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Entry version 156 (11 Dec 2019)
Sequence version 1 (01 Oct 2000)
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Protein

SET domain-containing protein 4

Gene

SETD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei272S-adenosyl-L-methioninePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SET domain-containing protein 4Curated (EC:2.1.1.-Curated)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SETD4Imported
Synonyms:C21orf18Imported, C21orf27Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000185917.13

Human Gene Nomenclature Database

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HGNCi
HGNC:1258 SETD4

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9NVD3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
54093

Open Targets

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OpenTargetsi
ENSG00000185917

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA25814

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NVD3 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SETD4

Domain mapping of disease mutations (DMDM)

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DMDMi
12229715

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000795091 – 440SET domain-containing protein 4Add BLAST440

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NVD3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NVD3

PeptideAtlas

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PeptideAtlasi
Q9NVD3

PRoteomics IDEntifications database

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PRIDEi
Q9NVD3

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
82779 [Q9NVD3-1]
82780 [Q9NVD3-2]
82781 [Q9NVD3-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9NVD3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9NVD3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000185917 Expressed in 192 organ(s), highest expression level in oviduct epithelium

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NVD3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NVD3 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA024073
HPA035405

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119892, 11 interactors

Protein interaction database and analysis system

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IntActi
Q9NVD3, 7 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000382163

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q9NVD3 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini48 – 273SETPROSITE-ProRule annotationAdd BLAST226

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family.PROSITE-ProRule annotationCurated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1337 Eukaryota
ENOG410Y7DR LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153577

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000010303

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NVD3

Identification of Orthologs from Complete Genome Data

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OMAi
GPHDNHR

Database of Orthologous Groups

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OrthoDBi
1209399at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NVD3

TreeFam database of animal gene trees

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TreeFami
TF106421

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.90.1420.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR015353 Rubisco_LSMT_subst-bd
IPR036464 Rubisco_LSMT_subst-bd_sf
IPR001214 SET_dom
IPR016852 SET_MeTrfase

Pfam protein domain database

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Pfami
View protein in Pfam
PF09273 Rubis-subs-bind, 1 hit
PF00856 SET, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF027158 Lys_MTase_YDR198C_prd, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50280 SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q9NVD3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQKGKGRTSR IRRRKLCGSS ESRGVNESHK SEFIELRKWL KARKFQDSNL
60 70 80 90 100
APACFPGTGR GLMSQTSLQE GQMIISLPES CLLTTDTVIR SYLGAYITKW
110 120 130 140 150
KPPPSPLLAL CTFLVSEKHA GHRSLWKPYL EILPKAYTCP VCLEPEVVNL
160 170 180 190 200
LPKSLKAKAE EQRAHVQEFF ASSRDFFSSL QPLFAEAVDS IFSYSALLWA
210 220 230 240 250
WCTVNTRAVY LRPRQRECLS AEPDTCALAP YLDLLNHSPH VQVKAAFNEE
260 270 280 290 300
THSYEIRTTS RWRKHEEVFI CYGPHDNQRL FLEYGFVSVH NPHACVYVSR
310 320 330 340 350
EILVKYLPST DKQMDKKISI LKDHGYIENL TFGWDGPSWR LLTALKLLCL
360 370 380 390 400
EAEKFTCWKK VLLGEVISDT NEKTSLDIAQ KICYYFIEET NAVLQKVSHM
410 420 430 440
KDEKEALINQ LTLVESLWTE ELKILRASAE TLHSLQTAFT
Length:440
Mass (Da):50,416
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9EBCAA05397BE287
GO
Isoform B (identifier: Q9NVD3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-440: EGQMIISLPE...TLHSLQTAFT → VEASSISSAG...PSSQIFKSKG

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:129
Mass (Da):14,013
Checksum:iA1FDB90CB2CE8420
GO
Isoform 3 (identifier: Q9NVD3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MQKGKGRTSRIRRRKLCGSSESRGV → M

Show »
Length:416
Mass (Da):47,731
Checksum:i63539282EE060837
GO
Isoform 4 (identifier: Q9NVD3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-307: EILVKYL → GWNQLCS
     308-440: Missing.

Show »
Length:307
Mass (Da):35,086
Checksum:i4B7520151BA3D9E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J256C9J256_HUMAN
SET domain-containing protein 4
SETD4
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JIU9C9JIU9_HUMAN
SET domain-containing protein 4
SETD4
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWV5C9JWV5_HUMAN
SET domain-containing protein 4
SETD4
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MTS1A8MTS1_HUMAN
SET domain-containing protein 4
SETD4
283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYV0C9JYV0_HUMAN
SET domain-containing protein 4
SETD4
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JPA1C9JPA1_HUMAN
SET domain-containing protein 4
SETD4
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti301 – 440EILVK…QTAFT → GWNQLCS in AAH02898 (PubMed:15489334).CuratedAdd BLAST140

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021948387I → V. Corresponds to variant dbSNP:rs2835239Ensembl.1
Natural variantiVAR_035988420E → G in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0265781 – 25MQKGK…ESRGV → M in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_00414670 – 440EGQMI…QTAFT → VEASSISSAGAVHLFSFRKA CWAPISLEALPGDFTQGVYL PCLFGAGSGEPSSQIFKSKG in isoform B. 2 PublicationsAdd BLAST371
Alternative sequenceiVSP_054087301 – 307EILVKYL → GWNQLCS in isoform 4. 1 Publication7
Alternative sequenceiVSP_054088308 – 440Missing in isoform 4. 1 PublicationAdd BLAST133

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF391112 mRNA Translation: AAL34503.1
AK001660 mRNA Translation: BAA91819.1
AK300009 mRNA Translation: BAG61826.1
AP000688 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09757.1
CH471079 Genomic DNA Translation: EAX09758.1
CH471079 Genomic DNA Translation: EAX09759.1
CH471079 Genomic DNA Translation: EAX09760.1
CH471079 Genomic DNA Translation: EAX09762.1
BC002898 mRNA Translation: AAH02898.1
BC036556 mRNA Translation: AAH36556.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13640.1 [Q9NVD3-1]
CCDS42923.1 [Q9NVD3-4]
CCDS74792.1 [Q9NVD3-3]

NCBI Reference Sequences

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RefSeqi
NP_001007260.1, NM_001007259.2 [Q9NVD3-4]
NP_001007262.1, NM_001007261.2
NP_001273681.1, NM_001286752.1 [Q9NVD3-3]
NP_059134.1, NM_017438.4 [Q9NVD3-1]
XP_011527938.1, XM_011529636.1 [Q9NVD3-1]
XP_011527939.1, XM_011529637.1 [Q9NVD3-1]
XP_011527940.1, XM_011529638.2 [Q9NVD3-1]
XP_011527941.1, XM_011529639.1 [Q9NVD3-1]
XP_011527942.1, XM_011529640.2 [Q9NVD3-1]
XP_011527944.1, XM_011529642.1 [Q9NVD3-3]
XP_011527945.1, XM_011529643.1 [Q9NVD3-3]
XP_011527946.1, XM_011529644.1 [Q9NVD3-3]
XP_016883892.1, XM_017028403.1
XP_016883893.1, XM_017028404.1 [Q9NVD3-3]
XP_016883894.1, XM_017028405.1 [Q9NVD3-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000332131; ENSP00000329189; ENSG00000185917 [Q9NVD3-1]
ENST00000399207; ENSP00000382158; ENSG00000185917 [Q9NVD3-4]
ENST00000399208; ENSP00000382159; ENSG00000185917 [Q9NVD3-4]
ENST00000399212; ENSP00000382161; ENSG00000185917 [Q9NVD3-3]
ENST00000399215; ENSP00000382163; ENSG00000185917 [Q9NVD3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54093

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54093

UCSC genome browser

More...
UCSCi
uc002yuw.3 human [Q9NVD3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF391112 mRNA Translation: AAL34503.1
AK001660 mRNA Translation: BAA91819.1
AK300009 mRNA Translation: BAG61826.1
AP000688 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09757.1
CH471079 Genomic DNA Translation: EAX09758.1
CH471079 Genomic DNA Translation: EAX09759.1
CH471079 Genomic DNA Translation: EAX09760.1
CH471079 Genomic DNA Translation: EAX09762.1
BC002898 mRNA Translation: AAH02898.1
BC036556 mRNA Translation: AAH36556.1
CCDSiCCDS13640.1 [Q9NVD3-1]
CCDS42923.1 [Q9NVD3-4]
CCDS74792.1 [Q9NVD3-3]
RefSeqiNP_001007260.1, NM_001007259.2 [Q9NVD3-4]
NP_001007262.1, NM_001007261.2
NP_001273681.1, NM_001286752.1 [Q9NVD3-3]
NP_059134.1, NM_017438.4 [Q9NVD3-1]
XP_011527938.1, XM_011529636.1 [Q9NVD3-1]
XP_011527939.1, XM_011529637.1 [Q9NVD3-1]
XP_011527940.1, XM_011529638.2 [Q9NVD3-1]
XP_011527941.1, XM_011529639.1 [Q9NVD3-1]
XP_011527942.1, XM_011529640.2 [Q9NVD3-1]
XP_011527944.1, XM_011529642.1 [Q9NVD3-3]
XP_011527945.1, XM_011529643.1 [Q9NVD3-3]
XP_011527946.1, XM_011529644.1 [Q9NVD3-3]
XP_016883892.1, XM_017028403.1
XP_016883893.1, XM_017028404.1 [Q9NVD3-3]
XP_016883894.1, XM_017028405.1 [Q9NVD3-4]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi119892, 11 interactors
IntActiQ9NVD3, 7 interactors
STRINGi9606.ENSP00000382163

PTM databases

iPTMnetiQ9NVD3
PhosphoSitePlusiQ9NVD3

Polymorphism and mutation databases

BioMutaiSETD4
DMDMi12229715

Proteomic databases

MassIVEiQ9NVD3
PaxDbiQ9NVD3
PeptideAtlasiQ9NVD3
PRIDEiQ9NVD3
ProteomicsDBi82779 [Q9NVD3-1]
82780 [Q9NVD3-2]
82781 [Q9NVD3-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
54093

Genome annotation databases

EnsembliENST00000332131; ENSP00000329189; ENSG00000185917 [Q9NVD3-1]
ENST00000399207; ENSP00000382158; ENSG00000185917 [Q9NVD3-4]
ENST00000399208; ENSP00000382159; ENSG00000185917 [Q9NVD3-4]
ENST00000399212; ENSP00000382161; ENSG00000185917 [Q9NVD3-3]
ENST00000399215; ENSP00000382163; ENSG00000185917 [Q9NVD3-1]
GeneIDi54093
KEGGihsa:54093
UCSCiuc002yuw.3 human [Q9NVD3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54093
DisGeNETi54093
EuPathDBiHostDB:ENSG00000185917.13

GeneCards: human genes, protein and diseases

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GeneCardsi
SETD4
HGNCiHGNC:1258 SETD4
HPAiHPA024073
HPA035405
neXtProtiNX_Q9NVD3
OpenTargetsiENSG00000185917
PharmGKBiPA25814

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1337 Eukaryota
ENOG410Y7DR LUCA
GeneTreeiENSGT00940000153577
HOGENOMiHOG000010303
InParanoidiQ9NVD3
OMAiGPHDNHR
OrthoDBi1209399at2759
PhylomeDBiQ9NVD3
TreeFamiTF106421

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SETD4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54093
PharosiQ9NVD3 Tdark

Protein Ontology

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PROi
PR:Q9NVD3
RNActiQ9NVD3 protein

Gene expression databases

BgeeiENSG00000185917 Expressed in 192 organ(s), highest expression level in oviduct epithelium
ExpressionAtlasiQ9NVD3 baseline and differential
GenevisibleiQ9NVD3 HS

Family and domain databases

Gene3Di3.90.1420.10, 1 hit
InterProiView protein in InterPro
IPR015353 Rubisco_LSMT_subst-bd
IPR036464 Rubisco_LSMT_subst-bd_sf
IPR001214 SET_dom
IPR016852 SET_MeTrfase
PfamiView protein in Pfam
PF09273 Rubis-subs-bind, 1 hit
PF00856 SET, 1 hit
PIRSFiPIRSF027158 Lys_MTase_YDR198C_prd, 1 hit
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSETD4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NVD3
Secondary accession number(s): B4DT14
, D3DSG2, D3DSG4, Q8NE19, Q9BU46
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: December 11, 2019
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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