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UniProtKB - Q9NVK5 (FGOP2_HUMAN)

Entry version 134 (10 Feb 2021)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
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Protein

FGFR1 oncogene partner 2

Gene

FGFR1OP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in wound healing pathway.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NVK5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1839117, Signaling by cytosolic FGFR1 fusion mutants
R-HSA-5655302, Signaling by FGFR1 in disease

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FGFR1 oncogene partner 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FGFR1OP2
ORF Names:HSPC123
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23098, FGFR1OP2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608858, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NVK5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000111790.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei132 – 133Breakpoint for translocation to form FGFR1OP2-FGFR12

Organism-specific databases

DisGeNET

More...DisGeNETi		26127

Open Targets

More...OpenTargetsi		ENSG00000111790

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134972108

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NVK5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FGFR1OP2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74734519

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002990411 – 253FGFR1 oncogene partner 2Add BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei141PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NVK5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NVK5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NVK5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NVK5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NVK5

PeptideAtlas

More...PeptideAtlasi		Q9NVK5

PRoteomics IDEntifications database

More...PRIDEi		Q9NVK5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82818 [Q9NVK5-1]
82819 [Q9NVK5-2]
82820 [Q9NVK5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NVK5

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9NVK5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NVK5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in bone marrow, spleen and thymus.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000111790, Expressed in corpus callosum and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NVK5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NVK5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000111790, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117566, 76 interactors

Protein interaction database and analysis system

More...IntActi		Q9NVK5, 57 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000229395

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NVK5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NVK5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili5 – 104Sequence analysisAdd BLAST100
Coiled coili160 – 223Sequence analysisAdd BLAST64

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SIKE family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSAD, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018003

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_073167_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NVK5

Identification of Orthologs from Complete Genome Data

More...OMAi		DHENTAD

Database of Orthologous Groups

More...OrthoDBi		1368908at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NVK5

TreeFam database of animal gene trees

More...TreeFami		TF324337

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008555, SIKE

The PANTHER Classification System

More...PANTHERi		PTHR12186, PTHR12186, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05769, SIKE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NVK5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSCTIEKALA DAKALVERLR DHDDAAESLI EQTTALNKRV EAMKQYQEEI 
        60         70         80         90        100
QELNEVARHR PRSTLVMGIQ QENRQIRELQ QENKELRTSL EEHQSALELI 
       110        120        130        140        150
MSKYREQMFR LLMASKKDDP GIIMKLKEQH SKIDMVHRNK SEGFFLDASR 
       160        170        180        190        200
HILEAPQHGL ERRHLEANQN ELQAHVDQIT EMAAVMRKAI EIDEQQGCKE 
       210        220        230        240        250
QERIFQLEQE NKGLREILQI TRESFLNLRK DDASESTSLS ALVTNSDLSL 

RKS
Length:253
Mass (Da):29,426
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i89F60BF3F96C3436
GO
Isoform 2 (identifier: Q9NVK5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-170: Missing.

Show »
Length:215
Mass (Da):24,977
Checksum:i7714CC13876AFF6D
GO
Isoform 3 (identifier: Q9NVK5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-172: EL → VH
     173-253: Missing.

Show »
Length:172
Mass (Da):20,175
Checksum:i9270EF83F7B77D0C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GX47F5GX47_HUMAN
FGFR1 oncogene partner 2
FGFR1OP2
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF29087 differs from that shown. Reason: Frameshift.Curated
The sequence CAB56012 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti47Q → W in CAB56012 (PubMed:17974005).Curated1
Sequence conflicti227N → T in AAR91611 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027538133 – 170Missing in isoform 2. 3 PublicationsAdd BLAST38
Alternative sequenceiVSP_027539171 – 172EL → VH in isoform 3. 1 Publication2
Alternative sequenceiVSP_027540173 – 253Missing in isoform 3. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF161472 mRNA Translation: AAF29087.1 Frameshift.
AK001534 mRNA Translation: BAA91745.1
AY506561 mRNA Translation: AAR91611.1
BC032143 mRNA Translation: AAH32143.1
AL117608 mRNA Translation: CAB56012.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53766.1 [Q9NVK5-3]
CCDS53767.1 [Q9NVK5-2]
CCDS8709.1 [Q9NVK5-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T17322

NCBI Reference Sequences

More...RefSeqi		NP_001165358.1, NM_001171887.1 [Q9NVK5-2]
NP_001165359.1, NM_001171888.1 [Q9NVK5-3]
NP_056448.1, NM_015633.2 [Q9NVK5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000229395; ENSP00000229395; ENSG00000111790 [Q9NVK5-1]
ENST00000327214; ENSP00000323763; ENSG00000111790 [Q9NVK5-2]
ENST00000546072; ENSP00000437556; ENSG00000111790 [Q9NVK5-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26127

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:26127

UCSC genome browser

More...UCSCi		uc001rhl.4, human [Q9NVK5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161472 mRNA Translation: AAF29087.1 Frameshift.
AK001534 mRNA Translation: BAA91745.1
AY506561 mRNA Translation: AAR91611.1
BC032143 mRNA Translation: AAH32143.1
AL117608 mRNA Translation: CAB56012.1 Frameshift.
CCDSiCCDS53766.1 [Q9NVK5-3]
CCDS53767.1 [Q9NVK5-2]
CCDS8709.1 [Q9NVK5-1]
PIRiT17322
RefSeqiNP_001165358.1, NM_001171887.1 [Q9NVK5-2]
NP_001165359.1, NM_001171888.1 [Q9NVK5-3]
NP_056448.1, NM_015633.2 [Q9NVK5-1]

3D structure databases

SMRiQ9NVK5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117566, 76 interactors
IntActiQ9NVK5, 57 interactors
STRINGi9606.ENSP00000229395

PTM databases

iPTMnetiQ9NVK5
MetOSiteiQ9NVK5
PhosphoSitePlusiQ9NVK5

Genetic variation databases

BioMutaiFGFR1OP2
DMDMi74734519

Proteomic databases

EPDiQ9NVK5
jPOSTiQ9NVK5
MassIVEiQ9NVK5
MaxQBiQ9NVK5
PaxDbiQ9NVK5
PeptideAtlasiQ9NVK5
PRIDEiQ9NVK5
ProteomicsDBi82818 [Q9NVK5-1]
82819 [Q9NVK5-2]
82820 [Q9NVK5-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24359, 208 antibodies

Genome annotation databases

EnsembliENST00000229395; ENSP00000229395; ENSG00000111790 [Q9NVK5-1]
ENST00000327214; ENSP00000323763; ENSG00000111790 [Q9NVK5-2]
ENST00000546072; ENSP00000437556; ENSG00000111790 [Q9NVK5-3]
GeneIDi26127
KEGGihsa:26127
UCSCiuc001rhl.4, human [Q9NVK5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26127
DisGeNETi26127

GeneCards: human genes, protein and diseases

More...GeneCardsi		FGFR1OP2
HGNCiHGNC:23098, FGFR1OP2
HPAiENSG00000111790, Low tissue specificity
MIMi608858, gene
neXtProtiNX_Q9NVK5
OpenTargetsiENSG00000111790
PharmGKBiPA134972108
VEuPathDBiHostDB:ENSG00000111790.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QSAD, Eukaryota
GeneTreeiENSGT00390000018003
HOGENOMiCLU_073167_1_0_1
InParanoidiQ9NVK5
OMAiDHENTAD
OrthoDBi1368908at2759
PhylomeDBiQ9NVK5
TreeFamiTF324337

Enzyme and pathway databases

PathwayCommonsiQ9NVK5
ReactomeiR-HSA-1839117, Signaling by cytosolic FGFR1 fusion mutants
R-HSA-5655302, Signaling by FGFR1 in disease

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		26127, 71 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FGFR1OP2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		26127
PharosiQ9NVK5, Tbio

Protein Ontology

More...PROi		PR:Q9NVK5
RNActiQ9NVK5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000111790, Expressed in corpus callosum and 216 other tissues
ExpressionAtlasiQ9NVK5, baseline and differential
GenevisibleiQ9NVK5, HS

Family and domain databases

InterProiView protein in InterPro
IPR008555, SIKE
PANTHERiPTHR12186, PTHR12186, 1 hit
PfamiView protein in Pfam
PF05769, SIKE, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFGOP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NVK5
Secondary accession number(s): Q6R955
, Q8N5L7, Q9P034, Q9UFK8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 1, 2000
Last modified: February 10, 2021
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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