UniProtKB - Q9NVR0 (KLH11_HUMAN)
Protein
Kelch-like protein 11
Gene
KLHL11
Organism
Homo sapiens (Human)
Status
Functioni
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.By similarity
GO - Biological processi
- post-translational protein modification Source: Reactome
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9NVR0 |
Reactomei | R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Recommended name: Kelch-like protein 11 |
Gene namesi | Name:KLHL11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000178502.5 |
HGNCi | HGNC:19008, KLHL11 |
neXtProti | NX_Q9NVR0 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 55175 |
OpenTargetsi | ENSG00000178502 |
PharmGKBi | PA38777 |
Miscellaneous databases
Pharosi | Q9NVR0, Tdark |
Polymorphism and mutation databases
BioMutai | KLHL11 |
DMDMi | 74734542 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | Sequence analysisAdd BLAST | 15 | |
ChainiPRO_0000243918 | 16 – 708 | Kelch-like protein 11Add BLAST | 693 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 465 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NVR0 |
jPOSTi | Q9NVR0 |
MassIVEi | Q9NVR0 |
MaxQBi | Q9NVR0 |
PaxDbi | Q9NVR0 |
PeptideAtlasi | Q9NVR0 |
PRIDEi | Q9NVR0 |
ProteomicsDBi | 82847 |
PTM databases
iPTMneti | Q9NVR0 |
PhosphoSitePlusi | Q9NVR0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000178502, Expressed in sperm and 125 other tissues |
ExpressionAtlasi | Q9NVR0, baseline and differential |
Genevisiblei | Q9NVR0, HS |
Organism-specific databases
HPAi | ENSG00000178502, Low tissue specificity |
Interactioni
Subunit structurei
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity). Homodimer.
Interacts with CUL3.
By similarity1 PublicationBinary interactionsi
Hide detailsQ9NVR0
With | #Exp. | IntAct |
---|---|---|
IHO1 [Q8IYA8] | 3 | EBI-2691832,EBI-8638439 |
POU6F2 [P78424] | 3 | EBI-2691832,EBI-12029004 |
UBQLN2 [Q9UHD9] | 3 | EBI-2691832,EBI-947187 |
Protein-protein interaction databases
BioGRIDi | 120474, 69 interactors |
IntActi | Q9NVR0, 12 interactors |
STRINGi | 9606.ENSP00000314608 |
Miscellaneous databases
RNActi | Q9NVR0, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9NVR0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NVR0 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 94 – 170 | BTBPROSITE-ProRule annotationAdd BLAST | 77 | |
Domaini | 205 – 307 | BACKAdd BLAST | 103 | |
Repeati | 360 – 407 | Kelch 1Add BLAST | 48 | |
Repeati | 408 – 453 | Kelch 2Add BLAST | 46 | |
Repeati | 455 – 501 | Kelch 3Add BLAST | 47 | |
Repeati | 503 – 556 | Kelch 4Add BLAST | 54 | |
Repeati | 610 – 661 | Kelch 5Add BLAST | 52 |
Keywords - Domaini
Kelch repeat, Repeat, SignalPhylogenomic databases
eggNOGi | KOG1072, Eukaryota |
GeneTreei | ENSGT00940000159275 |
HOGENOMi | CLU_024322_0_0_1 |
InParanoidi | Q9NVR0 |
OMAi | NLITRKH |
OrthoDBi | 789713at2759 |
PhylomeDBi | Q9NVR0 |
TreeFami | TF331981 |
Family and domain databases
Gene3Di | 2.120.10.80, 2 hits |
InterProi | View protein in InterPro IPR011705, BACK IPR000210, BTB/POZ_dom IPR015915, Kelch-typ_b-propeller IPR006652, Kelch_1 IPR011333, SKP1/BTB/POZ_sf |
Pfami | View protein in Pfam PF07707, BACK, 1 hit PF00651, BTB, 1 hit PF01344, Kelch_1, 1 hit |
SMARTi | View protein in SMART SM00875, BACK, 1 hit SM00225, BTB, 1 hit SM00612, Kelch, 4 hits |
SUPFAMi | SSF117281, SSF117281, 2 hits SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9NVR0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAAVAAAA AAAAAASLQV LEMESMETAA AGSAGLAAEV RGSGTVDFGP
60 70 80 90 100
GPGISAMEAS GGDPGPEAED FECSSHCSEL SWRQNEQRRQ GLFCDITLCF
110 120 130 140 150
GGAGGREFRA HRSVLAAATE YFTPLLSGQF SESRSGRVEM RKWSSEPGPE
160 170 180 190 200
PDTVEAVIEY MYTGRIRVST GSVHEVLELA DRFLLIRLKE FCGEFLKKKL
210 220 230 240 250
HLSNCVAIHS LAHMYTLSQL ALKAADMIRR NFHKVIQDEE FYTLPFHLIR
260 270 280 290 300
DWLSDLEITV DSEEVLFETV LKWVQRNAEE RERYFEELFK LLRLSQMKPT
310 320 330 340 350
YLTRHVKPER LVANNEVCVK LVADAVERHA LRAENIQSGT CQHPTSHVSL
360 370 380 390 400
LPRYGQNMDV IMVIGGVSEG GDYLSECVGY FVDEDRWVNL PHIHNHLDGH
410 420 430 440 450
AVAVTESYVY VAGSMEPGFA KTVERYNPNL NTWEHVCSLM TRKHSFGLTE
460 470 480 490 500
VKGKLYSIGG HGNFSPGFKD VTVYNPELDK WHNLESAPKI LRDVKALAIE
510 520 530 540 550
DRFVYIAART PVDRDTEDGL KAVITCYDTE TRQWQDVESL PLIDNYCFFQ
560 570 580 590 600
MSVVNSNFYQ TASCCPKSYC LENEEAVRKI ASQVSDEILE SLPPEVLSIE
610 620 630 640 650
GAAICYYKDD VFIIGGWKNS DDIDKQYRKE AYRYCAERKR WMLLPPMPQP
660 670 680 690 700
RCRATACHVR IPYRYLHGTQ RYPMPQNLMW QKDRIRQMQE IHRHALNMRR
VPSSQIEC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001434 mRNA Translation: BAA91689.1 BC034470 mRNA Translation: AAH34470.1 |
CCDSi | CCDS11411.1 |
RefSeqi | NP_060613.1, NM_018143.2 |
Genome annotation databases
Ensembli | ENST00000319121; ENSP00000314608; ENSG00000178502 |
GeneIDi | 55175 |
KEGGi | hsa:55175 |
UCSCi | uc002hyf.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001434 mRNA Translation: BAA91689.1 BC034470 mRNA Translation: AAH34470.1 |
CCDSi | CCDS11411.1 |
RefSeqi | NP_060613.1, NM_018143.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3I3N | X-ray | 2.60 | A/B | 67-340 | [»] | |
4AP2 | X-ray | 2.80 | A | 67-340 | [»] | |
4APF | X-ray | 3.10 | A | 67-340 | [»] | |
SMRi | Q9NVR0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120474, 69 interactors |
IntActi | Q9NVR0, 12 interactors |
STRINGi | 9606.ENSP00000314608 |
PTM databases
iPTMneti | Q9NVR0 |
PhosphoSitePlusi | Q9NVR0 |
Polymorphism and mutation databases
BioMutai | KLHL11 |
DMDMi | 74734542 |
Proteomic databases
EPDi | Q9NVR0 |
jPOSTi | Q9NVR0 |
MassIVEi | Q9NVR0 |
MaxQBi | Q9NVR0 |
PaxDbi | Q9NVR0 |
PeptideAtlasi | Q9NVR0 |
PRIDEi | Q9NVR0 |
ProteomicsDBi | 82847 |
Protocols and materials databases
Antibodypediai | 16791, 102 antibodies |
Genome annotation databases
Ensembli | ENST00000319121; ENSP00000314608; ENSG00000178502 |
GeneIDi | 55175 |
KEGGi | hsa:55175 |
UCSCi | uc002hyf.2, human |
Organism-specific databases
CTDi | 55175 |
DisGeNETi | 55175 |
EuPathDBi | HostDB:ENSG00000178502.5 |
GeneCardsi | KLHL11 |
HGNCi | HGNC:19008, KLHL11 |
HPAi | ENSG00000178502, Low tissue specificity |
neXtProti | NX_Q9NVR0 |
OpenTargetsi | ENSG00000178502 |
PharmGKBi | PA38777 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1072, Eukaryota |
GeneTreei | ENSGT00940000159275 |
HOGENOMi | CLU_024322_0_0_1 |
InParanoidi | Q9NVR0 |
OMAi | NLITRKH |
OrthoDBi | 789713at2759 |
PhylomeDBi | Q9NVR0 |
TreeFami | TF331981 |
Enzyme and pathway databases
PathwayCommonsi | Q9NVR0 |
Reactomei | R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 55175, 246 hits in 839 CRISPR screens |
ChiTaRSi | KLHL11, human |
EvolutionaryTracei | Q9NVR0 |
GenomeRNAii | 55175 |
Pharosi | Q9NVR0, Tdark |
PROi | PR:Q9NVR0 |
RNActi | Q9NVR0, protein |
Gene expression databases
Bgeei | ENSG00000178502, Expressed in sperm and 125 other tissues |
ExpressionAtlasi | Q9NVR0, baseline and differential |
Genevisiblei | Q9NVR0, HS |
Family and domain databases
Gene3Di | 2.120.10.80, 2 hits |
InterProi | View protein in InterPro IPR011705, BACK IPR000210, BTB/POZ_dom IPR015915, Kelch-typ_b-propeller IPR006652, Kelch_1 IPR011333, SKP1/BTB/POZ_sf |
Pfami | View protein in Pfam PF07707, BACK, 1 hit PF00651, BTB, 1 hit PF01344, Kelch_1, 1 hit |
SMARTi | View protein in SMART SM00875, BACK, 1 hit SM00225, BTB, 1 hit SM00612, Kelch, 4 hits |
SUPFAMi | SSF117281, SSF117281, 2 hits SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KLH11_HUMAN | |
Accessioni | Q9NVR0Primary (citable) accession number: Q9NVR0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM