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Entry version 143 (02 Jun 2021)
Sequence version 1 (01 Oct 2000)
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Protein

Protein eva-1 homolog B

Gene

EVA1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NVM1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein eva-1 homolog B
Alternative name(s):
Protein FAM176B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EVA1B
Synonyms:C1orf78, FAM176B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:25558, EVA1B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NVM1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000142694.6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei29 – 49HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000142694

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162387367

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NVM1, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EVA1B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752997

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002711121 – 165Protein eva-1 homolog BAdd BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei85PhosphothreonineBy similarity1
Modified residuei148PhosphothreonineBy similarity1
Modified residuei158PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NVM1

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NVM1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NVM1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NVM1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NVM1

PeptideAtlas

More...
PeptideAtlasi
Q9NVM1

PRoteomics IDEntifications database

More...
PRIDEi
Q9NVM1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82825

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9NVM1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NVM1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NVM1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000142694, Expressed in stomach and 195 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NVM1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000142694, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
120491, 51 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NVM1, 10 interactors

Molecular INTeraction database

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MINTi
Q9NVM1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000270824

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NVM1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NVM1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni57 – 109DisorderedSequence analysisAdd BLAST53
Regioni143 – 165DisorderedSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EVA1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RYRK, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154096

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_104871_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NVM1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VGRVHYY

Database of Orthologous Groups

More...
OrthoDBi
1563157at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NVM1

TreeFam database of animal gene trees

More...
TreeFami
TF352986

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039500, EVA1_dom
IPR039502, EVA1B

The PANTHER Classification System

More...
PANTHERi
PTHR46780:SF2, PTHR46780:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14851, FAM176, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NVM1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAPRRDMEL LSNSLAAYAH IRANPESFGL YFVLGVCFGL LLTLCLLVIS
60 70 80 90 100
ISWAPRPRPR GPAQRRDPRS STLEPEDDDE DEEDTVTRLG PDDTLPGPEL
110 120 130 140 150
SAEPDGPLNV NVFTSAEELE RAQRLEERER ILREIWRTGQ PDLLGTGTLG
160
PSPTATGTLG RMHYY
Length:165
Mass (Da):18,374
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i872485ABDE8B2565
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001509 mRNA Translation: BAA91729.1
AL591845 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07377.1
CH471059 Genomic DNA Translation: EAX07378.1
BC071697 mRNA Translation: AAH71697.1
BC006241 mRNA Translation: AAH06241.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS406.1

NCBI Reference Sequences

More...
RefSeqi
NP_001291691.1, NM_001304762.1
NP_060636.1, NM_018166.2
XP_016857116.1, XM_017001627.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000270824; ENSP00000270824; ENSG00000142694

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55194

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55194

UCSC genome browser

More...
UCSCi
uc001caj.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001509 mRNA Translation: BAA91729.1
AL591845 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07377.1
CH471059 Genomic DNA Translation: EAX07378.1
BC071697 mRNA Translation: AAH71697.1
BC006241 mRNA Translation: AAH06241.1
CCDSiCCDS406.1
RefSeqiNP_001291691.1, NM_001304762.1
NP_060636.1, NM_018166.2
XP_016857116.1, XM_017001627.1

3D structure databases

SMRiQ9NVM1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120491, 51 interactors
IntActiQ9NVM1, 10 interactors
MINTiQ9NVM1
STRINGi9606.ENSP00000270824

PTM databases

iPTMnetiQ9NVM1
PhosphoSitePlusiQ9NVM1

Genetic variation databases

BioMutaiEVA1B
DMDMi74752997

Proteomic databases

EPDiQ9NVM1
jPOSTiQ9NVM1
MassIVEiQ9NVM1
MaxQBiQ9NVM1
PaxDbiQ9NVM1
PeptideAtlasiQ9NVM1
PRIDEiQ9NVM1
ProteomicsDBi82825
TopDownProteomicsiQ9NVM1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
60829, 18 antibodies

The DNASU plasmid repository

More...
DNASUi
55194

Genome annotation databases

EnsembliENST00000270824; ENSP00000270824; ENSG00000142694
GeneIDi55194
KEGGihsa:55194
UCSCiuc001caj.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55194

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EVA1B
HGNCiHGNC:25558, EVA1B
HPAiENSG00000142694, Low tissue specificity
neXtProtiNX_Q9NVM1
OpenTargetsiENSG00000142694
PharmGKBiPA162387367
VEuPathDBiHostDB:ENSG00000142694.6

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RYRK, Eukaryota
GeneTreeiENSGT00940000154096
HOGENOMiCLU_104871_0_0_1
InParanoidiQ9NVM1
OMAiVGRVHYY
OrthoDBi1563157at2759
PhylomeDBiQ9NVM1
TreeFamiTF352986

Enzyme and pathway databases

PathwayCommonsiQ9NVM1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
55194, 2 hits in 992 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55194
PharosiQ9NVM1, Tdark

Protein Ontology

More...
PROi
PR:Q9NVM1
RNActiQ9NVM1, protein

Gene expression databases

BgeeiENSG00000142694, Expressed in stomach and 195 other tissues
GenevisibleiQ9NVM1, HS

Family and domain databases

InterProiView protein in InterPro
IPR039500, EVA1_dom
IPR039502, EVA1B
PANTHERiPTHR46780:SF2, PTHR46780:SF2, 1 hit
PfamiView protein in Pfam
PF14851, FAM176, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEVA1B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NVM1
Secondary accession number(s): D3DPS7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2000
Last modified: June 2, 2021
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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