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UniProtKB - Q9NVE4 (CCD87_HUMAN)
Protein
Coiled-coil domain-containing protein 87
Gene
CCDC87
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility.
By similarityGO - Biological processi
- cell differentiation Source: UniProtKB-KW
- positive regulation of acrosome reaction Source: UniProtKB
- positive regulation of fertilization Source: UniProtKB
- single fertilization Source: UniProtKB-KW
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Biological process | Differentiation, Fertilization, Spermatogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q9NVE4 |
SignaLinki | Q9NVE4 |
Names & Taxonomyi
Protein namesi | Recommended name: Coiled-coil domain-containing protein 87 |
Gene namesi | Name:CCDC87 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25579, CCDC87 |
neXtProti | NX_Q9NVE4 |
VEuPathDBi | HostDB:ENSG00000182791 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000182791 |
PharmGKBi | PA144596455 |
Miscellaneous databases
Pharosi | Q9NVE4, Tdark |
Genetic variation databases
BioMutai | CCDC87 |
DMDMi | 296434428 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000295145 | 1 – 849 | Coiled-coil domain-containing protein 87Add BLAST | 849 |
Proteomic databases
MassIVEi | Q9NVE4 |
PaxDbi | Q9NVE4 |
PeptideAtlasi | Q9NVE4 |
PRIDEi | Q9NVE4 |
ProteomicsDBi | 82784 |
PTM databases
GlyGeni | Q9NVE4, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9NVE4 |
PhosphoSitePlusi | Q9NVE4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000182791, Expressed in left testis and 72 other tissues |
Genevisiblei | Q9NVE4, HS |
Organism-specific databases
HPAi | ENSG00000182791, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Q9NVE4
Protein-protein interaction databases
BioGRIDi | 120526, 18 interactors |
IntActi | Q9NVE4, 13 interactors |
STRINGi | 9606.ENSP00000328487 |
Miscellaneous databases
RNActi | Q9NVE4, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q9NVE4 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 387 – 415 | Sequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the CCDC87 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QQN1, Eukaryota |
GeneTreei | ENSGT00390000018647 |
HOGENOMi | CLU_016540_0_0_1 |
InParanoidi | Q9NVE4 |
OMAi | WEKWSNK |
OrthoDBi | 365617at2759 |
PhylomeDBi | Q9NVE4 |
TreeFami | TF353429 |
Family and domain databases
InterProi | View protein in InterPro IPR037383, CCDC87 |
PANTHERi | PTHR16078, PTHR16078, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9NVE4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMEPPKPEPE LQRFYHRLLR PLSLFPTRTT SPEPQKRPPQ EGRILQSFPL
60 70 80 90 100
AKLTVASLCS QVAKLLAGSG IAAGVPPEAR LRLIKVILDE LKCSWREPPA
110 120 130 140 150
ELSLSHKNNQ KLRKRLEAYV LLSSEQLFLR YLHLLVTMST PRGVFTESAT
160 170 180 190 200
LTRLAASLAR DCTLFLTSPN VYRGLLADFQ ALLRAEQASG DVDKLHPVCP
210 220 230 240 250
AGTFKLCPIP WPHSTGFAQV QCSNLNLNYL IQLSRPPEFL NEPGRMDPVK
260 270 280 290 300
ELKSIPRLKR KKPFHWLPSI GKKREIDISS SQMVSLPSYP VAPTSRASPS
310 320 330 340 350
PFCPELRRGQ SMPSLREGWR LADELGLPPL PSRPLTPLVL ATESKPELTG
360 370 380 390 400
LIVAEDLKQL IKKMKLEGTR YPPLDSGLPP LLGVVTRHPA AGHRLEELEK
410 420 430 440 450
MLRNLQEEEA SGQWDPQPPK SFPLHPQPVT ITLKLRNEVV VQAAAVRVSD
460 470 480 490 500
RNFLDSFHIE GAGALYNHLA GELDPKAIEK MDIDNFVGST TREVYKELMS
510 520 530 540 550
HVSSDHLHFD QGPLVEPAAD KDWSTFLSSA FLRQEKQPQI INPELVGLYS
560 570 580 590 600
QRANTLQSNT KKMPSLPSLQ ATKSWEKWSN KASLMNSWKT TLSVDDYFKY
610 620 630 640 650
LTNHETDFLH VIFQMHEEEV PVEIVAPARE SLEIQHPPPL LEDEEPDFVP
660 670 680 690 700
GEWDWNTVLE HRLGAGKTPH LGEPHKILSL QKHLEQLWSV LEVPDKDQVD
710 720 730 740 750
MTIKYSSKAR LRQLPSLVNA WERALKPIQL REALLARLEW FEGQASNPNR
760 770 780 790 800
FFKKTNLSSS HFLEENQVRS HLHRKLNLME SSLVSLLEEI ELIFGEPVIF
810 820 830 840
KGRPYLDKMK SDKVEMLYWL QQQRRVRHLV SALKDPHQST LFRSSAASL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 738 | L → R in BAA91808 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 834 | K → R in BAA91808 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056782 | 156 | A → T. Corresponds to variant dbSNP:rs1110707Ensembl. | 1 | |
Natural variantiVAR_033224 | 217 | F → L1 PublicationCorresponds to variant dbSNP:rs17853294Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001648 mRNA Translation: BAA91808.1 AP001157 Genomic DNA No translation available. BC034469 mRNA Translation: AAH34469.1 |
CCDSi | CCDS8145.1 |
RefSeqi | NP_060689.2, NM_018219.2 |
Genome annotation databases
Ensembli | ENST00000333861.5; ENSP00000328487.3; ENSG00000182791.5 |
GeneIDi | 55231 |
KEGGi | hsa:55231 |
MANE-Selecti | ENST00000333861.5; ENSP00000328487.3; NM_018219.3; NP_060689.2 |
UCSCi | uc001oiq.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001648 mRNA Translation: BAA91808.1 AP001157 Genomic DNA No translation available. BC034469 mRNA Translation: AAH34469.1 |
CCDSi | CCDS8145.1 |
RefSeqi | NP_060689.2, NM_018219.2 |
3D structure databases
AlphaFoldDBi | Q9NVE4 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120526, 18 interactors |
IntActi | Q9NVE4, 13 interactors |
STRINGi | 9606.ENSP00000328487 |
PTM databases
GlyGeni | Q9NVE4, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9NVE4 |
PhosphoSitePlusi | Q9NVE4 |
Genetic variation databases
BioMutai | CCDC87 |
DMDMi | 296434428 |
Proteomic databases
MassIVEi | Q9NVE4 |
PaxDbi | Q9NVE4 |
PeptideAtlasi | Q9NVE4 |
PRIDEi | Q9NVE4 |
ProteomicsDBi | 82784 |
Protocols and materials databases
Antibodypediai | 44485, 100 antibodies from 15 providers |
DNASUi | 55231 |
Genome annotation databases
Ensembli | ENST00000333861.5; ENSP00000328487.3; ENSG00000182791.5 |
GeneIDi | 55231 |
KEGGi | hsa:55231 |
MANE-Selecti | ENST00000333861.5; ENSP00000328487.3; NM_018219.3; NP_060689.2 |
UCSCi | uc001oiq.5, human |
Organism-specific databases
CTDi | 55231 |
GeneCardsi | CCDC87 |
HGNCi | HGNC:25579, CCDC87 |
HPAi | ENSG00000182791, Tissue enriched (testis) |
neXtProti | NX_Q9NVE4 |
OpenTargetsi | ENSG00000182791 |
PharmGKBi | PA144596455 |
VEuPathDBi | HostDB:ENSG00000182791 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQN1, Eukaryota |
GeneTreei | ENSGT00390000018647 |
HOGENOMi | CLU_016540_0_0_1 |
InParanoidi | Q9NVE4 |
OMAi | WEKWSNK |
OrthoDBi | 365617at2759 |
PhylomeDBi | Q9NVE4 |
TreeFami | TF353429 |
Enzyme and pathway databases
PathwayCommonsi | Q9NVE4 |
SignaLinki | Q9NVE4 |
Miscellaneous databases
BioGRID-ORCSi | 55231, 11 hits in 1067 CRISPR screens |
GenomeRNAii | 55231 |
Pharosi | Q9NVE4, Tdark |
PROi | PR:Q9NVE4 |
RNActi | Q9NVE4, protein |
Gene expression databases
Bgeei | ENSG00000182791, Expressed in left testis and 72 other tissues |
Genevisiblei | Q9NVE4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR037383, CCDC87 |
PANTHERi | PTHR16078, PTHR16078, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CCD87_HUMAN | |
Accessioni | Q9NVE4Primary (citable) accession number: Q9NVE4 Secondary accession number(s): Q8NE76 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 10, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | May 25, 2022 | |
This is version 121 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families