UniProtKB - Q9NVF7 (FBX28_HUMAN)

BLAST

>sp|Q9NVF7|FBX28_HUMAN F-box only protein 28 OS=Homo sapiens OX=9606 GN=FBXO28 PE=1 SV=1
MAAAAEERMAEEGGGGQGDGGSSLASGSTQRQPPPPAPQHPQPGSQALPAPALAPDQLPQ
NNTLVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQRMLNQGFLKVERYHNLCQKQV
KAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKVIDEIYRV
LRYVNSTRAPQRAHEVLQELRDISSMAMEYFDEKIVPILKRKLPGSDVSGRLMGSPPVPG
PSAALTTMQLFSKQNPSRQEVTKLQQQVKTNGAGVTVLRREISELRTKVQEQQKQLQDQD
QKLLEQTQIIGEQNARLAELERKLREVMESAVGNSSGSGQNEESPRKRKKATEAIDSLRK
SKRLRNRK

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History
Entry version 135 (07 Nov 2018)
Sequence version 1 (01 Oct 2000)
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Protein

F-box only protein 28

Gene

FBXO28

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.By similarity

Keywordsⁱ

Biological process	Ubl conjugation pathway

Biological process

Ubl conjugation pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: F-box only protein 28
Gene namesⁱ	Name:FBXO28 Synonyms:CENP-301 Publication, KIAA0483
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000143756.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29046 FBXO28
MIMⁱ	609100 gene
neXtProtⁱ	NX_Q9NVF7

Keywords - Cellular componentⁱ

Centromere, Chromosome, Kinetochore

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23219
Open Targets More...OpenTargetsⁱ	ENSG00000143756
PharmGKBⁱ	PA134876528

Polymorphism and mutation databases

BioMutaⁱ	FBXO28
DMDMⁱ	59797970

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000119917	1 – 368	F-box only protein 28Add BLAST		368

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	235	PhosphoserineCombined sources	1
Modified residueⁱ	242	PhosphoserineCombined sources	1
Modified residueⁱ	270	PhosphothreonineCombined sources	1
Modified residueⁱ	344	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9NVF7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NVF7
PaxDbⁱ	Q9NVF7
PeptideAtlas More...PeptideAtlasⁱ	Q9NVF7
PRIDEⁱ	Q9NVF7
ProteomicsDBⁱ	82789

PTM databases

iPTMnetⁱ	Q9NVF7
PhosphoSitePlusⁱ	Q9NVF7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000143756 Expressed in 229 organ(s), highest expression level in hair follicle
CleanExⁱ	HS_FBXO28
ExpressionAtlasⁱ	Q9NVF7 baseline and differential
Genevisibleⁱ	Q9NVF7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003289

HPAⁱ

HPA003289

Interactionⁱ

Subunit structureⁱ

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
EMILIN3	Q9NT22	4	EBI-740282,EBI-3197883
GOLGA2	Q08379	6	EBI-740282,EBI-618309
PLEKHF2	Q9H8W4	5	EBI-740282,EBI-742388
SDCBP2	Q9H190	5	EBI-740282,EBI-742426
SKP1	P63208	7	EBI-740282,EBI-307486
SPAG5	Q96R06	3	EBI-740282,EBI-413317
TRAF2	Q12933	5	EBI-740282,EBI-355744

Protein-protein interaction databases

BioGridⁱ	116826, 64 interactors
Database of interacting proteins More...DIPⁱ	DIP-56683N
IntActⁱ	Q9NVF7, 28 interactors
Molecular INTeraction database More...MINTⁱ	Q9NVF7
STRINGⁱ	9606.ENSP00000355827

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NVF7
SMRⁱ	Q9NVF7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	61 – 109	F-boxPROSITE-ProRule annotationAdd BLAST		49

Phylogenomic databases

eggNOGⁱ	ENOG410IJHM Eukaryota ENOG410YPFN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002970
HOGENOMⁱ	HOG000048043
HOVERGENⁱ	HBG051573
InParanoidⁱ	Q9NVF7
KEGG Orthology (KO) More...KOⁱ	K10306
OMAⁱ	NRGFNLM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DWO
PhylomeDBⁱ	Q9NVF7
TreeFamⁱ	TF324672

Family and domain databases

InterProⁱ	View protein in InterPro IPR036047 F-box-like_dom_sf IPR001810 F-box_dom IPR039719 FBXO28
PANTHERⁱ	PTHR13252 PTHR13252, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00646 F-box, 1 hit
SUPFAMⁱ	SSF81383 SSF81383, 1 hit
PROSITEⁱ	View protein in PROSITE PS50181 FBOX, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NVF7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAEERMA EEGGGGQGDG GSSLASGSTQ RQPPPPAPQH PQPGSQALPA 
        60         70         80         90        100
PALAPDQLPQ NNTLVALPIV AIENILSFMS YDEISQLRLV CKRMDLVCQR 
       110        120        130        140        150
MLNQGFLKVE RYHNLCQKQV KAQLPRRESE RRNHSLARHA DILAAVETRL 
       160        170        180        190        200
SLLNMTFMKY VDSNLCCFIP GKVIDEIYRV LRYVNSTRAP QRAHEVLQEL 
       210        220        230        240        250
RDISSMAMEY FDEKIVPILK RKLPGSDVSG RLMGSPPVPG PSAALTTMQL 
       260        270        280        290        300
FSKQNPSRQE VTKLQQQVKT NGAGVTVLRR EISELRTKVQ EQQKQLQDQD 
       310        320        330        340        350
QKLLEQTQII GEQNARLAEL ERKLREVMES AVGNSSGSGQ NEESPRKRKK 
       360 
ATEAIDSLRK SKRLRNRK

Length:368

Mass (Da):41,149

Last modified:October 1, 2000 - v1

Checksum:ⁱ500A2583AB7315E6

Isoform 2 (identifier: Q9NVF7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
173-179: VIDEIYR → FQDRLQP
180-368: Missing.

« Hide

        10         20         30         40         50
MAAAAEERMA EEGGGGQGDG GSSLASGSTQ RQPPPPAPQH PQPGSQALPA 
        60         70         80         90        100
PALAPDQLPQ NNTLVALPIV AIENILSFMS YDEISQLRLV CKRMDLVCQR 
       110        120        130        140        150
MLNQGFLKVE RYHNLCQKQV KAQLPRRESE RRNHSLARHA DILAAVETRL 
       160        170 
SLLNMTFMKY VDSNLCCFIP GKFQDRLQP

Note: Gene prediction based on EST data.

Show »

Length:179

Mass (Da):19,747

Checksum:ⁱ31F64A57FD990AD5

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	B4E0H5	B4E0H5_HUMAN		cDNA FLJ50331, highly similar to F-... cDNA FLJ50331, highly similar to F-box only protein 28	FBXO28	126	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_064713	345	P → H Found in a renal cell carcinoma case; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047265	173 – 179	VIDEIYR → FQDRLQP in isoform 2. Curated		7
Alternative sequenceⁱVSP_047266	180 – 368	Missing in isoform 2. CuratedAdd BLAST		189

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK001628 mRNA Translation: BAA91795.1 AL390122 Genomic DNA No translation available. BC031576 mRNA Translation: AAH31576.1 AB007952 mRNA Translation: BAA32327.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1539.1 [Q9NVF7-1] CCDS44320.1 [Q9NVF7-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001129587.1, NM_001136115.2 [Q9NVF7-2] NP_055991.1, NM_015176.3 [Q9NVF7-1]
UniGeneⁱ	Hs.64691 Hs.713992

Genome annotation databases

Ensemblⁱ	ENST00000366862; ENSP00000355827; ENSG00000143756 [Q9NVF7-1] ENST00000424254; ENSP00000416888; ENSG00000143756 [Q9NVF7-2]
GeneIDⁱ	23219
KEGGⁱ	hsa:23219
UCSC genome browser More...UCSCⁱ	uc001hoh.3 human [Q9NVF7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NVF7	F-box protein 28, isoform CRA_a		HUMAN		368	UniRef100_Q9NVF7
F-box protein 28		PANTR		368
Uncharacterized protein		PANPA		368
F-box protein 28		GORGO		368
cDNA FLJ50331, highly similar to F-box only protein 28		HUMAN		126
+1
Q9NVF7-2	F-box protein 28		PANTR		179	UniRef100_K7B3K1
F-box protein 28		GORGO		179

Protein	Similar proteins		Species	Score	Length	Source
Q9NVF7	F-box only protein 28		BOVIN		368	UniRef90_Q9NVF7
F-box protein 28, isoform CRA_a		HUMAN		368
F-box protein 28		PANTR		368
Uncharacterized protein		PANPA		368
F-box protein 28		GORGO		368
+56
Q9NVF7-2	F-box protein 28		PANTR		179	UniRef90_K7B3K1
F-box protein 28		GORGO		179
Uncharacterized protein		FELCA		180
Uncharacterized protein		Cebus capucinus imitator		180
FBXO28 isoform 3		PONAB		179
+16

Protein	Similar proteins		Species	Score	Length	Source
Q9NVF7	F-box only protein 28		BOVIN		368	UniRef50_Q9NVF7
F-box protein 28, isoform CRA_a		HUMAN		368
F-box protein 28		PANTR		368
Uncharacterized protein		PANPA		368
F-box protein 28		GORGO		368
+72
Q9NVF7-2	F-box protein 28		PANTR		179	UniRef50_K7B3K1
F-box protein 28		GORGO		179
Uncharacterized protein		Cebus capucinus imitator		180
Uncharacterized protein		FELCA		180
FBXO28 isoform 3		PONAB		179
+29

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK001628 mRNA Translation: BAA91795.1 AL390122 Genomic DNA No translation available. BC031576 mRNA Translation: AAH31576.1 AB007952 mRNA Translation: BAA32327.1
CCDSⁱ	CCDS1539.1 [Q9NVF7-1] CCDS44320.1 [Q9NVF7-2]
RefSeqⁱ	NP_001129587.1, NM_001136115.2 [Q9NVF7-2] NP_055991.1, NM_015176.3 [Q9NVF7-1]
UniGeneⁱ	Hs.64691 Hs.713992

3D structure databases

ProteinModelPortalⁱ	Q9NVF7
SMRⁱ	Q9NVF7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116826, 64 interactors
DIPⁱ	DIP-56683N
IntActⁱ	Q9NVF7, 28 interactors
MINTⁱ	Q9NVF7
STRINGⁱ	9606.ENSP00000355827

PTM databases

iPTMnetⁱ	Q9NVF7
PhosphoSitePlusⁱ	Q9NVF7

Polymorphism and mutation databases

BioMutaⁱ	FBXO28
DMDMⁱ	59797970

Proteomic databases

EPDⁱ	Q9NVF7
MaxQBⁱ	Q9NVF7
PaxDbⁱ	Q9NVF7
PeptideAtlasⁱ	Q9NVF7
PRIDEⁱ	Q9NVF7
ProteomicsDBⁱ	82789

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23219
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000366862; ENSP00000355827; ENSG00000143756 [Q9NVF7-1] ENST00000424254; ENSP00000416888; ENSG00000143756 [Q9NVF7-2]
GeneIDⁱ	23219
KEGGⁱ	hsa:23219
UCSCⁱ	uc001hoh.3 human [Q9NVF7-1]

Organism-specific databases

CTDⁱ	23219
DisGeNETⁱ	23219
EuPathDBⁱ	HostDB:ENSG00000143756.11
GeneCardsⁱ	FBXO28
HGNCⁱ	HGNC:29046 FBXO28
HPAⁱ	HPA003289
MIMⁱ	609100 gene
neXtProtⁱ	NX_Q9NVF7
OpenTargetsⁱ	ENSG00000143756
PharmGKBⁱ	PA134876528
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJHM Eukaryota ENOG410YPFN LUCA
GeneTreeⁱ	ENSGT00390000002970
HOGENOMⁱ	HOG000048043
HOVERGENⁱ	HBG051573
InParanoidⁱ	Q9NVF7
KOⁱ	K10306
OMAⁱ	NRGFNLM
OrthoDBⁱ	EOG091G0DWO
PhylomeDBⁱ	Q9NVF7
TreeFamⁱ	TF324672

Miscellaneous databases

ChiTaRSⁱ	FBXO28 human
GeneWikiⁱ	FBXO28
GenomeRNAiⁱ	23219
Protein Ontology More...PROⁱ	PR:Q9NVF7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000143756 Expressed in 229 organ(s), highest expression level in hair follicle
CleanExⁱ	HS_FBXO28
ExpressionAtlasⁱ	Q9NVF7 baseline and differential
Genevisibleⁱ	Q9NVF7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036047 F-box-like_dom_sf IPR001810 F-box_dom IPR039719 FBXO28
PANTHERⁱ	PTHR13252 PTHR13252, 1 hit
Pfamⁱ	View protein in Pfam PF00646 F-box, 1 hit
SUPFAMⁱ	SSF81383 SSF81383, 1 hit
PROSITEⁱ	View protein in PROSITE PS50181 FBOX, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FBX28_HUMAN
Accessionⁱ	Q9NVF7Primary (citable) accession number: Q9NVF7 Secondary accession number(s): E9PEM8, O75070
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q9NVF7 (FBX28_HUMAN)

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F-box only protein 28

FBXO28

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ