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Entry version 133 (29 Sep 2021)
Sequence version 1 (01 Oct 2000)
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Protein

Transmembrane protein 39A

Gene

TMEM39A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates autophagy by controlling the spatial distribution and levels of the intracellular phosphatidylinositol 4-phosphate (PtdIns4P) pools (PubMed:31806350).

Modulates (PtdIns4P) levels by regulating the ER-to-Golgi trafficking of the phosphatidylinositide phosphatase SACM1L (PubMed:31806350).

1 Publication

(Microbial infection) Positively regulates the replication of encephalomyocarditis virus (EMCV) via autophagy-dependent pathway.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NV64

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.B.385.1.1, the tmem39a or susr2 (tmem39a) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 39A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM39A
Synonyms:SUSR21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25600, TMEM39A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NV64

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000176142

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55254

Open Targets

More...
OpenTargetsi
ENSG00000176142

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134956032

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NV64, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM39A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74734456

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002792241 – 488Transmembrane protein 39AAdd BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NV64

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NV64

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NV64

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NV64

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NV64

PeptideAtlas

More...
PeptideAtlasi
Q9NV64

PRoteomics IDEntifications database

More...
PRIDEi
Q9NV64

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82750 [Q9NV64-1]
82751 [Q9NV64-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9NV64, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NV64

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NV64

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Up-regulated in brain tumor glioblastoma multiforme cells (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176142, Expressed in stromal cell of endometrium and 218 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NV64, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NV64, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000176142, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SACM1L, SEC23A and SEC24A.

1 Publication

(Microbial infection) Interacts with encephalomyocarditis virus (EMCV) major capsid proteins VP1 and VP2.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120545, 35 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NV64, 23 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000326063

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NV64, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM39 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3828, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018895

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_028992_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NV64

Identification of Orthologs from Complete Genome Data

More...
OMAi
DYNYMVQ

Database of Orthologous Groups

More...
OrthoDBi
1460710at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NV64

TreeFam database of animal gene trees

More...
TreeFami
TF321110

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019397, Uncharacterised_TMEM39

The PANTHER Classification System

More...
PANTHERi
PTHR12995, PTHR12995, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10271, Tmp39, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NV64-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGGRRGPSR QQLSRSALPS LQTLVGGGCG NGTGLRNRNG SAIGLPVPPI
60 70 80 90 100
TALITPGPVR HCQIPDLPVD GSLLFEFLFF IYLLVALFIQ YINIYKTVWW
110 120 130 140 150
YPYNHPASCT SLNFHLIDYH LAAFITVMLA RRLVWALISE ATKAGAASMI
160 170 180 190 200
HYMVLISARL VLLTLCGWVL CWTLVNLFRS HSVLNLLFLG YPFGVYVPLC
210 220 230 240 250
CFHQDSRAHL LLTDYNYVVQ HEAVEESAST VGGLAKSKDF LSLLLESLKE
260 270 280 290 300
QFNNATPIPT HSCPLSPDLI RNEVECLKAD FNHRIKEVLF NSLFSAYYVA
310 320 330 340 350
FLPLCFVKST QYYDMRWSCE HLIMVWINAF VMLTTQLLPS KYCDLLHKSA
360 370 380 390 400
AHLGKWQKLE HGSYSNAPQH IWSENTIWPQ GVLVRHSRCL YRAMGPYNVA
410 420 430 440 450
VPSDVSHARF YFLFHRPLRL LNLLILIEGS VVFYQLYSLL RSEKWNHTLS
460 470 480
MALILFCNYY VLFKLLRDRI VLGRAYSYPL NSYELKAN
Length:488
Mass (Da):55,667
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC3EB5D8B05ED09B
GO
Isoform 2 (identifier: Q9NV64-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-146: ATKAGA → VCVCKL
     147-488: Missing.

Show »
Length:146
Mass (Da):16,154
Checksum:i5CB090676E67F358
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IYN1C9IYN1_HUMAN
Transmembrane protein 39A
TMEM39A
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JUZ6C9JUZ6_HUMAN
Transmembrane protein 39A
TMEM39A
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K0C7C9K0C7_HUMAN
Transmembrane protein 39A
TMEM39A
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYN8C9JYN8_HUMAN
Transmembrane protein 39A
TMEM39A
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAU1F8WAU1_HUMAN
Transmembrane protein 39A
TMEM39A
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5P7H7C5P7_HUMAN
Transmembrane protein 39A
TMEM39A
18Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti79F → L in BAD96968 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036095247S → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_030871487A → T1 PublicationCorresponds to variant dbSNP:rs1132200Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023416141 – 146ATKAGA → VCVCKL in isoform 2. 1 Publication6
Alternative sequenceiVSP_023417147 – 488Missing in isoform 2. 1 PublicationAdd BLAST342

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001764 mRNA Translation: BAA91893.1
AK223248 mRNA Translation: BAD96968.1
AK222950 mRNA Translation: BAD96670.1
CH471052 Genomic DNA Translation: EAW79571.1
CH471052 Genomic DNA Translation: EAW79572.1
BC003192 mRNA Translation: AAH03192.1
BC021277 mRNA Translation: AAH21277.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2987.1 [Q9NV64-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060736.1, NM_018266.2 [Q9NV64-1]
XP_006713750.1, XM_006713687.1 [Q9NV64-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000319172; ENSP00000326063; ENSG00000176142 [Q9NV64-1]
ENST00000438581; ENSP00000402149; ENSG00000176142 [Q9NV64-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55254

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55254

UCSC genome browser

More...
UCSCi
uc003eck.3, human [Q9NV64-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001764 mRNA Translation: BAA91893.1
AK223248 mRNA Translation: BAD96968.1
AK222950 mRNA Translation: BAD96670.1
CH471052 Genomic DNA Translation: EAW79571.1
CH471052 Genomic DNA Translation: EAW79572.1
BC003192 mRNA Translation: AAH03192.1
BC021277 mRNA Translation: AAH21277.1
CCDSiCCDS2987.1 [Q9NV64-1]
RefSeqiNP_060736.1, NM_018266.2 [Q9NV64-1]
XP_006713750.1, XM_006713687.1 [Q9NV64-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120545, 35 interactors
IntActiQ9NV64, 23 interactors
STRINGi9606.ENSP00000326063

Protein family/group databases

TCDBi9.B.385.1.1, the tmem39a or susr2 (tmem39a) family

PTM databases

GlyGeniQ9NV64, 2 sites
iPTMnetiQ9NV64
PhosphoSitePlusiQ9NV64

Genetic variation databases

BioMutaiTMEM39A
DMDMi74734456

Proteomic databases

EPDiQ9NV64
jPOSTiQ9NV64
MassIVEiQ9NV64
MaxQBiQ9NV64
PaxDbiQ9NV64
PeptideAtlasiQ9NV64
PRIDEiQ9NV64
ProteomicsDBi82750 [Q9NV64-1]
82751 [Q9NV64-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
49908, 25 antibodies

The DNASU plasmid repository

More...
DNASUi
55254

Genome annotation databases

EnsembliENST00000319172; ENSP00000326063; ENSG00000176142 [Q9NV64-1]
ENST00000438581; ENSP00000402149; ENSG00000176142 [Q9NV64-2]
GeneIDi55254
KEGGihsa:55254
UCSCiuc003eck.3, human [Q9NV64-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55254
DisGeNETi55254

GeneCards: human genes, protein and diseases

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GeneCardsi
TMEM39A
HGNCiHGNC:25600, TMEM39A
HPAiENSG00000176142, Low tissue specificity
neXtProtiNX_Q9NV64
OpenTargetsiENSG00000176142
PharmGKBiPA134956032
VEuPathDBiHostDB:ENSG00000176142

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3828, Eukaryota
GeneTreeiENSGT00390000018895
HOGENOMiCLU_028992_0_0_1
InParanoidiQ9NV64
OMAiDYNYMVQ
OrthoDBi1460710at2759
PhylomeDBiQ9NV64
TreeFamiTF321110

Enzyme and pathway databases

PathwayCommonsiQ9NV64

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
55254, 7 hits in 1022 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TMEM39A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55254
PharosiQ9NV64, Tbio

Protein Ontology

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PROi
PR:Q9NV64
RNActiQ9NV64, protein

Gene expression databases

BgeeiENSG00000176142, Expressed in stromal cell of endometrium and 218 other tissues
ExpressionAtlasiQ9NV64, baseline and differential
GenevisibleiQ9NV64, HS

Family and domain databases

InterProiView protein in InterPro
IPR019397, Uncharacterised_TMEM39
PANTHERiPTHR12995, PTHR12995, 1 hit
PfamiView protein in Pfam
PF10271, Tmp39, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM39A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NV64
Secondary accession number(s): D3DN80
, Q53FN4, Q53GI1, Q6PKB5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 1, 2000
Last modified: September 29, 2021
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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