UniProtKB - Q9NV29 (TM100_HUMAN)
Protein
Transmembrane protein 100
Gene
TMEM100
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.By similarity
GO - Biological processi
- angiogenesis Source: Ensembl
- arterial endothelial cell differentiation Source: Ensembl
- BMP signaling pathway Source: UniProtKB
- cellular response to BMP stimulus Source: UniProtKB
- epithelial to mesenchymal transition involved in endocardial cushion formation Source: Ensembl
- in utero embryonic development Source: Ensembl
- Notch signaling pathway Source: Ensembl
- positive regulation of endothelial cell differentiation Source: UniProtKB
- positive regulation of vasculogenesis Source: UniProtKB
- protein kinase B signaling Source: Ensembl
- regulation of calcium-mediated signaling Source: Ensembl
- regulation of sensory perception of pain Source: UniProtKB
- vasculogenesis Source: Ensembl
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation |
Enzyme and pathway databases
PathwayCommonsi | Q9NV29 |
SignaLinki | Q9NV29 |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 100 |
Gene namesi | Name:TMEM100 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000166292.11 |
HGNCi | HGNC:25607, TMEM100 |
MIMi | 616334, gene |
neXtProti | NX_Q9NV29 |
Subcellular locationi
Endoplasmic reticulum
Plasma membrane
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
- Perikaryon
- perinuclear region
Note: Colocalized with HSPA5 in the endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural fibers of the enteric nervous system.
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- perikaryon Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 56 – 76 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 84 – 104 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 55273 |
OpenTargetsi | ENSG00000166292 |
PharmGKBi | PA142670749 |
Miscellaneous databases
Pharosi | Q9NV29, Tbio |
Polymorphism and mutation databases
BioMutai | TMEM100 |
DMDMi | 109895209 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000240846 | 1 – 134 | Transmembrane protein 100Add BLAST | 134 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 121 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q9NV29 |
MassIVEi | Q9NV29 |
PaxDbi | Q9NV29 |
PeptideAtlasi | Q9NV29 |
PRIDEi | Q9NV29 |
ProteomicsDBi | 46810 82741 |
PTM databases
iPTMneti | Q9NV29 |
PhosphoSitePlusi | Q9NV29 |
Expressioni
Tissue specificityi
Expressed in neurons of the myenteric and submucosal plexuses in the gastric body, jejunum and proximal colon. Expressed in arterial endothelial cells and neurons of the central nervous system and peripheral nervous system. Expressed in umbilical artery endothelial cells (at protein level).2 Publications
Inductioni
Up-regulated by GDF2/BMP9 and BMP10 (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000166292, Expressed in right lung and 199 other tissues |
ExpressionAtlasi | Q9NV29, baseline and differential |
Genevisiblei | Q9NV29, HS |
Organism-specific databases
HPAi | ENSG00000166292, Tissue enhanced (breast, lung) |
Interactioni
Subunit structurei
Interacts (via C-terminus) with TRPA1 and TRPV1 (By similarity).
Interacts with TASOR (By similarity).
By similarityBinary interactionsi
Hide detailsQ9NV29
Protein-protein interaction databases
BioGRIDi | 120561, 33 interactors |
IntActi | Q9NV29, 33 interactors |
MINTi | Q9NV29 |
STRINGi | 9606.ENSP00000465638 |
Miscellaneous databases
RNActi | Q9NV29, protein |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RZCB, Eukaryota |
GeneTreei | ENSGT00940000154322 |
InParanoidi | Q9NV29 |
OMAi | ASSAVCW |
OrthoDBi | 1598239at2759 |
PhylomeDBi | Q9NV29 |
TreeFami | TF332068 |
Family and domain databases
InterProi | View protein in InterPro IPR032536, TMEM100 |
PANTHERi | PTHR16100:SF5, PTHR16100:SF5, 1 hit |
Pfami | View protein in Pfam PF16311, TMEM100, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9NV29-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEEPIKEIL GAPKAHMAAT MEKSPKSEVV ITTVPLVSEI QLMAATGGTE
60 70 80 90 100
LSCYRCIIPF AVVVFIAGIV VTAVAYSFNS HGSIISIFGL VVLSSGLFLL
110 120 130
ASSALCWKVR QRSKKAKRRE SQTALVANQR SLFA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MTR3 | A0A0A0MTR3_HUMAN | Transmembrane protein 100 | TMEM100 | 129 | Annotation score: |
Sequence cautioni
The sequence AC009837 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 133 | F → S in BAA91931 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001832 mRNA Translation: BAA91931.1 AC009837 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94537.1 CH471109 Genomic DNA Translation: EAW94538.1 CH471109 Genomic DNA Translation: EAW94539.1 BC010128 mRNA Translation: AAH10128.1 |
CCDSi | CCDS11587.1 |
RefSeqi | NP_001093110.1, NM_001099640.1 NP_060756.2, NM_018286.2 XP_016880303.1, XM_017024814.1 XP_016880304.1, XM_017024815.1 XP_016880305.1, XM_017024816.1 |
Genome annotation databases
Ensembli | ENST00000424486; ENSP00000395328; ENSG00000166292 ENST00000575734; ENSP00000465638; ENSG00000166292 |
GeneIDi | 55273 |
KEGGi | hsa:55273 |
UCSCi | uc002iuj.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001832 mRNA Translation: BAA91931.1 AC009837 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94537.1 CH471109 Genomic DNA Translation: EAW94538.1 CH471109 Genomic DNA Translation: EAW94539.1 BC010128 mRNA Translation: AAH10128.1 |
CCDSi | CCDS11587.1 |
RefSeqi | NP_001093110.1, NM_001099640.1 NP_060756.2, NM_018286.2 XP_016880303.1, XM_017024814.1 XP_016880304.1, XM_017024815.1 XP_016880305.1, XM_017024816.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120561, 33 interactors |
IntActi | Q9NV29, 33 interactors |
MINTi | Q9NV29 |
STRINGi | 9606.ENSP00000465638 |
PTM databases
iPTMneti | Q9NV29 |
PhosphoSitePlusi | Q9NV29 |
Polymorphism and mutation databases
BioMutai | TMEM100 |
DMDMi | 109895209 |
Proteomic databases
jPOSTi | Q9NV29 |
MassIVEi | Q9NV29 |
PaxDbi | Q9NV29 |
PeptideAtlasi | Q9NV29 |
PRIDEi | Q9NV29 |
ProteomicsDBi | 46810 82741 |
Protocols and materials databases
Antibodypediai | 56967, 158 antibodies |
Genome annotation databases
Ensembli | ENST00000424486; ENSP00000395328; ENSG00000166292 ENST00000575734; ENSP00000465638; ENSG00000166292 |
GeneIDi | 55273 |
KEGGi | hsa:55273 |
UCSCi | uc002iuj.5, human |
Organism-specific databases
CTDi | 55273 |
DisGeNETi | 55273 |
EuPathDBi | HostDB:ENSG00000166292.11 |
GeneCardsi | TMEM100 |
HGNCi | HGNC:25607, TMEM100 |
HPAi | ENSG00000166292, Tissue enhanced (breast, lung) |
MIMi | 616334, gene |
neXtProti | NX_Q9NV29 |
OpenTargetsi | ENSG00000166292 |
PharmGKBi | PA142670749 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RZCB, Eukaryota |
GeneTreei | ENSGT00940000154322 |
InParanoidi | Q9NV29 |
OMAi | ASSAVCW |
OrthoDBi | 1598239at2759 |
PhylomeDBi | Q9NV29 |
TreeFami | TF332068 |
Enzyme and pathway databases
PathwayCommonsi | Q9NV29 |
SignaLinki | Q9NV29 |
Miscellaneous databases
BioGRID-ORCSi | 55273, 4 hits in 844 CRISPR screens |
ChiTaRSi | TMEM100, human |
GenomeRNAii | 55273 |
Pharosi | Q9NV29, Tbio |
PROi | PR:Q9NV29 |
RNActi | Q9NV29, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166292, Expressed in right lung and 199 other tissues |
ExpressionAtlasi | Q9NV29, baseline and differential |
Genevisiblei | Q9NV29, HS |
Family and domain databases
InterProi | View protein in InterPro IPR032536, TMEM100 |
PANTHERi | PTHR16100:SF5, PTHR16100:SF5, 1 hit |
Pfami | View protein in Pfam PF16311, TMEM100, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM100_HUMAN | |
Accessioni | Q9NV29Primary (citable) accession number: Q9NV29 Secondary accession number(s): D3DTY7, I3L214, Q96FZ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | June 27, 2006 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM