UniProtKB - Q9NV58 (RN19A_HUMAN)
Protein
E3 ubiquitin-protein ligase RNF19A
Gene
RNF19A
Organism
Homo sapiens (Human)
Status
Functioni
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.5 Publications
Catalytic activityi
- [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.By similarity EC:2.3.2.31
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 132 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 135 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 150 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 152 | Zinc 2; via pros nitrogenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 155 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 158 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 176 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 179 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 219 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 224 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 241 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 246 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 251 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 254 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 259 | Zinc 4; via tele nitrogenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 264 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 301 | Zinc 5PROSITE-ProRule annotation | 1 | |
Metal bindingi | 304 | Zinc 5PROSITE-ProRule annotation | 1 | |
Active sitei | 316 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 321 | Zinc 5PROSITE-ProRule annotation | 1 | |
Metal bindingi | 324 | Zinc 5PROSITE-ProRule annotation | 1 | |
Metal bindingi | 329 | Zinc 6PROSITE-ProRule annotation | 1 | |
Metal bindingi | 332 | Zinc 6PROSITE-ProRule annotation | 1 | |
Metal bindingi | 340 | Zinc 6; via tele nitrogenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 347 | Zinc 6PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 132 – 179 | RING-type 1PROSITE-ProRule annotationAdd BLAST | 48 | |
Zinc fingeri | 199 – 264 | IBR-typePROSITE-ProRule annotationAdd BLAST | 66 | |
Zinc fingeri | 301 – 332 | RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 32 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- transcription factor binding Source: UniProtKB
- ubiquitin conjugating enzyme binding Source: GO_Central
- ubiquitin protein ligase activity Source: GO_Central
GO - Biological processi
- microtubule cytoskeleton organization Source: UniProtKB
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central
- protein polyubiquitination Source: GO_Central
- regulation of protein catabolic process at postsynapse, modulating synaptic transmission Source: Ensembl
- ubiquitin-dependent protein catabolic process Source: GO_Central
Keywordsi
Molecular function | Transferase |
Biological process | Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9NV58 |
Reactomei | R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase RNF19A (EC:2.3.2.31By similarity)Alternative name(s): Double ring-finger protein Short name: Dorfin RING finger protein 19A p38 |
Gene namesi | Name:RNF19A Synonyms:RNF19 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13432, RNF19A |
MIMi | 607119, gene |
neXtProti | NX_Q9NV58 |
VEuPathDBi | HostDB:ENSG00000034677.11 |
Subcellular locationi
Cytoskeleton
- centrosome 4 Publications
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Note: Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.
Cytoskeleton
- centrosome Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Other locations
- cytoplasm Source: GO_Central
- glutamatergic synapse Source: Ensembl
- hippocampal mossy fiber to CA3 synapse Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
- postsynapse Source: GOC
- ubiquitin ligase complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 368 – 388 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 424 – 444 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 132 | C → S: Abolishes interaction with VCP and E3 ligase activity toward mutant SOD1; when associated with S-135. 1 Publication | 1 | |
Mutagenesisi | 135 | C → S: Abolishes interaction with VCP and E3 ligase activity toward mutant SOD1; when associated with S-132. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 25897 |
OpenTargetsi | ENSG00000034677 |
PharmGKBi | PA162401601 |
Miscellaneous databases
Pharosi | Q9NV58, Tbio |
Genetic variation databases
BioMutai | RNF19A |
DMDMi | 116242764 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056061 | 1 – 838 | E3 ubiquitin-protein ligase RNF19AAdd BLAST | 838 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 631 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NV58 |
jPOSTi | Q9NV58 |
MassIVEi | Q9NV58 |
MaxQBi | Q9NV58 |
PaxDbi | Q9NV58 |
PeptideAtlasi | Q9NV58 |
PRIDEi | Q9NV58 |
ProteomicsDBi | 82747 [Q9NV58-1] 82748 [Q9NV58-2] 82749 [Q9NV58-3] |
PTM databases
iPTMneti | Q9NV58 |
PhosphoSitePlusi | Q9NV58 |
Expressioni
Tissue specificityi
Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system.1 Publication
Gene expression databases
Bgeei | ENSG00000034677, Expressed in calcaneal tendon and 222 other tissues |
ExpressionAtlasi | Q9NV58, baseline and differential |
Genevisiblei | Q9NV58, HS |
Organism-specific databases
HPAi | ENSG00000034677, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with UBE2L3 and UBE2L6.
Interacts with transcription factor Sp1.
Interacts with VCP, CASR, SNCAIP and with some SOD1 variants which cause amyotrophic lateral sclerosis, but not with wild-type SOD1.
6 PublicationsBinary interactionsi
Q9NV58
With | #Exp. | IntAct |
---|---|---|
SOD1 [P00441] | 3 | EBI-1390270,EBI-990792 |
GO - Molecular functioni
- transcription factor binding Source: UniProtKB
- ubiquitin conjugating enzyme binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 117405, 20 interactors |
IntActi | Q9NV58, 14 interactors |
MINTi | Q9NV58 |
STRINGi | 9606.ENSP00000428968 |
Miscellaneous databases
RNActi | Q9NV58, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 128 – 351 | TRIAD supradomainPROSITE-ProRule annotationAdd BLAST | 224 | |
Regioni | 660 – 838 | Interaction with CASR1 PublicationAdd BLAST | 179 |
Domaini
Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.By similarity
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 132 – 179 | RING-type 1PROSITE-ProRule annotationAdd BLAST | 48 | |
Zinc fingeri | 199 – 264 | IBR-typePROSITE-ProRule annotationAdd BLAST | 66 | |
Zinc fingeri | 301 – 332 | RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 32 |
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helix, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1815, Eukaryota |
GeneTreei | ENSGT00940000158703 |
HOGENOMi | CLU_016793_1_0_1 |
InParanoidi | Q9NV58 |
OMAi | DYHTRFT |
OrthoDBi | 257621at2759 |
PhylomeDBi | Q9NV58 |
TreeFami | TF324777 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR031127, E3_UB_ligase_RBR IPR002867, IBR_dom IPR044066, TRIAD_supradom IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR11685, PTHR11685, 1 hit |
Pfami | View protein in Pfam PF01485, IBR, 2 hits |
SMARTi | View protein in SMART SM00647, IBR, 2 hits SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS51873, TRIAD, 1 hit PS50089, ZF_RING_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NV58-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQEQEIGFIS KYNEGLCVNT DPVSILTSIL DMSLHRQMGS DRDLQSSASS
60 70 80 90 100
VSLPSVKKAP KKRRISIGSL FRRKKDNKRK SRELNGGVDG IASIESIHSE
110 120 130 140 150
MCTDKNSIFS TNTSSDNGLT SISKQIGDFI ECPLCLLRHS KDRFPDIMTC
160 170 180 190 200
HHRSCVDCLR QYLRIEISES RVNISCPECT ERFNPHDIRL ILSDDVLMEK
210 220 230 240 250
YEEFMLRRWL VADPDCRWCP APDCGYAVIA FGCASCPKLT CGREGCGTEF
260 270 280 290 300
CYHCKQIWHP NQTCDAARQE RAQSLRLRTI RSSSISYSQE SGAAADDIKP
310 320 330 340 350
CPRCAAYIIK MNDGSCNHMT CAVCGCEFCW LCMKEISDLH YLSPSGCTFW
360 370 380 390 400
GKKPWSRKKK ILWQLGTLVG APVGIALIAG IAIPAMIIGI PVYVGRKIHN
410 420 430 440 450
RYEGKDVSKH KRNLAIAGGV TLSVIVSPVV AAVTVGIGVP IMLAYVYGVV
460 470 480 490 500
PISLCRSGGC GVSAGNGKGV RIEFDDENDI NVGGTNTAVD TTSVAEARHN
510 520 530 540 550
PSIGEGSVGG LTGSLSASGS HMDRIGAIRD NLSETASTMA LAGASITGSL
560 570 580 590 600
SGSAMVNCFN RLEVQADVQK ERYSLSGESG TVSLGTVSDN ASTKAMAGSI
610 620 630 640 650
LNSYIPLDKE GNSMEVQVDI ESKPSKFRHN SGSSSVDDGS ATRSHAGGSS
660 670 680 690 700
SGLPEGKSSA TKWSKEATAG KKSKSGKLRK KGNMKINETR EDMDAQLLEQ
710 720 730 740 750
QSTNSSEFEA PSLSDSMPSV ADSHSSHFSE FSCSDLESMK TSCSHGSSDY
760 770 780 790 800
HTRFATVNIL PEVENDRLEN SPHQCSISVV TQTASCSEVS QLNHIAEEHG
810 820 830
NNGIKPNVDL YFGDALKETN NNHSHQTMEL KVAIQTEI
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA3KCU8 | A3KCU8_HUMAN | E3 ubiquitin-protein ligase RNF19A | RNF19A RNF19 | 89 | Annotation score: | ||
E7EQ63 | E7EQ63_HUMAN | E3 ubiquitin-protein ligase RNF19A | RNF19A | 113 | Annotation score: | ||
A0A0C4DGD6 | A0A0C4DGD6_HUMAN | E3 ubiquitin-protein ligase RNF19A | RNF19A | 58 | Annotation score: | ||
E7EQV8 | E7EQV8_HUMAN | E3 ubiquitin-protein ligase RNF19A | RNF19A | 156 | Annotation score: | ||
E7ETB2 | E7ETB2_HUMAN | E3 ubiquitin-protein ligase RNF19A | RNF19A | 165 | Annotation score: | ||
E5RJH6 | E5RJH6_HUMAN | E3 ubiquitin-protein ligase RNF19A | RNF19A | 14 | Annotation score: |
Sequence cautioni
The sequence BAB14581 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15647 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 645 | H → Y in BAB39353 (PubMed:11237715).Curated | 1 | |
Sequence conflicti | 744 | S → R in CAB53700 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028045 | 835 | Q → H. Corresponds to variant dbSNP:rs9642785Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028631 | 1 – 31 | Missing in isoform 3. 1 PublicationAdd BLAST | 31 | |
Alternative sequenceiVSP_021010 | 572 – 604 | RYSLS…ILNSY → AAVAAAGRWAYSPATLRCRR SEELKNIHDSS in isoform 2. 1 PublicationAdd BLAST | 33 | |
Alternative sequenceiVSP_021011 | 605 – 838 | Missing in isoform 2. 1 PublicationAdd BLAST | 234 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB029316 mRNA Translation: BAB39353.1 BC093938 mRNA Translation: AAH93938.1 BC093940 mRNA Translation: AAH93940.1 AB271914 mRNA Translation: BAF48117.1 AK001774 mRNA Translation: BAA91900.1 AK023455 mRNA Translation: BAB14581.1 Different initiation. AK027070 mRNA Translation: BAB15647.1 Different initiation. AJ242975 mRNA Translation: CAB45132.1 AL110253 mRNA Translation: CAB53700.1 AL122096 mRNA Translation: CAB59264.1 |
CCDSi | CCDS6286.1 [Q9NV58-1] |
PIRi | T34528 |
RefSeqi | NP_001267468.1, NM_001280539.1 [Q9NV58-1] NP_056250.3, NM_015435.4 [Q9NV58-1] NP_904355.1, NM_183419.3 [Q9NV58-1] XP_005250910.1, XM_005250853.3 XP_016868791.1, XM_017013302.1 [Q9NV58-1] XP_016868792.1, XM_017013303.1 [Q9NV58-1] |
Genome annotation databases
Ensembli | ENST00000341084; ENSP00000342667; ENSG00000034677 [Q9NV58-1] ENST00000519449; ENSP00000428968; ENSG00000034677 [Q9NV58-1] |
GeneIDi | 25897 |
KEGGi | hsa:25897 |
UCSCi | uc003yjj.3, human [Q9NV58-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB029316 mRNA Translation: BAB39353.1 BC093938 mRNA Translation: AAH93938.1 BC093940 mRNA Translation: AAH93940.1 AB271914 mRNA Translation: BAF48117.1 AK001774 mRNA Translation: BAA91900.1 AK023455 mRNA Translation: BAB14581.1 Different initiation. AK027070 mRNA Translation: BAB15647.1 Different initiation. AJ242975 mRNA Translation: CAB45132.1 AL110253 mRNA Translation: CAB53700.1 AL122096 mRNA Translation: CAB59264.1 |
CCDSi | CCDS6286.1 [Q9NV58-1] |
PIRi | T34528 |
RefSeqi | NP_001267468.1, NM_001280539.1 [Q9NV58-1] NP_056250.3, NM_015435.4 [Q9NV58-1] NP_904355.1, NM_183419.3 [Q9NV58-1] XP_005250910.1, XM_005250853.3 XP_016868791.1, XM_017013302.1 [Q9NV58-1] XP_016868792.1, XM_017013303.1 [Q9NV58-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 117405, 20 interactors |
IntActi | Q9NV58, 14 interactors |
MINTi | Q9NV58 |
STRINGi | 9606.ENSP00000428968 |
PTM databases
iPTMneti | Q9NV58 |
PhosphoSitePlusi | Q9NV58 |
Genetic variation databases
BioMutai | RNF19A |
DMDMi | 116242764 |
Proteomic databases
EPDi | Q9NV58 |
jPOSTi | Q9NV58 |
MassIVEi | Q9NV58 |
MaxQBi | Q9NV58 |
PaxDbi | Q9NV58 |
PeptideAtlasi | Q9NV58 |
PRIDEi | Q9NV58 |
ProteomicsDBi | 82747 [Q9NV58-1] 82748 [Q9NV58-2] 82749 [Q9NV58-3] |
Protocols and materials databases
Antibodypediai | 3140, 212 antibodies |
Genome annotation databases
Ensembli | ENST00000341084; ENSP00000342667; ENSG00000034677 [Q9NV58-1] ENST00000519449; ENSP00000428968; ENSG00000034677 [Q9NV58-1] |
GeneIDi | 25897 |
KEGGi | hsa:25897 |
UCSCi | uc003yjj.3, human [Q9NV58-1] |
Organism-specific databases
CTDi | 25897 |
DisGeNETi | 25897 |
GeneCardsi | RNF19A |
HGNCi | HGNC:13432, RNF19A |
HPAi | ENSG00000034677, Low tissue specificity |
MIMi | 607119, gene |
neXtProti | NX_Q9NV58 |
OpenTargetsi | ENSG00000034677 |
PharmGKBi | PA162401601 |
VEuPathDBi | HostDB:ENSG00000034677.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1815, Eukaryota |
GeneTreei | ENSGT00940000158703 |
HOGENOMi | CLU_016793_1_0_1 |
InParanoidi | Q9NV58 |
OMAi | DYHTRFT |
OrthoDBi | 257621at2759 |
PhylomeDBi | Q9NV58 |
TreeFami | TF324777 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q9NV58 |
Reactomei | R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 25897, 55 hits in 992 CRISPR screens |
ChiTaRSi | RNF19A, human |
GeneWikii | RNF19A |
GenomeRNAii | 25897 |
Pharosi | Q9NV58, Tbio |
PROi | PR:Q9NV58 |
RNActi | Q9NV58, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000034677, Expressed in calcaneal tendon and 222 other tissues |
ExpressionAtlasi | Q9NV58, baseline and differential |
Genevisiblei | Q9NV58, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR031127, E3_UB_ligase_RBR IPR002867, IBR_dom IPR044066, TRIAD_supradom IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR11685, PTHR11685, 1 hit |
Pfami | View protein in Pfam PF01485, IBR, 2 hits |
SMARTi | View protein in SMART SM00647, IBR, 2 hits SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS51873, TRIAD, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RN19A_HUMAN | |
Accessioni | Q9NV58Primary (citable) accession number: Q9NV58 Secondary accession number(s): A3KCU9 Q9Y4Y1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2001 |
Last sequence update: | October 17, 2006 | |
Last modified: | April 7, 2021 | |
This is version 183 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families