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Protein

Alpha-parvin

Gene

PARVA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration.By similarity4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processAngiogenesis, Cell adhesion, Cell shape, Chemotaxis, Cilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions
R-HSA-446353 Cell-extracellular matrix interactions
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-parvin
Alternative name(s):
Actopaxin
CH-ILKBP
Calponin-like integrin-linked kinase-binding protein
Matrix-remodeling-associated protein 2
Gene namesi
Name:PARVA
Synonyms:MXRA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:14652 PARVA
MIMi608120 gene
neXtProtiNX_Q9NVD7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55742
PharmGKBiPA32950

Polymorphism and mutation databases

BioMutaiPARVA
DMDMi20139236

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001215802 – 372Alpha-parvinAdd BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei8PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei62PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NVD7
MaxQBiQ9NVD7
PaxDbiQ9NVD7
PeptideAtlasiQ9NVD7
PRIDEiQ9NVD7
ProteomicsDBi82782
82783 [Q9NVD7-2]

PTM databases

iPTMnetiQ9NVD7
PhosphoSitePlusiQ9NVD7

Expressioni

Tissue specificityi

Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.3 Publications

Gene expression databases

CleanExiHS_PARVA

Organism-specific databases

HPAiHPA005964

Interactioni

Subunit structurei

Interacts with TGFB1I1 (By similarity). Interacts with ILK, LIMS1 and PXN (via LD motifs). Interacts with ARHGAP31. Interacts with the actin cytoskeleton.By similarity6 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120860, 37 interactors
IntActiQ9NVD7, 13 interactors
MINTiQ9NVD7
STRINGi9606.ENSP00000334008

Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi249 – 256Combined sources8
Helixi258 – 276Combined sources19
Helixi277 – 279Combined sources3
Turni286 – 292Combined sources7
Helixi294 – 303Combined sources10
Helixi310 – 312Combined sources3
Helixi320 – 336Combined sources17
Helixi346 – 350Combined sources5
Helixi354 – 368Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K2RNMR-A244-372[»]
2VZCX-ray1.05A/B242-372[»]
2VZDX-ray2.10A/B242-372[»]
2VZGX-ray1.80B242-372[»]
2VZIX-ray2.20B242-372[»]
3KMUX-ray1.80B248-372[»]
3KMWX-ray2.00B248-372[»]
3REPX-ray1.80B248-372[»]
ProteinModelPortaliQ9NVD7
SMRiQ9NVD7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NVD7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 202Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST108
Domaini262 – 369Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 25Interaction with ARHGAP311 Publication5

Sequence similaritiesi

Belongs to the parvin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3631 Eukaryota
ENOG410XQWH LUCA
HOGENOMiHOG000247027
HOVERGENiHBG053517
InParanoidiQ9NVD7
KOiK06275
PhylomeDBiQ9NVD7

Family and domain databases

Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR028433 Parvin
PANTHERiPTHR12114 PTHR12114, 1 hit
PfamiView protein in Pfam
PF00307 CH, 2 hits
PIRSFiPIRSF039131 Parvin, 1 hit
SMARTiView protein in SMART
SM00033 CH, 2 hits
SUPFAMiSSF47576 SSF47576, 2 hits
PROSITEiView protein in PROSITE
PS50021 CH, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NVD7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATSPQKSPS VPKSPTPKSP PSRKKDDSFL GKLGGTLARR KKAKEVSELQ
60 70 80 90 100
EEGMNAINLP LSPIPFELDP EDTMLEENEV RTMVDPNSRS DPKLQELMKV
110 120 130 140 150
LIDWINDVLV GERIIVKDLA EDLYDGQVLQ KLFEKLESEK LNVAEVTQSE
160 170 180 190 200
IAQKQKLQTV LEKINETLKL PPRSIKWNVD SVHAKSLVAI LHLLVALSQY
210 220 230 240 250
FRAPIRLPDH VSIQVVVVQK REGILQSRQI QEEITGNTEA LSGRHERDAF
260 270 280 290 300
DTLFDHAPDK LNVVKKTLIT FVNKHLNKLN LEVTELETQF ADGVYLVLLM
310 320 330 340 350
GLLEGYFVPL HSFFLTPDSF EQKVLNVSFA FELMQDGGLE KPKPRPEDIV
360 370
NCDLKSTLRV LYNLFTKYRN VE
Length:372
Mass (Da):42,244
Last modified:October 1, 2000 - v1
Checksum:iF48BB5B1E83F8CEF
GO
Isoform 2 (identifier: Q9NVD7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-182: EKLESEKLNV...RSIKWNVDSV → GRRVECCNGC...KCVEHGITAQ
     183-372: Missing.

Note: No experimental confirmation available.
Show »
Length:182
Mass (Da):20,625
Checksum:iB7D6685D209E628F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11V → A in AAH14535 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008884134 – 182EKLES…NVDSV → GRRVECCNGCVFNCRWLDHL LVARRSYSQFTVAYLEMDYK CVEHGITAQ in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_008885183 – 372Missing in isoform 2. 1 PublicationAdd BLAST190

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237771 mRNA Translation: AAG27173.1
AF325830 mRNA Translation: AAK49911.1
AK001655 mRNA Translation: BAA91815.1
AK022316 mRNA Translation: BAB14009.1
BC016713 mRNA Translation: AAH16713.1
BC014535 mRNA Translation: AAH14535.1
CCDSiCCDS44541.2 [Q9NVD7-1]
RefSeqiNP_060692.2, NM_018222.4 [Q9NVD7-1]
UniGeneiHs.432914
Hs.623732

Genome annotation databases

EnsembliENST00000550549; ENSP00000447198; ENSG00000197702
GeneIDi55742
KEGGihsa:55742

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPARVA_HUMAN
AccessioniPrimary (citable) accession number: Q9NVD7
Secondary accession number(s): Q96C85, Q9HA48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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