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Entry version 167 (07 Apr 2021)
Sequence version 1 (01 Oct 2000)
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Protein

DNA-directed RNA polymerase III subunit RPC5

Gene

POLR3E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiviral defense, Immunity, Innate immunity, Transcription

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NVU0

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1834949, Cytosolic sensors of pathogen-associated DNA
R-HSA-73780, RNA Polymerase III Chain Elongation
R-HSA-73980, RNA Polymerase III Transcription Termination
R-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-HSA-76071, RNA Polymerase III Transcription Initiation From Type 3 Promoter

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC5
Short name:
RNA polymerase III subunit C5
Alternative name(s):
DNA-directed RNA polymerase III 80 kDa polypeptide
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POLR3E
Synonyms:KIAA1452
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30347, POLR3E

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617815, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NVU0

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000058600.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55718

Open Targets

More...
OpenTargetsi
ENSG00000058600

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134964025

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NVU0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
POLR3E

Domain mapping of disease mutations (DMDM)

More...
DMDMi
29428028

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000739701 – 708DNA-directed RNA polymerase III subunit RPC5Add BLAST708

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei161PhosphoserineCombined sources1
Modified residuei162PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki171Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei192PhosphoserineCombined sources1
Modified residuei224PhosphotyrosineCombined sources1
Cross-linki432Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki498Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki498Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei503PhosphoserineCombined sources1
Modified residuei522PhosphoserineCombined sources1
Cross-linki659Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NVU0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NVU0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NVU0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NVU0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NVU0

PeptideAtlas

More...
PeptideAtlasi
Q9NVU0

PRoteomics IDEntifications database

More...
PRIDEi
Q9NVU0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
42503
4504
82857 [Q9NVU0-1]
82858 [Q9NVU0-2]
82859 [Q9NVU0-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NVU0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NVU0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000058600, Expressed in left lobe of thyroid gland and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NVU0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NVU0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000058600, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity).

Interacts with POLR3D/RPC4.

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120840, 57 interactors
3190820, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NVU0, 53 interactors

Molecular INTeraction database

More...
MINTi
Q9NVU0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299853

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NVU0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2354, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016123

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021012_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NVU0

Identification of Orthologs from Complete Genome Data

More...
OMAi
MSDQDCC

Database of Orthologous Groups

More...
OrthoDBi
1110776at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NVU0

TreeFam database of animal gene trees

More...
TreeFami
TF103050

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006886, RNA_pol_III_Rpc5

The PANTHER Classification System

More...
PANTHERi
PTHR12069, PTHR12069, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04801, Sin_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NVU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MANEEDDPVV QEIDVYLAKS LAEKLYLFQY PVRPASMTYD DIPHLSAKIK
60 70 80 90 100
PKQQKVELEM AIDTLNPNYC RSKGEQIALN VDGACADETS TYSSKLMDKQ
110 120 130 140 150
TFCSSQTTSN TSRYAAALYR QGELHLTPLH GILQLRPSFS YLDKADAKHR
160 170 180 190 200
EREAANEAGD SSQDEAEDDV KQITVRFSRP ESEQARQRRV QSYEFLQKKH
210 220 230 240 250
AEEPWVHLHY YGLRDSRSEH ERQYLLCPGS SGVENTELVK SPSEYLMMLM
260 270 280 290 300
PPSQEEEKDK PVAPSNVLSM AQLRTLPLAD QIKILMKNVK VMPFANLMSL
310 320 330 340 350
LGPSIDSVAV LRGIQKVAML VQGNWVVKSD ILYPKDSSSP HSGVPAEVLC
360 370 380 390 400
RGRDFVMWKF TQSRWVVRKE VATVTKLCAE DVKDFLEHMA VVRINKGWEF
410 420 430 440 450
ILPYDGEFIK KHPDVVQRQH MLWTGIQAKL EKVYNLVKET MPKKPDAQSG
460 470 480 490 500
PAGLVCGDQR IQVAKTKAQQ NHALLERELQ RRKEQLRVPA VPPGVRIKEE
510 520 530 540 550
PVSEEGEEDE EQEAEEEPMD TSPSGLHSKL ANGLPLGRAA GTDSFNGHPP
560 570 580 590 600
QGCASTPVAR ELKAFVEATF QRQFVLTLSE LKRLFNLHLA SLPPGHTLFS
610 620 630 640 650
GISDRMLQDT VLAAGCKQIL VPFPPQTAAS PDEQKVFALW ESGDMSDQHR
660 670 680 690 700
QVLLEIFSKN YRVRRNMIQS RLTQECGEDL SKQEVDKVLK DCCVSYGGMW

YLKGTVQS
Length:708
Mass (Da):79,898
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE9DB71615CC367A5
GO
Isoform 2 (identifier: Q9NVU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     649-690: Missing.

Show »
Length:666
Mass (Da):74,827
Checksum:iA4E140C8BB0288F4
GO
Isoform 3 (identifier: Q9NVU0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     623-708: FPPQTAASPD...MWYLKGTVQS → VSRALPARGMGGGGWGEPAVGRPRGDTGGHAW

Note: May result from the retention of an intron in the cDNA.Curated
Show »
Length:654
Mass (Da):73,139
Checksum:iCE65F08FBD429AE7
GO
Isoform 4 (identifier: Q9NVU0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     648-668: Missing.

Show »
Length:687
Mass (Da):77,215
Checksum:i0E1AEF649E9F5B70
GO
Isoform 5 (identifier: Q9NVU0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-48: Missing.

Show »
Length:672
Mass (Da):75,758
Checksum:i3B8AC9C189AF29DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DH01A0A0C4DH01_HUMAN
DNA-directed RNA polymerase III sub...
POLR3E
672Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMR4H3BMR4_HUMAN
DNA-directed RNA polymerase III sub...
POLR3E
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRY1H3BRY1_HUMAN
DNA-directed RNA polymerase III sub...
POLR3E
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNJ0H3BNJ0_HUMAN
DNA-directed RNA polymerase III sub...
POLR3E
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSI5H3BSI5_HUMAN
DNA-directed RNA polymerase III sub...
POLR3E
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BM46H3BM46_HUMAN
DNA-directed RNA polymerase III sub...
POLR3E
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BS41H3BS41_HUMAN
DNA-directed RNA polymerase III sub...
POLR3E
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSM3H3BSM3_HUMAN
DNA-directed RNA polymerase III sub...
POLR3E
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA95976 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14481 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14D → N in BAB14437 (PubMed:10819331).Curated1
Sequence conflicti80N → D in BAG62408 (PubMed:14702039).Curated1
Sequence conflicti148K → E in BAB14437 (PubMed:10819331).Curated1
Sequence conflicti316K → Q in AAM18215 (PubMed:12391170).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02462346S → A. Corresponds to variant dbSNP:rs2347Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04637413 – 48Missing in isoform 5. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_007064623 – 708FPPQT…GTVQS → VSRALPARGMGGGGWGEPAV GRPRGDTGGHAW in isoform 3. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_044710648 – 668Missing in isoform 4. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_007065649 – 690Missing in isoform 2. 2 PublicationsAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY092085 mRNA Translation: AAM18215.1
AB040885 mRNA Translation: BAA95976.1 Different initiation.
AK001371 mRNA Translation: BAA91655.1
AK023160 mRNA Translation: BAB14437.1
AK023231 mRNA Translation: BAB14481.1 Different initiation.
AK296813 mRNA Translation: BAG59386.1
AK300735 mRNA Translation: BAG62408.1
AC009034 Genomic DNA No translation available.
AC092338 Genomic DNA No translation available.
BC000285 mRNA Translation: AAH00285.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10605.1 [Q9NVU0-1]
CCDS58432.1 [Q9NVU0-4]
CCDS58433.1 [Q9NVU0-2]
CCDS58434.1 [Q9NVU0-5]

NCBI Reference Sequences

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RefSeqi
NP_001244962.1, NM_001258033.1 [Q9NVU0-4]
NP_001244963.1, NM_001258034.1 [Q9NVU0-5]
NP_001244964.1, NM_001258035.1
NP_001244965.1, NM_001258036.1 [Q9NVU0-2]
NP_060589.1, NM_018119.3 [Q9NVU0-1]
XP_006721126.1, XM_006721063.2
XP_006726676.1, XM_006726613.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000299853; ENSP00000299853; ENSG00000058600 [Q9NVU0-1]
ENST00000359210; ENSP00000352140; ENSG00000058600 [Q9NVU0-2]
ENST00000418581; ENSP00000399254; ENSG00000058600 [Q9NVU0-5]
ENST00000564209; ENSP00000456967; ENSG00000058600 [Q9NVU0-4]
ENST00000639550; ENSP00000492514; ENSG00000284282 [Q9NVU0-1]
ENST00000640588; ENSP00000492263; ENSG00000284282 [Q9NVU0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55718

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55718

UCSC genome browser

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UCSCi
uc002dkk.5, human [Q9NVU0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY092085 mRNA Translation: AAM18215.1
AB040885 mRNA Translation: BAA95976.1 Different initiation.
AK001371 mRNA Translation: BAA91655.1
AK023160 mRNA Translation: BAB14437.1
AK023231 mRNA Translation: BAB14481.1 Different initiation.
AK296813 mRNA Translation: BAG59386.1
AK300735 mRNA Translation: BAG62408.1
AC009034 Genomic DNA No translation available.
AC092338 Genomic DNA No translation available.
BC000285 mRNA Translation: AAH00285.1
CCDSiCCDS10605.1 [Q9NVU0-1]
CCDS58432.1 [Q9NVU0-4]
CCDS58433.1 [Q9NVU0-2]
CCDS58434.1 [Q9NVU0-5]
RefSeqiNP_001244962.1, NM_001258033.1 [Q9NVU0-4]
NP_001244963.1, NM_001258034.1 [Q9NVU0-5]
NP_001244964.1, NM_001258035.1
NP_001244965.1, NM_001258036.1 [Q9NVU0-2]
NP_060589.1, NM_018119.3 [Q9NVU0-1]
XP_006721126.1, XM_006721063.2
XP_006726676.1, XM_006726613.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7ASTelectron microscopy4.00K1-708[»]
7ASUX-ray2.23A1-708[»]
7ASVX-ray1.55A/B1-708[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120840, 57 interactors
3190820, 9 interactors
IntActiQ9NVU0, 53 interactors
MINTiQ9NVU0
STRINGi9606.ENSP00000299853

PTM databases

iPTMnetiQ9NVU0
PhosphoSitePlusiQ9NVU0

Genetic variation databases

BioMutaiPOLR3E
DMDMi29428028

Proteomic databases

EPDiQ9NVU0
jPOSTiQ9NVU0
MassIVEiQ9NVU0
MaxQBiQ9NVU0
PaxDbiQ9NVU0
PeptideAtlasiQ9NVU0
PRIDEiQ9NVU0
ProteomicsDBi42503
4504
82857 [Q9NVU0-1]
82858 [Q9NVU0-2]
82859 [Q9NVU0-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25851, 123 antibodies

Genome annotation databases

EnsembliENST00000299853; ENSP00000299853; ENSG00000058600 [Q9NVU0-1]
ENST00000359210; ENSP00000352140; ENSG00000058600 [Q9NVU0-2]
ENST00000418581; ENSP00000399254; ENSG00000058600 [Q9NVU0-5]
ENST00000564209; ENSP00000456967; ENSG00000058600 [Q9NVU0-4]
ENST00000639550; ENSP00000492514; ENSG00000284282 [Q9NVU0-1]
ENST00000640588; ENSP00000492263; ENSG00000284282 [Q9NVU0-1]
GeneIDi55718
KEGGihsa:55718
UCSCiuc002dkk.5, human [Q9NVU0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55718
DisGeNETi55718

GeneCards: human genes, protein and diseases

More...
GeneCardsi
POLR3E
HGNCiHGNC:30347, POLR3E
HPAiENSG00000058600, Low tissue specificity
MIMi617815, gene
neXtProtiNX_Q9NVU0
OpenTargetsiENSG00000058600
PharmGKBiPA134964025
VEuPathDBiHostDB:ENSG00000058600.15

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2354, Eukaryota
GeneTreeiENSGT00390000016123
HOGENOMiCLU_021012_1_0_1
InParanoidiQ9NVU0
OMAiMSDQDCC
OrthoDBi1110776at2759
PhylomeDBiQ9NVU0
TreeFamiTF103050

Enzyme and pathway databases

PathwayCommonsiQ9NVU0
ReactomeiR-HSA-1834949, Cytosolic sensors of pathogen-associated DNA
R-HSA-73780, RNA Polymerase III Chain Elongation
R-HSA-73980, RNA Polymerase III Transcription Termination
R-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-HSA-76071, RNA Polymerase III Transcription Initiation From Type 3 Promoter

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
55718, 697 hits in 1001 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
POLR3E, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
POLR3E
PharosiQ9NVU0, Tbio

Protein Ontology

More...
PROi
PR:Q9NVU0
RNActiQ9NVU0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000058600, Expressed in left lobe of thyroid gland and 237 other tissues
ExpressionAtlasiQ9NVU0, baseline and differential
GenevisibleiQ9NVU0, HS

Family and domain databases

InterProiView protein in InterPro
IPR006886, RNA_pol_III_Rpc5
PANTHERiPTHR12069, PTHR12069, 1 hit
PfamiView protein in Pfam
PF04801, Sin_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPC5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NVU0
Secondary accession number(s): B4DL24
, B4DUP6, H3BT11, Q9BWF7, Q9H8W8, Q9H907, Q9P276
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: October 1, 2000
Last modified: April 7, 2021
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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