UniProtKB - Q9NVC6 (MED17_HUMAN)
Mediator of RNA polymerase II transcription subunit 17
MED17
Functioni
GO - Molecular functioni
- nuclear receptor coactivator activity Source: UniProtKB
- thyroid hormone receptor binding Source: UniProtKB
- transcription coactivator activity Source: UniProtKB
- transcription coregulator activity Source: UniProtKB
- vitamin D receptor binding Source: UniProtKB
GO - Biological processi
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of transcription initiation from RNA polymerase II promoter Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription initiation from RNA polymerase II promoter Source: Reactome
- transcription initiation from RNA polymerase II promoter Source: ProtInc
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9NVC6 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-212436, Generic Transcription Pathway R-HSA-381340, Transcriptional regulation of white adipocyte differentiation |
Names & Taxonomyi
Protein namesi | Recommended name: Mediator of RNA polymerase II transcription subunit 17Alternative name(s): Activator-recruited cofactor 77 kDa component Short name: ARC77 Cofactor required for Sp1 transcriptional activation subunit 6 Short name: CRSP complex subunit 6 Mediator complex subunit 17 Thyroid hormone receptor-associated protein complex 80 kDa component Short name: Trap80 Transcriptional coactivator CRSP77 Vitamin D3 receptor-interacting protein complex 80 kDa component Short name: DRIP80 |
Gene namesi | Name:MED17 Synonyms:ARC77, CRSP6, DRIP77, DRIP80, TRAP80 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2375, MED17 |
MIMi | 603810, gene |
neXtProti | NX_Q9NVC6 |
VEuPathDBi | HostDB:ENSG00000042429.10 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- core mediator complex Source: GO_Central
- mediator complex Source: UniProtKB
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- membrane Source: UniProtKB
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Microcephaly, postnatal progressive, with seizures and brain atrophy (MCPHSBA)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065066 | 371 | L → P in MCPHSBA. 1 PublicationCorresponds to variant dbSNP:rs267607232EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 9440 |
MalaCardsi | MED17 |
MIMi | 613668, phenotype |
OpenTargetsi | ENSG00000042429 |
Orphaneti | 402364, Infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly |
PharmGKBi | PA162395443 |
Miscellaneous databases
Pharosi | Q9NVC6, Tbio |
Genetic variation databases
BioMutai | MED17 |
DMDMi | 296437366 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079359 | 1 – 651 | Mediator of RNA polymerase II transcription subunit 17Add BLAST | 651 |
Proteomic databases
EPDi | Q9NVC6 |
jPOSTi | Q9NVC6 |
MassIVEi | Q9NVC6 |
MaxQBi | Q9NVC6 |
PaxDbi | Q9NVC6 |
PeptideAtlasi | Q9NVC6 |
PRIDEi | Q9NVC6 |
ProteomicsDBi | 82777 [Q9NVC6-1] 82778 [Q9NVC6-2] |
PTM databases
iPTMneti | Q9NVC6 |
PhosphoSitePlusi | Q9NVC6 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000042429, Expressed in kidney and 228 other tissues |
ExpressionAtlasi | Q9NVC6, baseline and differential |
Genevisiblei | Q9NVC6, HS |
Organism-specific databases
HPAi | ENSG00000042429, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with GATA1 and PPARG (By similarity).
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
Interacts with STAT2.
By similarity8 PublicationsBinary interactionsi
Hide detailsQ9NVC6
GO - Molecular functioni
- thyroid hormone receptor binding Source: UniProtKB
- vitamin D receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114830, 110 interactors |
ComplexPortali | CPX-3227, Core mediator complex |
CORUMi | Q9NVC6 |
DIPi | DIP-31451N |
IntActi | Q9NVC6, 60 interactors |
MINTi | Q9NVC6 |
STRINGi | 9606.ENSP00000251871 |
Miscellaneous databases
RNActi | Q9NVC6, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4512, Eukaryota |
GeneTreei | ENSGT00390000011810 |
HOGENOMi | CLU_028003_1_0_1 |
InParanoidi | Q9NVC6 |
OMAi | CQIYQHQ |
OrthoDBi | 976669at2759 |
PhylomeDBi | Q9NVC6 |
TreeFami | TF323615 |
Family and domain databases
InterProi | View protein in InterPro IPR019313, Mediator_Med17 |
PANTHERi | PTHR13114, PTHR13114, 1 hit |
Pfami | View protein in Pfam PF10156, Med17, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGVRAVRIS IESACEKQVH EVGLDGTETY LPPLSMSQNL ARLAQRIDFS
60 70 80 90 100
QGSGSEEEEA AGTEGDAQEW PGAGSSADQD DEEGVVKFQP SLWPWDSVRN
110 120 130 140 150
NLRSALTEMC VLYDVLSIVR DKKFMTLDPV SQDALPPKQN PQTLQLISKK
160 170 180 190 200
KSLAGAAQIL LKGAERLTKS VTENQENKLQ RDFNSELLRL RQHWKLRKVG
210 220 230 240 250
DKILGDLSYR SAGSLFPHHG TFEVIKNTDL DLDKKIPEDY CPLDVQIPSD
260 270 280 290 300
LEGSAYIKVS IQKQAPDIGD LGTVNLFKRP LPKSKPGSPH WQTKLEAAQN
310 320 330 340 350
VLLCKEIFAQ LSREAVQIKS QVPHIVVKNQ IISQPFPSLQ LSISLCHSSN
360 370 380 390 400
DKKSQKFATE KQCPEDHLYV LEHNLHLLIR EFHKQTLSSI MMPHPASAPF
410 420 430 440 450
GHKRMRLSGP QAFDKNEINS LQSSEGLLEK IIKQAKHIFL RSRAAATIDS
460 470 480 490 500
LASRIEDPQI QAHWSNINDV YESSVKVLIT SQGYEQICKS IQLQLNIGVE
510 520 530 540 550
QIRVVHRDGR VITLSYQEQE LQDFLLSQMS QHQVHAVQQL AKVMGWQVLS
560 570 580 590 600
FSNHVGLGPI ESIGNASAIT VASPSGDYAI SVRNGPESGS KIMVQFPRNQ
610 620 630 640 650
CKDLPKSDVL QDNKWSHLRG PFKEVQWNKM EGRNFVYKME LLMSALSPCL
L
Computationally mapped potential isoform sequencesi
There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PM72 | E9PM72_HUMAN | Mediator of RNA polymerase II trans... | MED17 | 509 | Annotation score: | ||
A0A1W2PS27 | A0A1W2PS27_HUMAN | Mediator of RNA polymerase II trans... | MED17 | 652 | Annotation score: | ||
A0A1W2PNW7 | A0A1W2PNW7_HUMAN | Mediator of RNA polymerase II trans... | MED17 | 605 | Annotation score: | ||
A0A1W2PS69 | A0A1W2PS69_HUMAN | Mediator of RNA polymerase II trans... | MED17 | 500 | Annotation score: | ||
A0A1W2PQ48 | A0A1W2PQ48_HUMAN | Mediator of RNA polymerase II trans... | MED17 | 386 | Annotation score: | ||
E9PKQ4 | E9PKQ4_HUMAN | Cofactor required for Sp1 transcrip... | MED17 | 231 | Annotation score: | ||
A0A1W2PQE4 | A0A1W2PQE4_HUMAN | Cofactor required for Sp1 transcrip... | MED17 | 219 | Annotation score: | ||
A0A1W2PRX4 | A0A1W2PRX4_HUMAN | Cofactor required for Sp1 transcrip... | MED17 | 530 | Annotation score: | ||
A0A1W2PPC8 | A0A1W2PPC8_HUMAN | Cofactor required for Sp1 transcrip... | MED17 | 123 | Annotation score: | ||
A0A1W2PPJ7 | A0A1W2PPJ7_HUMAN | Cofactor required for Sp1 transcrip... | MED17 | 85 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 21 | E → G in BAB13973 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 58 | E → G in BAB13973 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 356 | K → N in AAD30856 (PubMed:10235266).Curated | 1 | |
Sequence conflicti | 409 | G → Q AA sequence (PubMed:10198638).Curated | 1 | |
Sequence conflicti | 531 | Q → H in AAD12723 (PubMed:9989412).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063126 | 69 | E → DCombined sources4 PublicationsCorresponds to variant dbSNP:rs2848477EnsemblClinVar. | 1 | |
Natural variantiVAR_057781 | 357 | F → L. Corresponds to variant dbSNP:rs35313315EnsemblClinVar. | 1 | |
Natural variantiVAR_065066 | 371 | L → P in MCPHSBA. 1 PublicationCorresponds to variant dbSNP:rs267607232EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028115 | 140 – 145 | NPQTLQ → VFVDFN in isoform 2. 1 Publication | 6 | |
Alternative sequenceiVSP_028116 | 146 – 651 | Missing in isoform 2. 1 PublicationAdd BLAST | 506 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117657 mRNA Translation: AAD22031.2 AF105421 mRNA Translation: AAD30856.1 Frameshift. AK001674 mRNA Translation: BAA91827.1 AK022156 mRNA Translation: BAB13973.1 AK023209 mRNA Translation: BAG51169.1 AC022150 Genomic DNA No translation available. BC021101 mRNA Translation: AAH21101.1 AF104254 mRNA Translation: AAD12723.1 |
CCDSi | CCDS8295.1 [Q9NVC6-1] |
RefSeqi | NP_004259.3, NM_004268.4 [Q9NVC6-1] |
Genome annotation databases
Ensembli | ENST00000251871; ENSP00000251871; ENSG00000042429 [Q9NVC6-1] |
GeneIDi | 9440 |
KEGGi | hsa:9440 |
UCSCi | uc001pel.3, human [Q9NVC6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117657 mRNA Translation: AAD22031.2 AF105421 mRNA Translation: AAD30856.1 Frameshift. AK001674 mRNA Translation: BAA91827.1 AK022156 mRNA Translation: BAB13973.1 AK023209 mRNA Translation: BAG51169.1 AC022150 Genomic DNA No translation available. BC021101 mRNA Translation: AAH21101.1 AF104254 mRNA Translation: AAD12723.1 |
CCDSi | CCDS8295.1 [Q9NVC6-1] |
RefSeqi | NP_004259.3, NM_004268.4 [Q9NVC6-1] |
3D structure databases
SMRi | Q9NVC6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114830, 110 interactors |
ComplexPortali | CPX-3227, Core mediator complex |
CORUMi | Q9NVC6 |
DIPi | DIP-31451N |
IntActi | Q9NVC6, 60 interactors |
MINTi | Q9NVC6 |
STRINGi | 9606.ENSP00000251871 |
PTM databases
iPTMneti | Q9NVC6 |
PhosphoSitePlusi | Q9NVC6 |
Genetic variation databases
BioMutai | MED17 |
DMDMi | 296437366 |
Proteomic databases
EPDi | Q9NVC6 |
jPOSTi | Q9NVC6 |
MassIVEi | Q9NVC6 |
MaxQBi | Q9NVC6 |
PaxDbi | Q9NVC6 |
PeptideAtlasi | Q9NVC6 |
PRIDEi | Q9NVC6 |
ProteomicsDBi | 82777 [Q9NVC6-1] 82778 [Q9NVC6-2] |
Protocols and materials databases
Antibodypediai | 17843, 282 antibodies |
Genome annotation databases
Ensembli | ENST00000251871; ENSP00000251871; ENSG00000042429 [Q9NVC6-1] |
GeneIDi | 9440 |
KEGGi | hsa:9440 |
UCSCi | uc001pel.3, human [Q9NVC6-1] |
Organism-specific databases
CTDi | 9440 |
DisGeNETi | 9440 |
GeneCardsi | MED17 |
HGNCi | HGNC:2375, MED17 |
HPAi | ENSG00000042429, Low tissue specificity |
MalaCardsi | MED17 |
MIMi | 603810, gene 613668, phenotype |
neXtProti | NX_Q9NVC6 |
OpenTargetsi | ENSG00000042429 |
Orphaneti | 402364, Infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly |
PharmGKBi | PA162395443 |
VEuPathDBi | HostDB:ENSG00000042429.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4512, Eukaryota |
GeneTreei | ENSGT00390000011810 |
HOGENOMi | CLU_028003_1_0_1 |
InParanoidi | Q9NVC6 |
OMAi | CQIYQHQ |
OrthoDBi | 976669at2759 |
PhylomeDBi | Q9NVC6 |
TreeFami | TF323615 |
Enzyme and pathway databases
PathwayCommonsi | Q9NVC6 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-212436, Generic Transcription Pathway R-HSA-381340, Transcriptional regulation of white adipocyte differentiation |
Miscellaneous databases
BioGRID-ORCSi | 9440, 717 hits in 1004 CRISPR screens |
ChiTaRSi | MED17, human |
GeneWikii | MED17 |
GenomeRNAii | 9440 |
Pharosi | Q9NVC6, Tbio |
PROi | PR:Q9NVC6 |
RNActi | Q9NVC6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000042429, Expressed in kidney and 228 other tissues |
ExpressionAtlasi | Q9NVC6, baseline and differential |
Genevisiblei | Q9NVC6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019313, Mediator_Med17 |
PANTHERi | PTHR13114, PTHR13114, 1 hit |
Pfami | View protein in Pfam PF10156, Med17, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MED17_HUMAN | |
Accessioni | Q9NVC6Primary (citable) accession number: Q9NVC6 Secondary accession number(s): B3KN07 Q9Y660 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2003 |
Last sequence update: | May 18, 2010 | |
Last modified: | April 7, 2021 | |
This is version 167 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- UniProtKB entry view manual
User manual for the UniProtKB entry view - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families