UniProtKB - Q9NV56 (MRGBP_HUMAN)
MRG/MORF4L-binding protein
MRGBP
Functioni
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
GO - Biological processi
- chromatin organization Source: UniProtKB-KW
- histone acetylation Source: GO_Central
- histone H2A acetylation Source: ComplexPortal
- histone H4 acetylation Source: ComplexPortal
- positive regulation of double-strand break repair via homologous recombination Source: ComplexPortal
- regulation of cell cycle Source: ComplexPortal
- regulation of growth Source: UniProtKB-KW
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, Chromatin regulator |
Biological process | Growth regulation, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9NV56 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
SignaLinki | Q9NV56 |
Names & Taxonomyi
Protein namesi | Recommended name: MRG/MORF4L-binding proteinAlternative name(s): MRG-binding protein Up-regulated in colon cancer 4 Short name: Urcc4 |
Gene namesi | Name:MRGBP Synonyms:C20orf20 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15866, MRGBP |
MIMi | 611157, gene |
neXtProti | NX_Q9NV56 |
VEuPathDBi | HostDB:ENSG00000101189 |
Subcellular locationi
Nucleus
Nucleus
- NuA4 histone acetyltransferase complex Source: ComplexPortal
- nucleoplasm Source: HPA
Other locations
- nucleosome Source: ComplexPortal
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 55257 |
OpenTargetsi | ENSG00000101189 |
PharmGKBi | PA25736 |
Miscellaneous databases
Pharosi | Q9NV56, Tbio |
Genetic variation databases
BioMutai | MRGBP |
DMDMi | 28201787 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000215876 | 2 – 204 | MRG/MORF4L-binding proteinAdd BLAST | 203 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylglycineCombined sources | 1 | |
Modified residuei | 22 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 23 | PhosphoserineCombined sources | 1 | |
Cross-linki | 127 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 191 | PhosphoserineCombined sources | 1 | |
Modified residuei | 195 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9NV56 |
jPOSTi | Q9NV56 |
MassIVEi | Q9NV56 |
MaxQBi | Q9NV56 |
PaxDbi | Q9NV56 |
PeptideAtlasi | Q9NV56 |
PRIDEi | Q9NV56 |
ProteomicsDBi | 82746 |
PTM databases
GlyGeni | Q9NV56, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9NV56 |
PhosphoSitePlusi | Q9NV56 |
Expressioni
Gene expression databases
Bgeei | ENSG00000101189, Expressed in testis and 209 other tissues |
Genevisiblei | Q9NV56, HS |
Organism-specific databases
HPAi | ENSG00000101189, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MRGBP may interact directly with MORF4L1/MRG15 and MORF4L2/MRGX.
1 PublicationBinary interactionsi
Q9NV56
Protein-protein interaction databases
BioGRIDi | 120548, 95 interactors |
ComplexPortali | CPX-978, NuA4 histone acetyltransferase complex |
CORUMi | Q9NV56 |
DIPi | DIP-29018N |
IntActi | Q9NV56, 52 interactors |
MINTi | Q9NV56 |
STRINGi | 9606.ENSP00000359518 |
Miscellaneous databases
RNActi | Q9NV56, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9NV56 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 27 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 128 – 204 | DisorderedSequence analysisAdd BLAST | 77 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 154 – 184 | Basic and acidic residuesSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4051, Eukaryota |
GeneTreei | ENSGT00390000007823 |
HOGENOMi | CLU_080546_0_0_1 |
InParanoidi | Q9NV56 |
OMAi | EEREFCL |
OrthoDBi | 1476852at2759 |
PhylomeDBi | Q9NV56 |
TreeFami | TF326334 |
Family and domain databases
InterProi | View protein in InterPro IPR012423, Eaf7/MRGBP |
PANTHERi | PTHR13581, PTHR13581, 1 hit |
Pfami | View protein in Pfam PF07904, Eaf7, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MGEAEVGGGG AAGDKGPGEA ATSPAEETVV WSPEVEVCLF HAMLGHKPVG
60 70 80 90 100
VNRHFHMICI RDKFSQNIGR QVPSKVIWDH LSTMYDMQAL HESEILPFPN
110 120 130 140 150
PERNFVLPEE IIQEVREGKV MIEEEMKEEM KEDVDPHNGA DDVFSSSGSL
160 170 180 190 200
GKASEKSSKD KEKNSSDLGC KEGADKRKRS RVTDKVLTAN SNPSSPSAAK
RRRT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB085682 mRNA Translation: BAF80630.1 AK001776 mRNA Translation: BAA91902.1 AL035669 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75342.1 CH471077 Genomic DNA Translation: EAW75343.1 BC009889 mRNA Translation: AAH09889.1 BC014235 mRNA Translation: AAH14235.1 BC018841 mRNA Translation: AAH18841.1 |
CCDSi | CCDS13503.1 |
RefSeqi | NP_060740.1, NM_018270.5 |
Genome annotation databases
Ensembli | ENST00000370487; ENSP00000359518; ENSG00000101189 |
GeneIDi | 55257 |
KEGGi | hsa:55257 |
MANE-Selecti | ENST00000370487.5; ENSP00000359518.3; NM_018270.6; NP_060740.1 |
UCSCi | uc002ydi.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB085682 mRNA Translation: BAF80630.1 AK001776 mRNA Translation: BAA91902.1 AL035669 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75342.1 CH471077 Genomic DNA Translation: EAW75343.1 BC009889 mRNA Translation: AAH09889.1 BC014235 mRNA Translation: AAH14235.1 BC018841 mRNA Translation: AAH18841.1 |
CCDSi | CCDS13503.1 |
RefSeqi | NP_060740.1, NM_018270.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2N1D | NMR | - | A | 69-119 | [»] | |
SMRi | Q9NV56 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120548, 95 interactors |
ComplexPortali | CPX-978, NuA4 histone acetyltransferase complex |
CORUMi | Q9NV56 |
DIPi | DIP-29018N |
IntActi | Q9NV56, 52 interactors |
MINTi | Q9NV56 |
STRINGi | 9606.ENSP00000359518 |
PTM databases
GlyGeni | Q9NV56, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9NV56 |
PhosphoSitePlusi | Q9NV56 |
Genetic variation databases
BioMutai | MRGBP |
DMDMi | 28201787 |
Proteomic databases
EPDi | Q9NV56 |
jPOSTi | Q9NV56 |
MassIVEi | Q9NV56 |
MaxQBi | Q9NV56 |
PaxDbi | Q9NV56 |
PeptideAtlasi | Q9NV56 |
PRIDEi | Q9NV56 |
ProteomicsDBi | 82746 |
Protocols and materials databases
Antibodypediai | 14923, 175 antibodies from 26 providers |
DNASUi | 55257 |
Genome annotation databases
Ensembli | ENST00000370487; ENSP00000359518; ENSG00000101189 |
GeneIDi | 55257 |
KEGGi | hsa:55257 |
MANE-Selecti | ENST00000370487.5; ENSP00000359518.3; NM_018270.6; NP_060740.1 |
UCSCi | uc002ydi.4, human |
Organism-specific databases
CTDi | 55257 |
DisGeNETi | 55257 |
GeneCardsi | MRGBP |
HGNCi | HGNC:15866, MRGBP |
HPAi | ENSG00000101189, Tissue enhanced (testis) |
MIMi | 611157, gene |
neXtProti | NX_Q9NV56 |
OpenTargetsi | ENSG00000101189 |
PharmGKBi | PA25736 |
VEuPathDBi | HostDB:ENSG00000101189 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4051, Eukaryota |
GeneTreei | ENSGT00390000007823 |
HOGENOMi | CLU_080546_0_0_1 |
InParanoidi | Q9NV56 |
OMAi | EEREFCL |
OrthoDBi | 1476852at2759 |
PhylomeDBi | Q9NV56 |
TreeFami | TF326334 |
Enzyme and pathway databases
PathwayCommonsi | Q9NV56 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
SignaLinki | Q9NV56 |
Miscellaneous databases
BioGRID-ORCSi | 55257, 555 hits in 1066 CRISPR screens |
ChiTaRSi | MRGBP, human |
GenomeRNAii | 55257 |
Pharosi | Q9NV56, Tbio |
PROi | PR:Q9NV56 |
RNActi | Q9NV56, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101189, Expressed in testis and 209 other tissues |
Genevisiblei | Q9NV56, HS |
Family and domain databases
InterProi | View protein in InterPro IPR012423, Eaf7/MRGBP |
PANTHERi | PTHR13581, PTHR13581, 1 hit |
Pfami | View protein in Pfam PF07904, Eaf7, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MRGBP_HUMAN | |
Accessioni | Q9NV56Primary (citable) accession number: Q9NV56 Secondary accession number(s): A8C4L5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2003 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families