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UniProtKB - Q9NVP2 (ASF1B_HUMAN)

Entry version 166 (23 Feb 2022)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
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Protein

Histone chaperone ASF1B

Gene

ASF1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis.

5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • histone binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone, Chromatin regulator, Developmental protein
Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NVP2

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NVP2

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NVP2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone chaperone ASF1B
Alternative name(s):
Anti-silencing function protein 1 homolog B
Short name:
hAsf1
Short name:
hAsf1b
CCG1-interacting factor A-II
Short name:
CIA-II
Short name:
hCIA-II
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASF1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20996, ASF1B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609190, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NVP2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000105011

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi36D → A: Abolishes CDAN1 interaction. 1 Publication1
Mutagenesisi37D → A: Abolishes CDAN1 interaction. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		55723

Open Targets

More...OpenTargetsi		ENSG00000105011

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134931112

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NVP2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ASF1B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002840151 – 202Histone chaperone ASF1BAdd BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei198Phosphoserine; by TLK21 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by TLK1 and TLK2.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-953

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NVP2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NVP2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NVP2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NVP2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NVP2

PeptideAtlas

More...PeptideAtlasi		Q9NVP2

PRoteomics IDEntifications database

More...PRIDEi		Q9NVP2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82838

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NVP2, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NVP2

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9NVP2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NVP2

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9NVP2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis and at lower levels in colon, small intestine and thymus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105011, Expressed in oocyte and 133 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NVP2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NVP2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000105011, Tissue enhanced (lymphoid tissue, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4.

Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex.

Interacts with HAT1, NASP, TAF1, TLK1 and TLK2.

Interacts with CDAN1.

Found in a cytosolic complex with CDAN1, ASF1A, IPO4 and histones H3.1 and H4.

Interacts with CREBBP.

9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120845, 83 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9NVP2

Database of interacting proteins

More...DIPi		DIP-29242N

Protein interaction database and analysis system

More...IntActi		Q9NVP2, 43 interactors

Molecular INTeraction database

More...MINTi		Q9NVP2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263382

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NVP2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1202
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NVP2

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 156Interaction with histone H3By similarityAdd BLAST156
Regioni1 – 155Interaction with CHAF1BAdd BLAST155

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ASF1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3265, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000004692

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_060354_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NVP2

Identification of Orthologs from Complete Genome Data

More...OMAi		SCTPVKG

Database of Orthologous Groups

More...OrthoDBi		1334998at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NVP2

TreeFam database of animal gene trees

More...TreeFami		TF106429

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006818, ASF1-like
IPR036747, ASF1-like_sf

The PANTHER Classification System

More...PANTHERi		PTHR12040, PTHR12040, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04729, ASF1_hist_chap, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101546, SSF101546, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9NVP2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKVSVLNVA VLENPSPFHS PFRFEISFEC SEALADDLEW KIIYVGSAES 
        60         70         80         90        100
EEFDQILDSV LVGPVPAGRH MFVFQADAPN PSLIPETDAV GVTVVLITCT 
       110        120        130        140        150
YHGQEFIRVG YYVNNEYLNP ELRENPPMKP DFSQLQRNIL ASNPRVTRFH 
       160        170        180        190        200
INWDNNMDRL EAIETQDPSL GCGLPLNCTP IKGLGLPGCI PGLLPENSMD 

CI
Length:202
Mass (Da):22,434
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD62F726610E3A70
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ES22K7ES22_HUMAN
Histone chaperone ASF1B
ASF1B
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELW9K7ELW9_HUMAN
Histone chaperone ASF1B
ASF1B
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIL9K7EIL9_HUMAN
Histone chaperone ASF1B
ASF1B
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM93K7EM93_HUMAN
Histone chaperone ASF1B
ASF1B
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11V → A in BAA91602 (PubMed:14702039).Curated1
Sequence conflicti23R → Q in BAD96800 (Ref. 5) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF279307 mRNA Translation: AAK82973.1
AB104486 mRNA Translation: BAC87709.1
CR457235 mRNA Translation: CAG33516.1
AK001288 mRNA Translation: BAA91602.1
AK001466 mRNA Translation: BAA91708.1
AK223080 mRNA Translation: BAD96800.1
AC022098 Genomic DNA No translation available.
BC007726 mRNA Translation: AAH07726.1
BC010014 mRNA Translation: AAH10014.1
BC036521 mRNA Translation: AAH36521.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12306.1

NCBI Reference Sequences

More...RefSeqi		NP_060624.1, NM_018154.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263382; ENSP00000263382; ENSG00000105011
ENST00000672225; ENSP00000499863; ENSG00000288210

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55723

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55723

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000263382.8; ENSP00000263382.3; NM_018154.3; NP_060624.1

UCSC genome browser

More...UCSCi		uc002mye.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279307 mRNA Translation: AAK82973.1
AB104486 mRNA Translation: BAC87709.1
CR457235 mRNA Translation: CAG33516.1
AK001288 mRNA Translation: BAA91602.1
AK001466 mRNA Translation: BAA91708.1
AK223080 mRNA Translation: BAD96800.1
AC022098 Genomic DNA No translation available.
BC007726 mRNA Translation: AAH07726.1
BC010014 mRNA Translation: AAH10014.1
BC036521 mRNA Translation: AAH36521.1
CCDSiCCDS12306.1
RefSeqiNP_060624.1, NM_018154.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5BNXX-ray2.31D1-158[»]
5BO0X-ray2.91D1-158[»]
SMRiQ9NVP2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120845, 83 interactors
CORUMiQ9NVP2
DIPiDIP-29242N
IntActiQ9NVP2, 43 interactors
MINTiQ9NVP2
STRINGi9606.ENSP00000263382

PTM databases

GlyGeniQ9NVP2, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9NVP2
MetOSiteiQ9NVP2
PhosphoSitePlusiQ9NVP2
SwissPalmiQ9NVP2

Genetic variation databases

BioMutaiASF1B

Proteomic databases

CPTACiCPTAC-953
EPDiQ9NVP2
jPOSTiQ9NVP2
MassIVEiQ9NVP2
MaxQBiQ9NVP2
PaxDbiQ9NVP2
PeptideAtlasiQ9NVP2
PRIDEiQ9NVP2
ProteomicsDBi82838

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9NVP2, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26631, 317 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		55723

Genome annotation databases

EnsembliENST00000263382; ENSP00000263382; ENSG00000105011
ENST00000672225; ENSP00000499863; ENSG00000288210
GeneIDi55723
KEGGihsa:55723
MANE-SelectiENST00000263382.8; ENSP00000263382.3; NM_018154.3; NP_060624.1
UCSCiuc002mye.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55723
DisGeNETi55723

GeneCards: human genes, protein and diseases

More...GeneCardsi		ASF1B
HGNCiHGNC:20996, ASF1B
HPAiENSG00000105011, Tissue enhanced (lymphoid tissue, testis)
MIMi609190, gene
neXtProtiNX_Q9NVP2
OpenTargetsiENSG00000105011
PharmGKBiPA134931112
VEuPathDBiHostDB:ENSG00000105011

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3265, Eukaryota
GeneTreeiENSGT00390000004692
HOGENOMiCLU_060354_1_2_1
InParanoidiQ9NVP2
OMAiSCTPVKG
OrthoDBi1334998at2759
PhylomeDBiQ9NVP2
TreeFamiTF106429

Enzyme and pathway databases

PathwayCommonsiQ9NVP2
SignaLinkiQ9NVP2
SIGNORiQ9NVP2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55723, 185 hits in 1057 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ASF1B, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ASF1B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55723
PharosiQ9NVP2, Tbio

Protein Ontology

More...PROi		PR:Q9NVP2
RNActiQ9NVP2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105011, Expressed in oocyte and 133 other tissues
ExpressionAtlasiQ9NVP2, baseline and differential
GenevisibleiQ9NVP2, HS

Family and domain databases

Gene3Di2.60.40.1490, 1 hit
InterProiView protein in InterPro
IPR006818, ASF1-like
IPR036747, ASF1-like_sf
PANTHERiPTHR12040, PTHR12040, 1 hit
PfamiView protein in Pfam
PF04729, ASF1_hist_chap, 1 hit
SUPFAMiSSF101546, SSF101546, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASF1B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NVP2
Secondary accession number(s): Q53G51, Q9NVZ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 1, 2000
Last modified: February 23, 2022
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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