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Protein

Pyridoxine-5'-phosphate oxidase

Gene

PNPO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FMN1 PublicationNote: Binds 1 FMN per subunit.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pyridoxal 5'-phosphate salvage

This protein is involved in step 1 of the subpathway that synthesizes pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Pyridoxine-5'-phosphate oxidase (PNPO)
This subpathway is part of the pathway pyridoxal 5'-phosphate salvage, which is itself part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate, the pathway pyridoxal 5'-phosphate salvage and in Cofactor metabolism.

Pathwayi: pyridoxal 5'-phosphate salvage

This protein is involved in step 1 of the subpathway that synthesizes pyridoxal 5'-phosphate from pyridoxine 5'-phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Pyridoxine-5'-phosphate oxidase (PNPO)
This subpathway is part of the pathway pyridoxal 5'-phosphate salvage, which is itself part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxal 5'-phosphate from pyridoxine 5'-phosphate, the pathway pyridoxal 5'-phosphate salvage and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei100Pyridoxal 5'-phosphate1 Publication1
Binding sitei139FMNBy similarity1
Binding sitei157Pyridoxal 5'-phosphate1 Publication1
Binding sitei161Pyridoxal 5'-phosphate1 Publication1
Binding sitei165Pyridoxal 5'-phosphate1 Publication1
Binding sitei219FMNBy similarity1
Binding sitei229FMNBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi95 – 98FMN1 Publication4
Nucleotide bindingi110 – 111FMN1 Publication2
Nucleotide bindingi116 – 117FMN1 Publication2
Nucleotide bindingi174 – 175FMN1 Publication2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processPyridoxine biosynthesis
LigandFlavoprotein, FMN, Pyridoxal phosphate

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS03105-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-964975 Vitamins B6 activation to pyridoxal phosphate

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9NVS9

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA01068;UER00304

UPA01068;UER00305

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pyridoxine-5'-phosphate oxidase (EC:1.4.3.5)
Alternative name(s):
Pyridoxamine-phosphate oxidase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PNPO
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000108439.9

Human Gene Nomenclature Database

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HGNCi
HGNC:30260 PNPO

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603287 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NVS9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pyridoxine-5'-phosphate oxidase deficiency (PNPOD)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionThe main feature of neonatal epileptic encephalopathy is the onset within hours of birth of a severe seizure disorder that does not respond to anticonvulsant drugs and can be fatal. Seizures can cease with the administration of PLP, being resistant to treatment with pyridoxine,.
See also OMIM:610090
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_078229225R → H in PNPOD. 1 PublicationCorresponds to variant dbSNP:rs550423482EnsemblClinVar.1
Natural variantiVAR_078643229R → Q in PNPOD. 1 PublicationCorresponds to variant dbSNP:rs773450573EnsemblClinVar.1
Natural variantiVAR_029360229R → W in PNPOD; strong activity decrease. 1 PublicationCorresponds to variant dbSNP:rs104894629EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Epilepsy

Organism-specific databases

DisGeNET

More...
DisGeNETi
55163

MalaCards human disease database

More...
MalaCardsi
PNPO
MIMi610090 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000108439

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
79096 Pyridoxal phosphate-responsive seizures

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134915565

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3271932

Drug and drug target database

More...
DrugBanki
DB03345 Beta-Mercaptoethanol
DB00114 Pyridoxal Phosphate
DB02209 Pyridoxine-5'-Phosphate
DB03247 Riboflavin Monophosphate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PNPO

Domain mapping of disease mutations (DMDM)

More...
DMDMi
37082126

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001677831 – 261Pyridoxine-5'-phosphate oxidaseAdd BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei238PhosphothreonineCombined sources1
Modified residuei241PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NVS9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NVS9

PeptideAtlas

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PeptideAtlasi
Q9NVS9

PRoteomics IDEntifications database

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PRIDEi
Q9NVS9

ProteomicsDB human proteome resource

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ProteomicsDBi
82855

2D gel databases

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00018272

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9NVS9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9NVS9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000108439 Expressed in 236 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

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CleanExi
HS_PNPO

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NVS9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NVS9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023204
HPA027776

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120463, 24 interactors

Protein interaction database and analysis system

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IntActi
Q9NVS9, 5 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000225573

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9NVS9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Database of protein disorder

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DisProti
DP00168

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9NVS9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NVS9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NVS9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni42 – 45Pyridoxal 5'-phosphate bindingBy similarity4
Regioni225 – 227Pyridoxal 5'-phosphate bindingBy similarity3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2586 Eukaryota
COG0259 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011219

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000242755

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG045634

KEGG Orthology (KO)

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KOi
K00275

Identification of Orthologs from Complete Genome Data

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OMAi
PEPNAMV

Database of Orthologous Groups

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OrthoDBi
EOG091G0J0R

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NVS9

TreeFam database of animal gene trees

More...
TreeFami
TF313411

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.110.10, 1 hit

HAMAP database of protein families

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HAMAPi
MF_01629 PdxH, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000659 Pyridox_Oxase
IPR019740 Pyridox_Oxase_CS
IPR011576 Pyridox_Oxase_put
IPR019576 Pyridoxamine_oxidase_dimer_C
IPR012349 Split_barrel_FMN-bd

The PANTHER Classification System

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PANTHERi
PTHR10851 PTHR10851, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10590 PNP_phzG_C, 1 hit
PF01243 Putative_PNPOx, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000190 Pyd_amn-ph_oxd, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00558 pdxH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01064 PYRIDOX_OXIDASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NVS9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTCWLRGVTA TFGRPAEWPG YLSHLCGRSA AMDLGPMRKS YRGDREAFEE
60 70 80 90 100
THLTSLDPVK QFAAWFEEAV QCPDIGEANA MCLATCTRDG KPSARMLLLK
110 120 130 140 150
GFGKDGFRFF TNFESRKGKE LDSNPFASLV FYWEPLNRQV RVEGPVKKLP
160 170 180 190 200
EEEAECYFHS RPKSSQIGAV VSHQSSVIPD REYLRKKNEE LEQLYQDQEV
210 220 230 240 250
PKPKSWGGYV LYPQVMEFWQ GQTNRLHDRI VFRRGLPTGD SPLGPMTHRG
260
EEDWLYERLA P
Length:261
Mass (Da):29,988
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C74E9F962FE2A95
GO
Isoform 2 (identifier: Q9NVS9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-69: AFEETHLTSLDPVKQFAAWFEEA → RWKTLCSHVAAEGLRERWLPLLH
     70-261: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:69
Mass (Da):7,943
Checksum:i51302508E18DED73
GO
Isoform 3 (identifier: Q9NVS9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-139: Missing.

Note: No experimental confirmation available.
Show »
Length:243
Mass (Da):27,823
Checksum:i0E1F950A074A37D7
GO
Isoform 4 (identifier: Q9NVS9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-182: Missing.

Note: No experimental confirmation available.
Show »
Length:218
Mass (Da):25,200
Checksum:i710BED8B9D98115F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QQZ9J3QQZ9_HUMAN
Pyridoxine-5'-phosphate oxidase
PNPO
238Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQV6J3QQV6_HUMAN
Pyridoxine-5'-phosphate oxidase
PNPO
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YFL3A0A286YFL3_HUMAN
Pyridoxine-5'-phosphate oxidase
PNPO
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS77J3KS77_HUMAN
Pyridoxine-5'-phosphate oxidase
PNPO
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YF16A0A286YF16_HUMAN
Pyridoxine-5'-phosphate oxidase
PNPO
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YF38A0A286YF38_HUMAN
Pyridoxine-5'-phosphate oxidase
PNPO
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YFA1A0A286YFA1_HUMAN
Pyridoxine-5'-phosphate oxidase
PNPO
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG64562 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02935850E → K1 PublicationCorresponds to variant dbSNP:rs549477447EnsemblClinVar.1
Natural variantiVAR_029359116R → Q. Corresponds to variant dbSNP:rs17679445EnsemblClinVar.1
Natural variantiVAR_078229225R → H in PNPOD. 1 PublicationCorresponds to variant dbSNP:rs550423482EnsemblClinVar.1
Natural variantiVAR_078643229R → Q in PNPOD. 1 PublicationCorresponds to variant dbSNP:rs773450573EnsemblClinVar.1
Natural variantiVAR_029360229R → W in PNPOD; strong activity decrease. 1 PublicationCorresponds to variant dbSNP:rs104894629EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05876947 – 69AFEET…WFEEA → RWKTLCSHVAAEGLRERWLP LLH in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_05877070 – 261Missing in isoform 2. 1 PublicationAdd BLAST192
Alternative sequenceiVSP_056410122 – 139Missing in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_056411140 – 182Missing in isoform 4. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF468030 mRNA Translation: AAM76918.1
AK001397 mRNA Translation: BAA91668.1
AK303536 mRNA Translation: BAG64562.1 Sequence problems.
AK303665 mRNA Translation: BAG64664.1
AK303792 mRNA Translation: BAG64749.1
CH471109 Genomic DNA Translation: EAW94770.1
CH471109 Genomic DNA Translation: EAW94771.1
BC006525 mRNA Translation: AAH06525.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11522.1 [Q9NVS9-1]

NCBI Reference Sequences

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RefSeqi
NP_060599.1, NM_018129.3 [Q9NVS9-1]
XP_011523270.1, XM_011524968.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.631742

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000225573; ENSP00000225573; ENSG00000108439 [Q9NVS9-4]
ENST00000434554; ENSP00000399960; ENSG00000108439 [Q9NVS9-3]
ENST00000582171; ENSP00000463994; ENSG00000108439 [Q9NVS9-2]
ENST00000585320; ENSP00000462345; ENSG00000108439 [Q9NVS9-2]
ENST00000641856; ENSP00000493224; ENSG00000108439 [Q9NVS9-2]
ENST00000642017; ENSP00000493302; ENSG00000108439 [Q9NVS9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55163

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55163

UCSC genome browser

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UCSCi
uc010wlb.3 human [Q9NVS9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF468030 mRNA Translation: AAM76918.1
AK001397 mRNA Translation: BAA91668.1
AK303536 mRNA Translation: BAG64562.1 Sequence problems.
AK303665 mRNA Translation: BAG64664.1
AK303792 mRNA Translation: BAG64749.1
CH471109 Genomic DNA Translation: EAW94770.1
CH471109 Genomic DNA Translation: EAW94771.1
BC006525 mRNA Translation: AAH06525.1
CCDSiCCDS11522.1 [Q9NVS9-1]
RefSeqiNP_060599.1, NM_018129.3 [Q9NVS9-1]
XP_011523270.1, XM_011524968.2
UniGeneiHs.631742

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NRGX-ray1.95A1-261[»]
3HY8X-ray2.50A1-261[»]
6H00X-ray1.66A1-261[»]
DisProtiDP00168
ProteinModelPortaliQ9NVS9
SMRiQ9NVS9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120463, 24 interactors
IntActiQ9NVS9, 5 interactors
STRINGi9606.ENSP00000225573

Chemistry databases

BindingDBiQ9NVS9
ChEMBLiCHEMBL3271932
DrugBankiDB03345 Beta-Mercaptoethanol
DB00114 Pyridoxal Phosphate
DB02209 Pyridoxine-5'-Phosphate
DB03247 Riboflavin Monophosphate

PTM databases

iPTMnetiQ9NVS9
PhosphoSitePlusiQ9NVS9

Polymorphism and mutation databases

BioMutaiPNPO
DMDMi37082126

2D gel databases

REPRODUCTION-2DPAGEiIPI00018272

Proteomic databases

EPDiQ9NVS9
PaxDbiQ9NVS9
PeptideAtlasiQ9NVS9
PRIDEiQ9NVS9
ProteomicsDBi82855

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225573; ENSP00000225573; ENSG00000108439 [Q9NVS9-4]
ENST00000434554; ENSP00000399960; ENSG00000108439 [Q9NVS9-3]
ENST00000582171; ENSP00000463994; ENSG00000108439 [Q9NVS9-2]
ENST00000585320; ENSP00000462345; ENSG00000108439 [Q9NVS9-2]
ENST00000641856; ENSP00000493224; ENSG00000108439 [Q9NVS9-2]
ENST00000642017; ENSP00000493302; ENSG00000108439 [Q9NVS9-1]
GeneIDi55163
KEGGihsa:55163
UCSCiuc010wlb.3 human [Q9NVS9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55163
DisGeNETi55163
EuPathDBiHostDB:ENSG00000108439.9

GeneCards: human genes, protein and diseases

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GeneCardsi
PNPO
HGNCiHGNC:30260 PNPO
HPAiHPA023204
HPA027776
MalaCardsiPNPO
MIMi603287 gene
610090 phenotype
neXtProtiNX_Q9NVS9
OpenTargetsiENSG00000108439
Orphaneti79096 Pyridoxal phosphate-responsive seizures
PharmGKBiPA134915565

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2586 Eukaryota
COG0259 LUCA
GeneTreeiENSGT00390000011219
HOGENOMiHOG000242755
HOVERGENiHBG045634
KOiK00275
OMAiPEPNAMV
OrthoDBiEOG091G0J0R
PhylomeDBiQ9NVS9
TreeFamiTF313411

Enzyme and pathway databases

UniPathwayi
UPA01068;UER00304

UPA01068;UER00305

BioCyciMetaCyc:HS03105-MONOMER
ReactomeiR-HSA-964975 Vitamins B6 activation to pyridoxal phosphate
SABIO-RKiQ9NVS9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PNPO human
EvolutionaryTraceiQ9NVS9

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PNPO

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55163

Protein Ontology

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PROi
PR:Q9NVS9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000108439 Expressed in 236 organ(s), highest expression level in liver
CleanExiHS_PNPO
ExpressionAtlasiQ9NVS9 baseline and differential
GenevisibleiQ9NVS9 HS

Family and domain databases

Gene3Di2.30.110.10, 1 hit
HAMAPiMF_01629 PdxH, 1 hit
InterProiView protein in InterPro
IPR000659 Pyridox_Oxase
IPR019740 Pyridox_Oxase_CS
IPR011576 Pyridox_Oxase_put
IPR019576 Pyridoxamine_oxidase_dimer_C
IPR012349 Split_barrel_FMN-bd
PANTHERiPTHR10851 PTHR10851, 1 hit
PfamiView protein in Pfam
PF10590 PNP_phzG_C, 1 hit
PF01243 Putative_PNPOx, 1 hit
PIRSFiPIRSF000190 Pyd_amn-ph_oxd, 1 hit
TIGRFAMsiTIGR00558 pdxH, 1 hit
PROSITEiView protein in PROSITE
PS01064 PYRIDOX_OXIDASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPNPO_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NVS9
Secondary accession number(s): B4E0V0
, B4E152, B4E1D7, D3DTT9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 1, 2000
Last modified: December 5, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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