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UniProtKB - Q9NVR0 (KLH11_HUMAN)

Entry version 146 (02 Dec 2020)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
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Protein

Kelch-like protein 11

Gene

KLHL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NVR0

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8951664, Neddylation
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kelch-like protein 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLHL11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000178502.5

Human Gene Nomenclature Database

More...HGNCi		HGNC:19008, KLHL11

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NVR0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55175

Open Targets

More...OpenTargetsi		ENSG00000178502

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38777

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NVR0, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KLHL11

Domain mapping of disease mutations (DMDM)

More...DMDMi		74734542

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 15Sequence analysisAdd BLAST15
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024391816 – 708Kelch-like protein 11Add BLAST693

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei465PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NVR0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NVR0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NVR0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NVR0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NVR0

PeptideAtlas

More...PeptideAtlasi		Q9NVR0

PRoteomics IDEntifications database

More...PRIDEi		Q9NVR0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82847

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NVR0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NVR0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000178502, Expressed in sperm and 125 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NVR0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NVR0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000178502, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity). Homodimer.

Interacts with CUL3.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120474, 69 interactors

Protein interaction database and analysis system

More...IntActi		Q9NVR0, 12 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000314608

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NVR0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1708
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NVR0

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9NVR0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini94 – 170BTBPROSITE-ProRule annotationAdd BLAST77
Domaini205 – 307BACKAdd BLAST103
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati360 – 407Kelch 1Add BLAST48
Repeati408 – 453Kelch 2Add BLAST46
Repeati455 – 501Kelch 3Add BLAST47
Repeati503 – 556Kelch 4Add BLAST54
Repeati610 – 661Kelch 5Add BLAST52

Keywords - Domaini

Kelch repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1072, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159275

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_024322_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NVR0

Identification of Orthologs from Complete Genome Data

More...OMAi		NLITRKH

Database of Orthologous Groups

More...OrthoDBi		789713at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NVR0

TreeFam database of animal gene trees

More...TreeFami		TF331981

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.120.10.80, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011705, BACK
IPR000210, BTB/POZ_dom
IPR015915, Kelch-typ_b-propeller
IPR006652, Kelch_1
IPR011333, SKP1/BTB/POZ_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07707, BACK, 1 hit
PF00651, BTB, 1 hit
PF01344, Kelch_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00875, BACK, 1 hit
SM00225, BTB, 1 hit
SM00612, Kelch, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF117281, SSF117281, 2 hits
SSF54695, SSF54695, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50097, BTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NVR0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAVAAAA AAAAAASLQV LEMESMETAA AGSAGLAAEV RGSGTVDFGP 
        60         70         80         90        100
GPGISAMEAS GGDPGPEAED FECSSHCSEL SWRQNEQRRQ GLFCDITLCF 
       110        120        130        140        150
GGAGGREFRA HRSVLAAATE YFTPLLSGQF SESRSGRVEM RKWSSEPGPE 
       160        170        180        190        200
PDTVEAVIEY MYTGRIRVST GSVHEVLELA DRFLLIRLKE FCGEFLKKKL 
       210        220        230        240        250
HLSNCVAIHS LAHMYTLSQL ALKAADMIRR NFHKVIQDEE FYTLPFHLIR 
       260        270        280        290        300
DWLSDLEITV DSEEVLFETV LKWVQRNAEE RERYFEELFK LLRLSQMKPT 
       310        320        330        340        350
YLTRHVKPER LVANNEVCVK LVADAVERHA LRAENIQSGT CQHPTSHVSL 
       360        370        380        390        400
LPRYGQNMDV IMVIGGVSEG GDYLSECVGY FVDEDRWVNL PHIHNHLDGH 
       410        420        430        440        450
AVAVTESYVY VAGSMEPGFA KTVERYNPNL NTWEHVCSLM TRKHSFGLTE 
       460        470        480        490        500
VKGKLYSIGG HGNFSPGFKD VTVYNPELDK WHNLESAPKI LRDVKALAIE 
       510        520        530        540        550
DRFVYIAART PVDRDTEDGL KAVITCYDTE TRQWQDVESL PLIDNYCFFQ 
       560        570        580        590        600
MSVVNSNFYQ TASCCPKSYC LENEEAVRKI ASQVSDEILE SLPPEVLSIE 
       610        620        630        640        650
GAAICYYKDD VFIIGGWKNS DDIDKQYRKE AYRYCAERKR WMLLPPMPQP 
       660        670        680        690        700
RCRATACHVR IPYRYLHGTQ RYPMPQNLMW QKDRIRQMQE IHRHALNMRR 

VPSSQIEC
Length:708
Mass (Da):80,148
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38733CE875172E12
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK001434 mRNA Translation: BAA91689.1
BC034470 mRNA Translation: AAH34470.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11411.1

NCBI Reference Sequences

More...RefSeqi		NP_060613.1, NM_018143.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000319121; ENSP00000314608; ENSG00000178502

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55175

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55175

UCSC genome browser

More...UCSCi		uc002hyf.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001434 mRNA Translation: BAA91689.1
BC034470 mRNA Translation: AAH34470.1
CCDSiCCDS11411.1
RefSeqiNP_060613.1, NM_018143.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I3NX-ray2.60A/B67-340[»]
4AP2X-ray2.80A67-340[»]
4APFX-ray3.10A67-340[»]
SMRiQ9NVR0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120474, 69 interactors
IntActiQ9NVR0, 12 interactors
STRINGi9606.ENSP00000314608

PTM databases

iPTMnetiQ9NVR0
PhosphoSitePlusiQ9NVR0

Polymorphism and mutation databases

BioMutaiKLHL11
DMDMi74734542

Proteomic databases

EPDiQ9NVR0
jPOSTiQ9NVR0
MassIVEiQ9NVR0
MaxQBiQ9NVR0
PaxDbiQ9NVR0
PeptideAtlasiQ9NVR0
PRIDEiQ9NVR0
ProteomicsDBi82847

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16791, 102 antibodies

Genome annotation databases

EnsembliENST00000319121; ENSP00000314608; ENSG00000178502
GeneIDi55175
KEGGihsa:55175
UCSCiuc002hyf.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55175
DisGeNETi55175
EuPathDBiHostDB:ENSG00000178502.5

GeneCards: human genes, protein and diseases

More...GeneCardsi		KLHL11
HGNCiHGNC:19008, KLHL11
HPAiENSG00000178502, Low tissue specificity
neXtProtiNX_Q9NVR0
OpenTargetsiENSG00000178502
PharmGKBiPA38777

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1072, Eukaryota
GeneTreeiENSGT00940000159275
HOGENOMiCLU_024322_0_0_1
InParanoidiQ9NVR0
OMAiNLITRKH
OrthoDBi789713at2759
PhylomeDBiQ9NVR0
TreeFamiTF331981

Enzyme and pathway databases

PathwayCommonsiQ9NVR0
ReactomeiR-HSA-8951664, Neddylation
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55175, 246 hits in 839 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KLHL11, human
EvolutionaryTraceiQ9NVR0

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55175
PharosiQ9NVR0, Tdark

Protein Ontology

More...PROi		PR:Q9NVR0
RNActiQ9NVR0, protein

Gene expression databases

BgeeiENSG00000178502, Expressed in sperm and 125 other tissues
ExpressionAtlasiQ9NVR0, baseline and differential
GenevisibleiQ9NVR0, HS

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705, BACK
IPR000210, BTB/POZ_dom
IPR015915, Kelch-typ_b-propeller
IPR006652, Kelch_1
IPR011333, SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707, BACK, 1 hit
PF00651, BTB, 1 hit
PF01344, Kelch_1, 1 hit
SMARTiView protein in SMART
SM00875, BACK, 1 hit
SM00225, BTB, 1 hit
SM00612, Kelch, 4 hits
SUPFAMiSSF117281, SSF117281, 2 hits
SSF54695, SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097, BTB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKLH11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NVR0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2000
Last modified: December 2, 2020
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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