UniProtKB - Q9NVK5 (FGOP2_HUMAN)
Protein
FGFR1 oncogene partner 2
Gene
FGFR1OP2
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in wound healing pathway.By similarity
GO - Molecular functioni
- identical protein binding Source: Ensembl
GO - Biological processi
- response to wounding Source: GO_Central
- wound healing Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q9NVK5 |
Reactomei | R-HSA-1839117, Signaling by cytosolic FGFR1 fusion mutants R-HSA-5655302, Signaling by FGFR1 in disease |
Names & Taxonomyi
Protein namesi | Recommended name: FGFR1 oncogene partner 2 |
Gene namesi | Name:FGFR1OP2 ORF Names:HSPC123 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23098, FGFR1OP2 |
MIMi | 608858, gene |
neXtProti | NX_Q9NVK5 |
VEuPathDBi | HostDB:ENSG00000111790.13 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 132 – 133 | Breakpoint for translocation to form FGFR1OP2-FGFR1 | 2 |
Organism-specific databases
DisGeNETi | 26127 |
OpenTargetsi | ENSG00000111790 |
PharmGKBi | PA134972108 |
Miscellaneous databases
Pharosi | Q9NVK5, Tbio |
Genetic variation databases
BioMutai | FGFR1OP2 |
DMDMi | 74734519 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299041 | 1 – 253 | FGFR1 oncogene partner 2Add BLAST | 253 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 141 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NVK5 |
jPOSTi | Q9NVK5 |
MassIVEi | Q9NVK5 |
MaxQBi | Q9NVK5 |
PaxDbi | Q9NVK5 |
PeptideAtlasi | Q9NVK5 |
PRIDEi | Q9NVK5 |
ProteomicsDBi | 82818 [Q9NVK5-1] 82819 [Q9NVK5-2] 82820 [Q9NVK5-3] |
PTM databases
iPTMneti | Q9NVK5 |
MetOSitei | Q9NVK5 |
PhosphoSitePlusi | Q9NVK5 |
Expressioni
Tissue specificityi
Expressed in bone marrow, spleen and thymus.
Gene expression databases
Bgeei | ENSG00000111790, Expressed in corpus callosum and 216 other tissues |
ExpressionAtlasi | Q9NVK5, baseline and differential |
Genevisiblei | Q9NVK5, HS |
Organism-specific databases
HPAi | ENSG00000111790, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9NVK5
With | #Exp. | IntAct |
---|---|---|
HAUS1 [Q96CS2] | 3 | EBI-1104764,EBI-2514791 |
Isoform 3 [Q9NVK5-3]
With | #Exp. | IntAct |
---|---|---|
UBASH3A - isoform 2 [P57075-2] | 3 | EBI-12377025,EBI-7353612 |
ZC2HC1C - isoform 2 [Q53FD0-2] | 3 | EBI-12377025,EBI-14104088 |
GO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 117566, 76 interactors |
IntActi | Q9NVK5, 57 interactors |
STRINGi | 9606.ENSP00000229395 |
Miscellaneous databases
RNActi | Q9NVK5, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 5 – 104 | Sequence analysisAdd BLAST | 100 | |
Coiled coili | 160 – 223 | Sequence analysisAdd BLAST | 64 |
Sequence similaritiesi
Belongs to the SIKE family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QSAD, Eukaryota |
GeneTreei | ENSGT00390000018003 |
HOGENOMi | CLU_073167_1_0_1 |
InParanoidi | Q9NVK5 |
OMAi | DHENTAD |
OrthoDBi | 1368908at2759 |
PhylomeDBi | Q9NVK5 |
TreeFami | TF324337 |
Family and domain databases
InterProi | View protein in InterPro IPR008555, SIKE |
PANTHERi | PTHR12186, PTHR12186, 1 hit |
Pfami | View protein in Pfam PF05769, SIKE, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NVK5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSCTIEKALA DAKALVERLR DHDDAAESLI EQTTALNKRV EAMKQYQEEI
60 70 80 90 100
QELNEVARHR PRSTLVMGIQ QENRQIRELQ QENKELRTSL EEHQSALELI
110 120 130 140 150
MSKYREQMFR LLMASKKDDP GIIMKLKEQH SKIDMVHRNK SEGFFLDASR
160 170 180 190 200
HILEAPQHGL ERRHLEANQN ELQAHVDQIT EMAAVMRKAI EIDEQQGCKE
210 220 230 240 250
QERIFQLEQE NKGLREILQI TRESFLNLRK DDASESTSLS ALVTNSDLSL
RKS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF5GX47 | F5GX47_HUMAN | FGFR1 oncogene partner 2 | FGFR1OP2 | 60 | Annotation score: |
Sequence cautioni
The sequence AAF29087 differs from that shown. Reason: Frameshift.Curated
The sequence CAB56012 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 47 | Q → W in CAB56012 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 227 | N → T in AAR91611 (Ref. 3) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027538 | 133 – 170 | Missing in isoform 2. 3 PublicationsAdd BLAST | 38 | |
Alternative sequenceiVSP_027539 | 171 – 172 | EL → VH in isoform 3. 1 Publication | 2 | |
Alternative sequenceiVSP_027540 | 173 – 253 | Missing in isoform 3. 1 PublicationAdd BLAST | 81 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF161472 mRNA Translation: AAF29087.1 Frameshift. AK001534 mRNA Translation: BAA91745.1 AY506561 mRNA Translation: AAR91611.1 BC032143 mRNA Translation: AAH32143.1 AL117608 mRNA Translation: CAB56012.1 Frameshift. |
CCDSi | CCDS53766.1 [Q9NVK5-3] CCDS53767.1 [Q9NVK5-2] CCDS8709.1 [Q9NVK5-1] |
PIRi | T17322 |
RefSeqi | NP_001165358.1, NM_001171887.1 [Q9NVK5-2] NP_001165359.1, NM_001171888.1 [Q9NVK5-3] NP_056448.1, NM_015633.2 [Q9NVK5-1] |
Genome annotation databases
Ensembli | ENST00000229395; ENSP00000229395; ENSG00000111790 [Q9NVK5-1] ENST00000327214; ENSP00000323763; ENSG00000111790 [Q9NVK5-2] ENST00000546072; ENSP00000437556; ENSG00000111790 [Q9NVK5-3] |
GeneIDi | 26127 |
KEGGi | hsa:26127 |
UCSCi | uc001rhl.4, human [Q9NVK5-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF161472 mRNA Translation: AAF29087.1 Frameshift. AK001534 mRNA Translation: BAA91745.1 AY506561 mRNA Translation: AAR91611.1 BC032143 mRNA Translation: AAH32143.1 AL117608 mRNA Translation: CAB56012.1 Frameshift. |
CCDSi | CCDS53766.1 [Q9NVK5-3] CCDS53767.1 [Q9NVK5-2] CCDS8709.1 [Q9NVK5-1] |
PIRi | T17322 |
RefSeqi | NP_001165358.1, NM_001171887.1 [Q9NVK5-2] NP_001165359.1, NM_001171888.1 [Q9NVK5-3] NP_056448.1, NM_015633.2 [Q9NVK5-1] |
3D structure databases
SMRi | Q9NVK5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117566, 76 interactors |
IntActi | Q9NVK5, 57 interactors |
STRINGi | 9606.ENSP00000229395 |
PTM databases
iPTMneti | Q9NVK5 |
MetOSitei | Q9NVK5 |
PhosphoSitePlusi | Q9NVK5 |
Genetic variation databases
BioMutai | FGFR1OP2 |
DMDMi | 74734519 |
Proteomic databases
EPDi | Q9NVK5 |
jPOSTi | Q9NVK5 |
MassIVEi | Q9NVK5 |
MaxQBi | Q9NVK5 |
PaxDbi | Q9NVK5 |
PeptideAtlasi | Q9NVK5 |
PRIDEi | Q9NVK5 |
ProteomicsDBi | 82818 [Q9NVK5-1] 82819 [Q9NVK5-2] 82820 [Q9NVK5-3] |
Protocols and materials databases
Antibodypediai | 24359, 208 antibodies |
Genome annotation databases
Ensembli | ENST00000229395; ENSP00000229395; ENSG00000111790 [Q9NVK5-1] ENST00000327214; ENSP00000323763; ENSG00000111790 [Q9NVK5-2] ENST00000546072; ENSP00000437556; ENSG00000111790 [Q9NVK5-3] |
GeneIDi | 26127 |
KEGGi | hsa:26127 |
UCSCi | uc001rhl.4, human [Q9NVK5-1] |
Organism-specific databases
CTDi | 26127 |
DisGeNETi | 26127 |
GeneCardsi | FGFR1OP2 |
HGNCi | HGNC:23098, FGFR1OP2 |
HPAi | ENSG00000111790, Low tissue specificity |
MIMi | 608858, gene |
neXtProti | NX_Q9NVK5 |
OpenTargetsi | ENSG00000111790 |
PharmGKBi | PA134972108 |
VEuPathDBi | HostDB:ENSG00000111790.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSAD, Eukaryota |
GeneTreei | ENSGT00390000018003 |
HOGENOMi | CLU_073167_1_0_1 |
InParanoidi | Q9NVK5 |
OMAi | DHENTAD |
OrthoDBi | 1368908at2759 |
PhylomeDBi | Q9NVK5 |
TreeFami | TF324337 |
Enzyme and pathway databases
PathwayCommonsi | Q9NVK5 |
Reactomei | R-HSA-1839117, Signaling by cytosolic FGFR1 fusion mutants R-HSA-5655302, Signaling by FGFR1 in disease |
Miscellaneous databases
BioGRID-ORCSi | 26127, 71 hits in 875 CRISPR screens |
ChiTaRSi | FGFR1OP2, human |
GenomeRNAii | 26127 |
Pharosi | Q9NVK5, Tbio |
PROi | PR:Q9NVK5 |
RNActi | Q9NVK5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000111790, Expressed in corpus callosum and 216 other tissues |
ExpressionAtlasi | Q9NVK5, baseline and differential |
Genevisiblei | Q9NVK5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008555, SIKE |
PANTHERi | PTHR12186, PTHR12186, 1 hit |
Pfami | View protein in Pfam PF05769, SIKE, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FGOP2_HUMAN | |
Accessioni | Q9NVK5Primary (citable) accession number: Q9NVK5 Secondary accession number(s): Q6R955 Q9UFK8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families