ARL8B

Functionⁱ

May play a role in lysosome motility (PubMed:16537643, PubMed:25898167). May play a role in chromosome segregation (PubMed:15331635).3 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	29 – 35	GTP	7
Nucleotide bindingⁱ	71 – 75	GTPBy similarity	5
Nucleotide bindingⁱ	130 – 133	GTP	4

GO - Molecular functionⁱ

alpha-tubulin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15331635
beta-tubulin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15331635
GDP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15331635
GTPase activity
Source: UniProtKB
Non-traceable author statementⁱ
- 15331635
GTP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15331635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cell division Source: UniProtKB-KW
chromosome segregation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 14871887
lysosome localization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25898167

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division
Ligand	GTP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ADP-ribosylation factor-like protein 8B Alternative name(s): ADP-ribosylation factor-like protein 10C Novel small G protein indispensable for equal chromosome segregation 1
Gene namesⁱ	Name:ARL8B Synonyms:ARL10C, GIE1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000134108.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25564 ARL8B
MIMⁱ	616596 gene
neXtProtⁱ	NX_Q9NVJ2

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Intramembraneⁱ	1 – 19	Note=Mediates targeting to membranesAdd BLAST		19

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Endosome, Lysosome, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	2	L → A: Diffuse cytoplasmic distribution and loss of localization to lysosomes. No effect on acetylation. 1 Publication	1
Mutagenesisⁱ	2	L → F: No effect on localization and acetylation. 1 Publication	1
Mutagenesisⁱ	5 – 12	ISRLLDWF → ASRALDWA: Diffuse cytoplasmic distribution and loss of localization to lysosomes. No effect on acetylation. 1 Publication	8
Mutagenesisⁱ	34	T → N: Preferentially binds GDP. Alters chromosome segregation. 1 Publication	1
Mutagenesisⁱ	49 – 58	Missing : Alters chromosome segregation. 1 Publication	10
Mutagenesisⁱ	70	W → R: Preferentially binds GTP. 1 Publication	1
Mutagenesisⁱ	74 – 85	Missing : Alters chromosome segregation. 1 PublicationAdd BLAST	12
Mutagenesisⁱ	75	Q → L: Prevents GTP hydrolysis. No effect on localization. Alters lysosomes cellular distribution and motility. 1 Publication	1
Mutagenesisⁱ	130	N → I: Loss of GTP/GDP-binding. Affects chromosome segregation. 1 Publication	1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000134108
PharmGKBⁱ	PA134959531

Polymorphism and mutation databases

BioMutaⁱ	ARL8B
DMDMⁱ	74752996

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000232921	1 – 186	ADP-ribosylation factor-like protein 8BAdd BLAST		186

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources1 Publication		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q9NVJ2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NVJ2
PaxDbⁱ	Q9NVJ2
PeptideAtlas More...PeptideAtlasⁱ	Q9NVJ2
PRIDEⁱ	Q9NVJ2
ProteomicsDBⁱ	82817
TopDownProteomicsⁱ	Q9NVJ2-1 [Q9NVJ2-1]

PTM databases

iPTMnetⁱ	Q9NVJ2
PhosphoSitePlusⁱ	Q9NVJ2
SwissPalmⁱ	Q9NVJ2

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000134108 Expressed in 229 organ(s), highest expression level in middle temporal gyrus
CleanExⁱ	HS_ARL8B
ExpressionAtlasⁱ	Q9NVJ2 baseline and differential
Genevisibleⁱ	Q9NVJ2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038759 HPA040515 HPA045924

HPAⁱ

HPA038759
HPA040515
HPA045924

Interactionⁱ

Subunit structureⁱ

Interacts with tubulin (PubMed:15331635, Ref. 16). Interacts with BORCS5; recruits ARL8B to lysosomes (PubMed:25898167).3 Publications

GO - Molecular functionⁱ

alpha-tubulin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15331635
beta-tubulin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15331635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	120503, 36 interactors
IntActⁱ	Q9NVJ2, 13 interactors
Molecular INTeraction database More...MINTⁱ	Q9NVJ2
STRINGⁱ	9606.ENSP00000256496

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	19 – 26	Combined sources	8
Helixⁱ	33 – 40	Combined sources	8
Beta strandⁱ	55 – 62	Combined sources	8
Beta strandⁱ	65 – 72	Combined sources	8
Helixⁱ	76 – 81	Combined sources	6
Helixⁱ	82 – 86	Combined sources	5
Beta strandⁱ	90 – 97	Combined sources	8
Helixⁱ	101 – 103	Combined sources	3
Helixⁱ	104 – 115	Combined sources	12
Helixⁱ	118 – 120	Combined sources	3
Beta strandⁱ	125 – 130	Combined sources	6
Helixⁱ	140 – 146	Combined sources	7
Helixⁱ	149 – 151	Combined sources	3
Beta strandⁱ	157 – 161	Combined sources	5
Turnⁱ	164 – 167	Combined sources	4
Helixⁱ	170 – 178	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9NVJ2
SMRⁱ	Q9NVJ2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9NVJ2

EvolutionaryTraceⁱ

Q9NVJ2

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0075 Eukaryota ENOG410XNUK LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00780000121855
HOGENOMⁱ	HOG000163692
HOVERGENⁱ	HBG105214
InParanoidⁱ	Q9NVJ2
KEGG Orthology (KO) More...KOⁱ	K07955
OMAⁱ	SCYSCSM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0USZ
PhylomeDBⁱ	Q9NVJ2
TreeFamⁱ	TF105470

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR006689 Small_GTPase_ARF/SAR
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00025 Arf, 1 hit
PRINTSⁱ	PR00328 SAR1GTPBP
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51417 ARF, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NVJ2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLALISRLLD WFRSLFWKEE MELTLVGLQY SGKTTFVNVI ASGQFSEDMI 
        60         70         80         90        100
PTVGFNMRKV TKGNVTIKIW DIGGQPRFRS MWERYCRGVN AIVYMIDAAD 
       110        120        130        140        150
REKIEASRNE LHNLLDKPQL QGIPVLVLGN KRDLPNALDE KQLIEKMNLS 
       160        170        180 
AIQDREICCY SISCKEKDNI DITLQWLIQH SKSRRS

Length:186

Mass (Da):21,539

Last modified:October 1, 2000 - v1

Checksum:ⁱ5030B01AFD749223

GO

Isoform 2 (identifier: Q9NVJ2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
125-186: VLVLGNKRDL...LIQHSKSRRS → ISHFSGLFSI...ILELLSVPLK

« Hide

        10         20         30         40         50
MLALISRLLD WFRSLFWKEE MELTLVGLQY SGKTTFVNVI ASGQFSEDMI 
        60         70         80         90        100
PTVGFNMRKV TKGNVTIKIW DIGGQPRFRS MWERYCRGVN AIVYMIDAAD 
       110        120        130        140        150
REKIEASRNE LHNLLDKPQL QGIPISHFSG LFSIQNLEEA EASPEVFQSF 
       160 
LAIILELLSV PLK

Note: No experimental confirmation available.

Show »

Length:163

Mass (Da):18,642

Checksum:ⁱBAD320672EA343D5

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F2Z344	F2Z344_HUMAN	ADP-ribosylation factor-like protei... ADP-ribosylation factor-like protein 8B	ARL8B	103	Annotation score:
F8WAW5	F8WAW5_HUMAN	ADP-ribosylation factor-like protei... ADP-ribosylation factor-like protein 8B	ARL8B	102	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056238	125 – 186	VLVLG…KSRRS → ISHFSGLFSIQNLEEAEASP EVFQSFLAIILELLSVPLK in isoform 2. 1 PublicationAdd BLAST		62

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB118751 mRNA Translation: BAD23992.1 AK001564 mRNA Translation: BAA91759.1 AK295465 mRNA Translation: BAG58397.1 CR457264 mRNA Translation: CAG33545.1 AC021999 Genomic DNA No translation available. AC026202 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW63919.1 BC013131 mRNA Translation: AAH13131.1 BC063125 mRNA Translation: AAH63125.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2566.1 [Q9NVJ2-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_060654.1, NM_018184.2 [Q9NVJ2-1]
UniGeneⁱ	Hs.250009

Genome annotation databases

Ensemblⁱ	ENST00000256496; ENSP00000256496; ENSG00000134108 [Q9NVJ2-1] ENST00000419534; ENSP00000402996; ENSG00000134108 [Q9NVJ2-2] ENST00000611208; ENSP00000479202; ENSG00000134108 [Q9NVJ2-1]
GeneIDⁱ	55207
KEGGⁱ	hsa:55207
UCSC genome browser More...UCSCⁱ	uc003bqg.4 human [Q9NVJ2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NVJ2	ADP-ribosylation factor-like protein 8B		MOUSE		186	UniRef100_Q9NVJ2
ADP-ribosylation factor-like protein 8B		RAT		186
Uncharacterized protein (Fragment)		AILME		93
ADP-ribosylation factor-like protein 8B (Fragment)		NEOVI		170
ADP-ribosylation factor-like protein 8B-like protein (Fragment)		HORSE		158
+38
Q9NVJ2-2	ADP ribosylation factor like GTPase 8B		PANTR		163	UniRef100_A0A2I3TXN1
ADP ribosylation factor like GTPase 8B		SAIBB		163
Uncharacterized protein		MACMU		163
Uncharacterized protein		COLAP		163
Uncharacterized protein		Cebus capucinus imitator		163
+9

Protein	Similar proteins		Species	Score	Length	Source
Q9NVJ2	ADP-ribosylation factor-like protein 8B		MOUSE		186	UniRef90_Q9NVJ2
ADP-ribosylation factor-like protein 8B		RAT		186
Uncharacterized protein (Fragment)		AILME		93
ADP-ribosylation factor-like protein 8B (Fragment)		NEOVI		170
ADP-ribosylation factor-like protein 8B-like protein (Fragment)		HORSE		158
+55
Q9NVJ2-2	ADP ribosylation factor like GTPase 8B		PANTR		163	UniRef90_A0A2I3TXN1
ADP ribosylation factor like GTPase 8B		SAIBB		163
Uncharacterized protein		MACMU		163
Uncharacterized protein		COLAP		163
Uncharacterized protein		Cebus capucinus imitator		163
+19

Protein	Similar proteins		Species	Score	Length	Source
Q9NVJ2	ADP-ribosylation factor-like protein 8B		MOUSE		186	UniRef50_Q9NVJ2
ADP-ribosylation factor-like protein 8B		RAT		186
Uncharacterized protein (Fragment)		AILME		93
ADP-ribosylation factor-like protein 8B (Fragment)		NEOVI		170
ADP-ribosylation factor-like protein 8B-like protein (Fragment)		HORSE		158
+66
Q9NVJ2-2	ADP ribosylation factor like GTPase 8B		FICAL		169	UniRef50_U3KGM0
Adp-ribosylation factor-like protein 8c		QUESU		170
Uncharacterized protein		PRUPE		147
p-loop containing nucleoside triphosphate hydrolase protein		Rhizoclosmatium globosum		178
Uncharacterized protein		RHIRO		163
+56

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB118751 mRNA Translation: BAD23992.1 AK001564 mRNA Translation: BAA91759.1 AK295465 mRNA Translation: BAG58397.1 CR457264 mRNA Translation: CAG33545.1 AC021999 Genomic DNA No translation available. AC026202 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW63919.1 BC013131 mRNA Translation: AAH13131.1 BC063125 mRNA Translation: AAH63125.1
CCDSⁱ	CCDS2566.1 [Q9NVJ2-1]
RefSeqⁱ	NP_060654.1, NM_018184.2 [Q9NVJ2-1]
UniGeneⁱ	Hs.250009

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2AL7	X-ray	1.85	A	18-184	[»]
ProteinModelPortalⁱ	Q9NVJ2
SMRⁱ	Q9NVJ2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120503, 36 interactors
IntActⁱ	Q9NVJ2, 13 interactors
MINTⁱ	Q9NVJ2
STRINGⁱ	9606.ENSP00000256496

PTM databases

iPTMnetⁱ	Q9NVJ2
PhosphoSitePlusⁱ	Q9NVJ2
SwissPalmⁱ	Q9NVJ2

Polymorphism and mutation databases

BioMutaⁱ	ARL8B
DMDMⁱ	74752996

Proteomic databases

EPDⁱ	Q9NVJ2
MaxQBⁱ	Q9NVJ2
PaxDbⁱ	Q9NVJ2
PeptideAtlasⁱ	Q9NVJ2
PRIDEⁱ	Q9NVJ2
ProteomicsDBⁱ	82817
TopDownProteomicsⁱ	Q9NVJ2-1 [Q9NVJ2-1]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000256496; ENSP00000256496; ENSG00000134108 [Q9NVJ2-1] ENST00000419534; ENSP00000402996; ENSG00000134108 [Q9NVJ2-2] ENST00000611208; ENSP00000479202; ENSG00000134108 [Q9NVJ2-1]
GeneIDⁱ	55207
KEGGⁱ	hsa:55207
UCSCⁱ	uc003bqg.4 human [Q9NVJ2-1]

Organism-specific databases

CTDⁱ	55207
EuPathDBⁱ	HostDB:ENSG00000134108.12
GeneCardsⁱ	ARL8B
HGNCⁱ	HGNC:25564 ARL8B
HPAⁱ	HPA038759 HPA040515 HPA045924
MIMⁱ	616596 gene
neXtProtⁱ	NX_Q9NVJ2
OpenTargetsⁱ	ENSG00000134108
PharmGKBⁱ	PA134959531
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0075 Eukaryota ENOG410XNUK LUCA
GeneTreeⁱ	ENSGT00780000121855
HOGENOMⁱ	HOG000163692
HOVERGENⁱ	HBG105214
InParanoidⁱ	Q9NVJ2
KOⁱ	K07955
OMAⁱ	SCYSCSM
OrthoDBⁱ	EOG091G0USZ
PhylomeDBⁱ	Q9NVJ2
TreeFamⁱ	TF105470

Miscellaneous databases

ChiTaRSⁱ	ARL8B human
EvolutionaryTraceⁱ	Q9NVJ2
GeneWikiⁱ	ARL8B
GenomeRNAiⁱ	55207
Protein Ontology More...PROⁱ	PR:Q9NVJ2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000134108 Expressed in 229 organ(s), highest expression level in middle temporal gyrus
CleanExⁱ	HS_ARL8B
ExpressionAtlasⁱ	Q9NVJ2 baseline and differential
Genevisibleⁱ	Q9NVJ2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR006689 Small_GTPase_ARF/SAR
Pfamⁱ	View protein in Pfam PF00025 Arf, 1 hit
PRINTSⁱ	PR00328 SAR1GTPBP
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51417 ARF, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ARL8B_HUMAN
Accessionⁱ	Q9NVJ2Primary (citable) accession number: Q9NVJ2 Secondary accession number(s): B4DI85
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NVJ2 (ARL8B_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

ADP-ribosylation factor-like protein 8B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Cytoskeleton

Endosome

Cytoskeleton

Endosome

Extracellular region or secreted

Lysosome

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ