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Protein

Putative sodium-coupled neutral amino acid transporter 7

Gene

SLC38A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates sodium-dependent transport of amino acids, preferentially L-glutamine.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Ion transport, Sodium transport, Transport
LigandSodium

Protein family/group databases

TCDBi2.A.18.6.13 the amino acid/auxin permease (aaap) family

Names & Taxonomyi

Protein namesi
Recommended name:
Putative sodium-coupled neutral amino acid transporter 7
Alternative name(s):
Solute carrier family 38 member 7
Gene namesi
Name:SLC38A7
Synonyms:SNAT7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103042.8
HGNCiHGNC:25582 SLC38A7
MIMi614236 gene
neXtProtiNX_Q9NVC3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55238
OpenTargetsiENSG00000103042
PharmGKBiPA162403772

Polymorphism and mutation databases

BioMutaiSLC38A7
DMDMi74734488

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003195971 – 462Putative sodium-coupled neutral amino acid transporter 7Add BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NVC3
MaxQBiQ9NVC3
PaxDbiQ9NVC3
PeptideAtlasiQ9NVC3
PRIDEiQ9NVC3
ProteomicsDBi82775
82776 [Q9NVC3-2]

PTM databases

iPTMnetiQ9NVC3
PhosphoSitePlusiQ9NVC3

Expressioni

Gene expression databases

BgeeiENSG00000103042 Expressed in 193 organ(s), highest expression level in testis
CleanExiHS_SLC38A7
ExpressionAtlasiQ9NVC3 baseline and differential
GenevisibleiQ9NVC3 HS

Organism-specific databases

HPAiHPA041777

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RNF5Q999423EBI-10314552,EBI-348482

Protein-protein interaction databases

BioGridi120531, 13 interactors
IntActiQ9NVC3, 44 interactors
STRINGi9606.ENSP00000219320

Structurei

3D structure databases

ProteinModelPortaliQ9NVC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305 Eukaryota
COG0814 LUCA
GeneTreeiENSGT00710000106751
HOGENOMiHOG000008036
HOVERGENiHBG055999
InParanoidiQ9NVC3
KOiK14994
OMAiWWALVSY
OrthoDBiEOG091G08A4
PhylomeDBiQ9NVC3
TreeFamiTF328787

Family and domain databases

InterProiView protein in InterPro
IPR013057 AA_transpt_TM
PfamiView protein in Pfam
PF01490 Aa_trans, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NVC3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQVSINNDY SEWDLSTDAG ERARLLQSPC VDTAPKSEWE ASPGGLDRGT
60 70 80 90 100
TSTLGAIFIV VNACLGAGLL NFPAAFSTAG GVAAGIALQM GMLVFIISGL
110 120 130 140 150
VILAYCSQAS NERTYQEVVW AVCGKLTGVL CEVAIAVYTF GTCIAFLIII
160 170 180 190 200
GDQQDKIIAV MAKEPEGASG PWYTDRKFTI SLTAFLFILP LSIPREIGFQ
210 220 230 240 250
KYASFLSVVG TWYVTAIVII KYIWPDKEMT PGNILTRPAS WMAVFNAMPT
260 270 280 290 300
ICFGFQCHVS SVPVFNSMQQ PEVKTWGGVV TAAMVIALAV YMGTGICGFL
310 320 330 340 350
TFGAAVDPDV LLSYPSEDMA VAVARAFIIL SVLTSYPILH FCGRAVVEGL
360 370 380 390 400
WLRYQGVPVE EDVGRERRRR VLQTLVWFLL TLLLALFIPD IGKVISVIGG
410 420 430 440 450
LAACFIFVFP GLCLIQAKLS EMEEVKPASW WVLVSYGVLL VTLGAFIFGQ
460
TTANAIFVDL LA
Length:462
Mass (Da):49,966
Last modified:October 1, 2000 - v1
Checksum:iB4F46C19D7E6EADB
GO
Isoform 2 (identifier: Q9NVC3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     345-462: Missing.

Note: No experimental confirmation available.
Show »
Length:344
Mass (Da):36,904
Checksum:iF48CBD890B7E928B
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPK8H3BPK8_HUMAN
Putative sodium-coupled neutral ami...
SLC38A7
373Annotation score:
H3BMC5H3BMC5_HUMAN
Putative sodium-coupled neutral ami...
SLC38A7
354Annotation score:
H3BP25H3BP25_HUMAN
Putative sodium-coupled neutral ami...
SLC38A7
260Annotation score:
H3BV81H3BV81_HUMAN
Putative sodium-coupled neutral ami...
SLC38A7
170Annotation score:
H3BPV9H3BPV9_HUMAN
Putative sodium-coupled neutral ami...
SLC38A7
140Annotation score:
H3BRZ0H3BRZ0_HUMAN
Putative sodium-coupled neutral ami...
SLC38A7
65Annotation score:
H3BN87H3BN87_HUMAN
Putative sodium-coupled neutral ami...
SLC38A7
94Annotation score:
H3BU46H3BU46_HUMAN
Putative sodium-coupled neutral ami...
SLC38A7
135Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145A → T in BAB14244 (PubMed:14702039).Curated1
Sequence conflicti208V → A in BAD96652 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03901546L → P. Corresponds to variant dbSNP:rs7193572Ensembl.1
Natural variantiVAR_03901678T → I. Corresponds to variant dbSNP:rs7191331Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031511345 – 462Missing in isoform 2. 1 PublicationAdd BLAST118

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001677 mRNA Translation: BAA91830.1
AK022786 mRNA Translation: BAB14244.1
CR457236 mRNA Translation: CAG33517.1
AK222932 mRNA Translation: BAD96652.1
CH471092 Genomic DNA Translation: EAW82985.1
BC001961 mRNA Translation: AAH01961.1
CCDSiCCDS10800.1 [Q9NVC3-1]
RefSeqiNP_060701.1, NM_018231.2 [Q9NVC3-1]
XP_016878882.1, XM_017023393.1
XP_016878886.1, XM_017023397.1
UniGeneiHs.10499
Hs.593499

Genome annotation databases

EnsembliENST00000219320; ENSP00000219320; ENSG00000103042 [Q9NVC3-1]
ENST00000570101; ENSP00000454646; ENSG00000103042 [Q9NVC3-1]
GeneIDi55238
KEGGihsa:55238
UCSCiuc002eod.2 human [Q9NVC3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001677 mRNA Translation: BAA91830.1
AK022786 mRNA Translation: BAB14244.1
CR457236 mRNA Translation: CAG33517.1
AK222932 mRNA Translation: BAD96652.1
CH471092 Genomic DNA Translation: EAW82985.1
BC001961 mRNA Translation: AAH01961.1
CCDSiCCDS10800.1 [Q9NVC3-1]
RefSeqiNP_060701.1, NM_018231.2 [Q9NVC3-1]
XP_016878882.1, XM_017023393.1
XP_016878886.1, XM_017023397.1
UniGeneiHs.10499
Hs.593499

3D structure databases

ProteinModelPortaliQ9NVC3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120531, 13 interactors
IntActiQ9NVC3, 44 interactors
STRINGi9606.ENSP00000219320

Protein family/group databases

TCDBi2.A.18.6.13 the amino acid/auxin permease (aaap) family

PTM databases

iPTMnetiQ9NVC3
PhosphoSitePlusiQ9NVC3

Polymorphism and mutation databases

BioMutaiSLC38A7
DMDMi74734488

Proteomic databases

EPDiQ9NVC3
MaxQBiQ9NVC3
PaxDbiQ9NVC3
PeptideAtlasiQ9NVC3
PRIDEiQ9NVC3
ProteomicsDBi82775
82776 [Q9NVC3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219320; ENSP00000219320; ENSG00000103042 [Q9NVC3-1]
ENST00000570101; ENSP00000454646; ENSG00000103042 [Q9NVC3-1]
GeneIDi55238
KEGGihsa:55238
UCSCiuc002eod.2 human [Q9NVC3-1]

Organism-specific databases

CTDi55238
DisGeNETi55238
EuPathDBiHostDB:ENSG00000103042.8
GeneCardsiSLC38A7
HGNCiHGNC:25582 SLC38A7
HPAiHPA041777
MIMi614236 gene
neXtProtiNX_Q9NVC3
OpenTargetsiENSG00000103042
PharmGKBiPA162403772
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1305 Eukaryota
COG0814 LUCA
GeneTreeiENSGT00710000106751
HOGENOMiHOG000008036
HOVERGENiHBG055999
InParanoidiQ9NVC3
KOiK14994
OMAiWWALVSY
OrthoDBiEOG091G08A4
PhylomeDBiQ9NVC3
TreeFamiTF328787

Miscellaneous databases

ChiTaRSiSLC38A7 human
GenomeRNAii55238
PROiPR:Q9NVC3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103042 Expressed in 193 organ(s), highest expression level in testis
CleanExiHS_SLC38A7
ExpressionAtlasiQ9NVC3 baseline and differential
GenevisibleiQ9NVC3 HS

Family and domain databases

InterProiView protein in InterPro
IPR013057 AA_transpt_TM
PfamiView protein in Pfam
PF01490 Aa_trans, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS38A7_HUMAN
AccessioniPrimary (citable) accession number: Q9NVC3
Secondary accession number(s): Q53GJ9, Q9H9I5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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