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Protein

Zinc finger protein 701

Gene

ZNF701

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri281 – 303C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 330C2H2-type 2PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri336 – 358C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 701
Gene namesi
Name:ZNF701
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167562.11
HGNCiHGNC:25597 ZNF701
neXtProtiNX_Q9NV72

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167562
PharmGKBiPA142670498

Polymorphism and mutation databases

BioMutaiZNF701
DMDMi296453055

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332811 – 531Zinc finger protein 701Add BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki271Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9NV72
MaxQBiQ9NV72
PaxDbiQ9NV72
PeptideAtlasiQ9NV72
PRIDEiQ9NV72
ProteomicsDBi82756
TopDownProteomicsiQ9NV72-2 [Q9NV72-2]

PTM databases

iPTMnetiQ9NV72
PhosphoSitePlusiQ9NV72

Expressioni

Gene expression databases

BgeeiENSG00000167562
CleanExiHS_ZNF701
ExpressionAtlasiQ9NV72 baseline and differential
GenevisibleiQ9NV72 HS

Organism-specific databases

HPAiHPA005532

Interactioni

Protein-protein interaction databases

BioGridi120880, 2 interactors
STRINGi9606.ENSP00000301093

Structurei

3D structure databases

ProteinModelPortaliQ9NV72
SMRiQ9NV72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 146KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri281 – 303C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 330C2H2-type 2PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri336 – 358C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149028
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9NV72
KOiK09228
OMAiDTCFQEI
OrthoDBiEOG091G02KC
PhylomeDBiQ9NV72

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NV72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFLHVGQDG LELPTSGDPP ASASQSAGIT GVSHRTQPPC FEGLTSKDLV
60 70 80 90 100
REEKTRKRKR KAKESGMALL QGLLTFRDVA IEFSQEEWKC LDPAQRTLYR
110 120 130 140 150
DVMLENYRNL VSLDTSSKCM MKMFSSTGQG NTEVVHTGTL QIHASHHIGD
160 170 180 190 200
TCFQEIEKDI HDFVFQWQEN ETNGHEALMT KTKKLMSSTE RHDQRHAGNK
210 220 230 240 250
PIKNELGSSF HSHLPEVHIF HPEGKIGNQV EKAINDAFSV SASQRISCRP
260 270 280 290 300
KTRISNKYRN NFLQSSLLTQ KREVHTREKS FQRNESGKAF NGSSLLKKHQ
310 320 330 340 350
IIHLGDKQYK CDVCGKDFHQ KRYLACHRCH TGENPYTCNE CGKTFSHNSA
360 370 380 390 400
LLVHKAIHTG EKPYKCNECG KVFNQQSNLA RHHRVHTGEK PYKCEECDKV
410 420 430 440 450
FSRKSHLERH RRIHTGEKPY KCKVCDKAFR RDSHLAQHTV IHTGEKPYKC
460 470 480 490 500
NECGKTFVQN SSLVMHKVIH TGEKRYKCNE CGKVFNHKSN LACHRRLHTG
510 520 530
EKPYKCNECG KVFNRKSNLE RHHRLHTGKK S
Length:531
Mass (Da):60,903
Last modified:October 1, 2014 - v3
Checksum:i0C93D18DC4B2BEBE
GO
Isoform 2 (identifier: Q9NV72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.

Note: No experimental confirmation available.
Show »
Length:465
Mass (Da):53,857
Checksum:i1D021303772C87E5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03359270L → P2 PublicationsCorresponds to variant dbSNP:rs162832Ensembl.1
Natural variantiVAR_033593182T → I2 PublicationsCorresponds to variant dbSNP:rs366793Ensembl.1
Natural variantiVAR_060432185L → V. Corresponds to variant dbSNP:rs12462687Ensembl.1
Natural variantiVAR_061964306D → E. Corresponds to variant dbSNP:rs427127Ensembl.1
Natural variantiVAR_052898337T → K2 PublicationsCorresponds to variant dbSNP:rs373554Ensembl.1
Natural variantiVAR_060433495R → H1 PublicationCorresponds to variant dbSNP:rs3745102Ensembl.1
Natural variantiVAR_033594521R → C. Corresponds to variant dbSNP:rs444172Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559691 – 66Missing in isoform 2. 2 PublicationsAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001753 mRNA Translation: BAA91884.1
AC022150 Genomic DNA No translation available.
BC080612 mRNA Translation: AAH80612.2
BC131719 mRNA Translation: AAI31720.1
BC136425 mRNA Translation: AAI36426.1
BC136426 mRNA Translation: AAI36427.1
CCDSiCCDS33092.1 [Q9NV72-2]
CCDS54311.1 [Q9NV72-1]
RefSeqiNP_001166126.1, NM_001172655.1 [Q9NV72-1]
NP_060730.2, NM_018260.2 [Q9NV72-2]
XP_011525394.1, XM_011527092.1 [Q9NV72-1]
UniGeneiHs.235167

Genome annotation databases

EnsembliENST00000301093; ENSP00000301093; ENSG00000167562 [Q9NV72-1]
ENST00000391785; ENSP00000375662; ENSG00000167562 [Q9NV72-2]
ENST00000540331; ENSP00000444339; ENSG00000167562 [Q9NV72-1]
GeneIDi55762
KEGGihsa:55762
UCSCiuc002pzs.3 human [Q9NV72-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN701_HUMAN
AccessioniPrimary (citable) accession number: Q9NV72
Secondary accession number(s): A2RRM8
, B9EGF2, F5GZM6, Q66K42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2014
Last modified: July 18, 2018
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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