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Protein

U3 small nucleolar ribonucleoprotein protein IMP3

Gene

IMP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.1 Publication

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • rRNA binding Source: UniProtKB-KW
  • snoRNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding, rRNA-binding
Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar ribonucleoprotein protein IMP3
Short name:
U3 snoRNP protein IMP3
Alternative name(s):
BRMS2
Gene namesi
Name:IMP3
Synonyms:C15orf12, MRPS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000177971.8
HGNCiHGNC:14497 IMP3
MIMi612980 gene
neXtProtiNX_Q9NV31

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55272
OpenTargetsiENSG00000177971
PharmGKBiPA25517

Polymorphism and mutation databases

BioMutaiIMP3
DMDMi52783099

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001327091 – 184U3 small nucleolar ribonucleoprotein protein IMP3Add BLAST184

Proteomic databases

EPDiQ9NV31
MaxQBiQ9NV31
PaxDbiQ9NV31
PeptideAtlasiQ9NV31
PRIDEiQ9NV31
ProteomicsDBi82742

PTM databases

iPTMnetiQ9NV31
PhosphoSitePlusiQ9NV31
SwissPalmiQ9NV31

Expressioni

Gene expression databases

BgeeiENSG00000177971 Expressed in 225 organ(s), highest expression level in prostate gland
CleanExiHS_IMP3
GenevisibleiQ9NV31 HS

Organism-specific databases

HPAiHPA060955
HPA061177

Interactioni

Subunit structurei

Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi120560, 45 interactors
CORUMiQ9NV31
IntActiQ9NV31, 23 interactors
MINTiQ9NV31
STRINGi9606.ENSP00000326981

Structurei

Secondary structure

1184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NV31
SMRiQ9NV31
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NV31

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 175S4 RNA-bindingPROSITE-ProRule annotationAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 74Arg-richAdd BLAST43

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4655 Eukaryota
COG0522 LUCA
GeneTreeiENSGT00550000075090
HOGENOMiHOG000213883
HOVERGENiHBG052121
InParanoidiQ9NV31
KOiK14560
OMAiKYNKICG
OrthoDBiEOG091G0QKK
PhylomeDBiQ9NV31
TreeFamiTF300149

Family and domain databases

CDDicd00165 S4, 1 hit
Gene3Di3.10.290.10, 1 hit
InterProiView protein in InterPro
IPR022801 Ribosomal_S4/S9
IPR001912 Ribosomal_S4/S9_N
IPR002942 S4_RNA-bd
IPR036986 S4_RNA-bd_sf
PANTHERiPTHR11831 PTHR11831, 1 hit
PfamiView protein in Pfam
PF00163 Ribosomal_S4, 1 hit
PF01479 S4, 1 hit
SMARTiView protein in SMART
SM01390 Ribosomal_S4, 1 hit
SM00363 S4, 1 hit
PROSITEiView protein in PROSITE
PS50889 S4, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NV31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRKLKFHEQ KLLKQVDFLN WEVTDHNLHE LRVLRRYRLQ RREDYTRYNQ
60 70 80 90 100
LSRAVRELAR RLRDLPERDQ FRVRASAALL DKLYALGLVP TRGSLELCDF
110 120 130 140 150
VTASSFCRRR LPTVLLKLRM AQHLQAAVAF VEQGHVRVGP DVVTDPAFLV
160 170 180
TRSMEDFVTW VDSSKIKRHV LEYNEERDDF DLEA
Length:184
Mass (Da):21,850
Last modified:October 1, 2000 - v1
Checksum:iAAE0352DF7C790F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15Q → R in BAD96841 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050497 mRNA Translation: AAL06639.1
AL136913 mRNA Translation: CAB66847.1
AK001830 mRNA Translation: BAA91929.1
AK057531 mRNA Translation: BAG51929.1
AK223121 mRNA Translation: BAD96841.1
CH471136 Genomic DNA Translation: EAW99244.1
BC006487 mRNA Translation: AAH06487.1
BC011745 mRNA Translation: AAH11745.1
CCDSiCCDS10282.1
RefSeqiNP_060755.1, NM_018285.3
UniGeneiHs.513043

Genome annotation databases

EnsembliENST00000314852; ENSP00000326981; ENSG00000177971
ENST00000403490; ENSP00000385217; ENSG00000177971
GeneIDi55272
KEGGihsa:55272
UCSCiuc002bat.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050497 mRNA Translation: AAL06639.1
AL136913 mRNA Translation: CAB66847.1
AK001830 mRNA Translation: BAA91929.1
AK057531 mRNA Translation: BAG51929.1
AK223121 mRNA Translation: BAD96841.1
CH471136 Genomic DNA Translation: EAW99244.1
BC006487 mRNA Translation: AAH06487.1
BC011745 mRNA Translation: AAH11745.1
CCDSiCCDS10282.1
RefSeqiNP_060755.1, NM_018285.3
UniGeneiHs.513043

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQJNMR-A109-166[»]
ProteinModelPortaliQ9NV31
SMRiQ9NV31
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120560, 45 interactors
CORUMiQ9NV31
IntActiQ9NV31, 23 interactors
MINTiQ9NV31
STRINGi9606.ENSP00000326981

PTM databases

iPTMnetiQ9NV31
PhosphoSitePlusiQ9NV31
SwissPalmiQ9NV31

Polymorphism and mutation databases

BioMutaiIMP3
DMDMi52783099

Proteomic databases

EPDiQ9NV31
MaxQBiQ9NV31
PaxDbiQ9NV31
PeptideAtlasiQ9NV31
PRIDEiQ9NV31
ProteomicsDBi82742

Protocols and materials databases

DNASUi55272
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314852; ENSP00000326981; ENSG00000177971
ENST00000403490; ENSP00000385217; ENSG00000177971
GeneIDi55272
KEGGihsa:55272
UCSCiuc002bat.3 human

Organism-specific databases

CTDi55272
DisGeNETi55272
EuPathDBiHostDB:ENSG00000177971.8
GeneCardsiIMP3
H-InvDBiHIX0172858
HGNCiHGNC:14497 IMP3
HPAiHPA060955
HPA061177
MIMi612980 gene
neXtProtiNX_Q9NV31
OpenTargetsiENSG00000177971
PharmGKBiPA25517
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4655 Eukaryota
COG0522 LUCA
GeneTreeiENSGT00550000075090
HOGENOMiHOG000213883
HOVERGENiHBG052121
InParanoidiQ9NV31
KOiK14560
OMAiKYNKICG
OrthoDBiEOG091G0QKK
PhylomeDBiQ9NV31
TreeFamiTF300149

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiIMP3 human
EvolutionaryTraceiQ9NV31
GeneWikiiIMP3
GenomeRNAii55272
PROiPR:Q9NV31
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177971 Expressed in 225 organ(s), highest expression level in prostate gland
CleanExiHS_IMP3
GenevisibleiQ9NV31 HS

Family and domain databases

CDDicd00165 S4, 1 hit
Gene3Di3.10.290.10, 1 hit
InterProiView protein in InterPro
IPR022801 Ribosomal_S4/S9
IPR001912 Ribosomal_S4/S9_N
IPR002942 S4_RNA-bd
IPR036986 S4_RNA-bd_sf
PANTHERiPTHR11831 PTHR11831, 1 hit
PfamiView protein in Pfam
PF00163 Ribosomal_S4, 1 hit
PF01479 S4, 1 hit
SMARTiView protein in SMART
SM01390 Ribosomal_S4, 1 hit
SM00363 S4, 1 hit
PROSITEiView protein in PROSITE
PS50889 S4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIMP3_HUMAN
AccessioniPrimary (citable) accession number: Q9NV31
Secondary accession number(s): B3KQ67, Q53G10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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