We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q9NVF7 (FBX28_HUMAN)
Protein
F-box only protein 28
Gene
FBXO28
Organism
Homo sapiens (Human)
Status
Functioni
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
By similarityGO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- protein polyubiquitination Source: GO_Central
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9NVF7 |
SignaLinki | Q9NVF7 |
Names & Taxonomyi
Protein namesi | Recommended name: F-box only protein 28 |
Gene namesi | Name:FBXO28 Synonyms:CENP-301 Publication, KIAA0483 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29046, FBXO28 |
MIMi | 609100, gene |
neXtProti | NX_Q9NVF7 |
VEuPathDBi | HostDB:ENSG00000143756 |
Subcellular locationi
Other locations
- kinetochore 1 Publication
Other locations
- kinetochore Source: UniProtKB
Keywords - Cellular componenti
Centromere, Chromosome, KinetochorePathology & Biotechi
Organism-specific databases
DisGeNETi | 23219 |
OpenTargetsi | ENSG00000143756 |
PharmGKBi | PA134876528 |
Miscellaneous databases
Pharosi | Q9NVF7, Tbio |
Genetic variation databases
BioMutai | FBXO28 |
DMDMi | 59797970 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119917 | 1 – 368 | F-box only protein 28Add BLAST | 368 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 235 | PhosphoserineCombined sources | 1 | |
Modified residuei | 242 | PhosphoserineCombined sources | 1 | |
Modified residuei | 270 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 344 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NVF7 |
jPOSTi | Q9NVF7 |
MassIVEi | Q9NVF7 |
MaxQBi | Q9NVF7 |
PaxDbi | Q9NVF7 |
PeptideAtlasi | Q9NVF7 |
PRIDEi | Q9NVF7 |
ProteomicsDBi | 19924 82789 [Q9NVF7-1] |
PTM databases
iPTMneti | Q9NVF7 |
PhosphoSitePlusi | Q9NVF7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000143756, Expressed in hair follicle and 243 other tissues |
ExpressionAtlasi | Q9NVF7, baseline and differential |
Genevisiblei | Q9NVF7, HS |
Organism-specific databases
HPAi | ENSG00000143756, Low tissue specificity |
Interactioni
Subunit structurei
Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
By similarityBinary interactionsi
Q9NVF7
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 116826, 92 interactors |
DIPi | DIP-56683N |
IntActi | Q9NVF7, 62 interactors |
MINTi | Q9NVF7 |
STRINGi | 9606.ENSP00000355827 |
Miscellaneous databases
RNActi | Q9NVF7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 61 – 109 | F-boxPROSITE-ProRule annotationAdd BLAST | 49 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 56 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 328 – 368 | DisorderedSequence analysisAdd BLAST | 41 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 31 – 45 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 342 – 360 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Phylogenomic databases
eggNOGi | ENOG502QT70, Eukaryota |
GeneTreei | ENSGT00390000002970 |
HOGENOMi | CLU_024146_1_1_1 |
InParanoidi | Q9NVF7 |
OMAi | HSLCQKQ |
PhylomeDBi | Q9NVF7 |
TreeFami | TF324672 |
Family and domain databases
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR039719, FBXO28 |
PANTHERi | PTHR13252, PTHR13252, 1 hit |
Pfami | View protein in Pfam PF00646, F-box, 1 hit |
SUPFAMi | SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NVF7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAAEERMA EEGGGGQGDG GSSLASGSTQ RQPPPPAPQH PQPGSQALPA
60 70 80 90 100
PALAPDQLPQ NNTLVALPIV AIENILSFMS YDEISQLRLV CKRMDLVCQR
110 120 130 140 150
MLNQGFLKVE RYHNLCQKQV KAQLPRRESE RRNHSLARHA DILAAVETRL
160 170 180 190 200
SLLNMTFMKY VDSNLCCFIP GKVIDEIYRV LRYVNSTRAP QRAHEVLQEL
210 220 230 240 250
RDISSMAMEY FDEKIVPILK RKLPGSDVSG RLMGSPPVPG PSAALTTMQL
260 270 280 290 300
FSKQNPSRQE VTKLQQQVKT NGAGVTVLRR EISELRTKVQ EQQKQLQDQD
310 320 330 340 350
QKLLEQTQII GEQNARLAEL ERKLREVMES AVGNSSGSGQ NEESPRKRKK
360
ATEAIDSLRK SKRLRNRK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB4E0H5 | B4E0H5_HUMAN | F-box only protein 28 | FBXO28 | 126 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_064713 | 345 | P → H Found in a renal cell carcinoma case; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047265 | 173 – 179 | VIDEIYR → FQDRLQP in isoform 2. Curated | 7 | |
Alternative sequenceiVSP_047266 | 180 – 368 | Missing in isoform 2. CuratedAdd BLAST | 189 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001628 mRNA Translation: BAA91795.1 AL390122 Genomic DNA No translation available. BC031576 mRNA Translation: AAH31576.1 AB007952 mRNA Translation: BAA32327.1 |
CCDSi | CCDS1539.1 [Q9NVF7-1] CCDS44320.1 [Q9NVF7-2] |
RefSeqi | NP_001129587.1, NM_001136115.2 [Q9NVF7-2] NP_055991.1, NM_015176.3 [Q9NVF7-1] |
Genome annotation databases
Ensembli | ENST00000366862; ENSP00000355827; ENSG00000143756 ENST00000424254; ENSP00000416888; ENSG00000143756 [Q9NVF7-2] |
GeneIDi | 23219 |
KEGGi | hsa:23219 |
MANE-Selecti | ENST00000366862.10; ENSP00000355827.5; NM_015176.4; NP_055991.1 |
UCSCi | uc001hoh.3, human [Q9NVF7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001628 mRNA Translation: BAA91795.1 AL390122 Genomic DNA No translation available. BC031576 mRNA Translation: AAH31576.1 AB007952 mRNA Translation: BAA32327.1 |
CCDSi | CCDS1539.1 [Q9NVF7-1] CCDS44320.1 [Q9NVF7-2] |
RefSeqi | NP_001129587.1, NM_001136115.2 [Q9NVF7-2] NP_055991.1, NM_015176.3 [Q9NVF7-1] |
3D structure databases
SMRi | Q9NVF7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116826, 92 interactors |
DIPi | DIP-56683N |
IntActi | Q9NVF7, 62 interactors |
MINTi | Q9NVF7 |
STRINGi | 9606.ENSP00000355827 |
PTM databases
iPTMneti | Q9NVF7 |
PhosphoSitePlusi | Q9NVF7 |
Genetic variation databases
BioMutai | FBXO28 |
DMDMi | 59797970 |
Proteomic databases
EPDi | Q9NVF7 |
jPOSTi | Q9NVF7 |
MassIVEi | Q9NVF7 |
MaxQBi | Q9NVF7 |
PaxDbi | Q9NVF7 |
PeptideAtlasi | Q9NVF7 |
PRIDEi | Q9NVF7 |
ProteomicsDBi | 19924 82789 [Q9NVF7-1] |
Protocols and materials databases
Antibodypediai | 34636, 187 antibodies from 26 providers |
DNASUi | 23219 |
Genome annotation databases
Ensembli | ENST00000366862; ENSP00000355827; ENSG00000143756 ENST00000424254; ENSP00000416888; ENSG00000143756 [Q9NVF7-2] |
GeneIDi | 23219 |
KEGGi | hsa:23219 |
MANE-Selecti | ENST00000366862.10; ENSP00000355827.5; NM_015176.4; NP_055991.1 |
UCSCi | uc001hoh.3, human [Q9NVF7-1] |
Organism-specific databases
CTDi | 23219 |
DisGeNETi | 23219 |
GeneCardsi | FBXO28 |
HGNCi | HGNC:29046, FBXO28 |
HPAi | ENSG00000143756, Low tissue specificity |
MIMi | 609100, gene |
neXtProti | NX_Q9NVF7 |
OpenTargetsi | ENSG00000143756 |
PharmGKBi | PA134876528 |
VEuPathDBi | HostDB:ENSG00000143756 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QT70, Eukaryota |
GeneTreei | ENSGT00390000002970 |
HOGENOMi | CLU_024146_1_1_1 |
InParanoidi | Q9NVF7 |
OMAi | HSLCQKQ |
PhylomeDBi | Q9NVF7 |
TreeFami | TF324672 |
Enzyme and pathway databases
PathwayCommonsi | Q9NVF7 |
SignaLinki | Q9NVF7 |
Miscellaneous databases
BioGRID-ORCSi | 23219, 48 hits in 1092 CRISPR screens |
ChiTaRSi | FBXO28, human |
GeneWikii | FBXO28 |
GenomeRNAii | 23219 |
Pharosi | Q9NVF7, Tbio |
PROi | PR:Q9NVF7 |
RNActi | Q9NVF7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143756, Expressed in hair follicle and 243 other tissues |
ExpressionAtlasi | Q9NVF7, baseline and differential |
Genevisiblei | Q9NVF7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR039719, FBXO28 |
PANTHERi | PTHR13252, PTHR13252, 1 hit |
Pfami | View protein in Pfam PF00646, F-box, 1 hit |
SUPFAMi | SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FBX28_HUMAN | |
Accessioni | Q9NVF7Primary (citable) accession number: Q9NVF7 Secondary accession number(s): E9PEM8, O75070 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot