UniProtKB - Q9NVM6 (DJC17_HUMAN)

BLAST

>sp|Q9NVM6|DJC17_HUMAN DnaJ homolog subfamily C member 17 OS=Homo sapiens OX=9606 GN=DNAJC17 PE=1 SV=1
MAVTKELLQMDLYALLGIEEKAADKEVKKAYRQKALSCHPDKNPDNPRAAELFHQLSQAL
EVLTDAAARAAYDKVRKAKKQAAERTQKLDEKRKKVKLDLEARERQAQAQESEEEEESRS
TRTLEQEIERLREEGSRQLEEQQRLIREQIRQERDQRLRGKAENTEGQGTPKLKLKWKCK
KEDESKGGYSKDVLLRLLQKYGEVLNLVLSSKKPGTAVVEFATVKAAELAVQNEVGLVDN
PLKISWLEGQPQDAVGRSHSGLSKGSVLSERDYESLVMMRMRQAAERQQLIARMQQEDQE
GPPT

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History
Entry version 150 (07 Nov 2018)
Sequence version 1 (01 Oct 2000)
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Protein

DnaJ homolog subfamily C member 17

Gene

DNAJC17

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May negatively affect PAX8-induced thyroglobulin/TG transcription.By similarity

GO - Molecular functionⁱ

RNA binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II Source: Ensembl
toxin transport Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone, RNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DnaJ homolog subfamily C member 17
Gene namesⁱ	Name:DNAJC17
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000104129.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25556 DNAJC17
MIMⁱ	616844 gene
neXtProtⁱ	NX_Q9NVM6

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000104129
PharmGKBⁱ	PA142671965

Polymorphism and mutation databases

BioMutaⁱ	DNAJC17
DMDMⁱ	74761740

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000247118	1 – 304	DnaJ homolog subfamily C member 17Add BLAST		304

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	112	PhosphoserineCombined sources		1
Modified residueⁱ	264	N6-methyllysineCombined sources		1

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9NVM6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NVM6
PaxDbⁱ	Q9NVM6
PeptideAtlas More...PeptideAtlasⁱ	Q9NVM6
PRIDEⁱ	Q9NVM6
ProteomicsDBⁱ	82830

PTM databases

iPTMnetⁱ	Q9NVM6
PhosphoSitePlusⁱ	Q9NVM6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000104129 Expressed in 147 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_DNAJC17
ExpressionAtlasⁱ	Q9NVM6 baseline and differential
Genevisibleⁱ	Q9NVM6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040914 HPA041187

HPAⁱ

HPA040914
HPA041187

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	120489, 13 interactors
IntActⁱ	Q9NVM6, 2 interactors
STRINGⁱ	9606.ENSP00000220496

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	172 – 176	Combined sources	5
Helixⁱ	191 – 199	Combined sources	9
Beta strandⁱ	204 – 222	Combined sources	19
Helixⁱ	224 – 232	Combined sources	9
Beta strandⁱ	238 – 241	Combined sources	4
Beta strandⁱ	243 – 245	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9NVM6
SMRⁱ	Q9NVM6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9NVM6

EvolutionaryTraceⁱ

Q9NVM6

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	11 – 76	JPROSITE-ProRule annotationAdd BLAST		66
Domainⁱ	178 – 249	RRMAdd BLAST		72

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	111 – 117	Poly-Glu		7

Phylogenomic databases

eggNOGⁱ	KOG0691 Eukaryota COG2214 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074688
HOGENOMⁱ	HOG000239711
HOVERGENⁱ	HBG062744
InParanoidⁱ	Q9NVM6
KEGG Orthology (KO) More...KOⁱ	K09537
OMAⁱ	DSAQHRI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L2J
PhylomeDBⁱ	Q9NVM6
TreeFamⁱ	TF321770

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06257 DnaJ, 1 hit cd12429 RRM_DNAJC17, 1 hit
Gene3Dⁱ	1.10.287.110, 1 hit 3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR001623 DnaJ_domain IPR034254 DNAJC17_RRM IPR036869 J_dom_sf IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00226 DnaJ, 1 hit PF00076 RRM_1, 1 hit
PRINTSⁱ	PR00625 JDOMAIN
SMARTⁱ	View protein in SMART SM00271 DnaJ, 1 hit
SUPFAMⁱ	SSF46565 SSF46565, 1 hit SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50076 DNAJ_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q9NVM6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAVTKELLQM DLYALLGIEE KAADKEVKKA YRQKALSCHP DKNPDNPRAA 
        60         70         80         90        100
ELFHQLSQAL EVLTDAAARA AYDKVRKAKK QAAERTQKLD EKRKKVKLDL 
       110        120        130        140        150
EARERQAQAQ ESEEEEESRS TRTLEQEIER LREEGSRQLE EQQRLIREQI 
       160        170        180        190        200
RQERDQRLRG KAENTEGQGT PKLKLKWKCK KEDESKGGYS KDVLLRLLQK 
       210        220        230        240        250
YGEVLNLVLS SKKPGTAVVE FATVKAAELA VQNEVGLVDN PLKISWLEGQ 
       260        270        280        290        300
PQDAVGRSHS GLSKGSVLSE RDYESLVMMR MRQAAERQQL IARMQQEDQE 

GPPT

Length:304

Mass (Da):34,687

Last modified:October 1, 2000 - v1

Checksum:ⁱ98A1BA8ABFF4120E

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YK99	H0YK99_HUMAN	DnaJ homolog subfamily C member 17 DnaJ homolog subfamily C member 17	DNAJC17	143	Annotation score:
H0YLQ7	H0YLQ7_HUMAN	DnaJ homolog subfamily C member 17 DnaJ homolog subfamily C member 17	DNAJC17	131	Annotation score:
S4R343	S4R343_HUMAN	DnaJ homolog subfamily C member 17 DnaJ homolog subfamily C member 17	DNAJC17	125	Annotation score:
H0YLV4	H0YLV4_HUMAN	DnaJ homolog subfamily C member 17 DnaJ homolog subfamily C member 17	DNAJC17	102	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK001496 mRNA Translation: BAA91724.1 BC000048 mRNA Translation: AAH00048.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10065.1
NCBI Reference Sequences More...RefSeqⁱ	NP_060633.1, NM_018163.2
UniGeneⁱ	Hs.511069

Genome annotation databases

Ensemblⁱ	ENST00000220496; ENSP00000220496; ENSG00000104129
GeneIDⁱ	55192
KEGGⁱ	hsa:55192
UCSC genome browser More...UCSCⁱ	uc001zms.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NVM6	DnaJ heat shock protein family (Hsp40) member C17		GORGO		304	UniRef100_Q9NVM6

Protein	Similar proteins		Species	Score	Length	Source
Q9NVM6	DnaJ heat shock protein family (Hsp40) member C17		GORGO		304	UniRef90_Q9NVM6
Uncharacterized protein		Cebus capucinus imitator		304
DnaJ homolog subfamily C member 17		MACMU		304
DnaJ heat shock protein family (Hsp40) member C17		MACFA		304
Uncharacterized protein		RHIRO		304
+30

Protein	Similar proteins		Species	Score	Length	Source
Q9NVM6	DnaJ homolog subfamily C member 17		RAT		303	UniRef50_D3ZSC8
Uncharacterized protein		FELCA		304
DnaJ-like subfamily C member 17		CRIGR		303
dnaJ homolog subfamily C member 17		DIPOR		303
DnaJ subfamily C member 17		CASCN		303
+153

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK001496 mRNA Translation: BAA91724.1 BC000048 mRNA Translation: AAH00048.1
CCDSⁱ	CCDS10065.1
RefSeqⁱ	NP_060633.1, NM_018163.2
UniGeneⁱ	Hs.511069

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2D9O	NMR	-	A	168-254	[»]
ProteinModelPortalⁱ	Q9NVM6
SMRⁱ	Q9NVM6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120489, 13 interactors
IntActⁱ	Q9NVM6, 2 interactors
STRINGⁱ	9606.ENSP00000220496

PTM databases

iPTMnetⁱ	Q9NVM6
PhosphoSitePlusⁱ	Q9NVM6

Polymorphism and mutation databases

BioMutaⁱ	DNAJC17
DMDMⁱ	74761740

Proteomic databases

EPDⁱ	Q9NVM6
MaxQBⁱ	Q9NVM6
PaxDbⁱ	Q9NVM6
PeptideAtlasⁱ	Q9NVM6
PRIDEⁱ	Q9NVM6
ProteomicsDBⁱ	82830

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000220496; ENSP00000220496; ENSG00000104129
GeneIDⁱ	55192
KEGGⁱ	hsa:55192
UCSCⁱ	uc001zms.3 human

Organism-specific databases

CTDⁱ	55192
EuPathDBⁱ	HostDB:ENSG00000104129.9
GeneCardsⁱ	DNAJC17
HGNCⁱ	HGNC:25556 DNAJC17
HPAⁱ	HPA040914 HPA041187
MIMⁱ	616844 gene
neXtProtⁱ	NX_Q9NVM6
OpenTargetsⁱ	ENSG00000104129
PharmGKBⁱ	PA142671965
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0691 Eukaryota COG2214 LUCA
GeneTreeⁱ	ENSGT00550000074688
HOGENOMⁱ	HOG000239711
HOVERGENⁱ	HBG062744
InParanoidⁱ	Q9NVM6
KOⁱ	K09537
OMAⁱ	DSAQHRI
OrthoDBⁱ	EOG091G0L2J
PhylomeDBⁱ	Q9NVM6
TreeFamⁱ	TF321770

Miscellaneous databases

ChiTaRSⁱ	DNAJC17 human
EvolutionaryTraceⁱ	Q9NVM6
GenomeRNAiⁱ	55192
Protein Ontology More...PROⁱ	PR:Q9NVM6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000104129 Expressed in 147 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_DNAJC17
ExpressionAtlasⁱ	Q9NVM6 baseline and differential
Genevisibleⁱ	Q9NVM6 HS

Family and domain databases

CDDⁱ	cd06257 DnaJ, 1 hit cd12429 RRM_DNAJC17, 1 hit
Gene3Dⁱ	1.10.287.110, 1 hit 3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR001623 DnaJ_domain IPR034254 DNAJC17_RRM IPR036869 J_dom_sf IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom
Pfamⁱ	View protein in Pfam PF00226 DnaJ, 1 hit PF00076 RRM_1, 1 hit
PRINTSⁱ	PR00625 JDOMAIN
SMARTⁱ	View protein in SMART SM00271 DnaJ, 1 hit
SUPFAMⁱ	SSF46565 SSF46565, 1 hit SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50076 DNAJ_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DJC17_HUMAN
Accessionⁱ	Q9NVM6Primary (citable) accession number: Q9NVM6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NVM6 (DJC17_HUMAN)

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DnaJ homolog subfamily C member 17

DNAJC17

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ