UniProtKB - Q9NVC6 (MED17_HUMAN)

BLAST

>sp|Q9NVC6|MED17_HUMAN Mediator of RNA polymerase II transcription subunit 17 OS=Homo sapiens OX=9606 GN=MED17 PE=1 SV=2
MSGVRAVRISIESACEKQVHEVGLDGTETYLPPLSMSQNLARLAQRIDFSQGSGSEEEEA
AGTEGDAQEWPGAGSSADQDDEEGVVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVR
DKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQ
RDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDLDLDKKIPEDY
CPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQN
VLLCKEIFAQLSREAVQIKSQVPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSQKFATE
KQCPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINS
LQSSEGLLEKIIKQAKHIFLRSRAAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLIT
SQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSYQEQELQDFLLSQMSQHQVHAVQQL
AKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQ
CKDLPKSDVLQDNKWSHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL

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History
Entry version 151 (12 Sep 2018)
Sequence version 2 (18 May 2010)
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Protein

Mediator of RNA polymerase II transcription subunit 17

Gene

MED17

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.1 Publication

GO - Molecular functionⁱ

nuclear receptor transcription coactivator activity
Source: UniProtKB
Non-traceable author statementⁱ
- 10235266
signaling receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12218053
thyroid hormone receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10198638
transcription coactivator activity
Source: MGI
Inferred from direct assayⁱ
- 12037571
transcription coregulator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10198638
- 12218053
vitamin D receptor binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10235266

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

androgen receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 12218053
intracellular steroid hormone receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 11867769
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 10198638
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 12037571
regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 9989412
transcription initiation from RNA polymerase II promoter
Source: UniProtKB
Inferred from direct assayⁱ
- 12218053

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-212436 Generic Transcription Pathway R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Reactomeⁱ

R-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mediator of RNA polymerase II transcription subunit 17 Alternative name(s): Activator-recruited cofactor 77 kDa component Short name: ARC77 Cofactor required for Sp1 transcriptional activation subunit 6 Short name: CRSP complex subunit 6 Mediator complex subunit 17 Thyroid hormone receptor-associated protein complex 80 kDa component Short name: Trap80 Transcriptional coactivator CRSP77 Vitamin D3 receptor-interacting protein complex 80 kDa component Short name: DRIP80
Gene namesⁱ	Name:MED17 Synonyms:ARC77, CRSP6, DRIP77, DRIP80, TRAP80
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000042429.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2375 MED17
MIMⁱ	603810 gene
neXtProtⁱ	NX_Q9NVC6

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Microcephaly, postnatal progressive, with seizures and brain atrophy (MCPHSBA)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by postnatal progressive microcephaly and severe developmental retardation associated with cerebral and cerebellar atrophy. Infants manifest swallowing difficulties leading to failure to thrive, jitteriness, poor visual fixation, truncal arching, seizures. There is no acquisition of developmental milestones and patients suffer from marked spasticity and profound retardation. Progressive microcephaly becomes evident few months after birth.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_065066	371	L → P in MCPHSBA. 1 PublicationCorresponds to variant dbSNP:rs267607232EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9440
MalaCards human disease database More...MalaCardsⁱ	MED17
MIMⁱ	613668 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000042429
Orphanetⁱ	402364 Infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly
PharmGKBⁱ	PA162395443

Polymorphism and mutation databases

BioMutaⁱ	MED17
DMDMⁱ	296437366

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000079359	1 – 651	Mediator of RNA polymerase II transcription subunit 17Add BLAST		651

Proteomic databases

EPDⁱ	Q9NVC6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NVC6
PaxDbⁱ	Q9NVC6
PeptideAtlas More...PeptideAtlasⁱ	Q9NVC6
PRIDEⁱ	Q9NVC6
ProteomicsDBⁱ	82777 82778 [Q9NVC6-2]

PTM databases

iPTMnetⁱ	Q9NVC6
PhosphoSitePlusⁱ	Q9NVC6

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000042429 Expressed in 217 organ(s), highest expression level in kidney
CleanExⁱ	HS_MED17
ExpressionAtlasⁱ	Q9NVC6 baseline and differential
Genevisibleⁱ	Q9NVC6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA064236

HPAⁱ

HPA064236

Interactionⁱ

Subunit structureⁱ

Interacts with GATA1 and PPARG (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with STAT2.By similarity8 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Med11	Q9D8C6	2	EBI-394562,EBI-6260909	From Mus musculus.
MED22	Q15528	3	EBI-394562,EBI-394687
MED27	Q6P2C8	2	EBI-394562,EBI-394603
Med30	Q9CQI9	2	EBI-394562,EBI-309220	From Mus musculus.
MED6	O75586	2	EBI-394562,EBI-394624
Med8	Q9D7W5	2	EBI-394562,EBI-7990252	From Mus musculus.

GO - Molecular functionⁱ

thyroid hormone receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10198638
vitamin D receptor binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10235266

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114830, 85 interactors
ComplexPortalⁱ	CPX-3227 Core mediator complex
CORUMⁱ	Q9NVC6
Database of interacting proteins More...DIPⁱ	DIP-31451N
IntActⁱ	Q9NVC6, 43 interactors
Molecular INTeraction database More...MINTⁱ	Q9NVC6
STRINGⁱ	9606.ENSP00000251871

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NVC6
SMRⁱ	Q9NVC6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Mediator complex subunit 17 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4512 Eukaryota ENOG410XRQ8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011810
HOGENOMⁱ	HOG000008073
HOVERGENⁱ	HBG103247
InParanoidⁱ	Q9NVC6
KEGG Orthology (KO) More...KOⁱ	K15133
OMAⁱ	PHHGTFE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03JX
PhylomeDBⁱ	Q9NVC6
TreeFamⁱ	TF323615

Family and domain databases

InterProⁱ	View protein in InterPro IPR019313 Mediator_Med17
PANTHERⁱ	PTHR13114 PTHR13114, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10156 Med17, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 15 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NVC6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGVRAVRIS IESACEKQVH EVGLDGTETY LPPLSMSQNL ARLAQRIDFS 
        60         70         80         90        100
QGSGSEEEEA AGTEGDAQEW PGAGSSADQD DEEGVVKFQP SLWPWDSVRN 
       110        120        130        140        150
NLRSALTEMC VLYDVLSIVR DKKFMTLDPV SQDALPPKQN PQTLQLISKK 
       160        170        180        190        200
KSLAGAAQIL LKGAERLTKS VTENQENKLQ RDFNSELLRL RQHWKLRKVG 
       210        220        230        240        250
DKILGDLSYR SAGSLFPHHG TFEVIKNTDL DLDKKIPEDY CPLDVQIPSD 
       260        270        280        290        300
LEGSAYIKVS IQKQAPDIGD LGTVNLFKRP LPKSKPGSPH WQTKLEAAQN 
       310        320        330        340        350
VLLCKEIFAQ LSREAVQIKS QVPHIVVKNQ IISQPFPSLQ LSISLCHSSN 
       360        370        380        390        400
DKKSQKFATE KQCPEDHLYV LEHNLHLLIR EFHKQTLSSI MMPHPASAPF 
       410        420        430        440        450
GHKRMRLSGP QAFDKNEINS LQSSEGLLEK IIKQAKHIFL RSRAAATIDS 
       460        470        480        490        500
LASRIEDPQI QAHWSNINDV YESSVKVLIT SQGYEQICKS IQLQLNIGVE 
       510        520        530        540        550
QIRVVHRDGR VITLSYQEQE LQDFLLSQMS QHQVHAVQQL AKVMGWQVLS 
       560        570        580        590        600
FSNHVGLGPI ESIGNASAIT VASPSGDYAI SVRNGPESGS KIMVQFPRNQ 
       610        620        630        640        650
CKDLPKSDVL QDNKWSHLRG PFKEVQWNKM EGRNFVYKME LLMSALSPCL 

L

Length:651

Mass (Da):72,890

Last modified:May 18, 2010 - v2

Checksum:ⁱ47011210952D287B

Isoform 2 (identifier: Q9NVC6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
140-145: NPQTLQ → VFVDFN
146-651: Missing.

« Hide

        10         20         30         40         50
MSGVRAVRIS IESACEKQVH EVGLDGTETY LPPLSMSQNL ARLAQRIDFS 
        60         70         80         90        100
QGSGSEEEEA AGTEGDAQEW PGAGSSADQD DEEGVVKFQP SLWPWDSVRN 
       110        120        130        140 
NLRSALTEMC VLYDVLSIVR DKKFMTLDPV SQDALPPKQV FVDFN

Note: May be due to intron retention.

Show »

Length:145

Mass (Da):15,951

Checksum:ⁱ20AE08169FD09570

Computationally mapped potential isoform sequencesⁱ

There are 15 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	E9PM72	E9PM72_HUMAN	Mediator of RNA polymerase II trans... Mediator of RNA polymerase II transcription subunit 17 (Mediator complex subunit 17)	MED17	509	Annotation score:
	A0A1W2PS27	A0A1W2PS27_HUMAN	Mediator of RNA polymerase II trans... Mediator of RNA polymerase II transcription subunit 17 (Mediator complex subunit 17)	MED17	652	Annotation score:
	A0A1W2PNW7	A0A1W2PNW7_HUMAN	Mediator of RNA polymerase II trans... Mediator of RNA polymerase II transcription subunit 17 (Mediator complex subunit 17)	MED17	605	Annotation score:
	A0A1W2PQ48	A0A1W2PQ48_HUMAN	Mediator of RNA polymerase II trans... Mediator of RNA polymerase II transcription subunit 17 (Mediator complex subunit 17)	MED17	386	Annotation score:
	A0A1W2PS69	A0A1W2PS69_HUMAN	Mediator of RNA polymerase II trans... Mediator of RNA polymerase II transcription subunit 17 (Mediator complex subunit 17)	MED17	500	Annotation score:
	E9PJZ4	E9PJZ4_HUMAN	Mediator of RNA polymerase II trans... Mediator of RNA polymerase II transcription subunit 17	MED17	72	Annotation score:
	E9PKQ4	E9PKQ4_HUMAN	Mediator of RNA polymerase II trans... Mediator of RNA polymerase II transcription subunit 17	MED17	231	Annotation score:
	A0A1W2PPC8	A0A1W2PPC8_HUMAN	Mediator of RNA polymerase II trans... Mediator of RNA polymerase II transcription subunit 17	MED17	123	Annotation score:
	A0A1W2PPJ7	A0A1W2PPJ7_HUMAN	Mediator of RNA polymerase II trans... Mediator of RNA polymerase II transcription subunit 17	MED17	85	Annotation score:
	A0A1W2PPP8	A0A1W2PPP8_HUMAN	Mediator of RNA polymerase II trans... Mediator of RNA polymerase II transcription subunit 17	MED17	233	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence AAD30856 differs from that shown. Reason: Frameshift at positions 333, 335, 341 and 346.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	21	E → G in BAB13973 (PubMed:14702039).Curated	1
Sequence conflictⁱ	58	E → G in BAB13973 (PubMed:14702039).Curated	1
Sequence conflictⁱ	356	K → N in AAD30856 (PubMed:10235266).Curated	1
Sequence conflictⁱ	409	G → Q AA sequence (PubMed:10198638).Curated	1
Sequence conflictⁱ	531	Q → H in AAD12723 (PubMed:9989412).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_063126	69	E → DCombined sources4 PublicationsCorresponds to variant dbSNP:rs2848477EnsemblClinVar.	1
Natural variantⁱVAR_057781	357	F → L. Corresponds to variant dbSNP:rs35313315EnsemblClinVar.	1
Natural variantⁱVAR_065066	371	L → P in MCPHSBA. 1 PublicationCorresponds to variant dbSNP:rs267607232EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_028115	140 – 145	NPQTLQ → VFVDFN in isoform 2. 1 Publication		6
Alternative sequenceⁱVSP_028116	146 – 651	Missing in isoform 2. 1 PublicationAdd BLAST		506

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF117657 mRNA Translation: AAD22031.2 AF105421 mRNA Translation: AAD30856.1 Frameshift. AK001674 mRNA Translation: BAA91827.1 AK022156 mRNA Translation: BAB13973.1 AK023209 mRNA Translation: BAG51169.1 AC022150 Genomic DNA No translation available. BC021101 mRNA Translation: AAH21101.1 AF104254 mRNA Translation: AAD12723.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8295.1 [Q9NVC6-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_004259.3, NM_004268.4 [Q9NVC6-1]
UniGeneⁱ	Hs.444931

Genome annotation databases

Ensemblⁱ	ENST00000251871; ENSP00000251871; ENSG00000042429 [Q9NVC6-1]
GeneIDⁱ	9440
KEGGⁱ	hsa:9440
UCSC genome browser More...UCSCⁱ	uc001pel.3 human [Q9NVC6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NVC6	Mediator of RNA polymerase II transcription subunit 17		BOVIN		651	UniRef90_Q9NVC6
Mediator of RNA polymerase II transcription subunit 17		MOUSE		649
Mediator of RNA polymerase II transcription subunit 17		CHICK		643
Mediator of RNA polymerase II transcription subunit 17		CEREH		751
Mediator of RNA polymerase II transcription subunit 17		ERIEU		657
+176
Q9NVC6-2	Mediator of RNA polymerase II transcription subunit 17 (Fragment)		HUMAN		123	UniRef90_Q9NVC6-2

Protein	Similar proteins		Species	Score	Length	Source
Q9NVC6	Mediator of RNA polymerase II transcription subunit 17		BOVIN		651	UniRef50_Q9NVC6
Mediator of RNA polymerase II transcription subunit 17		MOUSE		649
Mediator of RNA polymerase II transcription subunit 17		CHICK		643
Mediator of RNA polymerase II transcription subunit 17		CEREH		751
Mediator of RNA polymerase II transcription subunit 17		ERIEU		657
+243
Q9NVC6-2	Mediator of RNA polymerase II transcription subunit 17 (Fragment)		HUMAN		123	UniRef50_Q9NVC6-2
Uncharacterized protein		TAKRU		143
Mediator complex subunit 17		GASAC		140
Uncharacterized protein		MANLE		127

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF117657 mRNA Translation: AAD22031.2 AF105421 mRNA Translation: AAD30856.1 Frameshift. AK001674 mRNA Translation: BAA91827.1 AK022156 mRNA Translation: BAB13973.1 AK023209 mRNA Translation: BAG51169.1 AC022150 Genomic DNA No translation available. BC021101 mRNA Translation: AAH21101.1 AF104254 mRNA Translation: AAD12723.1
CCDSⁱ	CCDS8295.1 [Q9NVC6-1]
RefSeqⁱ	NP_004259.3, NM_004268.4 [Q9NVC6-1]
UniGeneⁱ	Hs.444931

3D structure databases

ProteinModelPortalⁱ	Q9NVC6
SMRⁱ	Q9NVC6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114830, 85 interactors
ComplexPortalⁱ	CPX-3227 Core mediator complex
CORUMⁱ	Q9NVC6
DIPⁱ	DIP-31451N
IntActⁱ	Q9NVC6, 43 interactors
MINTⁱ	Q9NVC6
STRINGⁱ	9606.ENSP00000251871

PTM databases

iPTMnetⁱ	Q9NVC6
PhosphoSitePlusⁱ	Q9NVC6

Polymorphism and mutation databases

BioMutaⁱ	MED17
DMDMⁱ	296437366

Proteomic databases

EPDⁱ	Q9NVC6
MaxQBⁱ	Q9NVC6
PaxDbⁱ	Q9NVC6
PeptideAtlasⁱ	Q9NVC6
PRIDEⁱ	Q9NVC6
ProteomicsDBⁱ	82777 82778 [Q9NVC6-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000251871; ENSP00000251871; ENSG00000042429 [Q9NVC6-1]
GeneIDⁱ	9440
KEGGⁱ	hsa:9440
UCSCⁱ	uc001pel.3 human [Q9NVC6-1]

Organism-specific databases

CTDⁱ	9440
DisGeNETⁱ	9440
EuPathDBⁱ	HostDB:ENSG00000042429.10
GeneCardsⁱ	MED17
H-InvDBⁱ	HIX0010027
HGNCⁱ	HGNC:2375 MED17
HPAⁱ	HPA064236
MalaCardsⁱ	MED17
MIMⁱ	603810 gene 613668 phenotype
neXtProtⁱ	NX_Q9NVC6
OpenTargetsⁱ	ENSG00000042429
Orphanetⁱ	402364 Infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly
PharmGKBⁱ	PA162395443
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4512 Eukaryota ENOG410XRQ8 LUCA
GeneTreeⁱ	ENSGT00390000011810
HOGENOMⁱ	HOG000008073
HOVERGENⁱ	HBG103247
InParanoidⁱ	Q9NVC6
KOⁱ	K15133
OMAⁱ	PHHGTFE
OrthoDBⁱ	EOG091G03JX
PhylomeDBⁱ	Q9NVC6
TreeFamⁱ	TF323615

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-212436 Generic Transcription Pathway R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Reactomeⁱ

R-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Miscellaneous databases

ChiTaRSⁱ	MED17 human
GeneWikiⁱ	MED17
GenomeRNAiⁱ	9440
Protein Ontology More...PROⁱ	PR:Q9NVC6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000042429 Expressed in 217 organ(s), highest expression level in kidney
CleanExⁱ	HS_MED17
ExpressionAtlasⁱ	Q9NVC6 baseline and differential
Genevisibleⁱ	Q9NVC6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019313 Mediator_Med17
PANTHERⁱ	PTHR13114 PTHR13114, 1 hit
Pfamⁱ	View protein in Pfam PF10156 Med17, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MED17_HUMAN
Accessionⁱ	Q9NVC6Primary (citable) accession number: Q9NVC6 Secondary accession number(s): B3KN07 , Q9HA81, Q9UNP7, Q9Y2W0, Q9Y660
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 28, 2003
	Last sequence update:	May 18, 2010
	Last modified:	September 12, 2018
	This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q9NVC6 (MED17_HUMAN)

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Mediator of RNA polymerase II transcription subunit 17

MED17

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ