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Protein

DnaJ homolog subfamily C member 11

Gene

DNAJC11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform 1: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex.Curated1 Publication

GO - Biological processi

  • cristae formation Source: UniProtKB

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-HSA-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 11
Gene namesi
Name:DNAJC11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000007923.15
HGNCiHGNC:25570 DNAJC11
MIMi614827 gene
neXtProtiNX_Q9NVH1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55735
OpenTargetsiENSG00000007923
PharmGKBiPA134893823

Polymorphism and mutation databases

BioMutaiDNAJC11
DMDMi110808199

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002471572 – 559DnaJ homolog subfamily C member 11Add BLAST558

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei204PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NVH1
MaxQBiQ9NVH1
PaxDbiQ9NVH1
PeptideAtlasiQ9NVH1
PRIDEiQ9NVH1
ProteomicsDBi82796
82797 [Q9NVH1-2]
82798 [Q9NVH1-3]

PTM databases

iPTMnetiQ9NVH1
PhosphoSitePlusiQ9NVH1
SwissPalmiQ9NVH1

Expressioni

Gene expression databases

BgeeiENSG00000007923
CleanExiHS_DNAJC11
ExpressionAtlasiQ9NVH1 baseline and differential
GenevisibleiQ9NVH1 HS

Organism-specific databases

HPAiHPA028705

Interactioni

Subunit structurei

Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (PubMed:25997101). The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both mitochondrial membranes termed the mitochondrial intermembrane space bridging (MIB) complex.Curated2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HTTP428583EBI-1055336,EBI-466029

Protein-protein interaction databases

BioGridi120854, 48 interactors
CORUMiQ9NVH1
IntActiQ9NVH1, 43 interactors
MINTiQ9NVH1
STRINGi9606.ENSP00000366800

Structurei

3D structure databases

ProteinModelPortaliQ9NVH1
SMRiQ9NVH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 82JPROSITE-ProRule annotationAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili417 – 457Sequence analysisAdd BLAST41

Sequence similaritiesi

Belongs to the DNAJC11 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0718 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00860000133842
HOGENOMiHOG000231113
HOVERGENiHBG080125
InParanoidiQ9NVH1
KOiK09531
OMAiNYYTFLN
OrthoDBiEOG091G050E
PhylomeDBiQ9NVH1
TreeFamiTF105170

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR024586 DnaJ-like_C11_C
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF11875 DUF3395, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.1 Publication
Isoform 1 (identifier: Q9NVH1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATALSEEEL DNEDYYSLLN VRREASSEEL KAAYRRLCML YHPDKHRDPE
60 70 80 90 100
LKSQAERLFN LVHQAYEVLS DPQTRAIYDI YGKRGLEMEG WEVVERRRTP
110 120 130 140 150
AEIREEFERL QREREERRLQ QRTNPKGTIS VGVDATDLFD RYDEEYEDVS
160 170 180 190 200
GSSFPQIEIN KMHISQSIEA PLTATDTAIL SGSLSTQNGN GGGSINFALR
210 220 230 240 250
RVTSAKGWGE LEFGAGDLQG PLFGLKLFRN LTPRCFVTTN CALQFSSRGI
260 270 280 290 300
RPGLTTVLAR NLDKNTVGYL QWRWGIQSAM NTSIVRDTKT SHFTVALQLG
310 320 330 340 350
IPHSFALISY QHKFQDDDQT RVKGSLKAGF FGTVVEYGAE RKISRHSVLG
360 370 380 390 400
AAVSVGVPQG VSLKVKLNRA SQTYFFPIHL TDQLLPSAMF YATVGPLVVY
410 420 430 440 450
FAMHRLIIKP YLRAQKEKEL EKQRESAATD VLQKKQEAES AVRLMQESVR
460 470 480 490 500
RIIEAEESRM GLIIVNAWYG KFVNDKSRKS EKVKVIDVTV PLQCLVKDSK
510 520 530 540 550
LILTEASKAG LPGFYDPCVG EEKNLKVLYQ FRGVLHQVMV LDSEALRIPK

QSHRIDTDG
Length:559
Mass (Da):63,278
Last modified:July 25, 2006 - v2
Checksum:iB16D49B296362800
GO
Isoform 2 (identifier: Q9NVH1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     465-502: Missing.

Show »
Length:521
Mass (Da):58,947
Checksum:iADEAB1206D3FF982
GO
Isoform 3 (identifier: Q9NVH1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     367-418: Missing.

Show »
Length:507
Mass (Da):57,197
Checksum:i72BD808620B5512A
GO

Sequence cautioni

The sequence AAH08772 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti309S → I in BAA91780 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027078267V → M1 PublicationCorresponds to variant dbSNP:rs12137794Ensembl.1
Natural variantiVAR_027079290T → A. Corresponds to variant dbSNP:rs200454Ensembl.1
Natural variantiVAR_055703290T → S1 PublicationCorresponds to variant dbSNP:rs200454Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019932367 – 418Missing in isoform 3. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_019933465 – 502Missing in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336749 mRNA Translation: AAR02411.1
AK001599 mRNA Translation: BAA91780.1
AL031447 Genomic DNA No translation available.
AL159177 Genomic DNA No translation available.
BC006086 mRNA Translation: AAH06086.1
BC008772 mRNA Translation: AAH08772.1 Different initiation.
BC014145 mRNA Translation: AAH14145.1
AL833841 mRNA Translation: CAD38701.1
CCDSiCCDS87.1 [Q9NVH1-1]
RefSeqiNP_060668.2, NM_018198.3 [Q9NVH1-1]
UniGeneiHs.462640

Genome annotation databases

EnsembliENST00000294401; ENSP00000294401; ENSG00000007923 [Q9NVH1-3]
ENST00000377577; ENSP00000366800; ENSG00000007923 [Q9NVH1-1]
GeneIDi55735
KEGGihsa:55735
UCSCiuc001aof.3 human [Q9NVH1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDJC11_HUMAN
AccessioniPrimary (citable) accession number: Q9NVH1
Secondary accession number(s): Q4VWF5
, Q5VZN0, Q6PK20, Q6PK70, Q8NDM2, Q96CL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: July 18, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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