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Entry version 143 (02 Jun 2021)
Sequence version 2 (31 Oct 2006)
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Protein

Integrator complex subunit 9

Gene

INTS9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).

1 Publication1 Publication

Miscellaneous

Although strongly related to RNA-specific endonuclease proteins, it lacks the HXHXDH motif that binds zinc and participates in the catalytic center. Its function as endonuclease is therefore unsure.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9NV88

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6807505, RNA polymerase II transcribes snRNA genes

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9NV88

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrator complex subunit 9
Short name:
Int9
Alternative name(s):
Protein related to CPSF subunits of 74 kDa
Short name:
RC-74
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INTS9
Synonyms:RC74
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:25592, INTS9

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611352, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NV88

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000104299.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55756

Open Targets

More...
OpenTargetsi
ENSG00000104299

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162392192

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NV88, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
INTS9

Domain mapping of disease mutations (DMDM)

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DMDMi
119371246

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002595571 – 658Integrator complex subunit 9Add BLAST658

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki58Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NV88

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NV88

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NV88

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NV88

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NV88

PeptideAtlas

More...
PeptideAtlasi
Q9NV88

PRoteomics IDEntifications database

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PRIDEi
Q9NV88

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
6659
82760 [Q9NV88-1]
82761 [Q9NV88-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NV88

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9NV88

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000104299, Expressed in right adrenal gland and 194 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NV88, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NV88, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000104299, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12 (PubMed:16239144).

Interacts with ESRRB, ESRRB is probably not a core component of the multiprotein complex Integrator and this association is a bridge for the interaction with the multiprotein complex Integrator; attracts the transcriptional machinery (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
120874, 48 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9NV88

Protein interaction database and analysis system

More...
IntActi
Q9NV88, 12 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000429065

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NV88, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1658
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NV88

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni548 – 574DisorderedSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1138, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000001445

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NV88

Identification of Orthologs from Complete Genome Data

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OMAi
CMLALPF

Database of Orthologous Groups

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OrthoDBi
617493at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NV88

TreeFam database of animal gene trees

More...
TreeFami
TF314100

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR022712, Beta_Casp
IPR027074, Integrator_9su
IPR001279, Metallo-B-lactamas
IPR036866, RibonucZ/Hydroxyglut_hydro

The PANTHER Classification System

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PANTHERi
PTHR46094, PTHR46094, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF16661, Lactamase_B_6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01027, Beta-Casp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56281, SSF56281, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NV88-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLYCLSGHP TLPCNVLKFK STTIMLDCGL DMTSTLNFLP LPLVQSPRLS
60 70 80 90 100
NLPGWSLKDG NAFLDKELKE CSGHVFVDSV PEFCLPETEL IDLSTVDVIL
110 120 130 140 150
ISNYHCMMAL PYITEHTGFT GTVYATEPTV QIGRLLMEEL VNFIERVPKA
160 170 180 190 200
QSASLWKNKD IQRLLPSPLK DAVEVSTWRR CYTMQEVNSA LSKIQLVGYS
210 220 230 240 250
QKIELFGAVQ VTPLSSGYAL GSSNWIIQSH YEKVSYVSGS SLLTTHPQPM
260 270 280 290 300
DQASLKNSDV LVLTGLTQIP TANPDGMVGE FCSNLALTVR NGGNVLVPCY
310 320 330 340 350
PSGVIYDLLE CLYQYIDSAG LSSVPLYFIS PVANSSLEFS QIFAEWLCHN
360 370 380 390 400
KQSKVYLPEP PFPHAELIQT NKLKHYPSIH GDFSNDFRQP CVVFTGHPSL
410 420 430 440 450
RFGDVVHFME LWGKSSLNTV IFTEPDFSYL EALAPYQPLA MKCIYCPIDT
460 470 480 490 500
RLNFIQVSKL LKEVQPLHVV CPEQYTQPPP AQSHRMDLMI DCQPPAMSYR
510 520 530 540 550
RAEVLALPFK RRYEKIEIMP ELADSLVPME IKPGISLATV SAVLHTKDNK
560 570 580 590 600
HLLQPPPRPA QPTSGKKRKR VSDDVPDCKV LKPLLSGSIP VEQFVQTLEK
610 620 630 640 650
HGFSDIKVED TAKGHIVLLQ EAETLIQIEE DSTHIICDND EMLRVRLRDL

VLKFLQKF
Length:658
Mass (Da):73,814
Last modified:October 31, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i81F1A24B99704684
GO
Isoform 2 (identifier: Q9NV88-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-87: Missing.

Show »
Length:637
Mass (Da):71,468
Checksum:iDF93CBBDE1A6061E
GO
Isoform 3 (identifier: Q9NV88-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Show »
Length:634
Mass (Da):71,137
Checksum:i327CFB70D6AB0649
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XAN1G3XAN1_HUMAN
Integrator complex subunit 9
INTS9 RC74, hCG_16729
525Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBK3H0YBK3_HUMAN
Integrator complex subunit 9
INTS9
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RG70E5RG70_HUMAN
Integrator complex subunit 9
INTS9
300Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBH8H0YBH8_HUMAN
Integrator complex subunit 9
INTS9
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJ88E5RJ88_HUMAN
Integrator complex subunit 9
INTS9
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RK47E5RK47_HUMAN
Integrator complex subunit 9
INTS9
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBQ3H0YBQ3_HUMAN
Integrator complex subunit 9
INTS9
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGY2E5RGY2_HUMAN
Integrator complex subunit 9
INTS9
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB67601 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti324V → A in BAA91867 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0443061 – 24Missing in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_04301167 – 87Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001733 mRNA Translation: BAA91867.1
AK298468 mRNA Translation: BAH12796.1
AK300593 mRNA Translation: BAH13311.1
AC040975 Genomic DNA No translation available.
AC131969 Genomic DNA No translation available.
BC025267 mRNA Translation: AAH25267.1
U96629 Genomic DNA Translation: AAB67601.1 Sequence problems.
BK005726 mRNA Translation: DAA05726.1
BK005674 mRNA Translation: DAA05670.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34873.1 [Q9NV88-1]
CCDS55215.1 [Q9NV88-3]
CCDS55216.1 [Q9NV88-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001138631.1, NM_001145159.2 [Q9NV88-2]
NP_001166033.1, NM_001172562.1 [Q9NV88-3]
NP_060720.2, NM_018250.3 [Q9NV88-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000416984; ENSP00000398208; ENSG00000104299 [Q9NV88-2]
ENST00000521022; ENSP00000429065; ENSG00000104299 [Q9NV88-1]
ENST00000521777; ENSP00000430943; ENSG00000104299 [Q9NV88-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55756

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55756

UCSC genome browser

More...
UCSCi
uc003xha.4, human [Q9NV88-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001733 mRNA Translation: BAA91867.1
AK298468 mRNA Translation: BAH12796.1
AK300593 mRNA Translation: BAH13311.1
AC040975 Genomic DNA No translation available.
AC131969 Genomic DNA No translation available.
BC025267 mRNA Translation: AAH25267.1
U96629 Genomic DNA Translation: AAB67601.1 Sequence problems.
BK005726 mRNA Translation: DAA05726.1
BK005674 mRNA Translation: DAA05670.1
CCDSiCCDS34873.1 [Q9NV88-1]
CCDS55215.1 [Q9NV88-3]
CCDS55216.1 [Q9NV88-2]
RefSeqiNP_001138631.1, NM_001145159.2 [Q9NV88-2]
NP_001166033.1, NM_001172562.1 [Q9NV88-3]
NP_060720.2, NM_018250.3 [Q9NV88-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5V8WX-ray2.10A/C/E/G581-658[»]
7CUNelectron microscopy3.50I1-658[»]
SMRiQ9NV88
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120874, 48 interactors
CORUMiQ9NV88
IntActiQ9NV88, 12 interactors
STRINGi9606.ENSP00000429065

PTM databases

iPTMnetiQ9NV88
PhosphoSitePlusiQ9NV88

Genetic variation databases

BioMutaiINTS9
DMDMi119371246

Proteomic databases

EPDiQ9NV88
jPOSTiQ9NV88
MassIVEiQ9NV88
MaxQBiQ9NV88
PaxDbiQ9NV88
PeptideAtlasiQ9NV88
PRIDEiQ9NV88
ProteomicsDBi6659
82760 [Q9NV88-1]
82761 [Q9NV88-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
23131, 129 antibodies

The DNASU plasmid repository

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DNASUi
55756

Genome annotation databases

EnsembliENST00000416984; ENSP00000398208; ENSG00000104299 [Q9NV88-2]
ENST00000521022; ENSP00000429065; ENSG00000104299 [Q9NV88-1]
ENST00000521777; ENSP00000430943; ENSG00000104299 [Q9NV88-3]
GeneIDi55756
KEGGihsa:55756
UCSCiuc003xha.4, human [Q9NV88-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55756
DisGeNETi55756

GeneCards: human genes, protein and diseases

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GeneCardsi
INTS9
HGNCiHGNC:25592, INTS9
HPAiENSG00000104299, Low tissue specificity
MIMi611352, gene
neXtProtiNX_Q9NV88
OpenTargetsiENSG00000104299
PharmGKBiPA162392192
VEuPathDBiHostDB:ENSG00000104299.14

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1138, Eukaryota
GeneTreeiENSGT00390000001445
InParanoidiQ9NV88
OMAiCMLALPF
OrthoDBi617493at2759
PhylomeDBiQ9NV88
TreeFamiTF314100

Enzyme and pathway databases

PathwayCommonsiQ9NV88
ReactomeiR-HSA-6807505, RNA polymerase II transcribes snRNA genes
SIGNORiQ9NV88

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
55756, 783 hits in 1001 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
INTS9, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
INTS9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55756
PharosiQ9NV88, Tbio

Protein Ontology

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PROi
PR:Q9NV88
RNActiQ9NV88, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000104299, Expressed in right adrenal gland and 194 other tissues
ExpressionAtlasiQ9NV88, baseline and differential
GenevisibleiQ9NV88, HS

Family and domain databases

InterProiView protein in InterPro
IPR022712, Beta_Casp
IPR027074, Integrator_9su
IPR001279, Metallo-B-lactamas
IPR036866, RibonucZ/Hydroxyglut_hydro
PANTHERiPTHR46094, PTHR46094, 1 hit
PfamiView protein in Pfam
PF16661, Lactamase_B_6, 1 hit
SMARTiView protein in SMART
SM01027, Beta-Casp, 1 hit
SUPFAMiSSF56281, SSF56281, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINT9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NV88
Secondary accession number(s): B7Z560
, B7Z6M5, O00224, Q8TB16
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: June 2, 2021
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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