UniProtKB - Q9NVA4 (T184C_HUMAN)
Protein
Transmembrane protein 184C
Gene
TMEM184C
Organism
Homo sapiens (Human)
Status
Functioni
Possible tumor suppressor which may play a role in cell growth.1 Publication
Enzyme and pathway databases
PathwayCommonsi | Q9NVA4 |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 184CAlternative name(s): Transmembrane protein 34 |
Gene namesi | Name:TMEM184C Synonyms:TMEM34 ORF Names:PRO1355 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25587, TMEM184C |
MIMi | 613937, gene |
neXtProti | NX_Q9NVA4 |
VEuPathDBi | HostDB:ENSG00000164168.7 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 17 – 37 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 48 – 68 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 86 – 106 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 179 – 199 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 212 – 232 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 254 – 274 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 287 – 307 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 55751 |
OpenTargetsi | ENSG00000164168 |
PharmGKBi | PA162406163 |
Miscellaneous databases
Pharosi | Q9NVA4, Tbio |
Genetic variation databases
BioMutai | TMEM184C |
DMDMi | 296452918 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287567 | 1 – 438 | Transmembrane protein 184CAdd BLAST | 438 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 422 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NVA4 |
jPOSTi | Q9NVA4 |
MassIVEi | Q9NVA4 |
MaxQBi | Q9NVA4 |
PaxDbi | Q9NVA4 |
PeptideAtlasi | Q9NVA4 |
PRIDEi | Q9NVA4 |
ProteomicsDBi | 82773 [Q9NVA4-1] 82774 [Q9NVA4-2] |
PTM databases
iPTMneti | Q9NVA4 |
PhosphoSitePlusi | Q9NVA4 |
SwissPalmi | Q9NVA4 |
Expressioni
Tissue specificityi
Widely expressed with higher expression in lung, kidney, spleen, pancreas, thymus, prostate, testis, ovary, small intestine and thyroid.1 Publication
Gene expression databases
Bgeei | ENSG00000164168, Expressed in parotid gland and 221 other tissues |
ExpressionAtlasi | Q9NVA4, baseline and differential |
Genevisiblei | Q9NVA4, HS |
Organism-specific databases
HPAi | ENSG00000164168, Tissue enhanced (parathyroid) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120869, 6 interactors |
IntActi | Q9NVA4, 5 interactors |
MINTi | Q9NVA4 |
STRINGi | 9606.ENSP00000296582 |
Miscellaneous databases
RNActi | Q9NVA4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TMEM184 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2641, Eukaryota |
GeneTreei | ENSGT00940000155201 |
HOGENOMi | CLU_012923_1_1_1 |
InParanoidi | Q9NVA4 |
OMAi | DWEMGRE |
OrthoDBi | 462913at2759 |
PhylomeDBi | Q9NVA4 |
TreeFami | TF324245 |
Family and domain databases
InterProi | View protein in InterPro IPR005178, Ostalpha/TMEM184C |
PANTHERi | PTHR23423, PTHR23423, 1 hit |
Pfami | View protein in Pfam PF03619, Solute_trans_a, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NVA4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPCTCTWRNW RQWIRPLVAV IYLVSIVVAV PLCVWELQKL EVGIHTKAWF
60 70 80 90 100
IAGIFLLLTI PISLWVILQH LVHYTQPELQ KPIIRILWMV PIYSLDSWIA
110 120 130 140 150
LKYPGIAIYV DTCRECYEAY VIYNFMGFLT NYLTNRYPNL VLILEAKDQQ
160 170 180 190 200
KHFPPLCCCP PWAMGEVLLF RCKLGVLQYT VVRPFTTIVA LICELLGIYD
210 220 230 240 250
EGNFSFSNAW TYLVIINNMS QLFAMYCLLL FYKVLKEELS PIQPVGKFLC
260 270 280 290 300
VKLVVFVSFW QAVVIALLVK VGVISEKHTW EWQTVEAVAT GLQDFIICIE
310 320 330 340 350
MFLAAIAHHY TFSYKPYVQE AEEGSCFDSF LAMWDVSDIR DDISEQVRHV
360 370 380 390 400
GRTVRGHPRK KLFPEDQDQN EHTSLLSSSS QDAISIASSM PPSPMGHYQG
410 420 430
FGHTVTPQTT PTTAKISDEI LSDTIGEKKE PSDKSVDS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y8I5 | H0Y8I5_HUMAN | Transmembrane protein 184C | TMEM184C | 72 | Annotation score: | ||
A0A0C4DGC8 | A0A0C4DGC8_HUMAN | Transmembrane protein 184C | TMEM184C | 261 | Annotation score: |
Sequence cautioni
The sequence AAK55526 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA90988 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 230 | L → P in BAA90988 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 252 | K → R in BAA91851 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 261 | Q → P in AAH46128 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 355 | R → G in BAA91851 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025566 | 262 – 438 | Missing in isoform 2. 1 PublicationAdd BLAST | 177 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000169 mRNA Translation: BAA90988.1 Different initiation. AK001708 mRNA Translation: BAA91851.1 BC008120 mRNA Translation: AAH08120.1 BC046128 mRNA Translation: AAH46128.1 AC093835 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX05015.1 CH471056 Genomic DNA Translation: EAX05016.1 AF305823 mRNA Translation: AAK55526.1 Different initiation. |
CCDSi | CCDS3770.1 [Q9NVA4-1] |
RefSeqi | NP_060711.2, NM_018241.2 [Q9NVA4-1] |
Genome annotation databases
Ensembli | ENST00000296582; ENSP00000296582; ENSG00000164168 [Q9NVA4-1] |
GeneIDi | 55751 |
KEGGi | hsa:55751 |
UCSCi | uc003ila.5, human [Q9NVA4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000169 mRNA Translation: BAA90988.1 Different initiation. AK001708 mRNA Translation: BAA91851.1 BC008120 mRNA Translation: AAH08120.1 BC046128 mRNA Translation: AAH46128.1 AC093835 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX05015.1 CH471056 Genomic DNA Translation: EAX05016.1 AF305823 mRNA Translation: AAK55526.1 Different initiation. |
CCDSi | CCDS3770.1 [Q9NVA4-1] |
RefSeqi | NP_060711.2, NM_018241.2 [Q9NVA4-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120869, 6 interactors |
IntActi | Q9NVA4, 5 interactors |
MINTi | Q9NVA4 |
STRINGi | 9606.ENSP00000296582 |
PTM databases
iPTMneti | Q9NVA4 |
PhosphoSitePlusi | Q9NVA4 |
SwissPalmi | Q9NVA4 |
Genetic variation databases
BioMutai | TMEM184C |
DMDMi | 296452918 |
Proteomic databases
EPDi | Q9NVA4 |
jPOSTi | Q9NVA4 |
MassIVEi | Q9NVA4 |
MaxQBi | Q9NVA4 |
PaxDbi | Q9NVA4 |
PeptideAtlasi | Q9NVA4 |
PRIDEi | Q9NVA4 |
ProteomicsDBi | 82773 [Q9NVA4-1] 82774 [Q9NVA4-2] |
Protocols and materials databases
Antibodypediai | 45494, 56 antibodies |
Genome annotation databases
Ensembli | ENST00000296582; ENSP00000296582; ENSG00000164168 [Q9NVA4-1] |
GeneIDi | 55751 |
KEGGi | hsa:55751 |
UCSCi | uc003ila.5, human [Q9NVA4-1] |
Organism-specific databases
CTDi | 55751 |
DisGeNETi | 55751 |
GeneCardsi | TMEM184C |
HGNCi | HGNC:25587, TMEM184C |
HPAi | ENSG00000164168, Tissue enhanced (parathyroid) |
MIMi | 613937, gene |
neXtProti | NX_Q9NVA4 |
OpenTargetsi | ENSG00000164168 |
PharmGKBi | PA162406163 |
VEuPathDBi | HostDB:ENSG00000164168.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2641, Eukaryota |
GeneTreei | ENSGT00940000155201 |
HOGENOMi | CLU_012923_1_1_1 |
InParanoidi | Q9NVA4 |
OMAi | DWEMGRE |
OrthoDBi | 462913at2759 |
PhylomeDBi | Q9NVA4 |
TreeFami | TF324245 |
Enzyme and pathway databases
PathwayCommonsi | Q9NVA4 |
Miscellaneous databases
BioGRID-ORCSi | 55751, 27 hits in 995 CRISPR screens |
ChiTaRSi | TMEM184C, human |
GenomeRNAii | 55751 |
Pharosi | Q9NVA4, Tbio |
PROi | PR:Q9NVA4 |
RNActi | Q9NVA4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164168, Expressed in parotid gland and 221 other tissues |
ExpressionAtlasi | Q9NVA4, baseline and differential |
Genevisiblei | Q9NVA4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR005178, Ostalpha/TMEM184C |
PANTHERi | PTHR23423, PTHR23423, 1 hit |
Pfami | View protein in Pfam PF03619, Solute_trans_a, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | T184C_HUMAN | |
Accessioni | Q9NVA4Primary (citable) accession number: Q9NVA4 Secondary accession number(s): D3DP04 Q9NXM2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | April 7, 2021 | |
This is version 122 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families