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Entry version 141 (17 Jun 2020)
Sequence version 2 (03 Apr 2007)
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Protein

S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

Gene

TYW1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: wybutosine-tRNA(Phe) biosynthesis

This protein is involved in the pathway wybutosine-tRNA(Phe) biosynthesis, which is part of tRNA modification.
View all proteins of this organism that are known to be involved in the pathway wybutosine-tRNA(Phe) biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi416Iron-sulfur (4Fe-4S-S-AdoMet)Sequence analysis1
Metal bindingi420Iron-sulfur (4Fe-4S-S-AdoMet)Sequence analysis1
Metal bindingi423Iron-sulfur (4Fe-4S-S-AdoMet)Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi85 – 89FMNPROSITE-ProRule annotation5
Nucleotide bindingi176 – 208FMNPROSITE-ProRule annotationAdd BLAST33

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processtRNA processing
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6782861 Synthesis of wybutosine at G37 of tRNA(Phe)

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00375

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 (EC:4.1.3.44)
Alternative name(s):
Radical S-adenosyl methionine and flavodoxin domain-containing protein 1
tRNA wybutosine-synthesizing protein 1 homolog
tRNA-yW-synthesizing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TYW1
Synonyms:RSAFD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198874.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25598 TYW1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611243 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NV66

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55253

Open Targets

More...
OpenTargetsi
ENSG00000198874

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134940167

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NV66 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TYW1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143678193

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002818261 – 732S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1Add BLAST732

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NV66

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NV66

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NV66

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NV66

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NV66

PeptideAtlas

More...
PeptideAtlasi
Q9NV66

PRoteomics IDEntifications database

More...
PRIDEi
Q9NV66

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82752 [Q9NV66-1]
82753 [Q9NV66-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NV66

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NV66

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198874 Expressed in ectocervix and 90 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NV66 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NV66 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000198874 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120544, 42 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NV66, 31 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000352645

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NV66 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NV66

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini79 – 237Flavodoxin-likePROSITE-ProRule annotationAdd BLAST159
Domaini400 – 644Radical SAM corePROSITE-ProRule annotationAdd BLAST245

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TYW1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1160 Eukaryota
COG0369 LUCA
COG0731 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000047059

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007952_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NV66

KEGG Orthology (KO)

More...
KOi
K15449

Identification of Orthologs from Complete Genome Data

More...
OMAi
AANDFRF

Database of Orthologous Groups

More...
OrthoDBi
731783at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NV66

TreeFam database of animal gene trees

More...
TreeFami
TF300773

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit
3.40.50.360, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785 Aldolase_TIM
IPR001094 Flavdoxin-like
IPR008254 Flavodoxin/NO_synth
IPR029039 Flavoprotein-like_sf
IPR007197 rSAM
IPR013917 tRNA_wybutosine-synth
IPR034556 tRNA_wybutosine-synthase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00258 Flavodoxin_1, 1 hit
PF04055 Radical_SAM, 1 hit
PF08608 Wyosine_form, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00369 FLAVODOXIN

Structure-Function Linkage Database

More...
SFLDi
SFLDS00029 Radical_SAM, 1 hit
SFLDF00284 tRNA_wybutosine-synthesizing, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52218 SSF52218, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50902 FLAVODOXIN_LIKE, 1 hit
PS51918 RADICAL_SAM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NV66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPSADTWDL FSPLISLWIN RFYIYLGFAV SISLWICVQI VIKTQGKNLQ
60 70 80 90 100
EKSVPKAAQD LMTNGYVSLQ EKDIFVSGVK IFYGSQTGTA KGFATVLAEA
110 120 130 140 150
VTSLDLPVAI INLKEYDPDD HLIEEVTSKN VCVFLVATYT DGLPTESAEW
160 170 180 190 200
FCKWLEEASI DFRFGKTYLK GMRYAVFGLG NSAYASHFNK VGKNVDKWLW
210 220 230 240 250
MLGAHRVMSR GEGDCDVVKS KHGSIEADFR AWKTKFISQL QALQKGERKK
260 270 280 290 300
SCGGHCKKGK CESHQHGSEE REEGSHEQDE LHHRDTEEEE PFESSSEEEF
310 320 330 340 350
GGEDHQSLNS IVDVEDLGKI MDHVKKEKRE KEQQEEKSGL FRNMGRNEDG
360 370 380 390 400
ERRAMITPAL REALTKQGYQ LIGSHSGVKL CRWTKSMLRG RGGCYKHTFY
410 420 430 440 450
GIESHRCMET TPSLACANKC VFCWRHHTNP VGTEWRWKMD QPEMILKEAI
460 470 480 490 500
ENHQNMIKQF KGVPGVKAER FEEGMTVKHC ALSLVGEPIM YPEINRFLKL
510 520 530 540 550
LHQCKISSFL VTNAQFPAEI RNLEPVTQLY VSVDASTKDS LKKIDRPLFK
560 570 580 590 600
DFWQRFLDSL KALAVKQQRT VYRLTLVKAW NVDELQAYAQ LVSLGNPDFI
610 620 630 640 650
EVKGVTYCGE SSASSLTMAH VPWHEEVVQF VHELVDLIPE YEIACEHEHS
660 670 680 690 700
NCLLIAHRKF KIGGEWWTWI DYNRFQELIQ EYEDSGGSKT FSAKDYMART
710 720 730
PHWALFGASE RGFDPKDTRH QRKNKSKAIS GC
Length:732
Mass (Da):83,702
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95E8E5C3F88ADD23
GO
Isoform 2 (identifier: Q9NV66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-384: GYQLIGSHSGVKLCRWT → VHAPRERRLLQTHILWN
     385-732: Missing.

Show »
Length:384
Mass (Da):43,700
Checksum:i43A06B3E5DFC86C6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUV9A0A087WUV9_HUMAN
S-adenosyl-L-methionine-dependent t...
TYW1
668Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9Q4C9J9Q4_HUMAN
S-adenosyl-L-methionine-dependent t...
TYW1
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH15591 differs from that shown. Reason: Frameshift.Curated
The sequence BAB14307 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti382R → M in BAB14307 (PubMed:14702039).Curated1
Sequence conflicti388L → F in BAB14307 (PubMed:14702039).Curated1
Sequence conflicti416C → Y in BAB14307 (PubMed:14702039).Curated1
Sequence conflicti543K → R in BAB14307 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031288462G → V. Corresponds to variant dbSNP:rs2261015Ensembl.1
Natural variantiVAR_031289632H → R1 PublicationCorresponds to variant dbSNP:rs2949097Ensembl.1
Natural variantiVAR_031290671D → N1 PublicationCorresponds to variant dbSNP:rs28450001Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024066368 – 384GYQLI…LCRWT → VHAPRERRLLQTHILWN in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_024067385 – 732Missing in isoform 2. 1 PublicationAdd BLAST348

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001762 mRNA Translation: BAA91891.1
AK022917 mRNA Translation: BAB14307.1 Different initiation.
AC079920 Genomic DNA No translation available.
AC006480 Genomic DNA Translation: AAS07568.1
AC073089 Genomic DNA Translation: AAS07520.1
BC015591 mRNA Translation: AAH15591.1 Frameshift.
BC042156 mRNA Translation: AAH42156.1 Different termination.
BC051888 mRNA Translation: AAH51888.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5538.1 [Q9NV66-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060734.2, NM_018264.3 [Q9NV66-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000359626; ENSP00000352645; ENSG00000198874 [Q9NV66-1]
ENST00000361660; ENSP00000354795; ENSG00000198874 [Q9NV66-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55253

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55253

UCSC genome browser

More...
UCSCi
uc003tvn.5 human [Q9NV66-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001762 mRNA Translation: BAA91891.1
AK022917 mRNA Translation: BAB14307.1 Different initiation.
AC079920 Genomic DNA No translation available.
AC006480 Genomic DNA Translation: AAS07568.1
AC073089 Genomic DNA Translation: AAS07520.1
BC015591 mRNA Translation: AAH15591.1 Frameshift.
BC042156 mRNA Translation: AAH42156.1 Different termination.
BC051888 mRNA Translation: AAH51888.1
CCDSiCCDS5538.1 [Q9NV66-1]
RefSeqiNP_060734.2, NM_018264.3 [Q9NV66-1]

3D structure databases

SMRiQ9NV66
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120544, 42 interactors
IntActiQ9NV66, 31 interactors
STRINGi9606.ENSP00000352645

PTM databases

iPTMnetiQ9NV66
PhosphoSitePlusiQ9NV66

Polymorphism and mutation databases

BioMutaiTYW1
DMDMi143678193

Proteomic databases

EPDiQ9NV66
jPOSTiQ9NV66
MassIVEiQ9NV66
MaxQBiQ9NV66
PaxDbiQ9NV66
PeptideAtlasiQ9NV66
PRIDEiQ9NV66
ProteomicsDBi82752 [Q9NV66-1]
82753 [Q9NV66-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2749 69 antibodies

Genome annotation databases

EnsembliENST00000359626; ENSP00000352645; ENSG00000198874 [Q9NV66-1]
ENST00000361660; ENSP00000354795; ENSG00000198874 [Q9NV66-2]
GeneIDi55253
KEGGihsa:55253
UCSCiuc003tvn.5 human [Q9NV66-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55253
DisGeNETi55253
EuPathDBiHostDB:ENSG00000198874.12

GeneCards: human genes, protein and diseases

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GeneCardsi
TYW1
HGNCiHGNC:25598 TYW1
HPAiENSG00000198874 Low tissue specificity
MIMi611243 gene
neXtProtiNX_Q9NV66
OpenTargetsiENSG00000198874
PharmGKBiPA134940167

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1160 Eukaryota
COG0369 LUCA
COG0731 LUCA
GeneTreeiENSGT00510000047059
HOGENOMiCLU_007952_2_0_1
InParanoidiQ9NV66
KOiK15449
OMAiAANDFRF
OrthoDBi731783at2759
PhylomeDBiQ9NV66
TreeFamiTF300773

Enzyme and pathway databases

UniPathwayiUPA00375
ReactomeiR-HSA-6782861 Synthesis of wybutosine at G37 of tRNA(Phe)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
55253 6 hits in 779 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TYW1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55253
PharosiQ9NV66 Tbio

Protein Ontology

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PROi
PR:Q9NV66
RNActiQ9NV66 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198874 Expressed in ectocervix and 90 other tissues
ExpressionAtlasiQ9NV66 baseline and differential
GenevisibleiQ9NV66 HS

Family and domain databases

Gene3Di3.20.20.70, 1 hit
3.40.50.360, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001094 Flavdoxin-like
IPR008254 Flavodoxin/NO_synth
IPR029039 Flavoprotein-like_sf
IPR007197 rSAM
IPR013917 tRNA_wybutosine-synth
IPR034556 tRNA_wybutosine-synthase
PfamiView protein in Pfam
PF00258 Flavodoxin_1, 1 hit
PF04055 Radical_SAM, 1 hit
PF08608 Wyosine_form, 1 hit
PRINTSiPR00369 FLAVODOXIN
SFLDiSFLDS00029 Radical_SAM, 1 hit
SFLDF00284 tRNA_wybutosine-synthesizing, 1 hit
SUPFAMiSSF52218 SSF52218, 1 hit
PROSITEiView protein in PROSITE
PS50902 FLAVODOXIN_LIKE, 1 hit
PS51918 RADICAL_SAM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTYW1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NV66
Secondary accession number(s): Q6PJG8
, Q75MG8, Q75MN3, Q86V12, Q8IVS7, Q9H9C4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: June 17, 2020
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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