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Entry version 106 (13 Feb 2019)
Sequence version 2 (18 May 2010)
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Protein

Coiled-coil domain-containing protein 87

Gene

CCDC87

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Fertilization, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 87
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC87
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000182791.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25579 CCDC87

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NVE4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000182791

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596455

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC87

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434428

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002951451 – 849Coiled-coil domain-containing protein 87Add BLAST849

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NVE4

PeptideAtlas

More...
PeptideAtlasi
Q9NVE4

PRoteomics IDEntifications database

More...
PRIDEi
Q9NVE4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82784

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NVE4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NVE4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182791 Expressed in 50 organ(s), highest expression level in left testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NVE4 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120526, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NVE4, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000328487

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NVE4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NVE4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili387 – 415Sequence analysisAdd BLAST29

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCDC87 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFC5 Eukaryota
ENOG410XQT4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018647

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290635

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG070861

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NVE4

Identification of Orthologs from Complete Genome Data

More...
OMAi
FVPGEWD

Database of Orthologous Groups

More...
OrthoDBi
365617at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NVE4

TreeFam database of animal gene trees

More...
TreeFami
TF353429

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037383 CCDC87

The PANTHER Classification System

More...
PANTHERi
PTHR16078 PTHR16078, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NVE4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMEPPKPEPE LQRFYHRLLR PLSLFPTRTT SPEPQKRPPQ EGRILQSFPL
60 70 80 90 100
AKLTVASLCS QVAKLLAGSG IAAGVPPEAR LRLIKVILDE LKCSWREPPA
110 120 130 140 150
ELSLSHKNNQ KLRKRLEAYV LLSSEQLFLR YLHLLVTMST PRGVFTESAT
160 170 180 190 200
LTRLAASLAR DCTLFLTSPN VYRGLLADFQ ALLRAEQASG DVDKLHPVCP
210 220 230 240 250
AGTFKLCPIP WPHSTGFAQV QCSNLNLNYL IQLSRPPEFL NEPGRMDPVK
260 270 280 290 300
ELKSIPRLKR KKPFHWLPSI GKKREIDISS SQMVSLPSYP VAPTSRASPS
310 320 330 340 350
PFCPELRRGQ SMPSLREGWR LADELGLPPL PSRPLTPLVL ATESKPELTG
360 370 380 390 400
LIVAEDLKQL IKKMKLEGTR YPPLDSGLPP LLGVVTRHPA AGHRLEELEK
410 420 430 440 450
MLRNLQEEEA SGQWDPQPPK SFPLHPQPVT ITLKLRNEVV VQAAAVRVSD
460 470 480 490 500
RNFLDSFHIE GAGALYNHLA GELDPKAIEK MDIDNFVGST TREVYKELMS
510 520 530 540 550
HVSSDHLHFD QGPLVEPAAD KDWSTFLSSA FLRQEKQPQI INPELVGLYS
560 570 580 590 600
QRANTLQSNT KKMPSLPSLQ ATKSWEKWSN KASLMNSWKT TLSVDDYFKY
610 620 630 640 650
LTNHETDFLH VIFQMHEEEV PVEIVAPARE SLEIQHPPPL LEDEEPDFVP
660 670 680 690 700
GEWDWNTVLE HRLGAGKTPH LGEPHKILSL QKHLEQLWSV LEVPDKDQVD
710 720 730 740 750
MTIKYSSKAR LRQLPSLVNA WERALKPIQL REALLARLEW FEGQASNPNR
760 770 780 790 800
FFKKTNLSSS HFLEENQVRS HLHRKLNLME SSLVSLLEEI ELIFGEPVIF
810 820 830 840
KGRPYLDKMK SDKVEMLYWL QQQRRVRHLV SALKDPHQST LFRSSAASL
Length:849
Mass (Da):96,402
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6FFEAD6E56B6BCD8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti738L → R in BAA91808 (PubMed:14702039).Curated1
Sequence conflicti834K → R in BAA91808 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_056782156A → T. Corresponds to variant dbSNP:rs1110707Ensembl.1
Natural variantiVAR_033224217F → L1 PublicationCorresponds to variant dbSNP:rs17853294Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001648 mRNA Translation: BAA91808.1
AP001157 Genomic DNA No translation available.
BC034469 mRNA Translation: AAH34469.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8145.1

NCBI Reference Sequences

More...
RefSeqi
NP_060689.2, NM_018219.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.121072

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000333861; ENSP00000328487; ENSG00000182791

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55231

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55231

UCSC genome browser

More...
UCSCi
uc001oiq.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001648 mRNA Translation: BAA91808.1
AP001157 Genomic DNA No translation available.
BC034469 mRNA Translation: AAH34469.1
CCDSiCCDS8145.1
RefSeqiNP_060689.2, NM_018219.2
UniGeneiHs.121072

3D structure databases

ProteinModelPortaliQ9NVE4
SMRiQ9NVE4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120526, 14 interactors
IntActiQ9NVE4, 11 interactors
STRINGi9606.ENSP00000328487

PTM databases

iPTMnetiQ9NVE4
PhosphoSitePlusiQ9NVE4

Polymorphism and mutation databases

BioMutaiCCDC87
DMDMi296434428

Proteomic databases

PaxDbiQ9NVE4
PeptideAtlasiQ9NVE4
PRIDEiQ9NVE4
ProteomicsDBi82784

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333861; ENSP00000328487; ENSG00000182791
GeneIDi55231
KEGGihsa:55231
UCSCiuc001oiq.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55231
EuPathDBiHostDB:ENSG00000182791.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC87
HGNCiHGNC:25579 CCDC87
neXtProtiNX_Q9NVE4
OpenTargetsiENSG00000182791
PharmGKBiPA144596455

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFC5 Eukaryota
ENOG410XQT4 LUCA
GeneTreeiENSGT00390000018647
HOGENOMiHOG000290635
HOVERGENiHBG070861
InParanoidiQ9NVE4
OMAiFVPGEWD
OrthoDBi365617at2759
PhylomeDBiQ9NVE4
TreeFamiTF353429

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55231

Protein Ontology

More...
PROi
PR:Q9NVE4

Gene expression databases

BgeeiENSG00000182791 Expressed in 50 organ(s), highest expression level in left testis
GenevisibleiQ9NVE4 HS

Family and domain databases

InterProiView protein in InterPro
IPR037383 CCDC87
PANTHERiPTHR16078 PTHR16078, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCD87_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NVE4
Secondary accession number(s): Q8NE76
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 18, 2010
Last modified: February 13, 2019
This is version 106 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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