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UniProtKB - Q9NV35 (NUD15_HUMAN)

Entry version 149 (10 Feb 2021)
Sequence version 1 (01 Oct 2000)
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Protein

Nucleotide triphosphate diphosphatase NUDT15

Gene

NUDT15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (PubMed:22556419, PubMed:26238318). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:26238318, PubMed:22556419). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (PubMed:26238318, PubMed:25108385). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (PubMed:19419956).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarityNote: Magnesium may be the real cofactor in vivo.By similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Has a 10-fold higher catalytic efficiency toward dGTP compared to 8-oxo-dGTP.1 Publication
  1. KM=42 µM for dGTP (at pH 7.5)1 Publication
  2. KM=110 µM for 8-oxo-dGTP (at pH 7.5)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi63Magnesium or manganeseBy similarity1
    Metal bindingi67Magnesium or manganeseBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    LigandMagnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		Q9NV35

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-2393930, Phosphate bond hydrolysis by NUDT proteins

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		Q9NV35

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Nucleotide triphosphate diphosphatase NUDT15Curated (EC:3.6.1.93 Publications)
    Alternative name(s):
    MutT homolog 21 Publication
    Short name:
    MTH21 Publication
    Nucleoside diphosphate-linked moiety X motif 15Curated
    Short name:
    Nudix motif 15Curated
    Nucleoside diphosphate-linked to another moiety X hydrolase 151 Publication
    Short name:
    Nudix hydrolase 15Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:NUDT15Imported
    Synonyms:MTH21 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:23063, NUDT15

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		615792, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q9NV35

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...    VEuPathDBi    		HostDB:ENSG00000136159.3

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		55270

    MalaCards human disease database

    More...    MalaCardsi    		NUDT15
    MIMi616903, phenotype

    Open Targets

    More...    OpenTargetsi    		ENSG00000136159

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...    Orphaneti    		413687, Azathioprine or 6-mercatopurine toxicity or dose selection

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA134963132

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		Q9NV35, Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL4105827

    Drug and drug target database

    More...    DrugBanki    		DB00993, Azathioprine

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		NUDT15

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		68565944

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000571151 – 164Nucleotide triphosphate diphosphatase NUDT15Add BLAST164

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		Q9NV35

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		Q9NV35

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		Q9NV35

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		Q9NV35

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q9NV35

    PeptideAtlas

    More...    PeptideAtlasi    		Q9NV35

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q9NV35

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		82743

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q9NV35

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q9NV35

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000136159, Expressed in female gonad and 220 other tissues

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q9NV35, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000136159, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer (PubMed:26238318).

    Interacts with PCNA; interaction is disrupted in response to UV irradiation (PubMed:19419956).

    2 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		120559, 8 interactors

    Protein interaction database and analysis system

    More...    IntActi    		Q9NV35, 6 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000258662

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		Q9NV35

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q9NV35, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1164
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q9NV35

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 145Nudix hydrolasePROSITE-ProRule annotationAdd BLAST137

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni76 – 164Interaction with PCNA1 PublicationAdd BLAST89

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi48 – 69Nudix boxAdd BLAST22

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the Nudix hydrolase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		ENOG502RXHF, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00390000003338

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_037162_9_2_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q9NV35

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		HYVTLFV

    Database of Orthologous Groups

    More...    OrthoDBi    		1602447at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q9NV35

    TreeFam database of animal gene trees

    More...    TreeFami    		TF106353

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR015797, NUDIX_hydrolase-like_dom_sf
    IPR000086, NUDIX_hydrolase_dom

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00293, NUDIX, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF55811, SSF55811, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS51462, NUDIX, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q9NV35-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MTASAQPRGR RPGVGVGVVV TSCKHPRCVL LGKRKGSVGA GSFQLPGGHL 
            60         70         80         90        100
    EFGETWEECA QRETWEEAAL HLKNVHFASV VNSFIEKENY HYVTILMKGE 
           110        120        130        140        150
    VDVTHDSEPK NVEPEKNESW EWVPWEELPP LDQLFWGLRC LKEQGYDPFK 
           160 
    EDLNHLVGYK GNHL
    Length:164
    Mass (Da):18,609
    Last modified:October 1, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9FF20DA411C9E9C7
    GO

    <p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

    Polymorphic NUDT15 variants define the poor metabolism of thiopurines 2 genetic locus (THPM2) [MIMi:616903]. Thiopurines are used as immunosuppressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with low NUDT15 activities have an increased risk for toxic effects after receiving standard doses of thiopurine drugs.2 Publications

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07680618V → I Associated with increased risk for thiopurines toxicity; decreased thermostability; decreased diphosphatase activity towards 6-thio-dGTP and 6-thio-GTP. 1 PublicationCorresponds to variant dbSNP:rs186364861EnsemblClinVar.1
    Natural variantiVAR_07680718V → VGV Associated with increased risk for thiopurines toxicity; decreased thermostability; decreased diphosphatase activity towards 6-thio-dGTP and 6-thio-GTP. 1 Publication1
    Natural variantiVAR_076808139R → C Associated with increased risk for thiopurines toxicity; decreased thermostability; loss of diphosphatase activity towards 6-thio-dGTP and 6-thio-GTP. 2 PublicationsCorresponds to variant dbSNP:rs116855232EnsemblClinVar.1
    Natural variantiVAR_076809139R → H Associated with increased risk for thiopurines toxicity; decreased thermostability; decreased diphosphatase activity towards 6-thio-dGTP and 6-thio-GTP. 1 PublicationCorresponds to variant dbSNP:rs147390019EnsemblClinVar.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AK001818 mRNA Translation: BAA91925.1
    AL158196 Genomic DNA No translation available.
    CH471075 Genomic DNA Translation: EAX08782.1
    BC064607 mRNA Translation: AAH64607.1
    BC107875 mRNA Translation: AAI07876.1
    BC133015 mRNA Translation: AAI33016.1
    BC133017 mRNA Translation: AAI33018.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS9407.1

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001291674.1, NM_001304745.1
    NP_060753.1, NM_018283.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000258662; ENSP00000258662; ENSG00000136159

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		55270

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:55270

    UCSC genome browser

    More...    UCSCi    		uc001vbw.2, human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AK001818 mRNA Translation: BAA91925.1
    AL158196 Genomic DNA No translation available.
    CH471075 Genomic DNA Translation: EAX08782.1
    BC064607 mRNA Translation: AAH64607.1
    BC107875 mRNA Translation: AAI07876.1
    BC133015 mRNA Translation: AAI33016.1
    BC133017 mRNA Translation: AAI33018.1
    CCDSiCCDS9407.1
    RefSeqiNP_001291674.1, NM_001304745.1
    NP_060753.1, NM_018283.3

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    5BONX-ray1.80A/B/C/D/E/F/G/H1-164[»]
    5LPGX-ray1.70A/B1-164[»]
    6T5JX-ray1.60A/B1-164[»]
    SMRiQ9NV35
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi120559, 8 interactors
    IntActiQ9NV35, 6 interactors
    STRINGi9606.ENSP00000258662

    Chemistry databases

    BindingDBiQ9NV35
    ChEMBLiCHEMBL4105827
    DrugBankiDB00993, Azathioprine

    PTM databases

    iPTMnetiQ9NV35
    PhosphoSitePlusiQ9NV35

    Genetic variation databases

    BioMutaiNUDT15
    DMDMi68565944

    Proteomic databases

    EPDiQ9NV35
    jPOSTiQ9NV35
    MassIVEiQ9NV35
    MaxQBiQ9NV35
    PaxDbiQ9NV35
    PeptideAtlasiQ9NV35
    PRIDEiQ9NV35
    ProteomicsDBi82743

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		49562, 141 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		55270

    Genome annotation databases

    EnsembliENST00000258662; ENSP00000258662; ENSG00000136159
    GeneIDi55270
    KEGGihsa:55270
    UCSCiuc001vbw.2, human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		55270
    DisGeNETi55270

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		NUDT15
    HGNCiHGNC:23063, NUDT15
    HPAiENSG00000136159, Low tissue specificity
    MalaCardsiNUDT15
    MIMi615792, gene
    616903, phenotype
    neXtProtiNX_Q9NV35
    OpenTargetsiENSG00000136159
    Orphaneti413687, Azathioprine or 6-mercatopurine toxicity or dose selection
    PharmGKBiPA134963132
    VEuPathDBiHostDB:ENSG00000136159.3

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiENOG502RXHF, Eukaryota
    GeneTreeiENSGT00390000003338
    HOGENOMiCLU_037162_9_2_1
    InParanoidiQ9NV35
    OMAiHYVTLFV
    OrthoDBi1602447at2759
    PhylomeDBiQ9NV35
    TreeFamiTF106353

    Enzyme and pathway databases

    PathwayCommonsiQ9NV35
    ReactomeiR-HSA-2393930, Phosphate bond hydrolysis by NUDT proteins
    SABIO-RKiQ9NV35

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		55270, 5 hits in 875 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		NUDT15, human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		55270
    PharosiQ9NV35, Tbio

    Protein Ontology

    More...    PROi    		PR:Q9NV35
    RNActiQ9NV35, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000136159, Expressed in female gonad and 220 other tissues
    GenevisibleiQ9NV35, HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR015797, NUDIX_hydrolase-like_dom_sf
    IPR000086, NUDIX_hydrolase_dom
    PfamiView protein in Pfam
    PF00293, NUDIX, 1 hit
    SUPFAMiSSF55811, SSF55811, 1 hit
    PROSITEiView protein in PROSITE
    PS51462, NUDIX, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUD15_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NV35
    Secondary accession number(s): A2RUR6, Q32Q27, Q6P2C9
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: October 1, 2000
    Last modified: February 10, 2021
    This is version 149 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with genetic variants
      List of human entries with genetic variants
    3. Human variants curated from literature reports
      Index of human variants curated from literature reports
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families
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