UniProtKB - Q9NV56 (MRGBP_HUMAN)

BLAST

>sp|Q9NV56|MRGBP_HUMAN MRG/MORF4L-binding protein OS=Homo sapiens OX=9606 GN=MRGBP PE=1 SV=1
MGEAEVGGGGAAGDKGPGEAATSPAEETVVWSPEVEVCLFHAMLGHKPVGVNRHFHMICI
RDKFSQNIGRQVPSKVIWDHLSTMYDMQALHESEILPFPNPERNFVLPEEIIQEVREGKV
MIEEEMKEEMKEDVDPHNGADDVFSSSGSLGKASEKSSKDKEKNSSDLGCKEGADKRKRS
RVTDKVLTANSNPSSPSAAKRRRT

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History
Entry version 145 (12 Sep 2018)
Sequence version 1 (01 Oct 2000)
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Protein

MRG/MORF4L-binding protein

Gene

MRGBP

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

GO - Biological processⁱ

histone acetylation Source: GO_Central
regulation of growth Source: UniProtKB-KW
regulation of transcription by RNA polymerase II Source: GO_Central
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Chromatin regulator
Biological process	Growth regulation, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214847 HATs acetylate histones

Reactomeⁱ

R-HSA-3214847 HATs acetylate histones

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: MRG/MORF4L-binding protein Alternative name(s): MRG-binding protein Up-regulated in colon cancer 4 Short name: Urcc4
Gene namesⁱ	Name:MRGBP Synonyms:C20orf20
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101189.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15866 MRGBP
MIMⁱ	611157 gene
neXtProtⁱ	NX_Q9NV56

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55257
Open Targets More...OpenTargetsⁱ	ENSG00000101189
PharmGKBⁱ	PA25736

Polymorphism and mutation databases

BioMutaⁱ	MRGBP
DMDMⁱ	28201787

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000215876	2 – 204	MRG/MORF4L-binding proteinAdd BLAST		203

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylglycineCombined sources	1
Modified residueⁱ	22	PhosphothreonineCombined sources	1
Modified residueⁱ	23	PhosphoserineCombined sources	1
Cross-linkⁱ	127	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	191	PhosphoserineCombined sources	1
Modified residueⁱ	195	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9NV56
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NV56
PaxDbⁱ	Q9NV56
PeptideAtlas More...PeptideAtlasⁱ	Q9NV56
PRIDEⁱ	Q9NV56
ProteomicsDBⁱ	82746

PTM databases

iPTMnetⁱ	Q9NV56
PhosphoSitePlusⁱ	Q9NV56

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000101189 Expressed in 198 organ(s), highest expression level in testis
CleanExⁱ	HS_C20orf20
Genevisibleⁱ	Q9NV56 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA017012

HPAⁱ

HPA017012

Interactionⁱ

Subunit structureⁱ

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MRGBP may interact directly with MORF4L1/MRG15 and MORF4L2/MRGX.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
KRTAP10-7	P60409	3	EBI-399076,EBI-10172290
MORF4L1	Q9UBU8	6	EBI-399076,EBI-399246
MORF4L1	Q9UBU8-2	13	EBI-399076,EBI-10288852
MORF4L2	Q15014	8	EBI-399076,EBI-399257
NOTCH2NL	Q7Z3S9	5	EBI-399076,EBI-945833

Protein-protein interaction databases

BioGridⁱ	120548, 66 interactors
ComplexPortalⁱ	CPX-978 NuA4 histone acetyltransferase complex
CORUMⁱ	Q9NV56
Database of interacting proteins More...DIPⁱ	DIP-29018N
IntActⁱ	Q9NV56, 37 interactors
Molecular INTeraction database More...MINTⁱ	Q9NV56
STRINGⁱ	9606.ENSP00000359518

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	73 – 75	Combined sources	3
Helixⁱ	77 – 83	Combined sources	7
Turnⁱ	84 – 87	Combined sources	4
Helixⁱ	88 – 93	Combined sources	6
Helixⁱ	109 – 115	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9NV56
SMRⁱ	Q9NV56
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	7 – 10	Poly-Gly		4

Sequence similaritiesⁱ

Belongs to the EAF7 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4051 Eukaryota ENOG4111Y7E LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007823
HOGENOMⁱ	HOG000008169
HOVERGENⁱ	HBG052509
InParanoidⁱ	Q9NV56
KEGG Orthology (KO) More...KOⁱ	K11343
OMAⁱ	NEEREFC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QWB
PhylomeDBⁱ	Q9NV56
TreeFamⁱ	TF326334

Family and domain databases

InterProⁱ	View protein in InterPro IPR012423 Eaf7/MRGBP
PANTHERⁱ	PTHR13581 PTHR13581, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07904 Eaf7, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9NV56-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGEAEVGGGG AAGDKGPGEA ATSPAEETVV WSPEVEVCLF HAMLGHKPVG 
        60         70         80         90        100
VNRHFHMICI RDKFSQNIGR QVPSKVIWDH LSTMYDMQAL HESEILPFPN 
       110        120        130        140        150
PERNFVLPEE IIQEVREGKV MIEEEMKEEM KEDVDPHNGA DDVFSSSGSL 
       160        170        180        190        200
GKASEKSSKD KEKNSSDLGC KEGADKRKRS RVTDKVLTAN SNPSSPSAAK 

RRRT

Length:204

Mass (Da):22,417

Last modified:October 1, 2000 - v1

Checksum:ⁱE6B87C2E14A67F9B

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB085682 mRNA Translation: BAF80630.1 AK001776 mRNA Translation: BAA91902.1 AL035669 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75342.1 CH471077 Genomic DNA Translation: EAW75343.1 BC009889 mRNA Translation: AAH09889.1 BC014235 mRNA Translation: AAH14235.1 BC018841 mRNA Translation: AAH18841.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13503.1
NCBI Reference Sequences More...RefSeqⁱ	NP_060740.1, NM_018270.5
UniGeneⁱ	Hs.443260 Hs.590870

Genome annotation databases

Ensemblⁱ	ENST00000370487; ENSP00000359518; ENSG00000101189
GeneIDⁱ	55257
KEGGⁱ	hsa:55257
UCSC genome browser More...UCSCⁱ	uc002ydi.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NV56	Chromosome 20 open reading frame 20		PANTR		204	UniRef100_Q9NV56

Protein	Similar proteins		Species	Score	Length	Source
Q9NV56	MRG/MORF4L-binding protein		MOUSE		204	UniRef90_Q9NV56
Chromosome 20 open reading frame 20		PANTR		204
Uncharacterized protein		OTOGA		213
MRG-binding protein		CALJA		204
Uncharacterized protein		PROCO		204
+53

Protein	Similar proteins		Species	Score	Length	Source
Q9NV56	MRG/MORF4L-binding protein		MOUSE		204	UniRef50_Q9NV56
Chromosome 20 open reading frame 20		PANTR		204
Uncharacterized protein		OTOGA		213
MRG-binding protein		CALJA		204
MRG/MORF4L-binding protein		MESAU		204
+54

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB085682 mRNA Translation: BAF80630.1 AK001776 mRNA Translation: BAA91902.1 AL035669 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75342.1 CH471077 Genomic DNA Translation: EAW75343.1 BC009889 mRNA Translation: AAH09889.1 BC014235 mRNA Translation: AAH14235.1 BC018841 mRNA Translation: AAH18841.1
CCDSⁱ	CCDS13503.1
RefSeqⁱ	NP_060740.1, NM_018270.5
UniGeneⁱ	Hs.443260 Hs.590870

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2N1D	NMR	-	A	69-119	[»]
ProteinModelPortalⁱ	Q9NV56
SMRⁱ	Q9NV56
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120548, 66 interactors
ComplexPortalⁱ	CPX-978 NuA4 histone acetyltransferase complex
CORUMⁱ	Q9NV56
DIPⁱ	DIP-29018N
IntActⁱ	Q9NV56, 37 interactors
MINTⁱ	Q9NV56
STRINGⁱ	9606.ENSP00000359518

PTM databases

iPTMnetⁱ	Q9NV56
PhosphoSitePlusⁱ	Q9NV56

Polymorphism and mutation databases

BioMutaⁱ	MRGBP
DMDMⁱ	28201787

Proteomic databases

EPDⁱ	Q9NV56
MaxQBⁱ	Q9NV56
PaxDbⁱ	Q9NV56
PeptideAtlasⁱ	Q9NV56
PRIDEⁱ	Q9NV56
ProteomicsDBⁱ	82746

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	55257
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000370487; ENSP00000359518; ENSG00000101189
GeneIDⁱ	55257
KEGGⁱ	hsa:55257
UCSCⁱ	uc002ydi.4 human

Organism-specific databases

CTDⁱ	55257
DisGeNETⁱ	55257
EuPathDBⁱ	HostDB:ENSG00000101189.6
GeneCardsⁱ	MRGBP
HGNCⁱ	HGNC:15866 MRGBP
HPAⁱ	HPA017012
MIMⁱ	611157 gene
neXtProtⁱ	NX_Q9NV56
OpenTargetsⁱ	ENSG00000101189
PharmGKBⁱ	PA25736
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4051 Eukaryota ENOG4111Y7E LUCA
GeneTreeⁱ	ENSGT00390000007823
HOGENOMⁱ	HOG000008169
HOVERGENⁱ	HBG052509
InParanoidⁱ	Q9NV56
KOⁱ	K11343
OMAⁱ	NEEREFC
OrthoDBⁱ	EOG091G0QWB
PhylomeDBⁱ	Q9NV56
TreeFamⁱ	TF326334

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214847 HATs acetylate histones

Reactomeⁱ

R-HSA-3214847 HATs acetylate histones

Miscellaneous databases

GenomeRNAiⁱ	55257
Protein Ontology More...PROⁱ	PR:Q9NV56
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101189 Expressed in 198 organ(s), highest expression level in testis
CleanExⁱ	HS_C20orf20
Genevisibleⁱ	Q9NV56 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR012423 Eaf7/MRGBP
PANTHERⁱ	PTHR13581 PTHR13581, 1 hit
Pfamⁱ	View protein in Pfam PF07904 Eaf7, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MRGBP_HUMAN
Accessionⁱ	Q9NV56Primary (citable) accession number: Q9NV56 Secondary accession number(s): A8C4L5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
	Last sequence update:	October 1, 2000
	Last modified:	September 12, 2018
	This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q9NV56 (MRGBP_HUMAN)

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MRG/MORF4L-binding protein

MRGBP

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ