UniProtKB - Q9NVM6 (DJC17_HUMAN)
Protein
DnaJ homolog subfamily C member 17
Gene
DNAJC17
Organism
Homo sapiens (Human)
Status
Functioni
May negatively affect PAX8-induced thyroglobulin/TG transcription.By similarity
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- toxin transport Source: Ensembl
Keywordsi
Molecular function | Chaperone, RNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9NVM6 |
Names & Taxonomyi
Protein namesi | Recommended name: DnaJ homolog subfamily C member 17 |
Gene namesi | Name:DNAJC17 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000104129.9 |
HGNCi | HGNC:25556, DNAJC17 |
MIMi | 616844, gene |
neXtProti | NX_Q9NVM6 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 55192 |
OpenTargetsi | ENSG00000104129 |
PharmGKBi | PA142671965 |
Miscellaneous databases
Pharosi | Q9NVM6, Tdark |
Polymorphism and mutation databases
BioMutai | DNAJC17 |
DMDMi | 74761740 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000247118 | 1 – 304 | DnaJ homolog subfamily C member 17Add BLAST | 304 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 112 | PhosphoserineCombined sources | 1 | |
Modified residuei | 264 | N6-methyllysineCombined sources | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q9NVM6 |
jPOSTi | Q9NVM6 |
MassIVEi | Q9NVM6 |
MaxQBi | Q9NVM6 |
PaxDbi | Q9NVM6 |
PeptideAtlasi | Q9NVM6 |
PRIDEi | Q9NVM6 |
ProteomicsDBi | 82830 |
PTM databases
iPTMneti | Q9NVM6 |
PhosphoSitePlusi | Q9NVM6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000104129, Expressed in sural nerve and 161 other tissues |
ExpressionAtlasi | Q9NVM6, baseline and differential |
Genevisiblei | Q9NVM6, HS |
Organism-specific databases
HPAi | ENSG00000104129, Low tissue specificity |
Interactioni
Binary interactionsi
Q9NVM6
With | #Exp. | IntAct |
---|---|---|
MEOX2 [Q6FHY5] | 3 | EBI-12260682,EBI-16439278 |
Protein-protein interaction databases
BioGRIDi | 120489, 20 interactors |
IntActi | Q9NVM6, 6 interactors |
STRINGi | 9606.ENSP00000220496 |
Miscellaneous databases
RNActi | Q9NVM6, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9NVM6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NVM6 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 76 | JPROSITE-ProRule annotationAdd BLAST | 66 | |
Domaini | 178 – 249 | RRMAdd BLAST | 72 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 111 – 117 | Poly-Glu | 7 |
Phylogenomic databases
eggNOGi | KOG0691, Eukaryota |
GeneTreei | ENSGT00940000155132 |
HOGENOMi | CLU_045732_1_0_1 |
InParanoidi | Q9NVM6 |
OMAi | DSAQHRI |
OrthoDBi | 1405648at2759 |
PhylomeDBi | Q9NVM6 |
TreeFami | TF321770 |
Family and domain databases
CDDi | cd06257, DnaJ, 1 hit cd12429, RRM_DNAJC17, 1 hit |
Gene3Di | 1.10.287.110, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR001623, DnaJ_domain IPR034254, DNAJC17_RRM IPR036869, J_dom_sf IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00226, DnaJ, 1 hit PF00076, RRM_1, 1 hit |
PRINTSi | PR00625, JDOMAIN |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit |
SUPFAMi | SSF46565, SSF46565, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50076, DNAJ_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q9NVM6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVTKELLQM DLYALLGIEE KAADKEVKKA YRQKALSCHP DKNPDNPRAA
60 70 80 90 100
ELFHQLSQAL EVLTDAAARA AYDKVRKAKK QAAERTQKLD EKRKKVKLDL
110 120 130 140 150
EARERQAQAQ ESEEEEESRS TRTLEQEIER LREEGSRQLE EQQRLIREQI
160 170 180 190 200
RQERDQRLRG KAENTEGQGT PKLKLKWKCK KEDESKGGYS KDVLLRLLQK
210 220 230 240 250
YGEVLNLVLS SKKPGTAVVE FATVKAAELA VQNEVGLVDN PLKISWLEGQ
260 270 280 290 300
PQDAVGRSHS GLSKGSVLSE RDYESLVMMR MRQAAERQQL IARMQQEDQE
GPPT
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketS4R343 | S4R343_HUMAN | DnaJ homolog subfamily C member 17 | DNAJC17 | 125 | Annotation score: | ||
H0YK99 | H0YK99_HUMAN | DnaJ homolog subfamily C member 17 | DNAJC17 | 143 | Annotation score: | ||
H0YLQ7 | H0YLQ7_HUMAN | DnaJ homolog subfamily C member 17 | DNAJC17 | 131 | Annotation score: | ||
H0YLV4 | H0YLV4_HUMAN | DnaJ homolog subfamily C member 17 | DNAJC17 | 102 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001496 mRNA Translation: BAA91724.1 BC000048 mRNA Translation: AAH00048.1 |
CCDSi | CCDS10065.1 |
RefSeqi | NP_060633.1, NM_018163.2 |
Genome annotation databases
Ensembli | ENST00000220496; ENSP00000220496; ENSG00000104129 |
GeneIDi | 55192 |
KEGGi | hsa:55192 |
UCSCi | uc001zms.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001496 mRNA Translation: BAA91724.1 BC000048 mRNA Translation: AAH00048.1 |
CCDSi | CCDS10065.1 |
RefSeqi | NP_060633.1, NM_018163.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2D9O | NMR | - | A | 168-254 | [»] | |
SMRi | Q9NVM6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120489, 20 interactors |
IntActi | Q9NVM6, 6 interactors |
STRINGi | 9606.ENSP00000220496 |
PTM databases
iPTMneti | Q9NVM6 |
PhosphoSitePlusi | Q9NVM6 |
Polymorphism and mutation databases
BioMutai | DNAJC17 |
DMDMi | 74761740 |
Proteomic databases
EPDi | Q9NVM6 |
jPOSTi | Q9NVM6 |
MassIVEi | Q9NVM6 |
MaxQBi | Q9NVM6 |
PaxDbi | Q9NVM6 |
PeptideAtlasi | Q9NVM6 |
PRIDEi | Q9NVM6 |
ProteomicsDBi | 82830 |
Protocols and materials databases
Antibodypediai | 49787, 162 antibodies |
Genome annotation databases
Ensembli | ENST00000220496; ENSP00000220496; ENSG00000104129 |
GeneIDi | 55192 |
KEGGi | hsa:55192 |
UCSCi | uc001zms.3, human |
Organism-specific databases
CTDi | 55192 |
DisGeNETi | 55192 |
EuPathDBi | HostDB:ENSG00000104129.9 |
GeneCardsi | DNAJC17 |
HGNCi | HGNC:25556, DNAJC17 |
HPAi | ENSG00000104129, Low tissue specificity |
MIMi | 616844, gene |
neXtProti | NX_Q9NVM6 |
OpenTargetsi | ENSG00000104129 |
PharmGKBi | PA142671965 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0691, Eukaryota |
GeneTreei | ENSGT00940000155132 |
HOGENOMi | CLU_045732_1_0_1 |
InParanoidi | Q9NVM6 |
OMAi | DSAQHRI |
OrthoDBi | 1405648at2759 |
PhylomeDBi | Q9NVM6 |
TreeFami | TF321770 |
Enzyme and pathway databases
PathwayCommonsi | Q9NVM6 |
Miscellaneous databases
BioGRID-ORCSi | 55192, 692 hits in 851 CRISPR screens |
ChiTaRSi | DNAJC17, human |
EvolutionaryTracei | Q9NVM6 |
GenomeRNAii | 55192 |
Pharosi | Q9NVM6, Tdark |
PROi | PR:Q9NVM6 |
RNActi | Q9NVM6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104129, Expressed in sural nerve and 161 other tissues |
ExpressionAtlasi | Q9NVM6, baseline and differential |
Genevisiblei | Q9NVM6, HS |
Family and domain databases
CDDi | cd06257, DnaJ, 1 hit cd12429, RRM_DNAJC17, 1 hit |
Gene3Di | 1.10.287.110, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR001623, DnaJ_domain IPR034254, DNAJC17_RRM IPR036869, J_dom_sf IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00226, DnaJ, 1 hit PF00076, RRM_1, 1 hit |
PRINTSi | PR00625, JDOMAIN |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit |
SUPFAMi | SSF46565, SSF46565, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50076, DNAJ_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DJC17_HUMAN | |
Accessioni | Q9NVM6Primary (citable) accession number: Q9NVM6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2006 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM