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Entry version 145 (12 Aug 2020)
Sequence version 3 (18 May 2010)
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Protein

Protein SDA1 homolog

Gene

SDAD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for 60S pre-ribosomal subunits export to the cytoplasm.By similarity

Miscellaneous

DAZL and PUM2 bind its 3'-UTR mRNA, suggesting that these proteins may regulate its translation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Ribosome biogenesis, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NVU7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein SDA1 homolog
Alternative name(s):
Nucleolar protein 130
SDA1 domain-containing protein 1
Short name:
hSDA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SDAD1
Synonyms:NUC130
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000198301.11

Human Gene Nomenclature Database

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HGNCi
HGNC:25537, SDAD1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NVU7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55153

Open Targets

More...
OpenTargetsi
ENSG00000198301

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134961441

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NVU7, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SDAD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452964

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002874821 – 687Protein SDA1 homologAdd BLAST687

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei232PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei236PhosphoserineCombined sources1
Modified residuei552PhosphothreonineCombined sources1
Modified residuei585PhosphoserineCombined sources1
Modified residuei595PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NVU7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NVU7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NVU7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NVU7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NVU7

PeptideAtlas

More...
PeptideAtlasi
Q9NVU7

PRoteomics IDEntifications database

More...
PRIDEi
Q9NVU7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82860 [Q9NVU7-1]
82861 [Q9NVU7-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9NVU7-1 [Q9NVU7-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NVU7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NVU7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9NVU7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis, kidney, spleen, brain and fetal tissues. Also expressed at lower level in heart, lung, liver, small intestine, ovary, uterus, mammary gland and placenta.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198301, Expressed in cerebellar vermis and 241 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NVU7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NVU7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000198301, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120456, 58 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NVU7, 27 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000348596

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NVU7, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili253 – 315Sequence analysisAdd BLAST63

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SDA1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2229, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010355

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009161_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NVU7

KEGG Orthology (KO)

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KOi
K14856

Identification of Orthologs from Complete Genome Data

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OMAi
AQVAQCY

Database of Orthologous Groups

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OrthoDBi
426305at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NVU7

TreeFam database of animal gene trees

More...
TreeFami
TF105727

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR027312, Sda1
IPR007949, SDA1_dom
IPR012977, Uncharacterised_NUC130/133_N

The PANTHER Classification System

More...
PANTHERi
PTHR12730, PTHR12730, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF08158, NUC130_3NT, 1 hit
PF05285, SDA1, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NVU7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNRNNNKLP SNLPQLQNLI KRDPPAYIEE FLQQYNHYKS NVEIFKLQPN
60 70 80 90 100
KPSKELAELV MFMAQISHCY PEYLSNFPQE VKDLLSCNHT VLDPDLRMTF
110 120 130 140 150
CKALILLRNK NLINPSSLLE LFFELFRCHD KLLRKTLYTH IVTDIKNINA
160 170 180 190 200
KHKNNKVNVV LQNFMYTMLR DSNATAAKMS LDVMIELYRR NIWNDAKTVN
210 220 230 240 250
VITTACFSKV TKILVAALTF FLGKDEDEKQ DSDSESEDDG PTARDLLVQY
260 270 280 290 300
ATGKKSSKNK KKLEKAMKVL KKQKKKKKPE VFNFSAIHLI HDPQDFAEKL
310 320 330 340 350
LKQLECCKER FEVKMMLMNL ISRLVGIHEL FLFNFYPFLQ RFLQPHQREV
360 370 380 390 400
TKILLFAAQA SHHLVPPEII QSLLMTVANN FVTDKNSGEV MTVGINAIKE
410 420 430 440 450
ITARCPLAMT EELLQDLAQY KTHKDKNVMM SARTLIHLFR TLNPQMLQKK
460 470 480 490 500
FRGKPTEASI EARVQEYGEL DAKDYIPGAE VLEVEKEENA ENDEDGWEST
510 520 530 540 550
SLSEEEDADG EWIDVQHSSD EEQQEISKKL NSMPMEERKA KAAAISTSRV
560 570 580 590 600
LTQEDFQKIR MAQMRKELDA APGKSQKRKY IEIDSDEEPR GELLSLRDIE
610 620 630 640 650
RLHKKPKSDK ETRLATAMAG KTDRKEFVRK KTKTNPFSSS TNKEKKKQKN
660 670 680
FMMMRYSQNV RSKNKRSFRE KQLALRDALL KKRKRMK
Length:687
Mass (Da):79,871
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB01EE09383EA959C
GO
Isoform 2 (identifier: Q9NVU7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Show »
Length:590
Mass (Da):68,455
Checksum:i06780B225C43F041
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EW05E7EW05_HUMAN
Protein SDA1
SDAD1
650Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC74D6RC74_HUMAN
Protein SDA1
SDAD1
88Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIR5D6RIR5_HUMAN
Protein SDA1
SDAD1
47Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W8T7F8W8T7_HUMAN
Protein SDA1
SDAD1
72Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI07896 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA91648 differs from that shown. Reason: Frameshift.Curated
The sequence BAB14177 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14790 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti186E → G in CAH18368 (PubMed:17974005).Curated1
Sequence conflicti288H → L in BAA91648 (PubMed:14702039).Curated1
Sequence conflicti319N → S in CAH18368 (PubMed:17974005).Curated1
Sequence conflicti396N → S in CAH18368 (PubMed:17974005).Curated1
Sequence conflicti617A → S in BAB14177 (PubMed:14702039).Curated1
Sequence conflicti634T → A in CAH18368 (PubMed:17974005).Curated1
Sequence conflicti651F → L in CAH18368 (PubMed:17974005).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Variations in SDAD1 may be a cause of susceptibility to seasonal allergic rhinitis (SAR). SAR is a common allergic disorder characterized by episodes of sneezing, rhinorrhea, and swelling of the nasal mucosa.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032312258K → Q. Corresponds to variant dbSNP:rs15481Ensembl.1
Natural variantiVAR_032313490A → D. Corresponds to variant dbSNP:rs34627298Ensembl.1
Natural variantiVAR_032314575S → C2 PublicationsCorresponds to variant dbSNP:rs2242471Ensembl.1
Natural variantiVAR_032315660V → I. Corresponds to variant dbSNP:rs17001276Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0255051 – 97Missing in isoform 2. 1 PublicationAdd BLAST97

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR749574 mRNA Translation: CAH18368.1
AC110615 Genomic DNA No translation available.
AC112719 Genomic DNA No translation available.
AC115628 Genomic DNA No translation available.
BC054040 mRNA Translation: AAH54040.1
BC063797 mRNA Translation: AAH63797.1
BC107895 mRNA Translation: AAI07896.1 Sequence problems.
AK001360 mRNA Translation: BAA91648.1 Frameshift.
AK022683 mRNA Translation: BAB14177.1 Different initiation.
AK024031 mRNA Translation: BAB14790.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3573.2 [Q9NVU7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001275912.1, NM_001288983.1
NP_001275913.1, NM_001288984.1 [Q9NVU7-2]
NP_060585.2, NM_018115.3 [Q9NVU7-1]
XP_005263162.1, XM_005263105.4 [Q9NVU7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356260; ENSP00000348596; ENSG00000198301 [Q9NVU7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55153

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55153

UCSC genome browser

More...
UCSCi
uc003hje.6, human [Q9NVU7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749574 mRNA Translation: CAH18368.1
AC110615 Genomic DNA No translation available.
AC112719 Genomic DNA No translation available.
AC115628 Genomic DNA No translation available.
BC054040 mRNA Translation: AAH54040.1
BC063797 mRNA Translation: AAH63797.1
BC107895 mRNA Translation: AAI07896.1 Sequence problems.
AK001360 mRNA Translation: BAA91648.1 Frameshift.
AK022683 mRNA Translation: BAB14177.1 Different initiation.
AK024031 mRNA Translation: BAB14790.1 Different initiation.
CCDSiCCDS3573.2 [Q9NVU7-1]
RefSeqiNP_001275912.1, NM_001288983.1
NP_001275913.1, NM_001288984.1 [Q9NVU7-2]
NP_060585.2, NM_018115.3 [Q9NVU7-1]
XP_005263162.1, XM_005263105.4 [Q9NVU7-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Protein-protein interaction databases

BioGRIDi120456, 58 interactors
IntActiQ9NVU7, 27 interactors
STRINGi9606.ENSP00000348596

PTM databases

iPTMnetiQ9NVU7
PhosphoSitePlusiQ9NVU7
SwissPalmiQ9NVU7

Polymorphism and mutation databases

BioMutaiSDAD1
DMDMi296452964

Proteomic databases

EPDiQ9NVU7
jPOSTiQ9NVU7
MassIVEiQ9NVU7
MaxQBiQ9NVU7
PaxDbiQ9NVU7
PeptideAtlasiQ9NVU7
PRIDEiQ9NVU7
ProteomicsDBi82860 [Q9NVU7-1]
82861 [Q9NVU7-2]
TopDownProteomicsiQ9NVU7-1 [Q9NVU7-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
49727, 39 antibodies

The DNASU plasmid repository

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DNASUi
55153

Genome annotation databases

EnsembliENST00000356260; ENSP00000348596; ENSG00000198301 [Q9NVU7-1]
GeneIDi55153
KEGGihsa:55153
UCSCiuc003hje.6, human [Q9NVU7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55153
DisGeNETi55153
EuPathDBiHostDB:ENSG00000198301.11

GeneCards: human genes, protein and diseases

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GeneCardsi
SDAD1
HGNCiHGNC:25537, SDAD1
HPAiENSG00000198301, Low tissue specificity
neXtProtiNX_Q9NVU7
OpenTargetsiENSG00000198301
PharmGKBiPA134961441

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2229, Eukaryota
GeneTreeiENSGT00390000010355
HOGENOMiCLU_009161_3_1_1
InParanoidiQ9NVU7
KOiK14856
OMAiAQVAQCY
OrthoDBi426305at2759
PhylomeDBiQ9NVU7
TreeFamiTF105727

Enzyme and pathway databases

PathwayCommonsiQ9NVU7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
55153, 668 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SDAD1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SDAD1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55153
PharosiQ9NVU7, Tdark

Protein Ontology

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PROi
PR:Q9NVU7
RNActiQ9NVU7, protein

Gene expression databases

BgeeiENSG00000198301, Expressed in cerebellar vermis and 241 other tissues
ExpressionAtlasiQ9NVU7, baseline and differential
GenevisibleiQ9NVU7, HS

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR027312, Sda1
IPR007949, SDA1_dom
IPR012977, Uncharacterised_NUC130/133_N
PANTHERiPTHR12730, PTHR12730, 1 hit
PfamiView protein in Pfam
PF08158, NUC130_3NT, 1 hit
PF05285, SDA1, 2 hits
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSDA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NVU7
Secondary accession number(s): Q32Q11
, Q68D52, Q7Z5U4, Q9H831, Q9H9P6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 145 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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