IMP3

Functionⁱ

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.1 Publication

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
snoRNA binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

rRNA processing Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, RNA-binding, rRNA-binding
Biological process	Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6790901 rRNA modification in the nucleus and cytosol R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: U3 small nucleolar ribonucleoprotein protein IMP3 Short name: U3 snoRNP protein IMP3 Alternative name(s): BRMS2
Gene namesⁱ	Name:IMP3 Synonyms:C15orf12, MRPS4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000177971.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14497 IMP3
MIMⁱ	612980 gene
neXtProtⁱ	NX_Q9NV31

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55272
Open Targets More...OpenTargetsⁱ	ENSG00000177971
PharmGKBⁱ	PA25517

Polymorphism and mutation databases

BioMutaⁱ	IMP3
DMDMⁱ	52783099

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000132709	1 – 184	U3 small nucleolar ribonucleoprotein protein IMP3Add BLAST		184

Proteomic databases

EPDⁱ	Q9NV31
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NV31
PaxDbⁱ	Q9NV31
PeptideAtlas More...PeptideAtlasⁱ	Q9NV31
PRIDEⁱ	Q9NV31
ProteomicsDBⁱ	82742

PTM databases

iPTMnetⁱ	Q9NV31
PhosphoSitePlusⁱ	Q9NV31
SwissPalmⁱ	Q9NV31

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000177971
CleanExⁱ	HS_IMP3
Genevisibleⁱ	Q9NV31 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA060955 HPA061177

HPAⁱ

HPA060955
HPA061177

Interactionⁱ

Subunit structureⁱ

Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CCNDBP1	O95273	5	EBI-747481,EBI-748961
KLC3	Q6P597	3	EBI-747481,EBI-1643885
TFIP11	Q9UBB9	3	EBI-747481,EBI-1105213
USHBP1	Q8N6Y0	5	EBI-747481,EBI-739895
ZYX	Q15942	5	EBI-747481,EBI-444225

Show more details

Protein-protein interaction databases

BioGridⁱ	120560, 45 interactors
CORUMⁱ	Q9NV31
IntActⁱ	Q9NV31, 22 interactors
Molecular INTeraction database More...MINTⁱ	Q9NV31
STRINGⁱ	9606.ENSP00000326981

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	111 – 117	Combined sources	7
Beta strandⁱ	121 – 123	Combined sources	3
Helixⁱ	124 – 132	Combined sources	9
Beta strandⁱ	136 – 138	Combined sources	3
Beta strandⁱ	149 – 151	Combined sources	3
Helixⁱ	152 – 155	Combined sources	4
Beta strandⁱ	158 – 161	Combined sources	4
Beta strandⁱ	164 – 166	Combined sources	3

3D structure databases

ProteinModelPortalⁱ	Q9NV31
SMRⁱ	Q9NV31
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9NV31

EvolutionaryTraceⁱ

Q9NV31

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	109 – 175	S4 RNA-bindingPROSITE-ProRule annotationAdd BLAST		67

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	32 – 74	Arg-richAdd BLAST		43

Sequence similaritiesⁱ

Belongs to the universal ribosomal protein uS4 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4655 Eukaryota COG0522 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000075090
HOGENOMⁱ	HOG000213883
HOVERGENⁱ	HBG052121
InParanoidⁱ	Q9NV31
KEGG Orthology (KO) More...KOⁱ	K14560
OMAⁱ	KVDFLNW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QKK
PhylomeDBⁱ	Q9NV31
TreeFamⁱ	TF300149

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00165 S4, 1 hit
Gene3Dⁱ	3.10.290.10, 1 hit
InterProⁱ	View protein in InterPro IPR022801 Ribosomal_S4/S9 IPR001912 Ribosomal_S4/S9_N IPR002942 S4_RNA-bd IPR036986 S4_RNA-bd_sf
PANTHERⁱ	PTHR11831 PTHR11831, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00163 Ribosomal_S4, 1 hit PF01479 S4, 1 hit
SMARTⁱ	View protein in SMART SM01390 Ribosomal_S4, 1 hit SM00363 S4, 1 hit
PROSITEⁱ	View protein in PROSITE PS50889 S4, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9NV31-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVRKLKFHEQ KLLKQVDFLN WEVTDHNLHE LRVLRRYRLQ RREDYTRYNQ 
        60         70         80         90        100
LSRAVRELAR RLRDLPERDQ FRVRASAALL DKLYALGLVP TRGSLELCDF 
       110        120        130        140        150
VTASSFCRRR LPTVLLKLRM AQHLQAAVAF VEQGHVRVGP DVVTDPAFLV 
       160        170        180 
TRSMEDFVTW VDSSKIKRHV LEYNEERDDF DLEA

Length:184

Mass (Da):21,850

Last modified:October 1, 2000 - v1

Checksum:ⁱAAE0352DF7C790F1

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	15	Q → R in BAD96841 (Ref. 4) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY050497 mRNA Translation: AAL06639.1 AL136913 mRNA Translation: CAB66847.1 AK001830 mRNA Translation: BAA91929.1 AK057531 mRNA Translation: BAG51929.1 AK223121 mRNA Translation: BAD96841.1 CH471136 Genomic DNA Translation: EAW99244.1 BC006487 mRNA Translation: AAH06487.1 BC011745 mRNA Translation: AAH11745.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10282.1
NCBI Reference Sequences More...RefSeqⁱ	NP_060755.1, NM_018285.3
UniGeneⁱ	Hs.513043

Genome annotation databases

Ensemblⁱ	ENST00000314852; ENSP00000326981; ENSG00000177971 ENST00000403490; ENSP00000385217; ENSG00000177971
GeneIDⁱ	55272
KEGGⁱ	hsa:55272
UCSC genome browser More...UCSCⁱ	uc002bat.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9NV31	IMP3 isoform 1		PANTR		184
IMP3, U3 small nucleolar ribonucleoprotein		MACMU		184
IMP3, U3 small nucleolar ribonucleoprotein		MACFA		184
IMP3, U3 small nucleolar ribonucleoprotein		COLAP		184
IMP3, U3 small nucleolar ribonucleoprotein		CERAT		184
+5

Protein	Similar proteins		Species	Score	Length
Q9NV31	IMP3 isoform 1		PANTR		184
IMP3, U3 small nucleolar ribonucleoprotein		MACMU		184
IMP3, U3 small nucleolar ribonucleoprotein		MACFA		184
IMP3, U3 small nucleolar ribonucleoprotein		COLAP		184
IMP3, U3 small nucleolar ribonucleoprotein		CERAT		184
+70

Protein	Similar proteins		Species	Score	Length
Q9NV31	IMP3 isoform 1		PANTR		184
IMP3, U3 small nucleolar ribonucleoprotein		MACMU		184
IMP3, U3 small nucleolar ribonucleoprotein		MACFA		184
IMP3, U3 small nucleolar ribonucleoprotein		COLAP		184
IMP3, U3 small nucleolar ribonucleoprotein		CERAT		184
+200

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY050497 mRNA Translation: AAL06639.1 AL136913 mRNA Translation: CAB66847.1 AK001830 mRNA Translation: BAA91929.1 AK057531 mRNA Translation: BAG51929.1 AK223121 mRNA Translation: BAD96841.1 CH471136 Genomic DNA Translation: EAW99244.1 BC006487 mRNA Translation: AAH06487.1 BC011745 mRNA Translation: AAH11745.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10282.1
NCBI Reference Sequences More...RefSeqⁱ	NP_060755.1, NM_018285.3
UniGeneⁱ	Hs.513043

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CQJ	NMR	-	A	109-166	[»]
ProteinModelPortalⁱ	Q9NV31
SMRⁱ	Q9NV31
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120560, 45 interactors
CORUMⁱ	Q9NV31
IntActⁱ	Q9NV31, 22 interactors
Molecular INTeraction database More...MINTⁱ	Q9NV31
STRINGⁱ	9606.ENSP00000326981

PTM databases

iPTMnetⁱ	Q9NV31
PhosphoSitePlusⁱ	Q9NV31
SwissPalmⁱ	Q9NV31

Polymorphism and mutation databases

BioMutaⁱ	IMP3
DMDMⁱ	52783099

Proteomic databases

EPDⁱ	Q9NV31
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NV31
PaxDbⁱ	Q9NV31
PeptideAtlas More...PeptideAtlasⁱ	Q9NV31
PRIDEⁱ	Q9NV31
ProteomicsDBⁱ	82742

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	55272
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000314852; ENSP00000326981; ENSG00000177971 ENST00000403490; ENSP00000385217; ENSG00000177971
GeneIDⁱ	55272
KEGGⁱ	hsa:55272
UCSC genome browser More...UCSCⁱ	uc002bat.3 human

Organism-specific databases

CTDⁱ	55272
DisGeNET More...DisGeNETⁱ	55272
EuPathDBⁱ	HostDB:ENSG00000177971.8
GeneCardsⁱ	IMP3
H-InvDBⁱ	HIX0172858
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14497 IMP3
Human Protein Atlas More...HPAⁱ	HPA060955 HPA061177
MIMⁱ	612980 gene
neXtProtⁱ	NX_Q9NV31
Open Targets More...OpenTargetsⁱ	ENSG00000177971
PharmGKBⁱ	PA25517
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4655 Eukaryota COG0522 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000075090
HOGENOMⁱ	HOG000213883
HOVERGENⁱ	HBG052121
InParanoidⁱ	Q9NV31
KEGG Orthology (KO) More...KOⁱ	K14560
OMAⁱ	KVDFLNW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QKK
PhylomeDBⁱ	Q9NV31
TreeFamⁱ	TF300149

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6790901 rRNA modification in the nucleus and cytosol R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSⁱ	IMP3 human
EvolutionaryTraceⁱ	Q9NV31
GeneWikiⁱ	IMP3
GenomeRNAiⁱ	55272
Protein Ontology More...PROⁱ	PR:Q9NV31
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000177971
CleanExⁱ	HS_IMP3
Genevisibleⁱ	Q9NV31 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00165 S4, 1 hit
Gene3Dⁱ	3.10.290.10, 1 hit
InterProⁱ	View protein in InterPro IPR022801 Ribosomal_S4/S9 IPR001912 Ribosomal_S4/S9_N IPR002942 S4_RNA-bd IPR036986 S4_RNA-bd_sf
PANTHERⁱ	PTHR11831 PTHR11831, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00163 Ribosomal_S4, 1 hit PF01479 S4, 1 hit
SMARTⁱ	View protein in SMART SM01390 Ribosomal_S4, 1 hit SM00363 S4, 1 hit
PROSITEⁱ	View protein in PROSITE PS50889 S4, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IMP3_HUMAN
Accessionⁱ	Q9NV31Primary (citable) accession number: Q9NV31 Secondary accession number(s): B3KQ67, Q53G10
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
	Last sequence update:	October 1, 2000
	Last modified:	July 18, 2018
	This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Ribosomal proteins
Ribosomal proteins families and list of entries
SIMILARITY comments
Index of protein domains and families

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UniRef

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Supporting data

UniProtKB - Q9NV31 (IMP3_HUMAN)

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U3 small nucleolar ribonucleoprotein protein IMP3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ