UniProtKB - Q9NV31 (IMP3_HUMAN)
Protein
U3 small nucleolar ribonucleoprotein protein IMP3
Gene
IMP3
Organism
Homo sapiens (Human)
Status
Functioni
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.1 Publication
GO - Molecular functioni
- RNA binding Source: UniProtKB
- rRNA binding Source: UniProtKB-KW
- snoRNA binding Source: GO_Central
GO - Biological processi
- rRNA processing Source: GO_Central
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding, rRNA-binding |
Biological process | Ribosome biogenesis, rRNA processing |
Enzyme and pathway databases
PathwayCommonsi | Q9NV31 |
Reactomei | R-HSA-6790901, rRNA modification in the nucleus and cytosol R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
SIGNORi | Q9NV31 |
Names & Taxonomyi
Protein namesi | Recommended name: U3 small nucleolar ribonucleoprotein protein IMP3Short name: U3 snoRNP protein IMP3 Alternative name(s): BRMS2 |
Gene namesi | Name:IMP3 Synonyms:C15orf12, MRPS4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000177971.8 |
HGNCi | HGNC:14497, IMP3 |
MIMi | 612980, gene |
neXtProti | NX_Q9NV31 |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
Nucleus
- Mpp10 complex Source: MGI
- nucleolus Source: HGNC-UCL
- nucleoplasm Source: HPA
- nucleus Source: LIFEdb
Other locations
- preribosome Source: MGI
- small-subunit processome Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 55272 |
OpenTargetsi | ENSG00000177971 |
PharmGKBi | PA25517 |
Miscellaneous databases
Pharosi | Q9NV31, Tbio |
Polymorphism and mutation databases
BioMutai | IMP3 |
DMDMi | 52783099 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000132709 | 1 – 184 | U3 small nucleolar ribonucleoprotein protein IMP3Add BLAST | 184 |
Proteomic databases
EPDi | Q9NV31 |
jPOSTi | Q9NV31 |
MassIVEi | Q9NV31 |
MaxQBi | Q9NV31 |
PaxDbi | Q9NV31 |
PeptideAtlasi | Q9NV31 |
PRIDEi | Q9NV31 |
ProteomicsDBi | 82742 |
PTM databases
iPTMneti | Q9NV31 |
PhosphoSitePlusi | Q9NV31 |
SwissPalmi | Q9NV31 |
Expressioni
Gene expression databases
Bgeei | ENSG00000177971, Expressed in prostate gland and 237 other tissues |
Genevisiblei | Q9NV31, HS |
Organism-specific databases
HPAi | ENSG00000177971, Low tissue specificity |
Interactioni
Subunit structurei
Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10.
Interacts with MPHOSPH10.
1 PublicationBinary interactionsi
Hide detailsQ9NV31
Protein-protein interaction databases
BioGRIDi | 120560, 60 interactors |
CORUMi | Q9NV31 |
IntActi | Q9NV31, 30 interactors |
MINTi | Q9NV31 |
STRINGi | 9606.ENSP00000326981 |
Miscellaneous databases
RNActi | Q9NV31, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9NV31 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NV31 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 109 – 175 | S4 RNA-bindingPROSITE-ProRule annotationAdd BLAST | 67 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 32 – 74 | Arg-richAdd BLAST | 43 |
Sequence similaritiesi
Belongs to the universal ribosomal protein uS4 family.Curated
Phylogenomic databases
eggNOGi | KOG4655, Eukaryota |
GeneTreei | ENSGT00550000075090 |
HOGENOMi | CLU_097281_0_0_1 |
InParanoidi | Q9NV31 |
OMAi | TRHMEDF |
OrthoDBi | 1336285at2759 |
PhylomeDBi | Q9NV31 |
TreeFami | TF300149 |
Family and domain databases
CDDi | cd00165, S4, 1 hit |
Gene3Di | 3.10.290.10, 1 hit |
InterProi | View protein in InterPro IPR022801, Ribosomal_S4/S9 IPR001912, Ribosomal_S4/S9_N IPR002942, S4_RNA-bd IPR036986, S4_RNA-bd_sf |
PANTHERi | PTHR11831, PTHR11831, 1 hit |
Pfami | View protein in Pfam PF00163, Ribosomal_S4, 1 hit PF01479, S4, 1 hit |
SMARTi | View protein in SMART SM01390, Ribosomal_S4, 1 hit SM00363, S4, 1 hit |
PROSITEi | View protein in PROSITE PS50889, S4, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9NV31-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVRKLKFHEQ KLLKQVDFLN WEVTDHNLHE LRVLRRYRLQ RREDYTRYNQ
60 70 80 90 100
LSRAVRELAR RLRDLPERDQ FRVRASAALL DKLYALGLVP TRGSLELCDF
110 120 130 140 150
VTASSFCRRR LPTVLLKLRM AQHLQAAVAF VEQGHVRVGP DVVTDPAFLV
160 170 180
TRSMEDFVTW VDSSKIKRHV LEYNEERDDF DLEA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 15 | Q → R in BAD96841 (Ref. 4) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY050497 mRNA Translation: AAL06639.1 AL136913 mRNA Translation: CAB66847.1 AK001830 mRNA Translation: BAA91929.1 AK057531 mRNA Translation: BAG51929.1 AK223121 mRNA Translation: BAD96841.1 CH471136 Genomic DNA Translation: EAW99244.1 BC006487 mRNA Translation: AAH06487.1 BC011745 mRNA Translation: AAH11745.1 |
CCDSi | CCDS10282.1 |
RefSeqi | NP_060755.1, NM_018285.3 |
Genome annotation databases
Ensembli | ENST00000314852; ENSP00000326981; ENSG00000177971 ENST00000403490; ENSP00000385217; ENSG00000177971 |
GeneIDi | 55272 |
KEGGi | hsa:55272 |
UCSCi | uc002bat.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY050497 mRNA Translation: AAL06639.1 AL136913 mRNA Translation: CAB66847.1 AK001830 mRNA Translation: BAA91929.1 AK057531 mRNA Translation: BAG51929.1 AK223121 mRNA Translation: BAD96841.1 CH471136 Genomic DNA Translation: EAW99244.1 BC006487 mRNA Translation: AAH06487.1 BC011745 mRNA Translation: AAH11745.1 |
CCDSi | CCDS10282.1 |
RefSeqi | NP_060755.1, NM_018285.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CQJ | NMR | - | A | 109-166 | [»] | |
SMRi | Q9NV31 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120560, 60 interactors |
CORUMi | Q9NV31 |
IntActi | Q9NV31, 30 interactors |
MINTi | Q9NV31 |
STRINGi | 9606.ENSP00000326981 |
PTM databases
iPTMneti | Q9NV31 |
PhosphoSitePlusi | Q9NV31 |
SwissPalmi | Q9NV31 |
Polymorphism and mutation databases
BioMutai | IMP3 |
DMDMi | 52783099 |
Proteomic databases
EPDi | Q9NV31 |
jPOSTi | Q9NV31 |
MassIVEi | Q9NV31 |
MaxQBi | Q9NV31 |
PaxDbi | Q9NV31 |
PeptideAtlasi | Q9NV31 |
PRIDEi | Q9NV31 |
ProteomicsDBi | 82742 |
Protocols and materials databases
Antibodypediai | 43256, 219 antibodies |
DNASUi | 55272 |
Genome annotation databases
Ensembli | ENST00000314852; ENSP00000326981; ENSG00000177971 ENST00000403490; ENSP00000385217; ENSG00000177971 |
GeneIDi | 55272 |
KEGGi | hsa:55272 |
UCSCi | uc002bat.3, human |
Organism-specific databases
CTDi | 55272 |
DisGeNETi | 55272 |
EuPathDBi | HostDB:ENSG00000177971.8 |
GeneCardsi | IMP3 |
HGNCi | HGNC:14497, IMP3 |
HPAi | ENSG00000177971, Low tissue specificity |
MIMi | 612980, gene |
neXtProti | NX_Q9NV31 |
OpenTargetsi | ENSG00000177971 |
PharmGKBi | PA25517 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4655, Eukaryota |
GeneTreei | ENSGT00550000075090 |
HOGENOMi | CLU_097281_0_0_1 |
InParanoidi | Q9NV31 |
OMAi | TRHMEDF |
OrthoDBi | 1336285at2759 |
PhylomeDBi | Q9NV31 |
TreeFami | TF300149 |
Enzyme and pathway databases
PathwayCommonsi | Q9NV31 |
Reactomei | R-HSA-6790901, rRNA modification in the nucleus and cytosol R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
SIGNORi | Q9NV31 |
Miscellaneous databases
BioGRID-ORCSi | 55272, 743 hits in 850 CRISPR screens |
ChiTaRSi | IMP3, human |
EvolutionaryTracei | Q9NV31 |
GeneWikii | IMP3 |
GenomeRNAii | 55272 |
Pharosi | Q9NV31, Tbio |
PROi | PR:Q9NV31 |
RNActi | Q9NV31, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177971, Expressed in prostate gland and 237 other tissues |
Genevisiblei | Q9NV31, HS |
Family and domain databases
CDDi | cd00165, S4, 1 hit |
Gene3Di | 3.10.290.10, 1 hit |
InterProi | View protein in InterPro IPR022801, Ribosomal_S4/S9 IPR001912, Ribosomal_S4/S9_N IPR002942, S4_RNA-bd IPR036986, S4_RNA-bd_sf |
PANTHERi | PTHR11831, PTHR11831, 1 hit |
Pfami | View protein in Pfam PF00163, Ribosomal_S4, 1 hit PF01479, S4, 1 hit |
SMARTi | View protein in SMART SM01390, Ribosomal_S4, 1 hit SM00363, S4, 1 hit |
PROSITEi | View protein in PROSITE PS50889, S4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IMP3_HUMAN | |
Accessioni | Q9NV31Primary (citable) accession number: Q9NV31 Secondary accession number(s): B3KQ67, Q53G10 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2004 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Ribosomal proteins
Ribosomal proteins families and list of entries