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Protein

Protein SDA1 homolog

Gene

SDAD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for 60S pre-ribosomal subunits export to the cytoplasm.By similarity

Miscellaneous

DAZL and PUM2 bind its 3'-UTR mRNA, suggesting that these proteins may regulate its translation.

GO - Biological processi

Keywordsi

Biological processProtein transport, Ribosome biogenesis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SDA1 homolog
Alternative name(s):
Nucleolar protein 130
SDA1 domain-containing protein 1
Short name:
hSDA
Gene namesi
Name:SDAD1
Synonyms:NUC130
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000198301.11
HGNCiHGNC:25537 SDAD1
neXtProtiNX_Q9NVU7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55153
OpenTargetsiENSG00000198301
PharmGKBiPA134961441

Polymorphism and mutation databases

BioMutaiSDAD1
DMDMi296452964

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002874821 – 687Protein SDA1 homologAdd BLAST687

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei232PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei236PhosphoserineCombined sources1
Modified residuei552PhosphothreonineCombined sources1
Modified residuei585PhosphoserineCombined sources1
Modified residuei595PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NVU7
MaxQBiQ9NVU7
PaxDbiQ9NVU7
PeptideAtlasiQ9NVU7
PRIDEiQ9NVU7
ProteomicsDBi82860
82861 [Q9NVU7-2]
TopDownProteomicsiQ9NVU7-1 [Q9NVU7-1]

PTM databases

iPTMnetiQ9NVU7
PhosphoSitePlusiQ9NVU7

Expressioni

Tissue specificityi

Highly expressed in testis, kidney, spleen, brain and fetal tissues. Also expressed at lower level in heart, lung, liver, small intestine, ovary, uterus, mammary gland and placenta.2 Publications

Gene expression databases

BgeeiENSG00000198301 Expressed in 227 organ(s), highest expression level in female gonad
CleanExiHS_SDAD1
ExpressionAtlasiQ9NVU7 baseline and differential
GenevisibleiQ9NVU7 HS

Organism-specific databases

HPAiHPA035949

Interactioni

Protein-protein interaction databases

BioGridi120456, 37 interactors
IntActiQ9NVU7, 10 interactors
STRINGi9606.ENSP00000348596

Structurei

3D structure databases

ProteinModelPortaliQ9NVU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili253 – 315Sequence analysisAdd BLAST63

Sequence similaritiesi

Belongs to the SDA1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2229 Eukaryota
ENOG410XPHI LUCA
GeneTreeiENSGT00390000010355
HOGENOMiHOG000204601
HOVERGENiHBG059552
InParanoidiQ9NVU7
KOiK14856
OMAiAQVAQCY
OrthoDBiEOG091G03LI
PhylomeDBiQ9NVU7
TreeFamiTF105727

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR027312 Sda1
IPR007949 SDA1_dom
IPR012977 Uncharacterised_NUC130/133_N
PANTHERiPTHR12730 PTHR12730, 1 hit
PfamiView protein in Pfam
PF08158 NUC130_3NT, 1 hit
PF05285 SDA1, 2 hits
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NVU7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNRNNNKLP SNLPQLQNLI KRDPPAYIEE FLQQYNHYKS NVEIFKLQPN
60 70 80 90 100
KPSKELAELV MFMAQISHCY PEYLSNFPQE VKDLLSCNHT VLDPDLRMTF
110 120 130 140 150
CKALILLRNK NLINPSSLLE LFFELFRCHD KLLRKTLYTH IVTDIKNINA
160 170 180 190 200
KHKNNKVNVV LQNFMYTMLR DSNATAAKMS LDVMIELYRR NIWNDAKTVN
210 220 230 240 250
VITTACFSKV TKILVAALTF FLGKDEDEKQ DSDSESEDDG PTARDLLVQY
260 270 280 290 300
ATGKKSSKNK KKLEKAMKVL KKQKKKKKPE VFNFSAIHLI HDPQDFAEKL
310 320 330 340 350
LKQLECCKER FEVKMMLMNL ISRLVGIHEL FLFNFYPFLQ RFLQPHQREV
360 370 380 390 400
TKILLFAAQA SHHLVPPEII QSLLMTVANN FVTDKNSGEV MTVGINAIKE
410 420 430 440 450
ITARCPLAMT EELLQDLAQY KTHKDKNVMM SARTLIHLFR TLNPQMLQKK
460 470 480 490 500
FRGKPTEASI EARVQEYGEL DAKDYIPGAE VLEVEKEENA ENDEDGWEST
510 520 530 540 550
SLSEEEDADG EWIDVQHSSD EEQQEISKKL NSMPMEERKA KAAAISTSRV
560 570 580 590 600
LTQEDFQKIR MAQMRKELDA APGKSQKRKY IEIDSDEEPR GELLSLRDIE
610 620 630 640 650
RLHKKPKSDK ETRLATAMAG KTDRKEFVRK KTKTNPFSSS TNKEKKKQKN
660 670 680
FMMMRYSQNV RSKNKRSFRE KQLALRDALL KKRKRMK
Length:687
Mass (Da):79,871
Last modified:May 18, 2010 - v3
Checksum:iB01EE09383EA959C
GO
Isoform 2 (identifier: Q9NVU7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Note: No experimental confirmation available.
Show »
Length:590
Mass (Da):68,455
Checksum:i06780B225C43F041
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EW05E7EW05_HUMAN
Protein SDA1
SDAD1
650Annotation score:
F8W8T7F8W8T7_HUMAN
Protein SDA1
SDAD1
72Annotation score:
D6RC74D6RC74_HUMAN
Protein SDA1
SDAD1
88Annotation score:
D6RIR5D6RIR5_HUMAN
Protein SDA1 homolog
SDAD1
47Annotation score:

Sequence cautioni

The sequence AAI07896 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA91648 differs from that shown. Reason: Frameshift at position 53.Curated
The sequence BAB14177 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14790 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186E → G in CAH18368 (PubMed:17974005).Curated1
Sequence conflicti288H → L in BAA91648 (PubMed:14702039).Curated1
Sequence conflicti319N → S in CAH18368 (PubMed:17974005).Curated1
Sequence conflicti396N → S in CAH18368 (PubMed:17974005).Curated1
Sequence conflicti617A → S in BAB14177 (PubMed:14702039).Curated1
Sequence conflicti634T → A in CAH18368 (PubMed:17974005).Curated1
Sequence conflicti651F → L in CAH18368 (PubMed:17974005).Curated1

Polymorphismi

Variations in SDAD1 may be a cause of susceptibility to seasonal allergic rhinitis (SAR). SAR is a common allergic disorder characterized by episodes of sneezing, rhinorrhea, and swelling of the nasal mucosa.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032312258K → Q. Corresponds to variant dbSNP:rs15481Ensembl.1
Natural variantiVAR_032313490A → D. Corresponds to variant dbSNP:rs34627298Ensembl.1
Natural variantiVAR_032314575S → C2 PublicationsCorresponds to variant dbSNP:rs2242471Ensembl.1
Natural variantiVAR_032315660V → I. Corresponds to variant dbSNP:rs17001276Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0255051 – 97Missing in isoform 2. 1 PublicationAdd BLAST97

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749574 mRNA Translation: CAH18368.1
AC110615 Genomic DNA No translation available.
AC112719 Genomic DNA No translation available.
AC115628 Genomic DNA No translation available.
BC054040 mRNA Translation: AAH54040.1
BC063797 mRNA Translation: AAH63797.1
BC107895 mRNA Translation: AAI07896.1 Sequence problems.
AK001360 mRNA Translation: BAA91648.1 Frameshift.
AK022683 mRNA Translation: BAB14177.1 Different initiation.
AK024031 mRNA Translation: BAB14790.1 Different initiation.
CCDSiCCDS3573.2 [Q9NVU7-1]
RefSeqiNP_001275912.1, NM_001288983.1
NP_001275913.1, NM_001288984.1 [Q9NVU7-2]
NP_060585.2, NM_018115.3 [Q9NVU7-1]
XP_005263162.1, XM_005263105.4 [Q9NVU7-2]
UniGeneiHs.632604

Genome annotation databases

EnsembliENST00000356260; ENSP00000348596; ENSG00000198301 [Q9NVU7-1]
GeneIDi55153
KEGGihsa:55153
UCSCiuc003hje.6 human [Q9NVU7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749574 mRNA Translation: CAH18368.1
AC110615 Genomic DNA No translation available.
AC112719 Genomic DNA No translation available.
AC115628 Genomic DNA No translation available.
BC054040 mRNA Translation: AAH54040.1
BC063797 mRNA Translation: AAH63797.1
BC107895 mRNA Translation: AAI07896.1 Sequence problems.
AK001360 mRNA Translation: BAA91648.1 Frameshift.
AK022683 mRNA Translation: BAB14177.1 Different initiation.
AK024031 mRNA Translation: BAB14790.1 Different initiation.
CCDSiCCDS3573.2 [Q9NVU7-1]
RefSeqiNP_001275912.1, NM_001288983.1
NP_001275913.1, NM_001288984.1 [Q9NVU7-2]
NP_060585.2, NM_018115.3 [Q9NVU7-1]
XP_005263162.1, XM_005263105.4 [Q9NVU7-2]
UniGeneiHs.632604

3D structure databases

ProteinModelPortaliQ9NVU7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120456, 37 interactors
IntActiQ9NVU7, 10 interactors
STRINGi9606.ENSP00000348596

PTM databases

iPTMnetiQ9NVU7
PhosphoSitePlusiQ9NVU7

Polymorphism and mutation databases

BioMutaiSDAD1
DMDMi296452964

Proteomic databases

EPDiQ9NVU7
MaxQBiQ9NVU7
PaxDbiQ9NVU7
PeptideAtlasiQ9NVU7
PRIDEiQ9NVU7
ProteomicsDBi82860
82861 [Q9NVU7-2]
TopDownProteomicsiQ9NVU7-1 [Q9NVU7-1]

Protocols and materials databases

DNASUi55153
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356260; ENSP00000348596; ENSG00000198301 [Q9NVU7-1]
GeneIDi55153
KEGGihsa:55153
UCSCiuc003hje.6 human [Q9NVU7-1]

Organism-specific databases

CTDi55153
DisGeNETi55153
EuPathDBiHostDB:ENSG00000198301.11
GeneCardsiSDAD1
H-InvDBiHIX0025559
HGNCiHGNC:25537 SDAD1
HPAiHPA035949
neXtProtiNX_Q9NVU7
OpenTargetsiENSG00000198301
PharmGKBiPA134961441
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2229 Eukaryota
ENOG410XPHI LUCA
GeneTreeiENSGT00390000010355
HOGENOMiHOG000204601
HOVERGENiHBG059552
InParanoidiQ9NVU7
KOiK14856
OMAiAQVAQCY
OrthoDBiEOG091G03LI
PhylomeDBiQ9NVU7
TreeFamiTF105727

Miscellaneous databases

ChiTaRSiSDAD1 human
GeneWikiiSDAD1
GenomeRNAii55153
PROiPR:Q9NVU7

Gene expression databases

BgeeiENSG00000198301 Expressed in 227 organ(s), highest expression level in female gonad
CleanExiHS_SDAD1
ExpressionAtlasiQ9NVU7 baseline and differential
GenevisibleiQ9NVU7 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR027312 Sda1
IPR007949 SDA1_dom
IPR012977 Uncharacterised_NUC130/133_N
PANTHERiPTHR12730 PTHR12730, 1 hit
PfamiView protein in Pfam
PF08158 NUC130_3NT, 1 hit
PF05285 SDA1, 2 hits
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSDA1_HUMAN
AccessioniPrimary (citable) accession number: Q9NVU7
Secondary accession number(s): Q32Q11
, Q68D52, Q7Z5U4, Q9H831, Q9H9P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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