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Protein

ATP-dependent RNA helicase DDX18

Gene

DDX18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable RNA-dependent helicase.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi223 – 230ATPCurated8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: ProtInc
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DDX18 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 18
Myc-regulated DEAD box protein
Short name:
MrDb
Gene namesi
Name:DDX18
Synonyms:cPERP-D1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000088205.12
HGNCiHGNC:2741 DDX18
MIMi606355 gene
neXtProtiNX_Q9NVP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8886
OpenTargetsiENSG00000088205
PharmGKBiPA27207

Polymorphism and mutation databases

BioMutaiDDX18
DMDMi20532388

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550011 – 670ATP-dependent RNA helicase DDX18Add BLAST670

Proteomic databases

EPDiQ9NVP1
MaxQBiQ9NVP1
PaxDbiQ9NVP1
PeptideAtlasiQ9NVP1
PRIDEiQ9NVP1
ProteomicsDBi82837

2D gel databases

SWISS-2DPAGEiQ9NVP1

PTM databases

iPTMnetiQ9NVP1
PhosphoSitePlusiQ9NVP1
SwissPalmiQ9NVP1

Expressioni

Gene expression databases

BgeeiENSG00000088205
CleanExiHS_DDX18
ExpressionAtlasiQ9NVP1 baseline and differential
GenevisibleiQ9NVP1 HS

Organism-specific databases

HPAiHPA035400
HPA041056

Interactioni

Subunit structurei

Interacts with NOL8; the interaction is RNA-dependent.2 Publications

Protein-protein interaction databases

BioGridi114404, 117 interactors
IntActiQ9NVP1, 33 interactors
MINTiQ9NVP1
STRINGi9606.ENSP00000263239

Structurei

Secondary structure

1670
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi175 – 177Combined sources3
Helixi188 – 196Combined sources9
Helixi204 – 215Combined sources12
Helixi229 – 243Combined sources15
Helixi248 – 250Combined sources3
Beta strandi254 – 257Combined sources4
Helixi261 – 274Combined sources14
Turni275 – 277Combined sources3
Beta strandi282 – 285Combined sources4
Beta strandi287 – 289Combined sources3
Helixi291 – 300Combined sources10
Beta strandi303 – 307Combined sources5
Helixi309 – 318Combined sources10
Beta strandi329 – 332Combined sources4
Helixi335 – 340Combined sources6
Helixi344 – 353Combined sources10
Beta strandi356 – 363Combined sources8
Helixi369 – 378Combined sources10

3D structure databases

ProteinModelPortaliQ9NVP1
SMRiQ9NVP1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NVP1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini210 – 385Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST176
Domaini399 – 569Helicase C-terminalPROSITE-ProRule annotationAdd BLAST171

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi179 – 207Q motifAdd BLAST29
Motifi333 – 336DEAD box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 116Poly-Lys9
Compositional biasi636 – 642Poly-Gly7

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0342 Eukaryota
COG0513 LUCA
GeneTreeiENSGT00680000100037
HOGENOMiHOG000268799
HOVERGENiHBG105702
InParanoidiQ9NVP1
KOiK13179
OMAiEMRQIVK
OrthoDBiEOG091G06N7
PhylomeDBiQ9NVP1
TreeFamiTF300471

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR025313 DUF4217
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF13959 DUF4217, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM01178 DUF4217, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NVP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLPMKLLR KKIEKRNLKL RQRNLKFQGA SNLTLSETQN GDVSEETMGS
60 70 80 90 100
RKVKKSKQKP MNVGLSETQN GGMSQEAVGN IKVTKSPQKS TVLTNGEAAM
110 120 130 140 150
QSSNSESKKK KKKKRKMVND AEPDTKKAKT ENKGKSEEES AETTKETENN
160 170 180 190 200
VEKPDNDEDE SEVPSLPLGL TGAFEDTSFA SLCNLVNENT LKAIKEMGFT
210 220 230 240 250
NMTEIQHKSI RPLLEGRDLL AAAKTGSGKT LAFLIPAVEL IVKLRFMPRN
260 270 280 290 300
GTGVLILSPT RELAMQTFGV LKELMTHHVH TYGLIMGGSN RSAEAQKLGN
310 320 330 340 350
GINIIVATPG RLLDHMQNTP GFMYKNLQCL VIDEADRILD VGFEEELKQI
360 370 380 390 400
IKLLPTRRQT MLFSATQTRK VEDLARISLK KEPLYVGVDD DKANATVDGL
410 420 430 440 450
EQGYVVCPSE KRFLLLFTFL KKNRKKKLMV FFSSCMSVKY HYELLNYIDL
460 470 480 490 500
PVLAIHGKQK QNKRTTTFFQ FCNADSGTLL CTDVAARGLD IPEVDWIVQY
510 520 530 540 550
DPPDDPKEYI HRVGRTARGL NGRGHALLIL RPEELGFLRY LKQSKVPLSE
560 570 580 590 600
FDFSWSKISD IQSQLEKLIE KNYFLHKSAQ EAYKSYIRAY DSHSLKQIFN
610 620 630 640 650
VNNLNLPQVA LSFGFKVPPF VDLNVNSNEG KQKKRGGGGG FGYQKTKKVE
660 670
KSKIFKHISK KSSDSRQFSH
Length:670
Mass (Da):75,407
Last modified:May 10, 2002 - v2
Checksum:i2FE653A98751F9DC
GO

Sequence cautioni

The sequence CAA67295 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti248P → T in BAA91709 (PubMed:14702039).Curated1
Sequence conflicti382E → G in CAG33341 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03584141G → R in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_01329394T → S2 PublicationsCorresponds to variant dbSNP:rs1052637Ensembl.1
Natural variantiVAR_033857647K → R. Corresponds to variant dbSNP:rs10179772Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001467 mRNA Translation: BAA91709.1
BC001238 mRNA Translation: AAH01238.1
BC003360 mRNA Translation: AAH03360.1
BC024739 mRNA Translation: AAH24739.1
X98743 mRNA Translation: CAA67295.1 Different initiation.
CR457060 mRNA Translation: CAG33341.1
CCDSiCCDS2120.1
PIRiS71758
RefSeqiNP_006764.3, NM_006773.3
UniGeneiHs.744922

Genome annotation databases

EnsembliENST00000263239; ENSP00000263239; ENSG00000088205
GeneIDi8886
KEGGihsa:8886
UCSCiuc002tlh.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDDX18_HUMAN
AccessioniPrimary (citable) accession number: Q9NVP1
Secondary accession number(s): Q6GTZ9
, Q6IAU4, Q92732, Q9BQB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 10, 2002
Last modified: July 18, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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