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Entry version 170 (29 Sep 2021)
Sequence version 1 (01 Oct 2000)
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Protein

4'-phosphopantetheine phosphatase

Gene

PANK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the physiological regulation of coenzyme A (CoA) intracellular levels (Probable). The phosphatase activity shows preference for normal or oxidatively damaged intermediates of 4'-phosphopantetheine, which provides strong indirect evidence that the phosphatase activity pre-empts damage in the CoA pathway (PubMed:27322068).

Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms (PubMed:27322068).

Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein (PubMed:27322068).

1 Publication1 Publication

Caution

Despite belonging to the type II pantothenate kinase family, the pantothenate kinase domain contains a Val residue at position 147 and a Trp residue at position 211 instead of the two conserved active site residues, Glu and Arg. Lacks pantothenate kinase activity.1 Publication

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+1 Publication, Ni2+1 PublicationNote: Phosphatase activity is strongly promoted by several divalent cation ions but is it suggested that Mn2+ and possibly Ni2+ represent biologically relevant metal ion cofactors for damage-control phosphatases.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activity is strongly promoted by Co2+, Ni2+, Mg2+ and Mn2+ (PubMed:27322068). Activity is inhibited by EDTA (PubMed:27322068).1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.17 sec(-1) with p-nitrophenylphosphate as substrate. kcat is 0.71 sec(-1) with phosphopantetheine as substrate. kcat is 0.09 sec(-1) with 4'-phosphopantothein-sulfonate as substrate.1 Publication
  1. KM=1920 µM for p-nitrophenylphosphate1 Publication
  2. KM=150 µM for phosphopantetheine1 Publication
  3. KM=3.90 µM for 4'-phosphopantotheine-sulfonate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei196Acetyl-CoABy similarity1
Binding sitei199Acetyl-CoABy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi623Manganese; catalytic; for phosphatase activityBy similarity1
Metal bindingi624Manganese; catalytic; for phosphatase activityBy similarity1
Metal bindingi659Manganese; catalytic; for phosphatase activityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Manganese, Metal-binding, Nickel, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS08249-MONOMER

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9NVE7

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-196783, Coenzyme A biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
4'-phosphopantetheine phosphatase1 Publication (EC:3.1.3.-1 Publication)
Alternative name(s):
Inactive pantothenic acid kinase 41 Publication
Short name:
hPanK4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PANK4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19366, PANK4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606162, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NVE7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000157881

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi147V → E: Does not induce acetyl-CoA production. Restores a moderate increase in acetyl-CoA production; when associated with R-211. 1 Publication1
Mutagenesisi211W → R: Does not induce acetyl-CoA production. Restores a moderate increase in acetyl-CoA production; when associated with E-147. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
55229

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
PANK4

MalaCards human disease database

More...
MalaCardsi
PANK4

Open Targets

More...
OpenTargetsi
ENSG00000157881

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
98993, Early-onset posterior polar cataract

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134887214

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NVE7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PANK4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
27805669

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001618062 – 7734'-phosphopantetheine phosphataseAdd BLAST772

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei3203'-nitrotyrosineBy similarity1
Modified residuei393PhosphoserineCombined sources1
Modified residuei404PhosphoserineCombined sources1
Modified residuei406PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Nitration, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NVE7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NVE7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NVE7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NVE7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NVE7

PeptideAtlas

More...
PeptideAtlasi
Q9NVE7

PRoteomics IDEntifications database

More...
PRIDEi
Q9NVE7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82788

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NVE7

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9NVE7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NVE7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9NVE7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed with higher expression in the muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000157881, Expressed in quadriceps femoris and 220 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NVE7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NVE7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000157881, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with PKM.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120524, 39 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NVE7, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000367727

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NVE7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NVE7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 402Pantothenate kinase1 PublicationAdd BLAST401
Regioni403 – 7734'-phosphopantetheine phosphatase1 PublicationAdd BLAST371

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi724 – 728Subfamily II EGMGR motif1 Publication5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Subfamily II proteins have an EGMGR motif about 50 residues from the C-terminus (Probable). This motif lies near the metal-binding residues in the putative substrate-binding cleft 2 (Probable). Subfamily II proteins occur only in eukaryotes, in two forms: as a stand-alone unit in plants, and as a C-terminal domain of pantothenate kinases in plants, animals, and chytrid fungi (Probable).1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the type II pantothenate kinase family.Curated
In the C-terminal section; belongs to the damage-control phosphatase family. Phosphopantetheine phosphatase II subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2201, Eukaryota
KOG4584, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158896

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012496_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NVE7

Identification of Orthologs from Complete Genome Data

More...
OMAi
NHPLSMH

Database of Orthologous Groups

More...
OrthoDBi
865329at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NVE7

TreeFam database of animal gene trees

More...
TreeFami
TF342917

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1700.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036075, AF1104-like_sf
IPR002791, ARMT1-like_metal-bd
IPR035073, At2g17340_3_helix_bundle
IPR043129, ATPase_NBD
IPR015844, PanK_long
IPR004567, Type_II_PanK

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01937, DUF89, 1 hit
PF03630, Fumble, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036939, PanK_long, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111321, SSF111321, 1 hit
SSF53067, SSF53067, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00555, panK_eukar, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q9NVE7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAECGASGSG SSGDSLDKSI TLPPDEIFRN LENAKRFAID IGGSLTKLAY
60 70 80 90 100
YSTVQHKVAK VRSFDHSGKD TEREHEPPYE ISVQEEITAR LHFIKFENTY
110 120 130 140 150
IEACLDFIKD HLVNTETKVI QATGGGAYKF KDLIEEKLRL KVDKEDVMTC
160 170 180 190 200
LIKGCNFVLK NIPHEAFVYQ KDSDPEFRFQ TNHPHIFPYL LVNIGSGVSI
210 220 230 240 250
VKVETEDRFE WVGGSSIGGG TFWGLGALLT KTKKFDELLH LASRGQHSNV
260 270 280 290 300
DMLVRDVYGG AHQTLGLSGN LIASSFGKSA TADQEFSKED MAKSLLHMIS
310 320 330 340 350
NDIGQLACLH ARLHSLDRVY FGGFFIRGHP VTMRTITYSI NFFSKGEVQA
360 370 380 390 400
LFLRHEGYLG AIGAFLKGAE QDNPNQYSWG ENYAGSSGLM SASPELGPAQ
410 420 430 440 450
RARSGTFDLL EMDRLERPLV DLPLLLDPPS YVPDTVDLTD DALARKYWLT
460 470 480 490 500
CFEEALDGVV KRAVASQPDS VDAAERAEKF RQKYWNKLQT LRQQPFAYGT
510 520 530 540 550
LTVRSLLDTR EHCLNEFNFP DPYSKVKQRE NGVALRCFPG VVRSLDALGW
560 570 580 590 600
EERQLALVKG LLAGNVFDWG AKAVSAVLES DPYFGFEEAK RKLQERPWLV
610 620 630 640 650
DSYSEWLQRL KGPPHKCALI FADNSGIDII LGVFPFVREL LLRGTEVILA
660 670 680 690 700
CNSGPALNDV THSESLIVAE RIAGMDPVVH SALQEERLLL VQTGSSSPCL
710 720 730 740 750
DLSRLDKGLA ALVRERGADL VVIEGMGRAV HTNYHAALRC ESLKLAVIKN
760 770
AWLAERLGGR LFSVIFKYEV PAE
Length:773
Mass (Da):85,991
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD55027171A85E8B6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PHT6E9PHT6_HUMAN
4'-phosphopantetheine phosphatase
PANK4
734Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA26H0YA26_HUMAN
Inactive pantothenic acid kinase 4
PANK4
473Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA31H0YA31_HUMAN
4'-phosphopantetheine phosphatase
PANK4
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9E4H0Y9E4_HUMAN
4'-phosphopantetheine phosphatase
PANK4
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA02H0YA02_HUMAN
4'-phosphopantetheine phosphatase
PANK4
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RJF3D6RJF3_HUMAN
4'-phosphopantetheine phosphatase
PANK4
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035470475E → K in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs966358882Ensembl.1
Natural variantiVAR_027409547A → V1 PublicationCorresponds to variant dbSNP:rs7535528Ensembl.1
Natural variantiVAR_015170684Q → R1 PublicationCorresponds to variant dbSNP:rs2494620Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK001644 mRNA Translation: BAA91805.1
AK223546 mRNA Translation: BAD97266.1
AL139246 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56097.1
BC043496 mRNA Translation: AAH43496.1
AL442072 mRNA Translation: CAC09438.1
BK000012 Genomic DNA Translation: DAA00006.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42.2

NCBI Reference Sequences

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RefSeqi
NP_060686.2, NM_018216.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000378466; ENSP00000367727; ENSG00000157881
ENST00000615291; ENSP00000478189; ENSG00000273494

Database of genes from NCBI RefSeq genomes

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GeneIDi
55229

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55229

UCSC genome browser

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UCSCi
uc001ajm.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001644 mRNA Translation: BAA91805.1
AK223546 mRNA Translation: BAD97266.1
AL139246 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56097.1
BC043496 mRNA Translation: AAH43496.1
AL442072 mRNA Translation: CAC09438.1
BK000012 Genomic DNA Translation: DAA00006.1
CCDSiCCDS42.2
RefSeqiNP_060686.2, NM_018216.2

3D structure databases

SMRiQ9NVE7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120524, 39 interactors
IntActiQ9NVE7, 8 interactors
STRINGi9606.ENSP00000367727

PTM databases

iPTMnetiQ9NVE7
MetOSiteiQ9NVE7
PhosphoSitePlusiQ9NVE7
SwissPalmiQ9NVE7

Genetic variation databases

BioMutaiPANK4
DMDMi27805669

Proteomic databases

EPDiQ9NVE7
jPOSTiQ9NVE7
MassIVEiQ9NVE7
MaxQBiQ9NVE7
PaxDbiQ9NVE7
PeptideAtlasiQ9NVE7
PRIDEiQ9NVE7
ProteomicsDBi82788

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1627, 134 antibodies

The DNASU plasmid repository

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DNASUi
55229

Genome annotation databases

EnsembliENST00000378466; ENSP00000367727; ENSG00000157881
ENST00000615291; ENSP00000478189; ENSG00000273494
GeneIDi55229
KEGGihsa:55229
UCSCiuc001ajm.2, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55229
DisGeNETi55229

GeneCards: human genes, protein and diseases

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GeneCardsi
PANK4
GeneReviewsiPANK4
HGNCiHGNC:19366, PANK4
HPAiENSG00000157881, Tissue enhanced (skeletal)
MalaCardsiPANK4
MIMi606162, gene
neXtProtiNX_Q9NVE7
OpenTargetsiENSG00000157881
Orphaneti98993, Early-onset posterior polar cataract
PharmGKBiPA134887214
VEuPathDBiHostDB:ENSG00000157881

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2201, Eukaryota
KOG4584, Eukaryota
GeneTreeiENSGT00940000158896
HOGENOMiCLU_012496_1_1_1
InParanoidiQ9NVE7
OMAiNHPLSMH
OrthoDBi865329at2759
PhylomeDBiQ9NVE7
TreeFamiTF342917

Enzyme and pathway databases

BioCyciMetaCyc:HS08249-MONOMER
PathwayCommonsiQ9NVE7
ReactomeiR-HSA-196783, Coenzyme A biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
55229, 12 hits in 1015 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PANK4, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PANK4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55229
PharosiQ9NVE7, Tbio

Protein Ontology

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PROi
PR:Q9NVE7
RNActiQ9NVE7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000157881, Expressed in quadriceps femoris and 220 other tissues
ExpressionAtlasiQ9NVE7, baseline and differential
GenevisibleiQ9NVE7, HS

Family and domain databases

Gene3Di1.20.1700.10, 1 hit
InterProiView protein in InterPro
IPR036075, AF1104-like_sf
IPR002791, ARMT1-like_metal-bd
IPR035073, At2g17340_3_helix_bundle
IPR043129, ATPase_NBD
IPR015844, PanK_long
IPR004567, Type_II_PanK
PfamiView protein in Pfam
PF01937, DUF89, 1 hit
PF03630, Fumble, 1 hit
PIRSFiPIRSF036939, PanK_long, 1 hit
SUPFAMiSSF111321, SSF111321, 1 hit
SSF53067, SSF53067, 2 hits
TIGRFAMsiTIGR00555, panK_eukar, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPANK4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NVE7
Secondary accession number(s): B9DI84
, Q53EU3, Q5TA84, Q7RTX3, Q9H3X5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: October 1, 2000
Last modified: September 29, 2021
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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