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Entry version 136 (18 Sep 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Trimeric intracellular cation channel type B

Gene

TMEM38B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei118Phosphatidylinositol 4,5-bisphosphate (PIP2)By similarity1
Binding sitei122Phosphatidylinositol 4,5-bisphosphate (PIP2)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • potassium channel activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.62.1.3 the homotrimeric cation channel (tric) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trimeric intracellular cation channel type B
Short name:
TRIC-B
Short name:
TRICB
Alternative name(s):
Transmembrane protein 38B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM38B
Synonyms:C9orf87
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25535 TMEM38B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611236 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NVV0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 19LumenalCuratedAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 33Helical;Name=1Sequence analysisAdd BLAST14
Topological domaini34 – 50CytoplasmicCuratedAdd BLAST17
Transmembranei51 – 70Helical;Name=2Sequence analysisAdd BLAST20
Topological domaini71 – 82LumenalCuratedAdd BLAST12
Transmembranei83 – 99Helical;Name=3Sequence analysisAdd BLAST17
Topological domaini100 – 104CytoplasmicCurated5
Transmembranei105 – 121Helical;Name=4Sequence analysisAdd BLAST17
Topological domaini122 – 139LumenalCuratedAdd BLAST18
Transmembranei140 – 156Helical;Name=5Sequence analysisAdd BLAST17
Topological domaini157 – 179CytoplasmicCuratedAdd BLAST23
Transmembranei180 – 195Helical;Name=6Sequence analysisAdd BLAST16
Topological domaini196 – 207LumenalCuratedAdd BLAST12
Transmembranei208 – 227Helical;Name=7Sequence analysisAdd BLAST20
Topological domaini228 – 291CytoplasmicCuratedAdd BLAST64

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Osteogenesis imperfecta 14 (OI14)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI14 is characterized by variable degrees of severity of multiple fractures and osteopenia, with normal teeth, sclerae, and hearing. Fractures first occur prenatally or by age 6 years.
Related information in OMIM

Keywords - Diseasei

Osteogenesis imperfecta

Organism-specific databases

DisGeNET

More...
DisGeNETi
55151

MalaCards human disease database

More...
MalaCardsi
TMEM38B
MIMi615066 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000095209

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
216820 Osteogenesis imperfecta type 4

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134916126

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM38B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74753001

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002915241 – 291Trimeric intracellular cation channel type BAdd BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei262PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NVV0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NVV0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NVV0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NVV0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NVV0

PeptideAtlas

More...
PeptideAtlasi
Q9NVV0

PRoteomics IDEntifications database

More...
PRIDEi
Q9NVV0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82862

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NVV0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NVV0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9NVV0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000095209 Expressed in 208 organ(s), highest expression level in sperm

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NVV0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NVV0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018465

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer; trimerization probably requires binding to phosphatidylinositol 4,5-bisphosphate (PIP2).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120454, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NVV0, 9 interactors

Molecular INTeraction database

More...
MINTi
Q9NVV0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363824

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NVV0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM38 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3944 Eukaryota
ENOG410XQ0P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018845

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000037929

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NVV0

Identification of Orthologs from Complete Genome Data

More...
OMAi
KMSYPSK

Database of Orthologous Groups

More...
OrthoDBi
1319985at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NVV0

TreeFam database of animal gene trees

More...
TreeFami
TF313483

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007866 TRIC_channel

The PANTHER Classification System

More...
PANTHERi
PTHR12454 PTHR12454, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05197 TRIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9NVV0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSPWDELAL AFSRTSMFPF FDIAHYLVSV MAVKRQPGAA ALAWKNPISS
60 70 80 90 100
WFTAMLHCFG GGILSCLLLA EPPLKFLANH TNILLASSIW YITFFCPHDL
110 120 130 140 150
VSQGYSYLPV QLLASGMKEV TRTWKIVGGV THANSYYKNG WIVMIAIGWA
160 170 180 190 200
RGAGGTIITN FERLVKGDWK PEGDEWLKMS YPAKVTLLGS VIFTFQHTQH
210 220 230 240 250
LAISKHNLMF LYTIFIVATK ITMMTTQTST MTFAPFEDTL SWMLFGWQQP
260 270 280 290
FSSCEKKSEA KSPSNGVGSL ASKPVDVASD NVKKKHTKKN E
Length:291
Mass (Da):32,510
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1975F1E0053EAE7B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRS4A0A0A0MRS4_HUMAN
Transmembrane protein 38B, isoform ...
TMEM38B hCG_1738357
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3B3H7C3B3_HUMAN
Trimeric intracellular cation chann...
TMEM38B
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4C1H7C4C1_HUMAN
Trimeric intracellular cation chann...
TMEM38B
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RGH1X6RGH1_HUMAN
Trimeric intracellular cation chann...
TMEM38B
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32A → E in CAG33539 (Ref. 2) Curated1
Sequence conflicti291E → D in CAG33539 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032811254C → S. Corresponds to variant dbSNP:rs35232724EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001355 mRNA Translation: BAA91645.1
CR457258 mRNA Translation: CAG33539.1
AL592437 Genomic DNA No translation available.
AL592488 Genomic DNA No translation available.
AL627247 Genomic DNA No translation available.
BC000049 mRNA Translation: AAH00049.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6768.1

NCBI Reference Sequences

More...
RefSeqi
NP_060582.1, NM_018112.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000374692; ENSP00000363824; ENSG00000095209

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55151

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55151

UCSC genome browser

More...
UCSCi
uc004bcu.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001355 mRNA Translation: BAA91645.1
CR457258 mRNA Translation: CAG33539.1
AL592437 Genomic DNA No translation available.
AL592488 Genomic DNA No translation available.
AL627247 Genomic DNA No translation available.
BC000049 mRNA Translation: AAH00049.1
CCDSiCCDS6768.1
RefSeqiNP_060582.1, NM_018112.2

3D structure databases

SMRiQ9NVV0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120454, 13 interactors
IntActiQ9NVV0, 9 interactors
MINTiQ9NVV0
STRINGi9606.ENSP00000363824

Protein family/group databases

TCDBi1.A.62.1.3 the homotrimeric cation channel (tric) family

PTM databases

iPTMnetiQ9NVV0
PhosphoSitePlusiQ9NVV0
SwissPalmiQ9NVV0

Polymorphism and mutation databases

BioMutaiTMEM38B
DMDMi74753001

Proteomic databases

EPDiQ9NVV0
jPOSTiQ9NVV0
MassIVEiQ9NVV0
MaxQBiQ9NVV0
PaxDbiQ9NVV0
PeptideAtlasiQ9NVV0
PRIDEiQ9NVV0
ProteomicsDBi82862

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55151
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374692; ENSP00000363824; ENSG00000095209
GeneIDi55151
KEGGihsa:55151
UCSCiuc004bcu.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55151
DisGeNETi55151

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM38B
HGNCiHGNC:25535 TMEM38B
HPAiHPA018465
MalaCardsiTMEM38B
MIMi611236 gene
615066 phenotype
neXtProtiNX_Q9NVV0
OpenTargetsiENSG00000095209
Orphaneti216820 Osteogenesis imperfecta type 4
PharmGKBiPA134916126

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3944 Eukaryota
ENOG410XQ0P LUCA
GeneTreeiENSGT00390000018845
HOGENOMiHOG000037929
InParanoidiQ9NVV0
OMAiKMSYPSK
OrthoDBi1319985at2759
PhylomeDBiQ9NVV0
TreeFamiTF313483

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMEM38B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55151

Pharos

More...
Pharosi
Q9NVV0

Protein Ontology

More...
PROi
PR:Q9NVV0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000095209 Expressed in 208 organ(s), highest expression level in sperm
ExpressionAtlasiQ9NVV0 baseline and differential
GenevisibleiQ9NVV0 HS

Family and domain databases

InterProiView protein in InterPro
IPR007866 TRIC_channel
PANTHERiPTHR12454 PTHR12454, 1 hit
PfamiView protein in Pfam
PF05197 TRIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM38B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NVV0
Secondary accession number(s): Q5JR63
, Q5SVN5, Q5SVN6, Q5VTE2, Q6IA97
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2000
Last modified: September 18, 2019
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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