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Protein

Androgen-induced gene 1 protein

Gene

AIG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in androgen-regulated growth of hair follicles.

GO - Molecular functioni

  • hydrolase activity Source: UniProtKB

GO - Biological processi

Protein family/group databases

TCDBi9.B.203.1.1 the aig1 lipid hydrolase (aig1) family

Chemistry databases

SwissLipidsiSLP:000001682

Names & Taxonomyi

Protein namesi
Recommended name:
Androgen-induced gene 1 protein
Short name:
AIG-1
Gene namesi
Name:AIG1
ORF Names:CGI-103
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000146416.16
HGNCiHGNC:21607 AIG1
MIMi608514 gene
neXtProtiNX_Q9NVV5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51390
OpenTargetsiENSG00000146416
PharmGKBiPA134991331

Polymorphism and mutation databases

DMDMi56748615

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900981 – 245Androgen-induced gene 1 proteinAdd BLAST245

Proteomic databases

EPDiQ9NVV5
MaxQBiQ9NVV5
PaxDbiQ9NVV5
PeptideAtlasiQ9NVV5
PRIDEiQ9NVV5
ProteomicsDBi82866
82867 [Q9NVV5-2]
82868 [Q9NVV5-3]
82869 [Q9NVV5-4]
82870 [Q9NVV5-5]
TopDownProteomicsiQ9NVV5-4 [Q9NVV5-4]

PTM databases

iPTMnetiQ9NVV5
PhosphoSitePlusiQ9NVV5

Expressioni

Tissue specificityi

Highly expressed in heart, ovary, testis, liver, and kidney, at lower levels in spleen, prostate, brain, skeletal muscle, pancreas, small intestine and colon, and undetected in peripheral blood leukocytes, thymus, lung and placenta. AIG1 expression is higher in hair follicles from males than from females.1 Publication

Inductioni

By dihydrotestosterone (DHT).1 Publication

Gene expression databases

BgeeiENSG00000146416 Expressed in 208 organ(s), highest expression level in liver
CleanExiHS_AIG1
ExpressionAtlasiQ9NVV5 baseline and differential
GenevisibleiQ9NVV5 HS

Organism-specific databases

HPAiHPA060766

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi119519, 7 interactors
IntActiQ9NVV5, 42 interactors
STRINGi9606.ENSP00000350509

Chemistry databases

BindingDBiQ9NVV5

Structurei

3D structure databases

ProteinModelPortaliQ9NVV5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIG1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3989 Eukaryota
ENOG4111HQA LUCA
GeneTreeiENSGT00390000012526
HOVERGENiHBG050468
InParanoidiQ9NVV5
OMAiHTNIVIF
OrthoDBiEOG091G0LUO
PhylomeDBiQ9NVV5
TreeFamiTF318170

Family and domain databases

InterProiView protein in InterPro
IPR006838 Far-17a_AIG1
PANTHERiPTHR10989 PTHR10989, 1 hit
PfamiView protein in Pfam
PF04750 Far-17a_AIG1, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NVV5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALVPCQVLR MAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLVIQ
60 70 80 90 100
AVFFGICVLT DLSSLLTRGS GNQEQERQLK KLISLRDWML AVLAFPVGVF
110 120 130 140 150
VVAVFWIIYA YDREMIYPKL LDNFIPGWLN HGMHTTVLPF ILIEMRTSHH
160 170 180 190 200
QYPSRSSGLT AICTFSVGYI LWVCWVHHVT GMWVYPFLEH IGPGARIIFF
210 220 230 240
GSTTILMNFL YLLGEVLNNY IWDTQKKPPS WQDMKIKFMY LGPSS
Length:245
Mass (Da):28,222
Last modified:December 21, 2004 - v2
Checksum:i06C0C8A6BDBF3694
GO
Isoform 2 (identifier: Q9NVV5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-245: KPPSWQDMKIKFMYLGPSS → SMEEEKEKPKLE

Show »
Length:238
Mass (Da):27,458
Checksum:iDF5D5B8FC41A2C95
GO
Isoform 3 (identifier: Q9NVV5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-99: Missing.
     227-245: KPPSWQDMKIKFMYLGPSS → SMEEEKEKPKLE

Show »
Length:186
Mass (Da):21,715
Checksum:i77322CC43C44F5C2
GO
Isoform 4 (identifier: Q9NVV5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.
     227-245: KPPSWQDMKIKFMYLGPSS → SMEEEKEKPKLE

Note: No experimental confirmation available.
Show »
Length:228
Mass (Da):26,347
Checksum:i761CD65BB7F9F159
GO
Isoform 5 (identifier: Q9NVV5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-137: TTV → FKA
     138-245: Missing.

Note: No experimental confirmation available.
Show »
Length:137
Mass (Da):15,713
Checksum:i7EEF2A92A3787CA3
GO
Isoform 6 (identifier: Q9NVV5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-245: HTTVLPFILI...IKFMYLGPSS → L

Note: No experimental confirmation available.
Show »
Length:134
Mass (Da):15,342
Checksum:i6463787CA31E154B
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5THU2Q5THU2_HUMAN
Androgen-induced gene 1 protein
AIG1
47Annotation score:
Q5T2H0Q5T2H0_HUMAN
Androgen-induced gene 1 protein
AIG1
138Annotation score:
Q5T2H4Q5T2H4_HUMAN
Androgen-induced gene 1 protein
AIG1
192Annotation score:
Q5T2H3Q5T2H3_HUMAN
Androgen-induced gene 1 protein
AIG1
123Annotation score:
A0A2R8YCJ8A0A2R8YCJ8_HUMAN
Androgen-induced gene 1 protein
AIG1
231Annotation score:

Sequence cautioni

The sequence AAD34098 differs from that shown. Reason: Frameshift at positions 182, 193 and 223.Curated
The sequence CAE45823 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70S → I in AAD41087 (PubMed:11266118).Curated1
Sequence conflicti191I → F in BAA91640 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057502151Q → E. Corresponds to variant dbSNP:rs1053193Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0123141 – 10Missing in isoform 4. 1 Publication10
Alternative sequenceiVSP_01231548 – 99Missing in isoform 3. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_054641134 – 245HTTVL…LGPSS → L in isoform 6. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_012316135 – 137TTV → FKA in isoform 5. 1 Publication3
Alternative sequenceiVSP_012317138 – 245Missing in isoform 5. 1 PublicationAdd BLAST108
Alternative sequenceiVSP_012318227 – 245KPPSW…LGPSS → SMEEEKEKPKLE in isoform 2, isoform 3 and isoform 4. 4 PublicationsAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153605 mRNA Translation: AAD41087.1
AF151861 mRNA Translation: AAD34098.1 Frameshift.
AK001347 mRNA Translation: BAA91640.1
BX538067 mRNA Translation: CAD97997.1
BX640703 mRNA Translation: CAE45823.1 Different initiation.
AK298533 mRNA Translation: BAG60734.1
AL023581 Genomic DNA No translation available.
AL136116 Genomic DNA No translation available.
AL391726 Genomic DNA No translation available.
AL450335 Genomic DNA No translation available.
BC025278 mRNA Translation: AAH25278.1
CCDSiCCDS5198.1 [Q9NVV5-2]
CCDS69215.1 [Q9NVV5-6]
CCDS69216.1 [Q9NVV5-5]
RefSeqiNP_001273516.1, NM_001286587.1 [Q9NVV5-4]
NP_001273517.1, NM_001286588.1 [Q9NVV5-6]
NP_001273518.1, NM_001286589.1 [Q9NVV5-5]
NP_057192.2, NM_016108.3 [Q9NVV5-2]
UniGeneiHs.567501

Genome annotation databases

EnsembliENST00000275235; ENSP00000275235; ENSG00000146416 [Q9NVV5-1]
ENST00000357847; ENSP00000350509; ENSG00000146416 [Q9NVV5-2]
ENST00000494282; ENSP00000473952; ENSG00000146416 [Q9NVV5-5]
ENST00000629020; ENSP00000485875; ENSG00000146416 [Q9NVV5-6]
GeneIDi51390
KEGGihsa:51390
UCSCiuc003qjg.5 human [Q9NVV5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153605 mRNA Translation: AAD41087.1
AF151861 mRNA Translation: AAD34098.1 Frameshift.
AK001347 mRNA Translation: BAA91640.1
BX538067 mRNA Translation: CAD97997.1
BX640703 mRNA Translation: CAE45823.1 Different initiation.
AK298533 mRNA Translation: BAG60734.1
AL023581 Genomic DNA No translation available.
AL136116 Genomic DNA No translation available.
AL391726 Genomic DNA No translation available.
AL450335 Genomic DNA No translation available.
BC025278 mRNA Translation: AAH25278.1
CCDSiCCDS5198.1 [Q9NVV5-2]
CCDS69215.1 [Q9NVV5-6]
CCDS69216.1 [Q9NVV5-5]
RefSeqiNP_001273516.1, NM_001286587.1 [Q9NVV5-4]
NP_001273517.1, NM_001286588.1 [Q9NVV5-6]
NP_001273518.1, NM_001286589.1 [Q9NVV5-5]
NP_057192.2, NM_016108.3 [Q9NVV5-2]
UniGeneiHs.567501

3D structure databases

ProteinModelPortaliQ9NVV5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119519, 7 interactors
IntActiQ9NVV5, 42 interactors
STRINGi9606.ENSP00000350509

Chemistry databases

BindingDBiQ9NVV5
SwissLipidsiSLP:000001682

Protein family/group databases

TCDBi9.B.203.1.1 the aig1 lipid hydrolase (aig1) family

PTM databases

iPTMnetiQ9NVV5
PhosphoSitePlusiQ9NVV5

Polymorphism and mutation databases

DMDMi56748615

Proteomic databases

EPDiQ9NVV5
MaxQBiQ9NVV5
PaxDbiQ9NVV5
PeptideAtlasiQ9NVV5
PRIDEiQ9NVV5
ProteomicsDBi82866
82867 [Q9NVV5-2]
82868 [Q9NVV5-3]
82869 [Q9NVV5-4]
82870 [Q9NVV5-5]
TopDownProteomicsiQ9NVV5-4 [Q9NVV5-4]

Protocols and materials databases

DNASUi51390
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275235; ENSP00000275235; ENSG00000146416 [Q9NVV5-1]
ENST00000357847; ENSP00000350509; ENSG00000146416 [Q9NVV5-2]
ENST00000494282; ENSP00000473952; ENSG00000146416 [Q9NVV5-5]
ENST00000629020; ENSP00000485875; ENSG00000146416 [Q9NVV5-6]
GeneIDi51390
KEGGihsa:51390
UCSCiuc003qjg.5 human [Q9NVV5-1]

Organism-specific databases

CTDi51390
DisGeNETi51390
EuPathDBiHostDB:ENSG00000146416.16
GeneCardsiAIG1
HGNCiHGNC:21607 AIG1
HPAiHPA060766
MIMi608514 gene
neXtProtiNX_Q9NVV5
OpenTargetsiENSG00000146416
PharmGKBiPA134991331
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3989 Eukaryota
ENOG4111HQA LUCA
GeneTreeiENSGT00390000012526
HOVERGENiHBG050468
InParanoidiQ9NVV5
OMAiHTNIVIF
OrthoDBiEOG091G0LUO
PhylomeDBiQ9NVV5
TreeFamiTF318170

Miscellaneous databases

ChiTaRSiAIG1 human
GeneWikiiAIG1
GenomeRNAii51390
PROiPR:Q9NVV5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146416 Expressed in 208 organ(s), highest expression level in liver
CleanExiHS_AIG1
ExpressionAtlasiQ9NVV5 baseline and differential
GenevisibleiQ9NVV5 HS

Family and domain databases

InterProiView protein in InterPro
IPR006838 Far-17a_AIG1
PANTHERiPTHR10989 PTHR10989, 1 hit
PfamiView protein in Pfam
PF04750 Far-17a_AIG1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAIG1_HUMAN
AccessioniPrimary (citable) accession number: Q9NVV5
Secondary accession number(s): B4DPX2
, C9J569, Q5T2H2, Q6N047, Q7Z378, Q8TB14, Q9Y3A9, Q9Y5B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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