UniProtKB - Q9NVD7 (PARVA_HUMAN)
Alpha-parvin
PARVA
Functioni
GO - Molecular functioni
- actin binding Source: GO_Central
- cadherin binding Source: BHF-UCL
- protein kinase inhibitor activity Source: UniProtKB
GO - Biological processi
- actin cytoskeleton reorganization Source: GO_Central
- actin-mediated cell contraction Source: UniProtKB
- cell projection assembly Source: GO_Central
- cilium assembly Source: UniProtKB
- establishment or maintenance of cell polarity Source: UniProtKB
- heterotypic cell-cell adhesion Source: UniProtKB
- outflow tract septum morphogenesis Source: UniProtKB
- protein stabilization Source: ARUK-UCL
- regulation of cell shape Source: UniProtKB-KW
- smooth muscle cell chemotaxis Source: UniProtKB
- sprouting angiogenesis Source: UniProtKB
- substrate adhesion-dependent cell spreading Source: UniProtKB
Keywordsi
Molecular function | Actin-binding |
Biological process | Angiogenesis, Cell adhesion, Cell shape, Chemotaxis, Cilium biogenesis/degradation |
Enzyme and pathway databases
PathwayCommonsi | Q9NVD7 |
Reactomei | R-HSA-446343, Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446353, Cell-extracellular matrix interactions R-HSA-446388, Regulation of cytoskeletal remodeling and cell spreading by IPP complex components |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-parvinAlternative name(s): Actopaxin CH-ILKBP Calponin-like integrin-linked kinase-binding protein Matrix-remodeling-associated protein 2 |
Gene namesi | Name:PARVA Synonyms:MXRA2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14652, PARVA |
MIMi | 608120, gene |
neXtProti | NX_Q9NVD7 |
Subcellular locationi
Cytoskeleton
Plasma membrane
Other locations
- focal adhesion
- Z line By similarity
Note: Constituent of focal adhesions. Associates with the actin cytoskeleton.
Cytoskeleton
- actin cytoskeleton Source: GO_Central
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: Ensembl
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
- focal adhesion Source: UniProtKB
- lamellipodium Source: Ensembl
- Z disc Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 4 | S → D: Loss of interaction with TESK1, however no effect on interaction with ILK; when associated with D-8. 1 Publication | 1 | |
Mutagenesisi | 8 | S → D: Loss of interaction with TESK1, however no effect on interaction with ILK; when associated with D-4. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 55742 |
OpenTargetsi | ENSG00000197702 |
PharmGKBi | PA32950 |
Miscellaneous databases
Pharosi | Q9NVD7, Tbio |
Genetic variation databases
BioMutai | PARVA |
DMDMi | 20139236 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000121580 | 2 – 372 | Alpha-parvinAdd BLAST | 371 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 8 | PhosphoserineCombined sources | 1 | |
Modified residuei | 14 | PhosphoserineCombined sources | 1 | |
Modified residuei | 19 | PhosphoserineCombined sources | 1 | |
Modified residuei | 28 | PhosphoserineCombined sources | 1 | |
Modified residuei | 62 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9NVD7 |
jPOSTi | Q9NVD7 |
MassIVEi | Q9NVD7 |
MaxQBi | Q9NVD7 |
PaxDbi | Q9NVD7 |
PeptideAtlasi | Q9NVD7 |
PRIDEi | Q9NVD7 |
ProteomicsDBi | 82782 [Q9NVD7-1] 82783 [Q9NVD7-2] |
PTM databases
iPTMneti | Q9NVD7 |
PhosphoSitePlusi | Q9NVD7 |
Expressioni
Tissue specificityi
Gene expression databases
ExpressionAtlasi | Q9NVD7, baseline and differential |
Interactioni
Subunit structurei
Interacts with TGFB1I1 (By similarity).
Interacts with LIMS1 (via LD motifs) (PubMed:11331308).
Interacts with ARHGAP31 (PubMed:16860736).
Interacts with the actin cytoskeleton (PubMed:11331308).
Interacts (via C-terminus) with ILK (PubMed:11331308, PubMed:15284246, PubMed:15817463, PubMed:20005845).
Interacts (via C-terminus) with TESK1 (via C-terminus); the interaction inhibits TESK1 kinase activity (PubMed:15817463).
Interacts with PXN/PAXILLIN (via LD motif 4) (PubMed:15817463, PubMed:18508764, PubMed:18940607).
By similarity7 PublicationsBinary interactionsi
Hide detailsQ9NVD7
Isoform 1 [Q9NVD7-1]
With | #Exp. | IntAct |
---|---|---|
PXN - isoform Alpha [P49023-2] | 3 | EBI-15735104,EBI-11954250 |
GO - Molecular functioni
- actin binding Source: GO_Central
- cadherin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 120860, 51 interactors |
CORUMi | Q9NVD7 |
IntActi | Q9NVD7, 29 interactors |
MINTi | Q9NVD7 |
STRINGi | 9606.ENSP00000334008 |
Miscellaneous databases
RNActi | Q9NVD7, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q9NVD7 |
SMRi | Q9NVD7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NVD7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 95 – 202 | Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 262 – 369 | Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST | 108 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 21 – 25 | Interaction with ARHGAP311 Publication | 5 | |
Regioni | 223 – 372 | Required for interaction with TESK1 and ILK1 PublicationAdd BLAST | 150 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3631, Eukaryota |
GeneTreei | ENSGT00950000183194 |
InParanoidi | Q9NVD7 |
OrthoDBi | 871306at2759 |
PhylomeDBi | Q9NVD7 |
Family and domain databases
Gene3Di | 1.10.418.10, 2 hits |
InterProi | View protein in InterPro IPR001715, CH-domain IPR036872, CH_dom_sf IPR028433, Parvin |
PANTHERi | PTHR12114, PTHR12114, 1 hit |
Pfami | View protein in Pfam PF00307, CH, 2 hits |
PIRSFi | PIRSF039131, Parvin, 1 hit |
SMARTi | View protein in SMART SM00033, CH, 2 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS50021, CH, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATSPQKSPS VPKSPTPKSP PSRKKDDSFL GKLGGTLARR KKAKEVSELQ
60 70 80 90 100
EEGMNAINLP LSPIPFELDP EDTMLEENEV RTMVDPNSRS DPKLQELMKV
110 120 130 140 150
LIDWINDVLV GERIIVKDLA EDLYDGQVLQ KLFEKLESEK LNVAEVTQSE
160 170 180 190 200
IAQKQKLQTV LEKINETLKL PPRSIKWNVD SVHAKSLVAI LHLLVALSQY
210 220 230 240 250
FRAPIRLPDH VSIQVVVVQK REGILQSRQI QEEITGNTEA LSGRHERDAF
260 270 280 290 300
DTLFDHAPDK LNVVKKTLIT FVNKHLNKLN LEVTELETQF ADGVYLVLLM
310 320 330 340 350
GLLEGYFVPL HSFFLTPDSF EQKVLNVSFA FELMQDGGLE KPKPRPEDIV
360 370
NCDLKSTLRV LYNLFTKYRN VE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PS97 | E9PS97_HUMAN | Alpha-parvin | PARVA | 209 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 | V → A in AAH14535 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008884 | 134 – 182 | EKLES…NVDSV → GRRVECCNGCVFNCRWLDHL LVARRSYSQFTVAYLEMDYK CVEHGITAQ in isoform 2. 1 PublicationAdd BLAST | 49 | |
Alternative sequenceiVSP_008885 | 183 – 372 | Missing in isoform 2. 1 PublicationAdd BLAST | 190 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF237771 mRNA Translation: AAG27173.1 AF325830 mRNA Translation: AAK49911.1 AK001655 mRNA Translation: BAA91815.1 AK022316 mRNA Translation: BAB14009.1 BC016713 mRNA Translation: AAH16713.1 BC014535 mRNA Translation: AAH14535.1 |
CCDSi | CCDS44541.2 [Q9NVD7-1] |
RefSeqi | NP_060692.2, NM_018222.4 [Q9NVD7-1] |
Genome annotation databases
Ensembli | ENST00000334956; ENSP00000334008; ENSG00000197702 [Q9NVD7-1] |
GeneIDi | 55742 |
KEGGi | hsa:55742 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF237771 mRNA Translation: AAG27173.1 AF325830 mRNA Translation: AAK49911.1 AK001655 mRNA Translation: BAA91815.1 AK022316 mRNA Translation: BAB14009.1 BC016713 mRNA Translation: AAH16713.1 BC014535 mRNA Translation: AAH14535.1 |
CCDSi | CCDS44541.2 [Q9NVD7-1] |
RefSeqi | NP_060692.2, NM_018222.4 [Q9NVD7-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2K2R | NMR | - | A | 244-372 | [»] | |
2VZC | X-ray | 1.05 | A/B | 242-372 | [»] | |
2VZD | X-ray | 2.10 | A/B | 242-372 | [»] | |
2VZG | X-ray | 1.80 | B | 242-372 | [»] | |
2VZI | X-ray | 2.20 | B | 242-372 | [»] | |
3KMU | X-ray | 1.80 | B | 248-372 | [»] | |
3KMW | X-ray | 2.00 | B | 248-372 | [»] | |
3REP | X-ray | 1.80 | B | 248-372 | [»] | |
6MIB | X-ray | 1.80 | B | 248-372 | [»] | |
BMRBi | Q9NVD7 | |||||
SMRi | Q9NVD7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120860, 51 interactors |
CORUMi | Q9NVD7 |
IntActi | Q9NVD7, 29 interactors |
MINTi | Q9NVD7 |
STRINGi | 9606.ENSP00000334008 |
PTM databases
iPTMneti | Q9NVD7 |
PhosphoSitePlusi | Q9NVD7 |
Genetic variation databases
BioMutai | PARVA |
DMDMi | 20139236 |
Proteomic databases
EPDi | Q9NVD7 |
jPOSTi | Q9NVD7 |
MassIVEi | Q9NVD7 |
MaxQBi | Q9NVD7 |
PaxDbi | Q9NVD7 |
PeptideAtlasi | Q9NVD7 |
PRIDEi | Q9NVD7 |
ProteomicsDBi | 82782 [Q9NVD7-1] 82783 [Q9NVD7-2] |
Protocols and materials databases
Antibodypediai | 993, 411 antibodies |
DNASUi | 55742 |
Genome annotation databases
Ensembli | ENST00000334956; ENSP00000334008; ENSG00000197702 [Q9NVD7-1] |
GeneIDi | 55742 |
KEGGi | hsa:55742 |
Organism-specific databases
CTDi | 55742 |
DisGeNETi | 55742 |
GeneCardsi | PARVA |
HGNCi | HGNC:14652, PARVA |
MIMi | 608120, gene |
neXtProti | NX_Q9NVD7 |
OpenTargetsi | ENSG00000197702 |
PharmGKBi | PA32950 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3631, Eukaryota |
GeneTreei | ENSGT00950000183194 |
InParanoidi | Q9NVD7 |
OrthoDBi | 871306at2759 |
PhylomeDBi | Q9NVD7 |
Enzyme and pathway databases
PathwayCommonsi | Q9NVD7 |
Reactomei | R-HSA-446343, Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446353, Cell-extracellular matrix interactions R-HSA-446388, Regulation of cytoskeletal remodeling and cell spreading by IPP complex components |
Miscellaneous databases
BioGRID-ORCSi | 55742, 30 hits in 985 CRISPR screens |
ChiTaRSi | PARVA, human |
EvolutionaryTracei | Q9NVD7 |
GeneWikii | PARVA |
GenomeRNAii | 55742 |
Pharosi | Q9NVD7, Tbio |
PROi | PR:Q9NVD7 |
RNActi | Q9NVD7, protein |
SOURCEi | Search... |
Gene expression databases
ExpressionAtlasi | Q9NVD7, baseline and differential |
Family and domain databases
Gene3Di | 1.10.418.10, 2 hits |
InterProi | View protein in InterPro IPR001715, CH-domain IPR036872, CH_dom_sf IPR028433, Parvin |
PANTHERi | PTHR12114, PTHR12114, 1 hit |
Pfami | View protein in Pfam PF00307, CH, 2 hits |
PIRSFi | PIRSF039131, Parvin, 1 hit |
SMARTi | View protein in SMART SM00033, CH, 2 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS50021, CH, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PARVA_HUMAN | |
Accessioni | Q9NVD7Primary (citable) accession number: Q9NVD7 Secondary accession number(s): Q96C85, Q9HA48 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2002 |
Last sequence update: | October 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 184 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families