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Entry version 144 (18 Sep 2019)
Sequence version 2 (30 Aug 2005)
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Protein

NEDD4 family-interacting protein 2

Gene

NDFIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity).By similarity4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei186Not phosphorylated by SRC1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • WW domain binding Source: BHF-UCL

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NEDD4 family-interacting protein 2
Alternative name(s):
NEDD4 WW domain-binding protein 5A
Putative MAPK-activating protein PM04/PM05/PM06/PM07
Putative NF-kappa-B-activating protein 413
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NDFIP2
Synonyms:KIAA1165, N4WBP5A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:18537 NDFIP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610041 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NV92

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 231CytoplasmicSequence analysisAdd BLAST231
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 257ExtracellularSequence analysis5
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 287CytoplasmicSequence analysis9
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Topological domaini309 – 336ExtracellularSequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi150 – 151PY → AG: Loss of E3 ubiquitin-protein ligase activation; when associated with 175-P--G-177 AND 184-P--G-186. Greatly decreases NEDD4-binding; when associated with 175-P--G-177 and 184-P--G-186. No effect on PTEN-binding; when associated with 175-P--G-177 AND 184-P--G-186. 2
Mutagenesisi167Y → F: Loss of NDFIP2 phosphorylation by SRC. 1 Publication1
Mutagenesisi176 – 177PY → AG: Loss of E3 ubiquitin-protein ligase activation; when associated with 149-P--G-151 AND 184-P--G-186. Greatly decreases NEDD4-binding; when associated with 149-P-G-151 AND 184-P--G-186. No effect on PTEN-binding; when associated with 149-P--G-151 AND 184-P--G-186. 2
Mutagenesisi185 – 186TY → AG: Loss of E3 ubiquitin-protein ligase activation; when associated with 149-P--G-151 AND 175-P--G-177. Greatly decreases NEDD4-binding; when associated with 149-P--G-151 AND 175-P--G-177. No effect on PTEN-binding; when associated with 149-P--G-151 AND 175-P--G-177. 2

Organism-specific databases

DisGeNET

More...
DisGeNETi
54602

Open Targets

More...
OpenTargetsi
ENSG00000102471

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134953250

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NDFIP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73921209

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000967941 – 336NEDD4 family-interacting protein 2Add BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei151Phosphotyrosine; by SRC1 Publication1
Modified residuei167Phosphotyrosine; by SRC1 Publication1
Modified residuei171Phosphotyrosine; by SRC1 Publication1
Modified residuei177Phosphotyrosine; by SRC1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by NEDD4 and ITCH. Also ubiquitinated by NEDD4L. Ubiquitination by NEDD4 or NEDD4L does not affect turnover (By similarity).By similarity
Undergoes transient tyrosine-phosphorylation following EGF stimulation, most probably catalyzed by SRC. Phosphorylation on Tyr-151, Tyr-171 and Tyr-177 are dependent on the phosphorylation on Tyr-167. Also phosphorylated by LYN and FYN.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NV92

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NV92

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NV92

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NV92

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NV92

PeptideAtlas

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PeptideAtlasi
Q9NV92

PRoteomics IDEntifications database

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PRIDEi
Q9NV92

ProteomicsDB human proteome resource

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ProteomicsDBi
82762

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9NV92

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NV92

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, lung, heart, skeletal muscle, kidney, liver and placenta.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By T-cell activation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000102471 Expressed in 204 organ(s), highest expression level in parietal lobe

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NV92 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NV92 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA009160

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms heterodimers with NDFIP1.

Interacts with HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 (PubMed:12796489).

Interacts with NEDD4L (PubMed:26363003).

Interacts with PTEN. When phosphorylated at Tyr-167, interacts with SRC and LYN SH2 domain. May thus act as a scaffold that recruits SRC to NDFIP1, enhancing NDFIP1 phosphorylation.

Interacts with SLC11A2/DMT1 (PubMed:18776082). May interact with phosphorylated EGFR.

Interacts with KCNH2 (PubMed:26363003).

By similarity4 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120074, 34 interactors

Protein interaction database and analysis system

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IntActi
Q9NV92, 6 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000480798

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni148 – 151Interaction with NEDD4By similarity4

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi148 – 151PPxY motif 14
Motifi174 – 177PPxY motif 24
Motifi184 – 186PPxY motif 33

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PPxY motifs are required for E3 ubiquitin-protein ligase activation and for ubiquitination.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4812 Eukaryota
ENOG4111M6U LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000012721

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000038752

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NV92

Identification of Orthologs from Complete Genome Data

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OMAi
GEFYPVP

Database of Orthologous Groups

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OrthoDBi
1495850at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NV92

TreeFam database of animal gene trees

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TreeFami
TF324911

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR019325 NEDD4/Bsd2

The PANTHER Classification System

More...
PANTHERi
PTHR13396 PTHR13396, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9NV92-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARRRSQRVC ASGPSMLNSA RGAPELLRGT ATNAEVSAAA AGATGSEELP
60 70 80 90 100
PGDRGCRNGG GRGPAATTSS TGVAVGAEHG EDSLSRKPDP EPGRMDHHQP
110 120 130 140 150
GTGRYQVLLN EEDNSESSAI EQPPTSNPAP QIVQAASSAP ALETDSSPPP
160 170 180 190 200
YSSITVEVPT TSDTEVYGEF YPVPPPYSVA TSLPTYDEAE KAKAAAMAAA
210 220 230 240 250
AAETSQRIQE EECPPRDDFS DADQLRVGND GIFMLAFFMA FIFNWLGFCL
260 270 280 290 300
SFCITNTIAG RYGAICGFGL SLIKWILIVR FSDYFTGYFN GQYWLWWIFL
310 320 330
VLGLLLFFRG FVNYLKVRNM SESMAAAHRT RYFFLL
Length:336
Mass (Da):36,390
Last modified:August 30, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7E386C12886321E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DGY6B4DGY6_HUMAN
NEDD4 family-interacting protein 2
NDFIP2
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGW0A0A0C4DGW0_HUMAN
NEDD4 family-interacting protein 2
NDFIP2
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5F7H7C5F7_HUMAN
NEDD4 family-interacting protein 2
NDFIP2
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRK3A0A3B3IRK3_HUMAN
NEDD4 family-interacting protein 2
NDFIP2
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH21988 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH26126 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91863 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061687124P → S. Corresponds to variant dbSNP:rs55887763Ensembl.1
Natural variantiVAR_023414136A → V3 PublicationsCorresponds to variant dbSNP:rs11549502Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB097019 mRNA Translation: BAC77372.1
AB097028 mRNA Translation: BAC77381.1
AB097029 mRNA Translation: BAC77382.1
AB097030 mRNA Translation: BAC77383.1
AB097031 mRNA Translation: BAC77384.1
AL136442 Genomic DNA No translation available.
AL355603 Genomic DNA No translation available.
AK001723 mRNA Translation: BAA91863.1 Different initiation.
AB032991 mRNA Translation: BAA86479.1
BC021988 mRNA Translation: AAH21988.1 Different initiation.
BC026126 mRNA Translation: AAH26126.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS31998.1

NCBI Reference Sequences

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RefSeqi
NP_061953.2, NM_019080.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000218652; ENSP00000218652; ENSG00000102471
ENST00000612570; ENSP00000480798; ENSG00000102471

Database of genes from NCBI RefSeq genomes

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GeneIDi
54602

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54602

UCSC genome browser

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UCSCi
uc001vlf.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097019 mRNA Translation: BAC77372.1
AB097028 mRNA Translation: BAC77381.1
AB097029 mRNA Translation: BAC77382.1
AB097030 mRNA Translation: BAC77383.1
AB097031 mRNA Translation: BAC77384.1
AL136442 Genomic DNA No translation available.
AL355603 Genomic DNA No translation available.
AK001723 mRNA Translation: BAA91863.1 Different initiation.
AB032991 mRNA Translation: BAA86479.1
BC021988 mRNA Translation: AAH21988.1 Different initiation.
BC026126 mRNA Translation: AAH26126.1 Different initiation.
CCDSiCCDS31998.1
RefSeqiNP_061953.2, NM_019080.2

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Protein-protein interaction databases

BioGridi120074, 34 interactors
IntActiQ9NV92, 6 interactors
STRINGi9606.ENSP00000480798

PTM databases

iPTMnetiQ9NV92
PhosphoSitePlusiQ9NV92

Polymorphism and mutation databases

BioMutaiNDFIP2
DMDMi73921209

Proteomic databases

EPDiQ9NV92
jPOSTiQ9NV92
MassIVEiQ9NV92
MaxQBiQ9NV92
PaxDbiQ9NV92
PeptideAtlasiQ9NV92
PRIDEiQ9NV92
ProteomicsDBi82762

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000218652; ENSP00000218652; ENSG00000102471
ENST00000612570; ENSP00000480798; ENSG00000102471
GeneIDi54602
KEGGihsa:54602
UCSCiuc001vlf.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54602
DisGeNETi54602

GeneCards: human genes, protein and diseases

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GeneCardsi
NDFIP2
HGNCiHGNC:18537 NDFIP2
HPAiHPA009160
MIMi610041 gene
neXtProtiNX_Q9NV92
OpenTargetsiENSG00000102471
PharmGKBiPA134953250

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4812 Eukaryota
ENOG4111M6U LUCA
GeneTreeiENSGT00390000012721
HOGENOMiHOG000038752
InParanoidiQ9NV92
OMAiGEFYPVP
OrthoDBi1495850at2759
PhylomeDBiQ9NV92
TreeFamiTF324911

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NDFIP2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NDFIP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54602

Pharos

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Pharosi
Q9NV92

Protein Ontology

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PROi
PR:Q9NV92

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000102471 Expressed in 204 organ(s), highest expression level in parietal lobe
ExpressionAtlasiQ9NV92 baseline and differential
GenevisibleiQ9NV92 HS

Family and domain databases

InterProiView protein in InterPro
IPR019325 NEDD4/Bsd2
PANTHERiPTHR13396 PTHR13396, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFIP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NV92
Secondary accession number(s): Q7Z2H3
, Q7Z428, Q8TAR3, Q9ULQ5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: September 18, 2019
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
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