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Protein

DnaJ homolog subfamily C member 17

Gene

DNAJC17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May negatively affect PAX8-induced thyroglobulin/TG transcription.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone, RNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 17
Gene namesi
Name:DNAJC17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000104129.9
HGNCiHGNC:25556 DNAJC17
MIMi616844 gene
neXtProtiNX_Q9NVM6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104129
PharmGKBiPA142671965

Polymorphism and mutation databases

BioMutaiDNAJC17
DMDMi74761740

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002471181 – 304DnaJ homolog subfamily C member 17Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei112PhosphoserineCombined sources1
Modified residuei264N6-methyllysineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9NVM6
MaxQBiQ9NVM6
PaxDbiQ9NVM6
PeptideAtlasiQ9NVM6
PRIDEiQ9NVM6
ProteomicsDBi82830

PTM databases

iPTMnetiQ9NVM6
PhosphoSitePlusiQ9NVM6

Expressioni

Gene expression databases

BgeeiENSG00000104129 Expressed in 147 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_DNAJC17
ExpressionAtlasiQ9NVM6 baseline and differential
GenevisibleiQ9NVM6 HS

Organism-specific databases

HPAiHPA040914
HPA041187

Interactioni

Protein-protein interaction databases

BioGridi120489, 13 interactors
IntActiQ9NVM6, 2 interactors
STRINGi9606.ENSP00000220496

Structurei

Secondary structure

1304
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NVM6
SMRiQ9NVM6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NVM6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 76JPROSITE-ProRule annotationAdd BLAST66
Domaini178 – 249RRMAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi111 – 117Poly-Glu7

Phylogenomic databases

eggNOGiKOG0691 Eukaryota
COG2214 LUCA
GeneTreeiENSGT00550000074688
HOGENOMiHOG000239711
HOVERGENiHBG062744
InParanoidiQ9NVM6
KOiK09537
OMAiDSAQHRI
OrthoDBiEOG091G0L2J
PhylomeDBiQ9NVM6
TreeFamiTF321770

Family and domain databases

CDDicd06257 DnaJ, 1 hit
cd12429 RRM_DNAJC17, 1 hit
Gene3Di1.10.287.110, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR034254 DNAJC17_RRM
IPR036869 J_dom_sf
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF00076 RRM_1, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9NVM6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVTKELLQM DLYALLGIEE KAADKEVKKA YRQKALSCHP DKNPDNPRAA
60 70 80 90 100
ELFHQLSQAL EVLTDAAARA AYDKVRKAKK QAAERTQKLD EKRKKVKLDL
110 120 130 140 150
EARERQAQAQ ESEEEEESRS TRTLEQEIER LREEGSRQLE EQQRLIREQI
160 170 180 190 200
RQERDQRLRG KAENTEGQGT PKLKLKWKCK KEDESKGGYS KDVLLRLLQK
210 220 230 240 250
YGEVLNLVLS SKKPGTAVVE FATVKAAELA VQNEVGLVDN PLKISWLEGQ
260 270 280 290 300
PQDAVGRSHS GLSKGSVLSE RDYESLVMMR MRQAAERQQL IARMQQEDQE

GPPT
Length:304
Mass (Da):34,687
Last modified:October 1, 2000 - v1
Checksum:i98A1BA8ABFF4120E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YK99H0YK99_HUMAN
DnaJ homolog subfamily C member 17
DNAJC17
143Annotation score:
H0YLQ7H0YLQ7_HUMAN
DnaJ homolog subfamily C member 17
DNAJC17
131Annotation score:
S4R343S4R343_HUMAN
DnaJ homolog subfamily C member 17
DNAJC17
125Annotation score:
H0YLV4H0YLV4_HUMAN
DnaJ homolog subfamily C member 17
DNAJC17
102Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001496 mRNA Translation: BAA91724.1
BC000048 mRNA Translation: AAH00048.1
CCDSiCCDS10065.1
RefSeqiNP_060633.1, NM_018163.2
UniGeneiHs.511069

Genome annotation databases

EnsembliENST00000220496; ENSP00000220496; ENSG00000104129
GeneIDi55192
KEGGihsa:55192
UCSCiuc001zms.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001496 mRNA Translation: BAA91724.1
BC000048 mRNA Translation: AAH00048.1
CCDSiCCDS10065.1
RefSeqiNP_060633.1, NM_018163.2
UniGeneiHs.511069

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D9ONMR-A168-254[»]
ProteinModelPortaliQ9NVM6
SMRiQ9NVM6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120489, 13 interactors
IntActiQ9NVM6, 2 interactors
STRINGi9606.ENSP00000220496

PTM databases

iPTMnetiQ9NVM6
PhosphoSitePlusiQ9NVM6

Polymorphism and mutation databases

BioMutaiDNAJC17
DMDMi74761740

Proteomic databases

EPDiQ9NVM6
MaxQBiQ9NVM6
PaxDbiQ9NVM6
PeptideAtlasiQ9NVM6
PRIDEiQ9NVM6
ProteomicsDBi82830

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000220496; ENSP00000220496; ENSG00000104129
GeneIDi55192
KEGGihsa:55192
UCSCiuc001zms.3 human

Organism-specific databases

CTDi55192
EuPathDBiHostDB:ENSG00000104129.9
GeneCardsiDNAJC17
HGNCiHGNC:25556 DNAJC17
HPAiHPA040914
HPA041187
MIMi616844 gene
neXtProtiNX_Q9NVM6
OpenTargetsiENSG00000104129
PharmGKBiPA142671965
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0691 Eukaryota
COG2214 LUCA
GeneTreeiENSGT00550000074688
HOGENOMiHOG000239711
HOVERGENiHBG062744
InParanoidiQ9NVM6
KOiK09537
OMAiDSAQHRI
OrthoDBiEOG091G0L2J
PhylomeDBiQ9NVM6
TreeFamiTF321770

Miscellaneous databases

ChiTaRSiDNAJC17 human
EvolutionaryTraceiQ9NVM6
GenomeRNAii55192
PROiPR:Q9NVM6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104129 Expressed in 147 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_DNAJC17
ExpressionAtlasiQ9NVM6 baseline and differential
GenevisibleiQ9NVM6 HS

Family and domain databases

CDDicd06257 DnaJ, 1 hit
cd12429 RRM_DNAJC17, 1 hit
Gene3Di1.10.287.110, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR034254 DNAJC17_RRM
IPR036869 J_dom_sf
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF00076 RRM_1, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDJC17_HUMAN
AccessioniPrimary (citable) accession number: Q9NVM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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