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UniProtKB - Q9NVV5 (AIG1_HUMAN)

Entry version 143 (02 Dec 2020)
Sequence version 3 (07 Oct 2020)
Previous versions | rss
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Protein

Androgen-induced gene 1 protein

Gene

AIG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by N-hydroxyhydantoin carbamate JJH260 and beta-lactone KC01.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei43Important for catalytic activity1 Publication1
Sitei134Important for catalytic activity1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • hydrolase activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid metabolism

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NVV5

Protein family/group databases

Transport Classification Database

More...TCDBi		9.B.203.1.1, the aig1 lipid hydrolase (aig1) family

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001682

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Androgen-induced gene 1 protein
Short name:
AIG-1
Alternative name(s):
Fatty acid esters of hydroxy fatty acids hydrolase AIG11 Publication (EC:3.1.-.-1 Publication)
Short name:
FAHFA hydrolase AIG11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AIG1
ORF Names:CGI-103
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000146416.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:21607, AIG1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608514, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NVV5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 12Cytoplasmic1 PublicationAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 30HelicalSequence analysisAdd BLAST18
Topological domaini31 – 44Extracellular1 PublicationAdd BLAST14
Transmembranei45 – 67HelicalSequence analysisAdd BLAST23
Topological domaini68 – 87Cytoplasmic1 PublicationAdd BLAST20
Transmembranei88 – 110HelicalSequence analysisAdd BLAST23
Topological domaini111 – 124Extracellular1 PublicationAdd BLAST14
Transmembranei125 – 144HelicalSequence analysisAdd BLAST20
Topological domaini145 – 156Cytoplasmic1 PublicationAdd BLAST12
Transmembranei157 – 179HelicalSequence analysisAdd BLAST23
Topological domaini180 – 193Extracellular1 PublicationAdd BLAST14
Transmembranei194 – 216HelicalSequence analysisAdd BLAST23
Topological domaini217 – 238Cytoplasmic1 PublicationAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi43T → A: Loss of hydrolase activity. 1 Publication1
Mutagenesisi134H → A: Loss of hydrolase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		51390

Open Targets

More...OpenTargetsi		ENSG00000146416

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134991331

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NVV5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AIG1

Domain mapping of disease mutations (DMDM)

More...DMDMi		56748615

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001900981 – 238Androgen-induced gene 1 proteinAdd BLAST238

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NVV5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NVV5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NVV5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NVV5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NVV5

PeptideAtlas

More...PeptideAtlasi		Q9NVV5

PRoteomics IDEntifications database

More...PRIDEi		Q9NVV5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4823
82866 [Q9NVV5-1]
82867 [Q9NVV5-2]
82868 [Q9NVV5-3]
82869 [Q9NVV5-4]
82870 [Q9NVV5-5]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q9NVV5-4 [Q9NVV5-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NVV5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NVV5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart, ovary, testis, liver, and kidney, at lower levels in spleen, prostate, brain, skeletal muscle, pancreas, small intestine and colon, and undetected in peripheral blood leukocytes, thymus, lung and placenta. AIG1 expression is higher in hair follicles from males than from females.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By dihydrotestosterone (DHT).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000146416, Expressed in liver and 223 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NVV5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NVV5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000146416, Tissue enhanced (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q9NVV5
With#Exp.IntAct
RCHY1 [Q96PM5]4EBI-3942989,EBI-947779
Isoform 1 [Q9NVV5-2]
With#Exp.IntAct
APOD [P05090]3EBI-11957045,EBI-715495
APOL2 [Q9BQE5]3EBI-11957045,EBI-4290634
AQP6 [Q13520]3EBI-11957045,EBI-13059134
AQP9 [O43315]3EBI-11957045,EBI-17444777
ARL13B [Q3SXY8]3EBI-11957045,EBI-11343438
ASGR2 - isoform 3 [P07307-3]3EBI-11957045,EBI-12808270
BCL2L13 [Q9BXK5]3EBI-11957045,EBI-747430
BIK [Q13323]3EBI-11957045,EBI-700794
CD53 [P19397]3EBI-11957045,EBI-6657396
CISD2 [Q8N5K1]3EBI-11957045,EBI-1045797
CLDN7 [O95471]3EBI-11957045,EBI-740744
CPLX4 [Q7Z7G2]3EBI-11957045,EBI-18013275
CYB5R3 [P00387]3EBI-11957045,EBI-1046040
CYBC1 [Q9BQA9]3EBI-11957045,EBI-2680384
ERGIC3 [Q9Y282]3EBI-11957045,EBI-781551
FAM209A [Q5JX71]3EBI-11957045,EBI-18304435
FNDC9 [Q8TBE3]3EBI-11957045,EBI-12142257
GOLM1 [Q8NBJ4]3EBI-11957045,EBI-712073
GPR152 [Q8TDT2]3EBI-11957045,EBI-13345167
GPX8 [Q8TED1]3EBI-11957045,EBI-11721746
HIBADH [P31937]3EBI-11957045,EBI-11427100
HSD17B13 [Q7Z5P4]3EBI-11957045,EBI-18053395
IER3IP1 [Q9Y5U9]3EBI-11957045,EBI-725665
KCNJ6 [P48051]3EBI-11957045,EBI-12017638
KIR2DL3 [P43628]3EBI-11957045,EBI-8632435
LAPTM5 [Q13571]3EBI-11957045,EBI-2865663
LEUTX [A8MZ59]3EBI-11957045,EBI-17490413
LIME1 [Q9H400]3EBI-11957045,EBI-2830566
LYVE1 [Q9Y5Y7]3EBI-11957045,EBI-10329546
MFF - isoform 5 [Q9GZY8-5]6EBI-11957045,EBI-11956541
MRM3 [Q9HC36]3EBI-11957045,EBI-1045440
PDZK1IP1 [Q13113]3EBI-11957045,EBI-716063
SAR1A [Q9NR31]3EBI-11957045,EBI-3920694
SEC22B [O75396]3EBI-11957045,EBI-1058865
SLC34A2 - isoform 2 [O95436-2]3EBI-11957045,EBI-12811757
SLC7A14 [Q8TBB6]3EBI-11957045,EBI-5235586
STOM [P27105]3EBI-11957045,EBI-1211440
STX1A [Q16623]3EBI-11957045,EBI-712466
THAP4 [Q8WY91]3EBI-11957045,EBI-726691
THBD [P07204]3EBI-11957045,EBI-941422
TMEM106C [Q9BVX2]3EBI-11957045,EBI-2821497
TMEM80 [Q96HE8]3EBI-11957045,EBI-11742770
TMX2 [Q9Y320]3EBI-11957045,EBI-6447886
VAMP3 [Q15836]3EBI-11957045,EBI-722343
VAPB [O95292]3EBI-11957045,EBI-1188298

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119519, 53 interactors

Protein interaction database and analysis system

More...IntActi		Q9NVV5, 52 interactors

Molecular INTeraction database

More...MINTi		Q9NVV5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000350509

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9NVV5

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NVV5, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AIG1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3989, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158696

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_073346_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NVV5

Identification of Orthologs from Complete Genome Data

More...OMAi		IWDTQKC

Database of Orthologous Groups

More...OrthoDBi		1482757at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NVV5

TreeFam database of animal gene trees

More...TreeFami		TF318170

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006838, Far-17a_AIG1

The PANTHER Classification System

More...PANTHERi		PTHR10989, PTHR10989, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04750, Far-17a_AIG1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NVV5-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALVPCQVLR MAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLVIQ 
        60         70         80         90        100
AVFFGICVLT DLSSLLTRGS GNQEQERQLK KLISLRDWML AVLAFPVGVF 
       110        120        130        140        150
VVAVFWIIYA YDREMIYPKL LDNFIPGWLN HGMHTTVLPF ILIEMRTSHH 
       160        170        180        190        200
QYPSRSSGLT AICTFSVGYI LWVCWVHHVT GMWVYPFLEH IGPGARIIFF 
       210        220        230 
GSTTILMNFL YLLGEVLNNY IWDTQKSMEE EKEKPKLE
Length:238
Mass (Da):27,458
Last modified:October 7, 2020 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF5D5B8FC41A2C95
GO
Isoform 2 (identifier: Q9NVV5-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-238: SMEEEKEKPKLE → KPPSWQDMKIKFMYLGPSS

Show »
Length:245
Mass (Da):28,222
Checksum:i06C0C8A6BDBF3694
GO
Isoform 3 (identifier: Q9NVV5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-99: Missing.

Show »
Length:186
Mass (Da):21,715
Checksum:i77322CC43C44F5C2
GO
Isoform 4 (identifier: Q9NVV5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.

Show »
Length:228
Mass (Da):26,347
Checksum:i761CD65BB7F9F159
GO
Isoform 5 (identifier: Q9NVV5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-137: TTV → FKA
     138-238: Missing.

Show »
Length:137
Mass (Da):15,713
Checksum:i7EEF2A92A3787CA3
GO
Isoform 6 (identifier: Q9NVV5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-134: H → L
     135-238: Missing.

Show »
Length:134
Mass (Da):15,342
Checksum:i6463787CA31E154B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5THU2Q5THU2_HUMAN
Androgen-induced gene 1 protein
AIG1
47Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T2H0Q5T2H0_HUMAN
Androgen-induced gene 1 protein
AIG1
138Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T2H4Q5T2H4_HUMAN
Androgen-induced gene 1 protein
AIG1
192Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T2H3Q5T2H3_HUMAN
Androgen-induced gene 1 protein
AIG1
123Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YCJ8A0A2R8YCJ8_HUMAN
Androgen-induced gene 1 protein
AIG1
231Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD34098 differs from that shown. Reason: Frameshift.Curated
The sequence CAE45823 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti70S → I in AAD41087 (PubMed:11266118).Curated1
Sequence conflicti191I → F in BAA91640 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057502151Q → E. Corresponds to variant dbSNP:rs1053193Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0606891 – 10Missing in isoform 4. 1 Publication10
Alternative sequenceiVSP_06069048 – 99Missing in isoform 3. CuratedAdd BLAST52
Alternative sequenceiVSP_060691134H → L in isoform 6. Curated1
Alternative sequenceiVSP_060692135 – 238Missing in isoform 6. CuratedAdd BLAST104
Alternative sequenceiVSP_060693135 – 137TTV → FKA in isoform 5. Curated3
Alternative sequenceiVSP_060694138 – 238Missing in isoform 5. CuratedAdd BLAST101
Alternative sequenceiVSP_060695227 – 238SMEEE…KPKLE → KPPSWQDMKIKFMYLGPSS in isoform 2. CuratedAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF153605 mRNA Translation: AAD41087.1
AF151861 mRNA Translation: AAD34098.1 Frameshift.
AK001347 mRNA Translation: BAA91640.1
BX538067 mRNA Translation: CAD97997.1
BX640703 mRNA Translation: CAE45823.1 Different initiation.
AK298533 mRNA Translation: BAG60734.1
AL023581 Genomic DNA No translation available.
AL136116 Genomic DNA No translation available.
AL391726 Genomic DNA No translation available.
AL450335 Genomic DNA No translation available.
BC025278 mRNA Translation: AAH25278.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5198.1 [Q9NVV5-2]
CCDS69215.1 [Q9NVV5-6]
CCDS69216.1 [Q9NVV5-5]

NCBI Reference Sequences

More...RefSeqi		NP_001273516.1, NM_001286587.1 [Q9NVV5-4]
NP_001273517.1, NM_001286588.1 [Q9NVV5-6]
NP_001273518.1, NM_001286589.1 [Q9NVV5-5]
NP_057192.2, NM_016108.3 [Q9NVV5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000275235; ENSP00000275235; ENSG00000146416 [Q9NVV5-1]
ENST00000357847; ENSP00000350509; ENSG00000146416 [Q9NVV5-2]
ENST00000494282; ENSP00000473952; ENSG00000146416 [Q9NVV5-5]
ENST00000629020; ENSP00000485875; ENSG00000146416 [Q9NVV5-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51390

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51390

UCSC genome browser

More...UCSCi		uc003qjg.5, human [Q9NVV5-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153605 mRNA Translation: AAD41087.1
AF151861 mRNA Translation: AAD34098.1 Frameshift.
AK001347 mRNA Translation: BAA91640.1
BX538067 mRNA Translation: CAD97997.1
BX640703 mRNA Translation: CAE45823.1 Different initiation.
AK298533 mRNA Translation: BAG60734.1
AL023581 Genomic DNA No translation available.
AL136116 Genomic DNA No translation available.
AL391726 Genomic DNA No translation available.
AL450335 Genomic DNA No translation available.
BC025278 mRNA Translation: AAH25278.1
CCDSiCCDS5198.1 [Q9NVV5-2]
CCDS69215.1 [Q9NVV5-6]
CCDS69216.1 [Q9NVV5-5]
RefSeqiNP_001273516.1, NM_001286587.1 [Q9NVV5-4]
NP_001273517.1, NM_001286588.1 [Q9NVV5-6]
NP_001273518.1, NM_001286589.1 [Q9NVV5-5]
NP_057192.2, NM_016108.3 [Q9NVV5-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi119519, 53 interactors
IntActiQ9NVV5, 52 interactors
MINTiQ9NVV5
STRINGi9606.ENSP00000350509

Chemistry databases

BindingDBiQ9NVV5
SwissLipidsiSLP:000001682

Protein family/group databases

TCDBi9.B.203.1.1, the aig1 lipid hydrolase (aig1) family

PTM databases

iPTMnetiQ9NVV5
PhosphoSitePlusiQ9NVV5

Polymorphism and mutation databases

BioMutaiAIG1
DMDMi56748615

Proteomic databases

EPDiQ9NVV5
jPOSTiQ9NVV5
MassIVEiQ9NVV5
MaxQBiQ9NVV5
PaxDbiQ9NVV5
PeptideAtlasiQ9NVV5
PRIDEiQ9NVV5
ProteomicsDBi4823
82866 [Q9NVV5-1]
82867 [Q9NVV5-2]
82868 [Q9NVV5-3]
82869 [Q9NVV5-4]
82870 [Q9NVV5-5]
TopDownProteomicsiQ9NVV5-4 [Q9NVV5-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		53852, 142 antibodies

The DNASU plasmid repository

More...DNASUi		51390

Genome annotation databases

EnsembliENST00000275235; ENSP00000275235; ENSG00000146416 [Q9NVV5-1]
ENST00000357847; ENSP00000350509; ENSG00000146416 [Q9NVV5-2]
ENST00000494282; ENSP00000473952; ENSG00000146416 [Q9NVV5-5]
ENST00000629020; ENSP00000485875; ENSG00000146416 [Q9NVV5-6]
GeneIDi51390
KEGGihsa:51390
UCSCiuc003qjg.5, human [Q9NVV5-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51390
DisGeNETi51390
EuPathDBiHostDB:ENSG00000146416.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		AIG1
HGNCiHGNC:21607, AIG1
HPAiENSG00000146416, Tissue enhanced (liver)
MIMi608514, gene
neXtProtiNX_Q9NVV5
OpenTargetsiENSG00000146416
PharmGKBiPA134991331

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3989, Eukaryota
GeneTreeiENSGT00940000158696
HOGENOMiCLU_073346_0_0_1
InParanoidiQ9NVV5
OMAiIWDTQKC
OrthoDBi1482757at2759
PhylomeDBiQ9NVV5
TreeFamiTF318170

Enzyme and pathway databases

PathwayCommonsiQ9NVV5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51390, 3 hits in 839 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AIG1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		AIG1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51390
PharosiQ9NVV5, Tbio

Protein Ontology

More...PROi		PR:Q9NVV5
RNActiQ9NVV5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000146416, Expressed in liver and 223 other tissues
ExpressionAtlasiQ9NVV5, baseline and differential
GenevisibleiQ9NVV5, HS

Family and domain databases

InterProiView protein in InterPro
IPR006838, Far-17a_AIG1
PANTHERiPTHR10989, PTHR10989, 1 hit
PfamiView protein in Pfam
PF04750, Far-17a_AIG1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAIG1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NVV5
Secondary accession number(s): B4DPX2
, C9J569, Q5T2H2, Q6N047, Q7Z378, Q8TB14, Q9Y3A9, Q9Y5B4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: October 7, 2020
Last modified: December 2, 2020
This is version 143 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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