416, Expressed in liver and 223 other tissues |
ExpressionAtlasi | Q9NVV5, baseline and differential |
Genevisiblei | Q9NVV5, HS |
Organism-specific databases
HPAi | ENSG00000146416, Tissue enhanced (liver) |
Interactioni
Binary interactionsi
Hide detailsQ9NVV5
With | #Exp. | IntAct |
---|---|---|
RCHY1 [Q96PM5] | 4 | EBI-3942989,EBI-947779 |
Isoform 1 [Q9NVV5-2]
Protein-protein interaction databases
BioGRIDi | 119519, 53 interactors |
IntActi | Q9NVV5, 52 interactors |
MINTi | Q9NVV5 |
STRINGi | 9606.ENSP00000350509 |
Chemistry databases
BindingDBi | Q9NVV5 |
Miscellaneous databases
RNActi | Q9NVV5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the AIG1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3989, Eukaryota |
GeneTreei | ENSGT00940000158696 |
HOGENOMi | CLU_073346_0_0_1 |
InParanoidi | Q9NVV5 |
OMAi | IWDTQKC |
OrthoDBi | 1482757at2759 |
PhylomeDBi | Q9NVV5 |
TreeFami | TF318170 |
Family and domain databases
InterProi | View protein in InterPro IPR006838, Far-17a_AIG1 |
PANTHERi | PTHR10989, PTHR10989, 1 hit |
Pfami | View protein in Pfam PF04750, Far-17a_AIG1, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NVV5-2) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALVPCQVLR MAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLVIQ
60 70 80 90 100
AVFFGICVLT DLSSLLTRGS GNQEQERQLK KLISLRDWML AVLAFPVGVF
110 120 130 140 150
VVAVFWIIYA YDREMIYPKL LDNFIPGWLN HGMHTTVLPF ILIEMRTSHH
160 170 180 190 200
QYPSRSSGLT AICTFSVGYI LWVCWVHHVT GMWVYPFLEH IGPGARIIFF
210 220 230
GSTTILMNFL YLLGEVLNNY IWDTQKSMEE EKEKPKLE
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5THU2 | Q5THU2_HUMAN | Androgen-induced gene 1 protein | AIG1 | 47 | Annotation score: | ||
Q5T2H0 | Q5T2H0_HUMAN | Androgen-induced gene 1 protein | AIG1 | 138 | Annotation score: | ||
Q5T2H4 | Q5T2H4_HUMAN | Androgen-induced gene 1 protein | AIG1 | 192 | Annotation score: | ||
Q5T2H3 | Q5T2H3_HUMAN | Androgen-induced gene 1 protein | AIG1 | 123 | Annotation score: | ||
A0A2R8YCJ8 | A0A2R8YCJ8_HUMAN | Androgen-induced gene 1 protein | AIG1 | 231 | Annotation score: |
Sequence cautioni
The sequence AAD34098 differs from that shown. Reason: Frameshift.Curated
The sequence CAE45823 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 70 | S → I in AAD41087 (PubMed:11266118).Curated | 1 | |
Sequence conflicti | 191 | I → F in BAA91640 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057502 | 151 | Q → E. Corresponds to variant dbSNP:rs1053193Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_060689 | 1 – 10 | Missing in isoform 4. 1 Publication | 10 | |
Alternative sequenceiVSP_060690 | 48 – 99 | Missing in isoform 3. CuratedAdd BLAST | 52 | |
Alternative sequenceiVSP_060691 | 134 | H → L in isoform 6. Curated | 1 | |
Alternative sequenceiVSP_060692 | 135 – 238 | Missing in isoform 6. CuratedAdd BLAST | 104 | |
Alternative sequenceiVSP_060693 | 135 – 137 | TTV → FKA in isoform 5. Curated | 3 | |
Alternative sequenceiVSP_060694 | 138 – 238 | Missing in isoform 5. CuratedAdd BLAST | 101 | |
Alternative sequenceiVSP_060695 | 227 – 238 | SMEEE…KPKLE → KPPSWQDMKIKFMYLGPSS in isoform 2. CuratedAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF153605 mRNA Translation: AAD41087.1 AF151861 mRNA Translation: AAD34098.1 Frameshift. AK001347 mRNA Translation: BAA91640.1 BX538067 mRNA Translation: CAD97997.1 BX640703 mRNA Translation: CAE45823.1 Different initiation. AK298533 mRNA Translation: BAG60734.1 AL023581 Genomic DNA No translation available. AL136116 Genomic DNA No translation available. AL391726 Genomic DNA No translation available. AL450335 Genomic DNA No translation available. BC025278 mRNA Translation: AAH25278.1 |
CCDSi | CCDS5198.1 [Q9NVV5-2] CCDS69215.1 [Q9NVV5-6] CCDS69216.1 [Q9NVV5-5] |
RefSeqi | NP_001273516.1, NM_001286587.1 [Q9NVV5-4] NP_001273517.1, NM_001286588.1 [Q9NVV5-6] NP_001273518.1, NM_001286589.1 [Q9NVV5-5] NP_057192.2, NM_016108.3 [Q9NVV5-2] |
Genome annotation databases
Ensembli | ENST00000275235; ENSP00000275235; ENSG00000146416 [Q9NVV5-1] ENST00000357847; ENSP00000350509; ENSG00000146416 [Q9NVV5-2] ENST00000494282; ENSP00000473952; ENSG00000146416 [Q9NVV5-5] ENST00000629020; ENSP00000485875; ENSG00000146416 [Q9NVV5-6] |
GeneIDi | 51390 |
KEGGi | hsa:51390 |
UCSCi | uc003qjg.5, human [Q9NVV5-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF153605 mRNA Translation: AAD41087.1 AF151861 mRNA Translation: AAD34098.1 Frameshift. AK001347 mRNA Translation: BAA91640.1 BX538067 mRNA Translation: CAD97997.1 BX640703 mRNA Translation: CAE45823.1 Different initiation. AK298533 mRNA Translation: BAG60734.1 AL023581 Genomic DNA No translation available. AL136116 Genomic DNA No translation available. AL391726 Genomic DNA No translation available. AL450335 Genomic DNA No translation available. BC025278 mRNA Translation: AAH25278.1 |
CCDSi | CCDS5198.1 [Q9NVV5-2] CCDS69215.1 [Q9NVV5-6] CCDS69216.1 [Q9NVV5-5] |
RefSeqi | NP_001273516.1, NM_001286587.1 [Q9NVV5-4] NP_001273517.1, NM_001286588.1 [Q9NVV5-6] NP_001273518.1, NM_001286589.1 [Q9NVV5-5] NP_057192.2, NM_016108.3 [Q9NVV5-2] |
3D structure databases
SMRi | Q9NVV5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119519, 53 interactors |
IntActi | Q9NVV5, 52 interactors |
MINTi | Q9NVV5 |
STRINGi | 9606.ENSP00000350509 |
Chemistry databases
BindingDBi | Q9NVV5 |
SwissLipidsi | SLP:000001682 |
Protein family/group databases
TCDBi | 9.B.203.1.1, the aig1 lipid hydrolase (aig1) family |
PTM databases
iPTMneti | Q9NVV5 |
PhosphoSitePlusi | Q9NVV5 |
Genetic variation databases
BioMutai | AIG1 |
DMDMi | 56748615 |
Proteomic databases
EPDi | Q9NVV5 |
jPOSTi | Q9NVV5 |
MassIVEi | Q9NVV5 |
MaxQBi | Q9NVV5 |
PaxDbi | Q9NVV5 |
PeptideAtlasi | Q9NVV5 |
PRIDEi | Q9NVV5 |
ProteomicsDBi | 4823 82866 [Q9NVV5-1] 82867 [Q9NVV5-2] 82868 [Q9NVV5-3] 82869 [Q9NVV5-4] 82870 [Q9NVV5-5] |
TopDownProteomicsi | Q9NVV5-4 [Q9NVV5-4] |
Protocols and materials databases
Antibodypediai | 53852, 143 antibodies |
DNASUi | 51390 |
Genome annotation databases
Ensembli | ENST00000275235; ENSP00000275235; ENSG00000146416 [Q9NVV5-1] ENST00000357847; ENSP00000350509; ENSG00000146416 [Q9NVV5-2] ENST00000494282; ENSP00000473952; ENSG00000146416 [Q9NVV5-5] ENST00000629020; ENSP00000485875; ENSG00000146416 [Q9NVV5-6] |
GeneIDi | 51390 |
KEGGi | hsa:51390 |
UCSCi | uc003qjg.5, human [Q9NVV5-2] |
Organism-specific databases
CTDi | 51390 |
DisGeNETi | 51390 |
GeneCardsi | AIG1 |
HGNCi | HGNC:21607, AIG1 |
HPAi | ENSG00000146416, Tissue enhanced (liver) |
MIMi | 608514, gene |
neXtProti | NX_Q9NVV5 |
OpenTargetsi | ENSG00000146416 |
PharmGKBi | PA134991331 |
VEuPathDBi | HostDB:ENSG00000146416.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3989, Eukaryota |
GeneTreei | ENSGT00940000158696 |
HOGENOMi | CLU_073346_0_0_1 |
InParanoidi | Q9NVV5 |
OMAi | IWDTQKC |
OrthoDBi | 1482757at2759 |
PhylomeDBi | Q9NVV5 |
TreeFami | TF318170 |
Enzyme and pathway databases
PathwayCommonsi | Q9NVV5 |
Miscellaneous databases
BioGRID-ORCSi | 51390, 3 hits in 870 CRISPR screens |
ChiTaRSi | AIG1, human |
GeneWikii | AIG1 |
GenomeRNAii | 51390 |
Pharosi | Q9NVV5, Tbio |
PROi | PR:Q9NVV5 |
RNActi | Q9NVV5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000146416, Expressed in liver and 223 other tissues |
ExpressionAtlasi | Q9NVV5, baseline and differential |
Genevisiblei | Q9NVV5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006838, Far-17a_AIG1 |
PANTHERi | PTHR10989, PTHR10989, 1 hit |
Pfami | View protein in Pfam PF04750, Far-17a_AIG1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AIG1_HUMAN | |
Accessioni | Q9NVV5Primary (citable) accession number: Q9NVV5 Secondary accession number(s): B4DPX2 Q9Y5B4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 21, 2004 |
Last sequence update: | October 7, 2020 | |
Last modified: | February 10, 2021 | |
This is version 144 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants