UniProtKB - Q9NVU0 (RPC5_HUMAN)

BLAST

>sp|Q9NVU0|RPC5_HUMAN DNA-directed RNA polymerase III subunit RPC5 OS=Homo sapiens OX=9606 GN=POLR3E PE=1 SV=1
MANEEDDPVVQEIDVYLAKSLAEKLYLFQYPVRPASMTYDDIPHLSAKIKPKQQKVELEM
AIDTLNPNYCRSKGEQIALNVDGACADETSTYSSKLMDKQTFCSSQTTSNTSRYAAALYR
QGELHLTPLHGILQLRPSFSYLDKADAKHREREAANEAGDSSQDEAEDDVKQITVRFSRP
ESEQARQRRVQSYEFLQKKHAEEPWVHLHYYGLRDSRSEHERQYLLCPGSSGVENTELVK
SPSEYLMMLMPPSQEEEKDKPVAPSNVLSMAQLRTLPLADQIKILMKNVKVMPFANLMSL
LGPSIDSVAVLRGIQKVAMLVQGNWVVKSDILYPKDSSSPHSGVPAEVLCRGRDFVMWKF
TQSRWVVRKEVATVTKLCAEDVKDFLEHMAVVRINKGWEFILPYDGEFIKKHPDVVQRQH
MLWTGIQAKLEKVYNLVKETMPKKPDAQSGPAGLVCGDQRIQVAKTKAQQNHALLERELQ
RRKEQLRVPAVPPGVRIKEEPVSEEGEEDEEQEAEEEPMDTSPSGLHSKLANGLPLGRAA
GTDSFNGHPPQGCASTPVARELKAFVEATFQRQFVLTLSELKRLFNLHLASLPPGHTLFS
GISDRMLQDTVLAAGCKQILVPFPPQTAASPDEQKVFALWESGDMSDQHRQVLLEIFSKN
YRVRRNMIQSRLTQECGEDLSKQEVDKVLKDCCVSYGGMWYLKGTVQS

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History
Entry version 150 (12 Sep 2018)
Sequence version 1 (01 Oct 2000)
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Protein

DNA-directed RNA polymerase III subunit RPC5

Gene

POLR3E

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).By similarity2 Publications

GO - Molecular functionⁱ

DNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

defense response to virus Source: UniProtKB-KW
innate immune response Source: UniProtKB-KW
transcription by RNA polymerase III Source: GOC

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Antiviral defense, Immunity, Innate immunity, Transcription

Biological process

Antiviral defense, Immunity, Innate immunity, Transcription

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA R-HSA-73780 RNA Polymerase III Chain Elongation R-HSA-73980 RNA Polymerase III Transcription Termination R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Reactomeⁱ

R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-73780 RNA Polymerase III Chain Elongation
R-HSA-73980 RNA Polymerase III Transcription Termination
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DNA-directed RNA polymerase III subunit RPC5 Short name: RNA polymerase III subunit C5 Alternative name(s): DNA-directed RNA polymerase III 80 kDa polypeptide
Gene namesⁱ	Name:POLR3E Synonyms:KIAA1452
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000058600.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30347 POLR3E
MIMⁱ	617815 gene
neXtProtⁱ	NX_Q9NVU0

Keywords - Cellular componentⁱ

DNA-directed RNA polymerase, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	101060521 55718
Open Targets More...OpenTargetsⁱ	ENSG00000058600
PharmGKBⁱ	PA134964025

Polymorphism and mutation databases

BioMutaⁱ	POLR3E
DMDMⁱ	29428028

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000073970	1 – 708	DNA-directed RNA polymerase III subunit RPC5Add BLAST		708

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	161	PhosphoserineCombined sources	1
Modified residueⁱ	162	PhosphoserineCombined sources	1
Cross-linkⁱ	171	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	192	PhosphoserineCombined sources	1
Modified residueⁱ	224	PhosphotyrosineCombined sources	1
Cross-linkⁱ	432	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	498	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linkⁱ	498	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	503	PhosphoserineCombined sources	1
Modified residueⁱ	522	PhosphoserineCombined sources	1
Cross-linkⁱ	659	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9NVU0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NVU0
PaxDbⁱ	Q9NVU0
PeptideAtlas More...PeptideAtlasⁱ	Q9NVU0
PRIDEⁱ	Q9NVU0
ProteomicsDBⁱ	82857 82858 [Q9NVU0-2] 82859 [Q9NVU0-3]

PTM databases

iPTMnetⁱ	Q9NVU0
PhosphoSitePlusⁱ	Q9NVU0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000058600 Expressed in 227 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_POLR3E
ExpressionAtlasⁱ	Q9NVU0 baseline and differential
Genevisibleⁱ	Q9NVU0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041419 HPA041477

HPAⁱ

HPA041419
HPA041477

Interactionⁱ

Subunit structureⁱ

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). Interacts with POLR3D/RPC4.By similarity1 Publication

Protein-protein interaction databases

BioGridⁱ	120840, 54 interactors 3190820, 9 interactors
IntActⁱ	Q9NVU0, 39 interactors
Molecular INTeraction database More...MINTⁱ	Q9NVU0
STRINGⁱ	9606.ENSP00000299853

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NVU0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	KOG2354 Eukaryota ENOG410Y1X8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016123
HOGENOMⁱ	HOG000069875
HOVERGENⁱ	HBG039706
InParanoidⁱ	Q9NVU0
KEGG Orthology (KO) More...KOⁱ	K14721
OMAⁱ	RNMIQSR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BTS
PhylomeDBⁱ	Q9NVU0
TreeFamⁱ	TF103050

Family and domain databases

InterProⁱ	View protein in InterPro IPR006886 RNA_pol_III_Rpc5
PANTHERⁱ	PTHR12069 PTHR12069, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04801 Sin_N, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q9NVU0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MANEEDDPVV QEIDVYLAKS LAEKLYLFQY PVRPASMTYD DIPHLSAKIK 
        60         70         80         90        100
PKQQKVELEM AIDTLNPNYC RSKGEQIALN VDGACADETS TYSSKLMDKQ 
       110        120        130        140        150
TFCSSQTTSN TSRYAAALYR QGELHLTPLH GILQLRPSFS YLDKADAKHR 
       160        170        180        190        200
EREAANEAGD SSQDEAEDDV KQITVRFSRP ESEQARQRRV QSYEFLQKKH 
       210        220        230        240        250
AEEPWVHLHY YGLRDSRSEH ERQYLLCPGS SGVENTELVK SPSEYLMMLM 
       260        270        280        290        300
PPSQEEEKDK PVAPSNVLSM AQLRTLPLAD QIKILMKNVK VMPFANLMSL 
       310        320        330        340        350
LGPSIDSVAV LRGIQKVAML VQGNWVVKSD ILYPKDSSSP HSGVPAEVLC 
       360        370        380        390        400
RGRDFVMWKF TQSRWVVRKE VATVTKLCAE DVKDFLEHMA VVRINKGWEF 
       410        420        430        440        450
ILPYDGEFIK KHPDVVQRQH MLWTGIQAKL EKVYNLVKET MPKKPDAQSG 
       460        470        480        490        500
PAGLVCGDQR IQVAKTKAQQ NHALLERELQ RRKEQLRVPA VPPGVRIKEE 
       510        520        530        540        550
PVSEEGEEDE EQEAEEEPMD TSPSGLHSKL ANGLPLGRAA GTDSFNGHPP 
       560        570        580        590        600
QGCASTPVAR ELKAFVEATF QRQFVLTLSE LKRLFNLHLA SLPPGHTLFS 
       610        620        630        640        650
GISDRMLQDT VLAAGCKQIL VPFPPQTAAS PDEQKVFALW ESGDMSDQHR 
       660        670        680        690        700
QVLLEIFSKN YRVRRNMIQS RLTQECGEDL SKQEVDKVLK DCCVSYGGMW 

YLKGTVQS

Length:708

Mass (Da):79,898

Last modified:October 1, 2000 - v1

Checksum:ⁱE9DB71615CC367A5

Isoform 2 (identifier: Q9NVU0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
649-690: Missing.

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        10         20         30         40         50
MANEEDDPVV QEIDVYLAKS LAEKLYLFQY PVRPASMTYD DIPHLSAKIK 
        60         70         80         90        100
PKQQKVELEM AIDTLNPNYC RSKGEQIALN VDGACADETS TYSSKLMDKQ 
       110        120        130        140        150
TFCSSQTTSN TSRYAAALYR QGELHLTPLH GILQLRPSFS YLDKADAKHR 
       160        170        180        190        200
EREAANEAGD SSQDEAEDDV KQITVRFSRP ESEQARQRRV QSYEFLQKKH 
       210        220        230        240        250
AEEPWVHLHY YGLRDSRSEH ERQYLLCPGS SGVENTELVK SPSEYLMMLM 
       260        270        280        290        300
PPSQEEEKDK PVAPSNVLSM AQLRTLPLAD QIKILMKNVK VMPFANLMSL 
       310        320        330        340        350
LGPSIDSVAV LRGIQKVAML VQGNWVVKSD ILYPKDSSSP HSGVPAEVLC 
       360        370        380        390        400
RGRDFVMWKF TQSRWVVRKE VATVTKLCAE DVKDFLEHMA VVRINKGWEF 
       410        420        430        440        450
ILPYDGEFIK KHPDVVQRQH MLWTGIQAKL EKVYNLVKET MPKKPDAQSG 
       460        470        480        490        500
PAGLVCGDQR IQVAKTKAQQ NHALLERELQ RRKEQLRVPA VPPGVRIKEE 
       510        520        530        540        550
PVSEEGEEDE EQEAEEEPMD TSPSGLHSKL ANGLPLGRAA GTDSFNGHPP 
       560        570        580        590        600
QGCASTPVAR ELKAFVEATF QRQFVLTLSE LKRLFNLHLA SLPPGHTLFS 
       610        620        630        640        650
GISDRMLQDT VLAAGCKQIL VPFPPQTAAS PDEQKVFALW ESGDMSDQDC 
       660 
CVSYGGMWYL KGTVQS

Show »

Length:666

Mass (Da):74,827

Checksum:ⁱA4E140C8BB0288F4

Isoform 3 (identifier: Q9NVU0-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
623-708: FPPQTAASPD...MWYLKGTVQS → VSRALPARGMGGGGWGEPAVGRPRGDTGGHAW

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        10         20         30         40         50
MANEEDDPVV QEIDVYLAKS LAEKLYLFQY PVRPASMTYD DIPHLSAKIK 
        60         70         80         90        100
PKQQKVELEM AIDTLNPNYC RSKGEQIALN VDGACADETS TYSSKLMDKQ 
       110        120        130        140        150
TFCSSQTTSN TSRYAAALYR QGELHLTPLH GILQLRPSFS YLDKADAKHR 
       160        170        180        190        200
EREAANEAGD SSQDEAEDDV KQITVRFSRP ESEQARQRRV QSYEFLQKKH 
       210        220        230        240        250
AEEPWVHLHY YGLRDSRSEH ERQYLLCPGS SGVENTELVK SPSEYLMMLM 
       260        270        280        290        300
PPSQEEEKDK PVAPSNVLSM AQLRTLPLAD QIKILMKNVK VMPFANLMSL 
       310        320        330        340        350
LGPSIDSVAV LRGIQKVAML VQGNWVVKSD ILYPKDSSSP HSGVPAEVLC 
       360        370        380        390        400
RGRDFVMWKF TQSRWVVRKE VATVTKLCAE DVKDFLEHMA VVRINKGWEF 
       410        420        430        440        450
ILPYDGEFIK KHPDVVQRQH MLWTGIQAKL EKVYNLVKET MPKKPDAQSG 
       460        470        480        490        500
PAGLVCGDQR IQVAKTKAQQ NHALLERELQ RRKEQLRVPA VPPGVRIKEE 
       510        520        530        540        550
PVSEEGEEDE EQEAEEEPMD TSPSGLHSKL ANGLPLGRAA GTDSFNGHPP 
       560        570        580        590        600
QGCASTPVAR ELKAFVEATF QRQFVLTLSE LKRLFNLHLA SLPPGHTLFS 
       610        620        630        640        650
GISDRMLQDT VLAAGCKQIL VPVSRALPAR GMGGGGWGEP AVGRPRGDTG 

GHAW

Note: No experimental confirmation available. May result from the retention of an intron in the cDNA.

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Length:654

Mass (Da):73,139

Checksum:ⁱCE65F08FBD429AE7

Isoform 4 (identifier: Q9NVU0-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
648-668: Missing.

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        10         20         30         40         50
MANEEDDPVV QEIDVYLAKS LAEKLYLFQY PVRPASMTYD DIPHLSAKIK 
        60         70         80         90        100
PKQQKVELEM AIDTLNPNYC RSKGEQIALN VDGACADETS TYSSKLMDKQ 
       110        120        130        140        150
TFCSSQTTSN TSRYAAALYR QGELHLTPLH GILQLRPSFS YLDKADAKHR 
       160        170        180        190        200
EREAANEAGD SSQDEAEDDV KQITVRFSRP ESEQARQRRV QSYEFLQKKH 
       210        220        230        240        250
AEEPWVHLHY YGLRDSRSEH ERQYLLCPGS SGVENTELVK SPSEYLMMLM 
       260        270        280        290        300
PPSQEEEKDK PVAPSNVLSM AQLRTLPLAD QIKILMKNVK VMPFANLMSL 
       310        320        330        340        350
LGPSIDSVAV LRGIQKVAML VQGNWVVKSD ILYPKDSSSP HSGVPAEVLC 
       360        370        380        390        400
RGRDFVMWKF TQSRWVVRKE VATVTKLCAE DVKDFLEHMA VVRINKGWEF 
       410        420        430        440        450
ILPYDGEFIK KHPDVVQRQH MLWTGIQAKL EKVYNLVKET MPKKPDAQSG 
       460        470        480        490        500
PAGLVCGDQR IQVAKTKAQQ NHALLERELQ RRKEQLRVPA VPPGVRIKEE 
       510        520        530        540        550
PVSEEGEEDE EQEAEEEPMD TSPSGLHSKL ANGLPLGRAA GTDSFNGHPP 
       560        570        580        590        600
QGCASTPVAR ELKAFVEATF QRQFVLTLSE LKRLFNLHLA SLPPGHTLFS 
       610        620        630        640        650
GISDRMLQDT VLAAGCKQIL VPFPPQTAAS PDEQKVFALW ESGDMSDQSR 
       660        670        680 
LTQECGEDLS KQEVDKVLKD CCVSYGGMWY LKGTVQS

Note: No experimental confirmation available.

Show »

Length:687

Mass (Da):77,215

Checksum:ⁱ0E1AEF649E9F5B70

Isoform 5 (identifier: Q9NVU0-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
13-48: Missing.

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        10         20         30         40         50
MANEEDDPVV QEIKPKQQKV ELEMAIDTLN PNYCRSKGEQ IALNVDGACA 
        60         70         80         90        100
DETSTYSSKL MDKQTFCSSQ TTSNTSRYAA ALYRQGELHL TPLHGILQLR 
       110        120        130        140        150
PSFSYLDKAD AKHREREAAN EAGDSSQDEA EDDVKQITVR FSRPESEQAR 
       160        170        180        190        200
QRRVQSYEFL QKKHAEEPWV HLHYYGLRDS RSEHERQYLL CPGSSGVENT 
       210        220        230        240        250
ELVKSPSEYL MMLMPPSQEE EKDKPVAPSN VLSMAQLRTL PLADQIKILM 
       260        270        280        290        300
KNVKVMPFAN LMSLLGPSID SVAVLRGIQK VAMLVQGNWV VKSDILYPKD 
       310        320        330        340        350
SSSPHSGVPA EVLCRGRDFV MWKFTQSRWV VRKEVATVTK LCAEDVKDFL 
       360        370        380        390        400
EHMAVVRINK GWEFILPYDG EFIKKHPDVV QRQHMLWTGI QAKLEKVYNL 
       410        420        430        440        450
VKETMPKKPD AQSGPAGLVC GDQRIQVAKT KAQQNHALLE RELQRRKEQL 
       460        470        480        490        500
RVPAVPPGVR IKEEPVSEEG EEDEEQEAEE EPMDTSPSGL HSKLANGLPL 
       510        520        530        540        550
GRAAGTDSFN GHPPQGCAST PVARELKAFV EATFQRQFVL TLSELKRLFN 
       560        570        580        590        600
LHLASLPPGH TLFSGISDRM LQDTVLAAGC KQILVPFPPQ TAASPDEQKV 
       610        620        630        640        650
FALWESGDMS DQHRQVLLEI FSKNYRVRRN MIQSRLTQEC GEDLSKQEVD 
       660        670 
KVLKDCCVSY GGMWYLKGTV QS

Note: No experimental confirmation available.

Show »

Length:672

Mass (Da):75,758

Checksum:ⁱ3B8AC9C189AF29DB

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
A0A0C4DH01	A0A0C4DH01_HUMAN	DNA-directed RNA polymerase III sub... DNA-directed RNA polymerase III subunit RPC5	POLR3E	672	Annotation score:
H3BMR4	H3BMR4_HUMAN	DNA-directed RNA polymerase III sub... DNA-directed RNA polymerase III subunit RPC5	POLR3E	139	Annotation score:
H3BRY1	H3BRY1_HUMAN	DNA-directed RNA polymerase III sub... DNA-directed RNA polymerase III subunit RPC5	POLR3E	99	Annotation score:
H3BNJ0	H3BNJ0_HUMAN	DNA-directed RNA polymerase III sub... DNA-directed RNA polymerase III subunit RPC5	POLR3E	90	Annotation score:
H3BS41	H3BS41_HUMAN	DNA-directed RNA polymerase III sub... DNA-directed RNA polymerase III subunit RPC5	POLR3E	92	Annotation score:
H3BSI5	H3BSI5_HUMAN	DNA-directed RNA polymerase III sub... DNA-directed RNA polymerase III subunit RPC5	POLR3E	110	Annotation score:
H3BSM3	H3BSM3_HUMAN	DNA-directed RNA polymerase III sub... DNA-directed RNA polymerase III subunit RPC5	POLR3E	62	Annotation score:
H3BM46	H3BM46_HUMAN	DNA-directed RNA polymerase III sub... DNA-directed RNA polymerase III subunit RPC5	POLR3E	63	Annotation score:

Sequence cautionⁱ

The sequence BAA95976 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAB14481 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	14	D → N in BAB14437 (PubMed:10819331).Curated	1
Sequence conflictⁱ	80	N → D in BAG62408 (PubMed:14702039).Curated	1
Sequence conflictⁱ	148	K → E in BAB14437 (PubMed:10819331).Curated	1
Sequence conflictⁱ	316	K → Q in AAM18215 (PubMed:12391170).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_024623	46	S → A. Corresponds to variant dbSNP:rs2347Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_046374	13 – 48	Missing in isoform 5. 1 PublicationAdd BLAST	36
Alternative sequenceⁱVSP_007064	623 – 708	FPPQT…GTVQS → VSRALPARGMGGGGWGEPAV GRPRGDTGGHAW in isoform 3. 1 PublicationAdd BLAST	86
Alternative sequenceⁱVSP_044710	648 – 668	Missing in isoform 4. 1 PublicationAdd BLAST	21
Alternative sequenceⁱVSP_007065	649 – 690	Missing in isoform 2. 2 PublicationsAdd BLAST	42

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY092085 mRNA Translation: AAM18215.1 AB040885 mRNA Translation: BAA95976.1 Different initiation. AK001371 mRNA Translation: BAA91655.1 AK023160 mRNA Translation: BAB14437.1 AK023231 mRNA Translation: BAB14481.1 Different initiation. AK296813 mRNA Translation: BAG59386.1 AK300735 mRNA Translation: BAG62408.1 AC009034 Genomic DNA No translation available. AC092338 Genomic DNA No translation available. BC000285 mRNA Translation: AAH00285.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10605.1 [Q9NVU0-1] CCDS58432.1 [Q9NVU0-4] CCDS58433.1 [Q9NVU0-2] CCDS58434.1 [Q9NVU0-5]
NCBI Reference Sequences More...RefSeqⁱ	NP_001244962.1, NM_001258033.1 [Q9NVU0-4] NP_001244963.1, NM_001258034.1 [Q9NVU0-5] NP_001244964.1, NM_001258035.1 NP_001244965.1, NM_001258036.1 [Q9NVU0-2] NP_060589.1, NM_018119.3 [Q9NVU0-1] XP_006721126.1, XM_006721063.2 [Q9NVU0-1] XP_006726676.1, XM_006726613.1 [Q9NVU0-1]
UniGeneⁱ	Hs.460298

Genome annotation databases

Ensemblⁱ	ENST00000299853; ENSP00000299853; ENSG00000058600 [Q9NVU0-1] ENST00000359210; ENSP00000352140; ENSG00000058600 [Q9NVU0-2] ENST00000418581; ENSP00000399254; ENSG00000058600 [Q9NVU0-5] ENST00000564209; ENSP00000456967; ENSG00000058600 [Q9NVU0-4] ENST00000638476; ENSP00000492534; ENSG00000284282 [Q9NVU0-5] ENST00000638525; ENSP00000492639; ENSG00000284282 [Q9NVU0-2] ENST00000639149; ENSP00000492586; ENSG00000284282 [Q9NVU0-4] ENST00000640588; ENSP00000492263; ENSG00000284282 [Q9NVU0-1]
GeneIDⁱ	55718
KEGGⁱ	hsa:101060521 hsa:55718
UCSC genome browser More...UCSCⁱ	uc002dkk.5 human [Q9NVU0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NVU0	DNA-directed RNA polymerase III subunit RPC5		MOUSE		710	UniRef90_Q9NVU0
DNA-directed RNA polymerase III subunit RPC5		HUMAN		672
DNA-directed RNA polymerase III subunit RPC5 isoform X4		Enhydra lutris kenyoni		740
RNA polymerase III subunit E		RHIBE		739
RNA polymerase III subunit E		RHIRO		709
+304

Protein	Similar proteins		Species	Score	Length	Source
Q9NVU0	DNA-directed RNA polymerase III subunit RPC5		MOUSE		710	UniRef50_Q9NVU0
DNA-directed RNA polymerase III subunit RPC5		HUMAN		672
DNA-directed RNA polymerase III subunit RPC5 isoform X4		Enhydra lutris kenyoni		740
RNA polymerase III subunit E		RHIBE		739
RNA polymerase III subunit E		RHIRO		709
+458

Entry informationⁱ

Entry nameⁱ	RPC5_HUMAN
Accessionⁱ	Q9NVU0Primary (citable) accession number: Q9NVU0 Secondary accession number(s): B4DL24 Q9P276
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
	Last sequence update:	October 1, 2000
	Last modified:	September 12, 2018
	This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - Q9NVU0 (RPC5_HUMAN)

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DNA-directed RNA polymerase III subunit RPC5

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Functionⁱ

GO - Molecular functionⁱ

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Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

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Miscellaneousⁱ

Keywords - Technical termⁱ