Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 151 (07 Oct 2020)
Sequence version 3 (15 Feb 2005)
Previous versions | rss
Add a publicationFeedback
Protein

Ubiquitin carboxyl-terminal hydrolase 40

Gene

USP40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be catalytically inactive.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei50NucleophilePROSITE-ProRule annotation1
Active sitei305Proton acceptorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NVE5

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C19.069

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 40 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 40
Ubiquitin thioesterase 40
Ubiquitin-specific-processing protease 40
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USP40
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000085982.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20069, USP40

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610570, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NVE5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55230

Open Targets

More...
OpenTargetsi
ENSG00000085982

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134909324

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NVE5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
USP40

Domain mapping of disease mutations (DMDM)

More...
DMDMi
59803114

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000806701 – 1235Ubiquitin carboxyl-terminal hydrolase 40Add BLAST1235

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NVE5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NVE5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NVE5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NVE5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NVE5

PeptideAtlas

More...
PeptideAtlasi
Q9NVE5

PRoteomics IDEntifications database

More...
PRIDEi
Q9NVE5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82785 [Q9NVE5-1]
82786 [Q9NVE5-2]
82787 [Q9NVE5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NVE5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NVE5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000085982, Expressed in intestine and 190 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NVE5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NVE5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000085982, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120525, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NVE5, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000415434

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NVE5, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 482USPAdd BLAST442

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1863, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157267

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009719_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NVE5

KEGG Orthology (KO)

More...
KOi
K11869

Identification of Orthologs from Complete Genome Data

More...
OMAi
HYHVYIR

Database of Orthologous Groups

More...
OrthoDBi
77113at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NVE5

TreeFam database of animal gene trees

More...
TreeFami
TF106281

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR018200, USP_CS
IPR028889, USP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443, UCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NVE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFGDLFEEEY STVSNNQYGK GKKLKTKALE PPAPREFTNL SGIRNQGGTC
60 70 80 90 100
YLNSLLQTLH FTPEFREALF SLGPEELGLF EDKDKPDAKV RIIPLQLQRL
110 120 130 140 150
FAQLLLLDQE AASTADLTDS FGWTSNEEMR QHDVQELNRI LFSALETSLV
160 170 180 190 200
GTSGHDLIYR LYHGTIVNQI VCKECKNVSE RQEDFLDLTV AVKNVSGLED
210 220 230 240 250
ALWNMYVEEE VFDCDNLYHC GTCDRLVKAA KSAKLRKLPP FLTVSLLRFN
260 270 280 290 300
FDFVKCERYK ETSCYTFPLR INLKPFCEQS ELDDLEYIYD LFSVIIHKGG
310 320 330 340 350
CYGGHYHVYI KDVDHLGNWQ FQEEKSKPDV NLKDLQSEEE IDHPLMILKA
360 370 380 390 400
ILLEENNLIP VDQLGQKLLK KIGISWNKKY RKQHGPLRKF LQLHSQIFLL
410 420 430 440 450
SSDESTVRLL KNSSLQAESD FQRNDQQIFK MLPPESPGLN NSISCPHWFD
460 470 480 490 500
INDSKVQPIR EKDIEQQFQG KESAYMLFYR KSQLQRPPEA RANPRYGVPC
510 520 530 540 550
HLLNEMDAAN IELQTKRAEC DSANNTFELH LHLGPQYHFF NGALHPVVSQ
560 570 580 590 600
TESVWDLTFD KRKTLGDLRQ SIFQLLEFWE GDMVLSVAKL VPAGLHIYQS
610 620 630 640 650
LGGDELTLCE TEIADGEDIF VWNGVEVGGV HIQTGIDCEP LLLNVLHLDT
660 670 680 690 700
SSDGEKCCQV IESPHVFPAN AEVGTVLTAL AIPAGVIFIN SAGCPGGEGW
710 720 730 740 750
TAIPKEDMRK TFREQGLRNG SSILIQDSHD DNSLLTKEEK WVTSMNEIDW
760 770 780 790 800
LHVKNLCQLE SEEKQVKISA TVNTMVFDIR IKAIKELKLM KELADNSCLR
810 820 830 840 850
PIDRNGKLLC PVPDSYTLKE AELKMGSSLG LCLGKAPSSS QLFLFFAMGS
860 870 880 890 900
DVQPGTEMEI VVEETISVRD CLKLMLKKSG LQGDAWHLRK MDWCYEAGEP
910 920 930 940 950
LCEEDATLKE LLICSGDTLL LIEGQLPPLG FLKVPIWWYQ LQGPSGHWES
960 970 980 990 1000
HQDQTNCTSS WGRVWRATSS QGASGNEPAQ VSLLYLGDIE ISEDATLAEL
1010 1020 1030 1040 1050
KSQAMTLPPF LEFGVPSPAH LRAWTVERKR PGRLLRTDRQ PLREYKLGRR
1060 1070 1080 1090 1100
IEICLEPLQK GENLGPQDVL LRTQVRIPGE RTYAPALDLV WNAAQGGTAG
1110 1120 1130 1140 1150
SLRQRVADFY RLPVEKIEIA KYFPEKFEWL PISSWNQQIT KRKKKKKQDY
1160 1170 1180 1190 1200
LQGAPYYLKD GDTIGVKNLL IDDDDDFSTI RDDTGKEKQK QRALGRRKSQ
1210 1220 1230
EALHEQSSYI LSSAETPARP RAPETSLSIH VGSFR
Length:1,235
Mass (Da):140,130
Last modified:February 15, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBEB20702566D39A8
GO
Isoform 2 (identifier: Q9NVE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-824: Missing.
     973-987: ASGNEPAQVSLLYLG → ENRMGFQQPVHHKEK
     988-1235: Missing.

Show »
Length:163
Mass (Da):18,298
Checksum:i6DFD238BB2810182
GO
Isoform 3 (identifier: Q9NVE5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSLFLRVVFSFTM

Show »
Length:1,247
Mass (Da):141,558
Checksum:iEB6B19218247C3FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JK14C9JK14_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP40
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2T9H7C2T9_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP40
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0C4H7C0C4_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP40
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C307H7C307_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP40
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ71H7BZ71_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP40
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91807 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti277 – 318CEQSE…DHLGN → FFSFNQKMHNVCVNRRYGGS GMPLLRCGRCVGSAQPLSSV FR in AAH67300 (PubMed:15489334).CuratedAdd BLAST42

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017123666V → A. Corresponds to variant dbSNP:rs838543Ensembl.1
Natural variantiVAR_0597531025T → M. Corresponds to variant dbSNP:rs34026756Ensembl.1
Natural variantiVAR_0171241111R → C. Corresponds to variant dbSNP:rs1048603Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0085951 – 824Missing in isoform 2. 1 PublicationAdd BLAST824
Alternative sequenceiVSP_0409381M → MSLFLRVVFSFTM in isoform 3. 1 Publication1
Alternative sequenceiVSP_008596973 – 987ASGNE…LLYLG → ENRMGFQQPVHHKEK in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_012819988 – 1235Missing in isoform 2. 1 PublicationAdd BLAST248

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ583821 mRNA Translation: CAE47748.2
AK001647 mRNA Translation: BAA91807.1 Different initiation.
AK124094 mRNA Translation: BAC85770.1
AC019221 Genomic DNA No translation available.
AC019072 Genomic DNA No translation available.
BC067300 mRNA Translation: AAH67300.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46547.1 [Q9NVE5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060688.1, NM_018218.2 [Q9NVE5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000251722; ENSP00000251722; ENSG00000085982 [Q9NVE5-1]
ENST00000409945; ENSP00000386664; ENSG00000085982 [Q9NVE5-2]
ENST00000427112; ENSP00000387898; ENSG00000085982 [Q9NVE5-1]
ENST00000450966; ENSP00000415434; ENSG00000085982 [Q9NVE5-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55230

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55230

UCSC genome browser

More...
UCSCi
uc002vuo.1, human [Q9NVE5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ583821 mRNA Translation: CAE47748.2
AK001647 mRNA Translation: BAA91807.1 Different initiation.
AK124094 mRNA Translation: BAC85770.1
AC019221 Genomic DNA No translation available.
AC019072 Genomic DNA No translation available.
BC067300 mRNA Translation: AAH67300.1
CCDSiCCDS46547.1 [Q9NVE5-1]
RefSeqiNP_060688.1, NM_018218.2 [Q9NVE5-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120525, 4 interactors
IntActiQ9NVE5, 1 interactor
STRINGi9606.ENSP00000415434

Protein family/group databases

MEROPSiC19.069

PTM databases

iPTMnetiQ9NVE5
PhosphoSitePlusiQ9NVE5

Polymorphism and mutation databases

BioMutaiUSP40
DMDMi59803114

Proteomic databases

EPDiQ9NVE5
jPOSTiQ9NVE5
MassIVEiQ9NVE5
MaxQBiQ9NVE5
PaxDbiQ9NVE5
PeptideAtlasiQ9NVE5
PRIDEiQ9NVE5
ProteomicsDBi82785 [Q9NVE5-1]
82786 [Q9NVE5-2]
82787 [Q9NVE5-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
965, 105 antibodies

Genome annotation databases

EnsembliENST00000251722; ENSP00000251722; ENSG00000085982 [Q9NVE5-1]
ENST00000409945; ENSP00000386664; ENSG00000085982 [Q9NVE5-2]
ENST00000427112; ENSP00000387898; ENSG00000085982 [Q9NVE5-1]
ENST00000450966; ENSP00000415434; ENSG00000085982 [Q9NVE5-3]
GeneIDi55230
KEGGihsa:55230
UCSCiuc002vuo.1, human [Q9NVE5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55230
DisGeNETi55230
EuPathDBiHostDB:ENSG00000085982.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
USP40
HGNCiHGNC:20069, USP40
HPAiENSG00000085982, Low tissue specificity
MIMi610570, gene
neXtProtiNX_Q9NVE5
OpenTargetsiENSG00000085982
PharmGKBiPA134909324

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1863, Eukaryota
GeneTreeiENSGT00940000157267
HOGENOMiCLU_009719_0_0_1
InParanoidiQ9NVE5
KOiK11869
OMAiHYHVYIR
OrthoDBi77113at2759
PhylomeDBiQ9NVE5
TreeFamiTF106281

Enzyme and pathway databases

PathwayCommonsiQ9NVE5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
55230, 6 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
USP40, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
USP40

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55230
PharosiQ9NVE5, Tbio

Protein Ontology

More...
PROi
PR:Q9NVE5
RNActiQ9NVE5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000085982, Expressed in intestine and 190 other tissues
ExpressionAtlasiQ9NVE5, baseline and differential
GenevisibleiQ9NVE5, HS

Family and domain databases

InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR018200, USP_CS
IPR028889, USP_dom
PfamiView protein in Pfam
PF00443, UCH, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBP40_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NVE5
Secondary accession number(s): Q6NX38, Q70EL0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 15, 2005
Last modified: October 7, 2020
This is version 151 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again